{"id":515,"date":"2026-05-05T14:05:10","date_gmt":"2026-05-05T05:05:10","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=515"},"modified":"2026-05-05T14:05:11","modified_gmt":"2026-05-05T05:05:11","slug":"rm12-%e7%ac%ac%e5%8d%81%e4%ba%8c%e7%ab%a0-%e5%91%bc%e5%90%b8%e5%99%a8%e5%86%85%e7%a7%91","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=515","title":{"rendered":"RM12. \u7b2c\u5341\u4e8c\u7ae0 \u547c\u5438\u5668\u5185\u79d1"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM12. \u7b2c\u5341\u4e8c\u7ae0 \u547c\u5438\u5668\u5185\u79d1\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/U9i02bNdn9Q?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" 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class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u672c\u6587\u66f8\u306f\u3001\u547c\u5438\u5668\u75be\u60a3\uff08\u7279\u306bARDS\u3001COPD\u3001IPF\uff09\u306b\u5bfe\u3059\u308b\u518d\u751f\u533b\u7642\u306e\u73fe\u72b6\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3001\u54c1\u8cea\u7ba1\u7406\u57fa\u6e96\u3001\u304a\u3088\u3073\u502b\u7406\u7684\u8ab2\u984c\u306b\u3064\u3044\u3066\u5305\u62ec\u7684\u306b\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u73fe\u5728\u306e\u547c\u5438\u5668\u5185\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306e\u6700\u524d\u7dda\u3067\u306f\u3001\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u3084\u7d30\u80de\u5916\u5c0f\u80de\uff08EV\uff09\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001ARDS\u3092\u5bfe\u8c61\u3068\u3057\u305fSTAT\u8a66\u9a13\u304c\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u30cd\u30ac\u30c6\u30a3\u30d6\u306a\u7d50\u679c\u3092\u793a\u3059\u306a\u3069\u3001\u81e8\u5e8a\u5fdc\u7528\u306b\u306f\u4f9d\u7136\u3068\u3057\u3066\u8ab2\u984c\u304c\u6b8b\u308b\u3002\u4e00\u65b9\u3067\u3001\u65e5\u672c\u518d\u751f\u533b\u7642\u5b66\u4f1a\uff08JSRM\uff09\u306b\u3088\u308bEV\u30ac\u30a4\u30c0\u30f3\u30b9\u306e\u767a\u884c\uff082024\u5e74\uff09\u3084\u3001\u7d30\u80de\u751f\u5b58\u7387\uff08Viability\uff09\u7ba1\u7406\u306e\u91cd\u8981\u6027\u306e\u518d\u8a8d\u8b58\u306a\u3069\u3001\u793e\u4f1a\u5b9f\u88c5\u306b\u5411\u3051\u305f\u54c1\u8cea\u7ba1\u7406\u57fa\u6e96\u306e\u6574\u5099\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u904e\u53bb\u306e\u30c8\u30d4\u30c3\u30af\u3068\u3057\u3066Paolo Macchiarini\u306b\u3088\u308b\u4eba\u5de5\u6c17\u7ba1\u79fb\u690d\u306e\u4e0d\u6b63\u4e8b\u4ef6\u3068\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u8ad6\u6587\u64a4\u56de\u30fb\u6709\u7f6a\u5224\u6c7a\u306f\u3001\u518d\u751f\u533b\u7642\u306b\u304a\u3051\u308b\u502b\u7406\u9075\u5b88\u306e\u91cd\u8981\u6027\u3092\u6539\u3081\u3066\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u305f\u3002\u81ea\u7531\u8a3a\u7642\u9818\u57df\u306b\u304a\u3051\u308b\u4e0d\u9069\u5207\u306a\u7d30\u80de\u6cbb\u7642\u306b\u3088\u308b\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3084\u3001FDA\u306b\u3088\u308b\u8b66\u544a\u66f8\u306e\u76f8\u6b21\u3050\u767a\u51fa\u3082\u3001\u4eca\u5f8c\u306e\u898f\u5236\u5bfe\u5fdc\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u8ad6\u70b9\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u4e3b\u8981\u75be\u60a3\u306b\u304a\u3051\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3068\u518d\u751f\u533b\u7642\u306e\u9032\u5c55<\/h2>\n\n\n\n<p>\u547c\u5438\u5668\u75be\u60a3\u306e\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u3001\u518d\u751f\u533b\u7642\u3084\u65b0\u898f\u6cbb\u7642\u6cd5\u3078\u306e\u8a00\u53ca\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1.1 \u6025\u6027\u547c\u5438\u4e0d\u5168\uff08ARDS\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3:<\/strong> \u300cARDS\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32021\u300d\u304a\u3088\u30732023\u5e749\u6708\u306e\u6539\u8a02\u7248\u306b\u57fa\u3065\u304d\u3001\u4f4e\u4e00\u56de\u63db\u6c17\u91cf\uff086 mL\/kg\uff09\u3001\u30d7\u30ed\u30f3\u30dd\u30b8\u30b7\u30e7\u30cb\u30f3\u30b0\uff08\u8179\u81e5\u4f4d\u7642\u6cd5\uff09\u3001ECMO\uff08\u4f53\u5916\u5f0f\u819c\u578b\u4eba\u5de5\u80ba\uff09\u304c\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u518d\u751f\u533b\u7642\u306e\u691c\u8a0e:<\/strong> MSC\u304a\u3088\u3073MSC\u7531\u6765EV\u3001\u3042\u308b\u3044\u306fiPS\u7d30\u80de\u3092\u7528\u3044\u305f\u81e8\u5e8a\u8cea\u554f\uff08CQ\uff09\u304c\u8a2d\u5b9a\u3055\u308c\u3001\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u304c\u6a21\u7d22\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1.2 \u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\uff08COPD\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6700\u65b0\u52d5\u5411:<\/strong> \u300cGOLD 2025 Report\u300d\uff082024\u5e7411\u6708\u516c\u8868\u4e88\u5b9a\uff09\u306b\u304a\u3044\u3066\u3001\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u5019\u88dc\u3068\u3057\u3066dupilumab\uff08IL-4R\u963b\u5bb3\u85ac\uff09\u3084ensifentrine\uff08PDE3\/4\u963b\u5bb3\u85ac\uff09\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u518d\u751f\u533b\u7642:<\/strong> MSC\u3092\u7528\u3044\u305f\u300cREGEND001\u300d\u8a66\u9a13\u306a\u3069\u306e\u81e8\u5e8a\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1.3 \u7279\u767a\u6027\u80ba\u7dda\u7dad\u75c7\uff08IPF\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3:<\/strong> ATS\/ERS\/JRS\/ALAT 2022\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u3001\u9032\u884c\u6027\u80ba\u7dda\u7dad\u75c7\uff08PPF\uff09\u306b\u5bfe\u3059\u308b\u30cb\u30f3\u30c6\u30c0\u30cb\u30d6\u3084\u7d4c\u6c17\u7ba1\u652f\u80ba\u751f\u691c\uff08TBLC\uff09\u306e\u691c\u8a0e\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5148\u7aef\u7814\u7a76:<\/strong> iPS\u7d30\u80de\u7531\u6765\u306e\u80ba\u80de\u4e0a\u76ae\u7d30\u80de\uff08AT2\u7d30\u80de\uff09\u79fb\u690d\u306b\u5411\u3051\u305f\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u81e8\u5e8a\u8a66\u9a13\u306e\u6700\u65b0\u7d50\u679c\u3068\u5206\u6790<\/h2>\n\n\n\n<p>MSC\u304a\u3088\u3073EV\u3092\u7528\u3044\u305f\u4e3b\u8981\u306a\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u518d\u751f\u533b\u7642\u306e\u6709\u52b9\u6027\u3068\u9650\u754c\u3092\u540c\u6642\u306b\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 STAT\u8a66\u9a13\uff08ARDS\u5bfe\u8c61\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d50\u679c:<\/strong> 2025\u5e747\u6708\u306b\u516c\u8868\u3055\u308c\u305f\u7b2c2b\u76f8\u8a66\u9a13\u7d50\u679c\u306b\u3088\u308b\u3068\u3001ARDS\u60a3\u8005120\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305fBM-MSC\uff08\u9aa8\u9ac4\u7531\u6765MSC\uff09\u6295\u4e0e\u306f\u3001\u507d\u85ac\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u4eba\u5de5\u547c\u5438\u5668\u96e2\u8131\u65e5\u6570\uff08VFD\uff09\u306b\u304a\u3044\u3066\u6709\u610f\u5dee\u3092\u793a\u305b\u305a\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30cd\u30ac\u30c6\u30a3\u30d6\uff08\u9670\u6027\uff09\u3067\u3042\u3063\u305f\u3002<\/li>\n\n\n\n<li><strong>\u793a\u5506:<\/strong> 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2026\u5e74\u7b2c4\u56db\u534a\u671f\u306b\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u5b8c\u4e86\u3092\u4e88\u5b9a\u3002\u7b2c2\u76f8\u8a66\u9a13\u3067\u306fCOVID-ARDS\u60a3\u8005\u306e\u751f\u5b58\u7387\u306b\u304a\u3044\u3066\u4e00\u5b9a\u306e\u6539\u5584\u50be\u5411\uff08RR 0.423\uff09\u304c\u898b\u3089\u308c\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 \u65e5\u672c\u306b\u304a\u3051\u308b\u52d5\u5411\uff08Healios\u793e\u7b49\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ONE-BRIDGE\u8a66\u9a13:<\/strong> ARDS\u306b\u5bfe\u3059\u308bMultiStem\uff08HLCM051\uff09\u306e\u7b2c2\u76f8\u8a66\u9a13\u3002<\/li>\n\n\n\n<li><strong>REVIVE-ARDS\u8a66\u9a13:<\/strong> \u7b2c3\u76f8\u8a66\u9a13\u306b\u5411\u3051\u305fFDA\u3068\u306e\u5354\u8b70\uff08Type B\/EOP2\uff09\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3. 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class=\"wp-block-heading\">3.2 \u52b9\u529b\u8a66\u9a13\uff08Potency Assay\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ISCT\uff08\u56fd\u969b\u7d30\u80de\u6cbb\u7642\u5b66\u4f1a\uff09\u306e\u57fa\u6e96\u306b\u57fa\u3065\u304d\u3001IDO\u6d3b\u6027\u3001IL-10\u5206\u6ccc\u3001MLR\uff08\u6df7\u5408\u30ea\u30f3\u30d1\u7403\u8a66\u9a13\uff09\u306a\u3069\u3001\u514d\u75ab\u8abf\u7bc0\u80fd\u3092\u53cd\u6620\u3059\u308b\u8907\u6570\u306e\u6307\u6a19\uff08Matrix approach\uff09\u3092\u5b9f\u88c5\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 \u7d30\u80de\u5916\u5c0f\u80de\uff08EV\uff09\u306e\u7ba1\u7406<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>JSRM EV\u30ac\u30a4\u30c0\u30f3\u30b9\uff082024\u5e74\uff09:<\/strong> 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