{"id":503,"date":"2026-05-05T13:54:38","date_gmt":"2026-05-05T04:54:38","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=503"},"modified":"2026-05-05T13:54:39","modified_gmt":"2026-05-05T04:54:39","slug":"rm09-%e7%ac%ac%e4%b9%9d%e7%ab%a0-%e5%86%85%e5%88%86%e6%b3%8c%e5%86%85%e7%a7%91%e3%83%bb%e7%b3%96%e5%b0%bf%e7%97%85%e7%a7%91","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=503","title":{"rendered":"RM09.\u7b2c\u4e5d\u7ae0 \u5185\u5206\u6ccc\u5185\u79d1\u30fb\u7cd6\u5c3f\u75c5\u79d1"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM09.\u7b2c\u4e5d\u7ae0 \u5185\u5206\u6ccc\u5185\u79d1\u30fb\u7cd6\u5c3f\u75c5\u79d1\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/rqNGqNT2aaw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6NTA0LCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9STTA5Llx1N2IyY1x1NGU1ZFx1N2FlMC1cdTUxODVcdTUyMDZcdTZjY2NcdTUxODVcdTc5ZDFcdTMwZmJcdTdjZDZcdTVjM2ZcdTc1YzVcdTc5ZDEucGRmIiwiaW5kZXgiOjF9\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"504\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u7cd6\u5c3f\u75c5\u9818\u57df\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u3068\u6700\u65b0\u6cbb\u7642\u306e\u52d5\u5411\u306b\u95a2\u3059\u308b\u30d6\u30ea\u30fc\u30d5\u30a3\u30f3\u30b0\u30fb\u30c9\u30ad\u30e5\u30e1\u30f3\u30c8<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u672c\u8cc7\u6599\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u7279\u306b1\u578b\u7cd6\u5c3f\u75c5\uff08T1D\uff09\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u6027\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\uff08DPN\uff09\u306b\u5bfe\u3059\u308b\u518d\u751f\u533b\u7642\u304a\u3088\u3073\u5148\u7aef\u6cbb\u7642\u306e\u73fe\u72b6\u3092\u5305\u62ec\u7684\u306b\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>1\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u3001\u5f93\u6765\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u88dc\u5145\u7642\u6cd5\u304b\u3089\u3001\u81b5\u5cf6\u79fb\u690d\u3084\u5e79\u7d30\u80de\u7531\u6765\u306e\u7d30\u80de\u7642\u6cd5\u306b\u3088\u308b\u300c\u6a5f\u80fd\u7684\u5b8c\u6cbb\u300d\u3078\u3068\u5927\u304d\u304f\u8235\u3092\u5207\u3063\u3066\u3044\u308b\u30022023\u5e74\u306b\u306f\u3001\u4e16\u754c\u521d\u306e1\u578b\u7cd6\u5c3f\u75c5\u5411\u3051\u540c\u7a2e\u81b5\u5cf6\u7d30\u80de\u7642\u6cd5\u300cLantidra\u00ae\u300d\u304cFDA\u627f\u8a8d\u3092\u53d7\u3051\u3001\u5b9f\u7528\u5316\u306e\u6bb5\u968e\u306b\u5165\u3063\u305f\u3002\u3055\u3089\u306b\u3001Vertex Pharmaceuticals\u3084\u30aa\u30ea\u30ba\u30eb\u30b9\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\uff08Orizuru Therapeutics\uff09\u306a\u3069\u306e\u4f01\u696d\u304c\u3001hESC\uff08\u30d2\u30c8\u80da\u6027\u5e79\u7d30\u80de\uff09\u3084iPS\u7d30\u80de\u3092\u7528\u3044\u305f\u9769\u65b0\u7684\u306a\u7d30\u80de\u7642\u6cd5\u306e\u6cbb\u9a13\u3092\u9032\u3081\u3066\u304a\u308a\u3001\u826f\u597d\u306a\u81e8\u5e8a\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u6cbb\u7642\u306e\u666e\u53ca\u306b\u306f\u300c\u30c9\u30ca\u30fc\u4e0d\u8db3\u306e\u89e3\u6d88\u300d\u300c\u514d\u75ab\u6291\u5236\u5264\u306e\u526f\u4f5c\u7528\u300d\u300c\u30ab\u30d7\u30bb\u30eb\u5316\u6280\u8853\u306b\u3088\u308b\u514d\u75ab\u56de\u907f\u300d\u3068\u3044\u3063\u305f\u8ab2\u984c\u304c\u6b8b\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u3084\u30c7\u30d0\u30a4\u30b9\u958b\u767a\u306e\u53d6\u308a\u7d44\u307f\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u7cd6\u5c3f\u75c5\u306e\u4e3b\u8981\u306a\u5408\u4f75\u75c7\u3067\u3042\u308b\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\uff08DPN\uff09\u306b\u5bfe\u3057\u3066\u3082\u3001PRP\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff09\u7642\u6cd5\u306a\u3069\u306e\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. 1\u578b\u7cd6\u5c3f\u75c5\u306e\u73fe\u72b6\u3068\u6cbb\u7642\u4e0a\u306e\u8ab2\u984c<\/h2>\n\n\n\n<p>1\u578b\u7cd6\u5c3f\u75c5\u306f\u3001\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u308a\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u304c\u7834\u58ca\u3055\u308c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u7d76\u5bfe\u7684\u306b\u6b20\u4e4f\u3059\u308b\u75be\u60a3\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1.1 \u75be\u60a3\u306e\u7279\u5fb4<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0:<\/strong> HLA-DR3\/DR4\u306a\u3069\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3084\u3001GAD\u6297\u4f53\u3001IA-2\u6297\u4f53\u306a\u3069\u306e\u81ea\u5df1\u6297\u4f53\u304c\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u6027:<\/strong> \u751f\u5b58\u306e\u305f\u3081\u306b\u5916\u90e8\u304b\u3089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u88dc\u5145\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u4e0d\u5b89\u5b9a\u578b\u7cd6\u5c3f\u75c5 (Brittle Diabetes):<\/strong> \u8840\u7cd6\u5024\u304c\u6fc0\u3057\u304f\u5909\u52d5\u3057\u3001\u91cd\u75c7\u4f4e\u8840\u7cd6\u3084\u4f4e\u8840\u7cd6\u7121\u81ea\u899a\u75c7\uff08hypoglycemia unawareness\uff09\u3092\u5448\u3059\u308b\u60a3\u8005\u304c\u5b58\u5728\u3057\u3001QOL\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1.2 \u73fe\u884c\u6cbb\u7642\u306e\u9650\u754c<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CGM\/CSII\u306e\u9032\u6b69:<\/strong> \u9023\u7d9a\u8840\u7cd6\u6e2c\u5b9a\uff08CGM\uff09\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u30dd\u30f3\u30d7\uff08CSII\uff09\u306e\u666e\u53ca\u306b\u3088\u308a\u7ba1\u7406\u7cbe\u5ea6\u306f\u5411\u4e0a\u3057\u305f\u304c\u3001\u4f9d\u7136\u3068\u3057\u3066\u81ea\u5df1\u7ba1\u7406\u306e\u8ca0\u62c5\u306f\u91cd\u304f\u3001\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u306f\u6b8b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u81b5\u5cf6\u79fb\u690d\u3068\u300cLantidra\u00ae\u300d\u306e\u627f\u8a8d<\/h2>\n\n\n\n<p>\u81b5\u5cf6\u79fb\u690d\u306f\u3001\u91cd\u75c7\u4f4e\u8840\u7cd6\u3092\u7e70\u308a\u8fd4\u30591\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u3064\u3064\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 \u30a8\u30c9\u30e2\u30f3\u30c8\u30f3\u30fb\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u885d\u6483<\/h3>\n\n\n\n<p>2000\u5e74\u306bShapiro\u3089\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u300c\u30a8\u30c9\u30e2\u30f3\u30c8\u30f3\u30fb\u30d7\u30ed\u30c8\u30b3\u30eb\u300d\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u30d5\u30ea\u30fc\u306e\u514d\u75ab\u6291\u5236\u5264\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u79fb\u690d\u5f8c1\u5e74\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u96e2\u8131\u7387100%\u3092\u9054\u6210\u3057\u3001\u81b5\u5cf6\u79fb\u690d\u306e\u6b74\u53f2\u7684\u8ee2\u63db\u70b9\u3068\u306a\u3063\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 Lantidra\u00ae (donislecel-jujn)<\/h3>\n\n\n\n<p>2023\u5e746\u670828\u65e5\u3001FDA\u306fCellTrans\u793e\u306b\u3088\u308b\u540c\u7a2e\u81b5\u5cf6\u7d30\u80de\u7642\u6cd5\u300cLantidra\u00ae\u300d\u3092\u627f\u8a8d\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bfe\u8c61:<\/strong> \u91cd\u75c7\u4f4e\u8840\u7cd6\u3092\u7e70\u308a\u8fd4\u30591\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002<\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u6210\u7e3e:<\/strong> \u79fb\u690d\u5f8c1\u5e74\u4ee5\u4e0a\u30a4\u30f3\u30b9\u30ea\u30f3\u96e2\u8131\u3092\u9054\u6210\u3057\u305f\u5272\u5408\u306f70%\u306b\u9054\u3057\u30015\u5e74\u4ee5\u4e0a\u7dad\u6301\u3057\u305f\u5272\u5408\u308233%\uff0830\u540d\u4e2d10\u540d\uff09\u306b\u4e0a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8ab2\u984c:<\/strong> \u9ad8\u984d\u306a\u30b3\u30b9\u30c8\uff08\u7d0430\u4e07\u30c9\u30eb\uff09\u3084\u3001\u751f\u6daf\u306b\u308f\u305f\u308b\u514d\u75ab\u6291\u5236\u5264\u306e\u4f7f\u7528\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 CITR (Clinical Islet Transplantation Registry) \u306e\u30c7\u30fc\u30bf<\/h3>\n\n\n\n<p>2025\u5e74\u306e\u6700\u65b0\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u30011999\u5e74\u304b\u30892023\u5e74\u307e\u3067\u306b\u5b9f\u65bd\u3055\u308c\u305f\u79fb\u690d\u306b\u304a\u3044\u3066\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u96e2\u8131\u7387:<\/strong> 1\u5e74\u5f8c\u306740\u301c60%\u30015\u5e74\u5f8c\u3067\u7d0425%\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>C-\u30da\u30d7\u30c1\u30c9\u967d\u6027\u7dad\u6301:<\/strong> \u96e2\u8131\u306b\u81f3\u3089\u306a\u304f\u3066\u3082\u3001C-\u30da\u30d7\u30c1\u30c9\u304c\u967d\u6027\uff08\u5206\u6ccc\u3042\u308a\uff09\u3067\u3042\u308c\u3070\u3001\u8840\u7cd6\u5024\u306e\u5b89\u5b9a\u3084HbA1c\u306e\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u5e79\u7d30\u80de\u7531\u6765\u306e\u7d30\u80de\u7642\u6cd5\uff1a\u6b21\u4e16\u4ee3\u306e\u6311\u6226<\/h2>\n\n\n\n<p>\u30c9\u30ca\u30fc\u4e0d\u8db3\u3092\u89e3\u6d88\u3059\u308b\u305f\u3081\u3001ES\u7d30\u80de\u3084iPS\u7d30\u80de\u304b\u3089\u81b5\u5cf6\u7d30\u80de\uff08ILCs\uff09\u3092\u4f5c\u88fd\u3059\u308b\u6280\u8853\u958b\u767a\u304c\u6025\u901f\u306b\u9032\u5c55\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 Vertex Pharmaceuticals\u306e\u52d5\u5411<\/h3>\n\n\n\n<p>Vertex\u306f\u3001ViaCyte\u793e\u306e\u8cb7\u53ce\uff082022\u5e74\uff09\u3092\u7d4c\u3066\u3001\u3053\u306e\u5206\u91ce\u306e\u30d5\u30ed\u30f3\u30c8\u30e9\u30f3\u30ca\u30fc\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u88fd\u54c1\u30b3\u30fc\u30c9<\/td><td>\u7d30\u80de\u6e90<\/td><td>\u514d\u75ab\u56de\u907f\u6226\u7565<\/td><td>\u30b9\u30c6\u30fc\u30bf\u30b9<\/td><\/tr><tr><td><strong>VX-880<\/strong><\/td><td>hESC<\/td><td>\u514d\u75ab\u6291\u5236\u5264\u4f7f\u7528<\/td><td>Phase I\/II\u3002NEJM 2025\u3067\u306e\u5831\u544a\u3067\u306f\u300112\u540d\u4e2d10\u540d(83%)\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u96e2\u8131\u3092\u9054\u6210\u3002<\/td><\/tr><tr><td><strong>VX-264<\/strong><\/td><td>hESC<\/td><td>\u30ab\u30d7\u30bb\u30eb\u5316\uff08\u7269\u7406\u7684\u906e\u65ad\uff09<\/td><td>\u6cbb\u9a13\u9032\u884c\u4e2d\u3002\u514d\u75ab\u6291\u5236\u5264\u4e0d\u8981\u3092\u76ee\u6307\u3059\u3002<\/td><\/tr><tr><td><strong>VCTX210\/211<\/strong><\/td><td>hESC<\/td><td>\u907a\u4f1d\u5b50\u7de8\u96c6\uff08\u4f4e\u514d\u75ab\u539f\u6027\uff09<\/td><td>CRISPR Therapeutics\u3068\u306e\u5171\u540c\u958b\u767a\u3002HLA\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u7b49\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">3.2 \u30aa\u30ea\u30ba\u30eb\u30b9\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9 (Orizuru Therapeutics)<\/h3>\n\n\n\n<p>\u6b66\u7530\u85ac\u54c1\u5de5\u696d\u3068CiRA\u306e\u5171\u540c\u7814\u7a76\u304b\u3089\u8a95\u751f\u3057\u305f\u65e5\u672c\u767a\u306e\u30d9\u30f3\u30c1\u30e3\u30fc\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OZTx-410:<\/strong> iPS\u7d30\u80de\u7531\u6765\u81b5\u5cf6\u7d30\u80de\uff08iPIC\uff09\u3002<\/li>\n\n\n\n<li><strong>\u9032\u6357:<\/strong> 2025\u5e741\u6708\u306b\u6cbb\u9a13\u5c4a\u3092\u63d0\u51fa\u3057\u30012025\u5e742\u6708\u3088\u308a\u30a4\u30ea\u30ce\u30a4\u5927\u5b66\u75c5\u9662\u306b\u3066\u6cbb\u9a13\u958b\u59cb\u4e88\u5b9a\u3002\u65e5\u672c\u767a\u306eiPS\u7531\u6765\u7d30\u80de\u306b\u3088\u308b\u4e16\u754c\u5c55\u958b\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 ViaCyte\u306e\u88fd\u54c1\u7fa4<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PEC-Direct (VC-02):<\/strong> \u8840\u7ba1\u4fb5\u5165\u3092\u8a31\u5bb9\u3059\u308b\u30c7\u30d0\u30a4\u30b9\u3092\u4f7f\u7528\u3002\u514d\u75ab\u6291\u5236\u5264\u304c\u5fc5\u8981\u3002<\/li>\n\n\n\n<li><strong>PEC-Encap (VC-01):<\/strong> \u7269\u7406\u7684\u306a\u30ab\u30d7\u30bb\u30eb\u5316\uff08\u514d\u75ab\u906e\u65ad\uff09\u3092\u8a66\u307f\u305f\u304c\u3001\u819c\u5468\u56f2\u306e\u7dda\u7dad\u5316\uff08PFO\uff09\u306b\u3088\u308b\u9178\u7d20\u4f9b\u7d66\u4e0d\u8db3\u304c\u8ab2\u984c\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u514d\u75ab\u56de\u907f\u306e\u6226\u7565\u3068\u6280\u8853\u7684\u8ab2\u984c<\/h2>\n\n\n\n<p>\u7d30\u80de\u79fb\u690d\u306b\u304a\u3051\u308b\u6700\u5927\u306e\u969c\u58c1\u306f\u3001\u5bbf\u4e3b\u306e\u514d\u75ab\u62d2\u7d76\u304a\u3088\u3073\u81ea\u5df1\u514d\u75ab\u306e\u518d\u767a\u3067\u3042\u308b\u3002\u73fe\u5728\u30012\u3064\u306e\u4e3b\u8981\u306a\u6226\u7565\u304c\u3068\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">4.1 \u6226\u75651\uff1a\u30ab\u30d7\u30bb\u30eb\u5316 (Macroencapsulation)<\/h3>\n\n\n\n<p>\u534a\u900f\u819c\u5185\u306b\u7d30\u80de\u3092\u5c01\u5165\u3057\u3001\u514d\u75ab\u7d30\u80de\u306e\u4fb5\u5165\u3092\u7269\u7406\u7684\u306b\u963b\u6b62\u3059\u308b\u624b\u6cd5\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e1\u30ea\u30c3\u30c8:<\/strong> \u514d\u75ab\u6291\u5236\u5264\u304c\u4e0d\u8981\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8ab2\u984c:<\/strong> <strong>PFO (Pericapsular Fibrotic Overgrowth)<\/strong>\u3002\u819c\u306e\u5468\u56f2\u306b\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u4ed8\u7740\u3057\u3001\u9178\u7d20\u3084\u6804\u990a\u306e\u4f9b\u7d66\u304c\u906e\u65ad\u3055\u308c\u3001\u79fb\u690d\u7d30\u80de\u304c\u6b7b\u6ec5\u3059\u308b\u554f\u984c\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4.2 \u6226\u75652\uff1a\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u4f4e\u514d\u75ab\u539f\u6027\u5316<\/h3>\n\n\n\n<p>CRISPR\/Cas9\u7b49\u3092\u7528\u3044\u3066\u7d30\u80de\u5074\u306e\u6297\u539f\u3092\u66f8\u304d\u63db\u3048\u308b\u624b\u6cd5\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HLA\u30af\u30e9\u30b9I\/II\u306e\u767a\u73fe\u6291\u5236:<\/strong> T\u7d30\u80de\u304b\u3089\u306e\u8a8d\u8b58\u3092\u56de\u907f\u3002<\/li>\n\n\n\n<li><strong>CD47\uff08don&#8217;t-eat-me\u30b7\u30b0\u30ca\u30eb\uff09\u306e\u904e\u5270\u767a\u73fe:<\/strong> \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u653b\u6483\u3092\u6291\u5236\u3002<\/li>\n\n\n\n<li><strong>\u8ab2\u984c:<\/strong> \u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u5b89\u5168\u6027\u3084\u3001\u816b\u760d\u5316\u30ea\u30b9\u30af\u306e\u9577\u671f\u7684\u8a55\u4fa1\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u7cd6\u5c3f\u75c5\u6027\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\uff08DPN\uff09\u306b\u5bfe\u3059\u308bPRP\u7642\u6cd5<\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u306e\u4e09\u5927\u5408\u4f75\u75c7\u306e\u4e00\u3064\u3067\u3042\u308bDPN\u306b\u5bfe\u3057\u3001PRP\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff09\u7642\u6cd5\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">5.1 DPN\u306e\u75c5\u614b<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u7ba1\u969c\u5bb3:<\/strong> \u795e\u7d4c\u6804\u990a\u8840\u7ba1\uff08vasa nervorum\uff09\u306e\u9589\u585e\u3002<\/li>\n\n\n\n<li><strong>\u4ee3\u8b1d\u7570\u5e38:<\/strong> AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u306e\u84c4\u7a4d\u3002<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u306e\u6b20\u4e4f:<\/strong> NGF\u3084BDNF\u306e\u6e1b\u5c11\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">5.2 PRP\u7642\u6cd5\u306e\u6a5f\u5e8f<\/h3>\n\n\n\n<p>PRP\u306b\u542b\u307e\u308c\u308b\u6210\u9577\u56e0\u5b50\uff08PDGF, VEGF, IGF-1, TGF-\u03b2, EGF, bFGF\u7b49\uff09\u304c\u3001\u795e\u7d4c\u518d\u751f\u3001\u8840\u7ba1\u65b0\u751f\u3001\u708e\u75c7\u6291\u5236\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9:<\/strong> Hassanien\u3089(2020)\u306eRCT\u306b\u304a\u3044\u3066\u3001\u795e\u7d4c\u5468\u56f2\u3078\u306ePRP\u6ce8\u5165\u304c\u3001VAS\u30b9\u30b3\u30a2\u3084\u795e\u7d4c\u4f1d\u5c0e\u901f\u5ea6\uff08NCV\uff09\u306e\u6709\u610f\u306a\u6539\u5584\u3092\u793a\u3057\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u4eca\u5f8c\u306e\u5c55\u671b\u3068\u898f\u5236\u72b6\u6cc1<\/h2>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u306e\u5b9f\u7528\u5316\u306b\u5411\u3051\u305f\u898f\u5236\u5f53\u5c40\u306e\u52d5\u304d\u3082\u6d3b\u767a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PMDA (\u65e5\u672c):<\/strong> 2020\u5e74\u306e\u300c\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u306e\u6761\u4ef6\u53ca\u3073\u671f\u9650\u4ed8\u627f\u8a8d\u300d\u5236\u5ea6\u306b\u57fa\u3065\u304d\u3001OZTx-410\u7b49\u306e\u56fd\u5185\u6cbb\u9a13\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>FDA (\u7c73\u56fd):<\/strong> Lantidra\u00ae\u306e\u627f\u8a8d\u306b\u52a0\u3048\u3001VX-880\u306b\u5bfe\u3057\u3066Fast Track\u304a\u3088\u3073RMAT\u6307\u5b9a\u3092\u884c\u3044\u3001\u5be9\u67fb\u3092\u8fc5\u901f\u5316\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u4e3b\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3:<\/strong>\n<ul class=\"wp-block-list\">\n<li>2025\u5e74\uff1aVertex VX-880\u306ePhase 3\u958b\u59cb\u304a\u3088\u3073\u627f\u8a8d\u7533\u8acb\u6e96\u5099\u3002<\/li>\n\n\n\n<li>2026\u5e74\uff1a\u30aa\u30ea\u30ba\u30eb\u30b9 OZTx-410\u306e\u4e3b\u8981\u30c7\u30fc\u30bf\u306e\u516c\u8868\u3002<\/li>\n\n\n\n<li>2026\u5e74\uff1aSernova Cell Pouch\u306a\u3069\u306e\u300c\u8840\u7ba1\u5c0e\u5165\u578b\u30c7\u30d0\u30a4\u30b9\u300d\u306e\u9577\u671f\u6709\u52b9\u6027\u78ba\u8a8d\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u7d30\u80de\u7642\u6cd5\u306f\u3001\u5f93\u6765\u306e\u300c\u5bfe\u75c7\u7642\u6cd5\u300d\u304b\u3089\u300c\u6839\u6cbb\u300d\u3078\u306e\u6249\u3092\u958b\u3053\u3046\u3068\u3057\u3066\u304a\u308a\u30012025\u5e74\u304b\u30892026\u5e74\u306b\u304b\u3051\u3066\u591a\u304f\u306e\u91cd\u8981\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u304c\u81e8\u5e8a\u8a66\u9a13\u306e\u6700\u7d42\u6bb5\u968e\u3092\u8fce\u3048\u308b\u898b\u901a\u3057\u3067\u3042\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5c3f\u75c5\u9818\u57df\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u3068\u6700\u65b0\u6cbb\u7642\u306e\u52d5\u5411\u306b\u95a2\u3059\u308b\u30d6\u30ea\u30fc\u30d5\u30a3\u30f3\u30b0\u30fb\u30c9\u30ad\u30e5\u30e1\u30f3\u30c8 \u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc \u672c\u8cc7\u6599\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u7279\u306b1\u578b\u7cd6\u5c3f\u75c5\uff08T1D\uff09\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u6027\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\uff08DPN\uff09\u306b\u5bfe\u3059\u308b\u518d\u751f\u533b\u7642\u304a\u3088\u3073\u5148\u7aef\u6cbb\u7642\u306e\u73fe\u72b6 [&hellip;]","protected":false},"author":1,"featured_media":505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,24,32,33],"tags":[],"class_list":["post-503","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-textbook","category-24","category-32","category-33"],"jetpack_featured_media_url":"https:\/\/rmnw.jp\/teams\/wp-content\/uploads\/2026\/05\/\u518d\u751f\u533b\u7642\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e6\u30fc\u30b6\u30fc-69f977f78d54f.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=503"}],"version-history":[{"count":1,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/503\/revisions"}],"predecessor-version":[{"id":506,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/503\/revisions\/506"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/media\/505"}],"wp:attachment":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}