{"id":495,"date":"2026-05-05T13:48:11","date_gmt":"2026-05-05T04:48:11","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=495"},"modified":"2026-05-05T13:48:12","modified_gmt":"2026-05-05T04:48:12","slug":"rm07-%e7%ac%ac%e4%b8%83%e7%ab%a0-%e8%a1%80%e6%b6%b2%e5%86%85%e7%a7%91%e3%83%bb%e5%85%8d%e7%96%ab%e7%a7%91%e3%83%bb%e8%85%ab%e7%98%8d%e5%86%85%e7%a7%91","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=495","title":{"rendered":"RM07.\u7b2c\u4e03\u7ae0 \u8840\u6db2\u5185\u79d1\u30fb\u514d\u75ab\u79d1\u30fb\u816b\u760d\u5185\u79d1"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM07.\u7b2c\u4e03\u7ae0 \u8840\u6db2\u5185\u79d1\u30fb\u514d\u75ab\u79d1\u30fb\u816b\u760d\u5185\u79d1\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/ak2iSzMubAg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6NDk2LCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9STTA3Llx1N2IyY1x1NGUwM1x1N2FlMC1cdTg4NDBcdTZkYjJcdTUxODVcdTc5ZDFcdTMwZmJcdTUxNGRcdTc1YWJcdTc5ZDFcdTMwZmJcdTgxNmJcdTc2MGRcdTUxODVcdTc5ZDEucGRmIiwiaW5kZXgiOjF9\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"496\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u8840\u6db2\u75be\u60a3\u30fb\u514d\u75ab\u75be\u60a3\u306b\u304a\u3051\u308b\u7d30\u80de\u907a\u4f1d\u5b50\u6cbb\u7642\uff08CGT\uff09\u306e\u73fe\u72b6\u3068\u5c55\u671b<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u672c\u8cc7\u6599\u306f\u3001\u8840\u6db2\u5185\u79d1\u3001\u514d\u75ab\u79d1\u3001\u304a\u3088\u3073\u816b\u760d\u5185\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u7d30\u80de\u907a\u4f1d\u5b50\u6cbb\u7642\uff08CGT\uff09\u306e\u6025\u901f\u306a\u9032\u6b69\u3001\u4e3b\u8981\u306a\u88fd\u54c1\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3001\u304a\u3088\u3073\u76f4\u9762\u3057\u3066\u3044\u308b\u8ab2\u984c\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>2017\u5e74\u306eCD19\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\uff08tisa-cel\uff09\u306e\u627f\u8a8d\u3092\u76ae\u5207\u308a\u306b\u3001\u9020\u8840\u5668\u816b\u760d\u306e\u6cbb\u7642\u4f53\u7cfb\u306f\u5287\u7684\u306b\u5909\u5316\u3057\u305f\u3002\u73fe\u5728\u3001\u6a19\u7684\u306fCD19\u304b\u3089BCMA\u3078\u3068\u62e1\u5927\u3057\u3001\u591a\u767a\u6027\u9aa8\u9ac4\u816b\uff08MM\uff09\u306b\u304a\u3044\u3066\u3082\u9ad8\u3044\u594f\u52b9\u7387\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001CRISPR\/Cas9\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\uff08Casgevy\uff09\u3084\u3001iPSC\u7531\u6765\u306eCAR-T\u7d30\u80de\u3001\u4ed6\u5bb6\uff08Off-the-shelf\uff09\u88fd\u54c1\u306e\u958b\u767a\u304c\u9032\u307f\u3001\u6cbb\u7642\u306e\u30a2\u30af\u30bb\u30b7\u30d3\u30ea\u30c6\u30a3\u5411\u4e0a\u3068\u9069\u5fdc\u62e1\u5927\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u75c7\u5019\u7fa4\uff08CRS\uff09\u3084\u795e\u7d4c\u6bd2\u6027\uff08ICANS\uff09\u3068\u3044\u3063\u305f\u7279\u6709\u306e\u526f\u4f5c\u7528\u3001\u88fd\u9020\u671f\u9593\uff08Vein-to-Vein Time\uff09\u306e\u77ed\u7e2e\u3001\u6975\u3081\u3066\u9ad8\u984d\u306a\u85ac\u5264\u8cbb\uff081\u88fd\u54c1\u3042\u305f\u308a\u6570\u5343\u4e07\u5186\u304b\u3089\u6570\u5104\u5186\uff09\u3001\u305d\u3057\u30662024\u5e74\u306bFDA\u304c\u8b66\u544a\u3092\u767a\u3057\u305f\u300c\u4e8c\u6b21\u6027T\u7d30\u80de\u816b\u760d\u300d\u306e\u30ea\u30b9\u30af\u7ba1\u7406\u306a\u3069\u3001\u89e3\u6c7a\u3059\u3079\u304d\u8ab2\u984c\u3082\u4f9d\u7136\u3068\u3057\u3066\u591a\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u304b\u3089\u6b21\u4e16\u4ee3CGT\u3078\u306e\u5909\u9077<\/h2>\n\n\n\n<p>\u9020\u8840\u5668\u816b\u760d\u304a\u3088\u3073\u514d\u75ab\u75be\u60a3\u306b\u5bfe\u3059\u308b\u7d30\u80de\u7642\u6cd5\u306e\u57fa\u76e4\u306f\u30011950\u5e74\u4ee3\u306bE. Donnall Thomas\u3089\u306b\u3088\u3063\u3066\u78ba\u7acb\u3055\u308c\u305f\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08HSCT\uff09\u306b\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6b74\u53f2\u7684\u80cc\u666f:<\/strong>\n<ul class=\"wp-block-list\">\n<li>1956\u5e74\uff1aThomas\u3089\u306b\u3088\u308b\u521d\u306e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3002<\/li>\n\n\n\n<li>1990\u5e74\uff1aThomas\u304cHSCT\u306e\u78ba\u7acb\u306b\u3088\u308a\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3002<\/li>\n\n\n\n<li>1991\u5e74\uff1a\u65e5\u672c\u9aa8\u9ac4\u30d0\u30f3\u30af\uff08JMDP\uff09\u8a2d\u7acb\u30022024\u5e74\u6642\u70b9\u3067\u767b\u9332\u8005\u6570\u306f\u7d0456\u4e07\u4eba\u3001\u7d2f\u8a08\u79fb\u690d\u6570\u306f5,500\u4ef6\u3092\u8d85\u3048\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6280\u8853\u306e\u9032\u5316:<\/strong>\n<ul class=\"wp-block-list\">\n<li>1990\u5e74\u4ee3\u306b\u306f\u81ea\u5df1\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08auto-HSCT\uff09\u304c\u6a19\u6e96\u5316\u3002<\/li>\n\n\n\n<li>2010\u5e74\u4ee3\u4ee5\u964d\u3001CAR-T\u7d30\u80de\u7642\u6cd5\u306b\u4ee3\u8868\u3055\u308c\u308b\u300c\u907a\u4f1d\u5b50\u6539\u5909\u7d30\u80de\u6cbb\u7642\u300d\u3078\u3068\u30d1\u30e9\u30c0\u30a4\u30e0\u304c\u30b7\u30d5\u30c8\u3057\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. CD19\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\uff1aB\u7d30\u80de\u6027\u816b\u760d\u306e\u9769\u65b0<\/h2>\n\n\n\n<p>CD19\u3092\u6a19\u7684\u3068\u3057\u305fCAR-T\u7642\u6cd5\u306f\u3001\u518d\u767a\u30fb\u96e3\u6cbb\u6027\uff08R\/R\uff09\u306eB\u7d30\u80de\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\uff08B-ALL\uff09\u3084\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u306b\u304a\u3044\u3066\u3001\u5f93\u6765\u306e\u5316\u5b66\u7642\u6cd5\u3067\u306f\u5230\u9054\u3057\u5f97\u306a\u304b\u3063\u305f\u9577\u671f\u751f\u5b58\u306e\u53ef\u80fd\u6027\u3092\u63d0\u793a\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 \u4e3b\u89813\u88fd\u54c1\u306e\u6bd4\u8f03<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u7279\u5fb4<\/td><td>tisa-cel (\u30ad\u30e0\u30ea\u30a2)<\/td><td>axi-cel (\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf)<\/td><td>liso-cel (\u30d6\u30ec\u30e4\u30f3\u30b8)<\/td><\/tr><tr><td><strong>\u5171\u523a\u6fc0\u30c9\u30e1\u30a4\u30f3<\/strong><\/td><td>4-1BB<\/td><td>CD28<\/td><td>4-1BB<\/td><\/tr><tr><td><strong>\u7d30\u80de\u7d44\u6210<\/strong><\/td><td>\u672a\u8abf\u6574\uff08\u30d0\u30eb\u30af\uff09<\/td><td>\u672a\u8abf\u6574\uff08\u30d0\u30eb\u30af\uff09<\/td><td>CD4\/CD8\u6bd4\u30921:1\u306b\u8abf\u6574<\/td><\/tr><tr><td><strong>\u4e3b\u306a\u9069\u5fdc<\/strong><\/td><td>B-ALL, DLBCL<\/td><td>DLBCL<\/td><td>DLBCL<\/td><\/tr><tr><td><strong>V2V Time<\/strong><\/td><td>48.4\u65e5\uff08\u6700\u9577\uff09<\/td><td>30.6\u65e5\uff08\u6700\u77ed\uff09<\/td><td>35.9\u65e5<\/td><\/tr><tr><td><strong>\u7279\u5fb4<\/strong><\/td><td>\u7de9\u3084\u304b\u306a\u5897\u6b96\u3001\u4f4e\u6bd2\u6027<\/td><td>\u6025\u901f\u306a\u5897\u6b96\u3001\u9ad8\u3044\u594f\u52b9\u7387<\/td><td>\u6bd2\u6027\u3068\u52b9\u679c\u306e\u30d0\u30e9\u30f3\u30b9<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 \u4e3b\u8981\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ELIANA\u8a66\u9a13 (tisa-cel):<\/strong> R\/R B-ALL\u306b\u304a\u3044\u3066ORR 81%\u300112\u30f6\u6708OS 76%\u3092\u9054\u6210\u3002<\/li>\n\n\n\n<li><strong>ZUMA-7\u8a66\u9a13 (axi-cel):<\/strong> DLBCL\u306e\u4e8c\u6b21\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u7642\u6cd5\uff08\u5316\u5b66\u7642\u6cd5\uff0bHSCT\uff09\u306b\u5bfe\u3057EFS\u3067\u6709\u610f\u306a\u512a\u4f4d\u6027\uff088.3\u30f6\u6708 vs 2.0\u30f6\u6708\uff09\u3092\u793a\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>TRANSCEND NHL 001\u8a66\u9a13 (liso-cel):<\/strong> DLBCL\u306b\u304a\u3044\u3066ORR 73%\u3001Grade 3\u4ee5\u4e0a\u306eCRS\u767a\u751f\u7387\u304c2%\u3068\u6975\u3081\u3066\u4f4e\u3044\u5b89\u5168\u6027\u3092\u793a\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3. BCMA\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\uff1a\u591a\u767a\u6027\u9aa8\u9ac4\u816b\uff08MM\uff09\u306e\u9032\u5c55<\/h2>\n\n\n\n<p>\u591a\u767a\u6027\u9aa8\u9ac4\u816b\uff08MM\uff09\u9818\u57df\u3067\u306f\u3001BCMA\u3092\u6a19\u7684\u3068\u3057\u305fide-cel\u3068cilta-cel\u304c\u627f\u8a8d\u3055\u308c\u3001\u6cbb\u7642\u306e\u67f1\u3068\u306a\u308a\u3064\u3064\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ide-cel (\u30a2\u30d9\u30af\u30de):<\/strong> KarMMa-3\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u6cbb\u7642\u7fa4\uff08PFS 4.4\u30f6\u6708\uff09\u306b\u5bfe\u305713.3\u30f6\u6708\u306ePFS\u3092\u9054\u6210\u3002<\/li>\n\n\n\n<li><strong>cilta-cel (\u30ab\u30fc\u30d3\u30af\u30c6\u30a3):<\/strong> CARTITUDE-4\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u6cbb\u7642\u7fa4\u306b\u5bfe\u3057PFS\u306e\u30cf\u30b6\u30fc\u30c9\u6bd40.26\u3068\u3044\u3046\u5727\u5012\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u7d4c\u6e08\u7684\u5074\u9762:<\/strong> ide-cel\u306f\u7d0441.9\u4e07\u30c9\u30eb\u3001cilta-cel\u306f\u7d0446.5\u4e07\u30c9\u30eb\u3068\u9ad8\u984d\u3067\u3042\u308a\u3001\u65e5\u672c\u56fd\u5185\u4fa1\u683c\uff08\u7d043,264\u4e07\u301c7,761\u4e07\u5186\uff09\u3068\u306e\u4e56\u96e2\u3082\u8b70\u8ad6\u306e\u5bfe\u8c61\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5c55\u958b\uff1a\u5e0c\u5c11\u75be\u60a3\u3068\u30b2\u30ce\u30e0\u7de8\u96c6<\/h2>\n\n\n\n<p>\u5e0c\u5c11\u75be\u60a3\u3084\u907a\u4f1d\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u3082\u3001CGT\u306f\u6839\u672c\u6cbb\u7642\u3068\u3057\u3066\u306e\u5730\u4f4d\u3092\u56fa\u3081\u3064\u3064\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">4.1 \u30b2\u30ce\u30e0\u7de8\u96c6\uff08CRISPR\/Cas9\uff09\u306e\u5c0e\u5165<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Casgevy (exa-cel):<\/strong> \u938c\u72b6\u8d64\u8840\u7403\u75c7\uff08SCD\uff09\u304a\u3088\u3073\u8f38\u8840\u4f9d\u5b58\u6027\u03b2\u30b5\u30e9\u30bb\u30df\u30a2\uff08TDT\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u88fd\u54c1\u3002BCL11A\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u3001\u80ce\u5150\u6027\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\uff08HbF\uff09\u306e\u7523\u751f\u3092\u518d\u958b\u3055\u305b\u308b\u3002CLIMB\u8a66\u9a13\u3067\u306f\u3001SCD\u60a3\u8005\u306e96.7%\u3067\u8840\u7ba1\u9589\u585e\u306b\u3088\u308b\u5371\u6a5f\uff08VOC\uff09\u3092\u56de\u907f\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4.2 \u5e0c\u5c11\u75be\u60a3\u3078\u306e\u9069\u5fdc<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Strimvelis:<\/strong> ADA-SCID\u5bfe\u8c61\u3002<\/li>\n\n\n\n<li><strong>Libmeldy:<\/strong> \u7570\u67d3\u6027\u767d\u8cea\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\uff08MLD\uff09\u5bfe\u8c61\u3002\u85ac\u5264\u8cbb\u306f\u7d04425\u4e07\u30c9\u30eb\uff08\u7d046\u5104\u5186\uff09\u3068\u4e16\u754c\u6700\u9ad8\u984d\u6c34\u6e96\u3002<\/li>\n\n\n\n<li><strong>Skysona:<\/strong> \u5927\u8133\u578b\u526f\u814e\u767d\u8cea\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\uff08CALD\uff09\u5bfe\u8c61\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u5b89\u5168\u6027\u7ba1\u7406\u3068\u898f\u5236\u5f53\u5c40\u306e\u52d5\u5411<\/h2>\n\n\n\n<p>CGT\u7279\u6709\u306e\u6bd2\u6027\u3068\u30ea\u30b9\u30af\u7ba1\u7406\u304c\u3001\u898f\u5236\u4e0a\u306e\u6700\u91cd\u8981\u4e8b\u9805\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRS\u3068ICANS:<\/strong> ASTCT 2019\u57fa\u6e96\u306b\u3088\u308aGrade\u5206\u985e\u3055\u308c\u3001IL-6\u963b\u5bb3\u85ac\uff08\u30c8\u30b7\u30ea\u30ba\u30de\u30d6\uff09\u7b49\u306b\u3088\u308b\u7ba1\u7406\u304c\u6a19\u6e96\u5316\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>FDA Boxed Warning (2024\u5e74):<\/strong> CD19\u304a\u3088\u3073BCMA\u6a19\u7684CAR-T\u88fd\u54c1\u306b\u304a\u3044\u3066\u3001\u6cbb\u7642\u5f8c\u306b\u300c\u4e8c\u6b21\u6027T\u7d30\u80de\u816b\u760d\u300d\u304c\u767a\u751f\u3057\u305f\u5831\u544a\u3092\u53d7\u3051\u3001FDA\u306f\u5168\u3066\u306eCAR-T\u88fd\u54c1\u306bBoxed Warning\uff08\u67a0\u7d44\u307f\u8b66\u544a\uff09\u3092\u7fa9\u52d9\u4ed8\u3051\u305f\u3002<\/li>\n\n\n\n<li><strong>\u88fd\u9020\u7ba1\u7406:<\/strong> \u6cbb\u7642\u6210\u529f\u306b\u306f\u3001\u60a3\u8005\u304b\u3089\u7d30\u80de\u3092\u63a1\u53d6\u3057\u6295\u4e0e\u3059\u308b\u307e\u3067\u306e\u671f\u9593\uff08Vein-to-Vein Time\uff09\u306e\u77ed\u7e2e\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u6b21\u4e16\u4ee3\u6280\u8853\u3068\u4eca\u5f8c\u306e\u8ab2\u984c<\/h2>\n\n\n\n<p>\u73fe\u5728\u306eCGT\u304c\u62b1\u3048\u308b\u300c\u9ad8\u30b3\u30b9\u30c8\u300d\u300c\u500b\u5225\u88fd\u9020\u306e\u8907\u96d1\u3055\u300d\u300c\u56fa\u5f62\u304c\u3093\u3078\u306e\u52b9\u679c\u300d\u3068\u3044\u3063\u305f\u8ab2\u984c\u306b\u5bfe\u3057\u3001\u4ee5\u4e0b\u306e\u6280\u8853\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4ed6\u5bb6\uff08Allogeneic\uff09\u88fd\u54c1:<\/strong> TALEN\u7b49\u3092\u7528\u3044\u3066TCR\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u3001GVHD\u3092\u9632\u304e\u3064\u3064\u65e2\u88fd\u54c1\uff08Off-the-shelf\uff09\u3068\u3057\u3066\u63d0\u4f9b\u3059\u308b\u8a66\u307f\uff08ALLO-501\u7b49\uff09\u3002<\/li>\n\n\n\n<li><strong>iPSC\u7531\u6765CAR-T:<\/strong> \u7121\u9650\u5897\u6b96\u80fd\u3092\u6301\u3064iPSC\u304b\u3089\u5747\u8cea\u306aCAR-T\u7d30\u80de\u3092\u88fd\u9020\u3059\u308b\u6280\u8853\uff08FT819\uff09\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6a19\u7684CAR:<\/strong> \u6297\u539f\u9003\u907f\uff08CD19-loss\u7b49\uff09\u3092\u9632\u3050\u305f\u3081\u3001CD19\/CD22\u3092\u540c\u6642\u306b\u6a19\u7684\u3068\u3059\u308b\u8a2d\u8a08\u3002<\/li>\n\n\n\n<li><strong>MSC\uff08\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff09\u7642\u6cd5:<\/strong> \u6025\u6027GVHD\u306b\u5bfe\u3057\u3001\u514d\u75ab\u8abf\u6574\u4f5c\u7528\u3092\u6301\u3064MSC\u88fd\u54c1\uff08Ryoncil\/\u30b9\u30c6\u30df\u30e9\u30c3\u30af\u7b49\uff09\u306e\u6d3b\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">7. \u7d50\u8ad6<\/h2>\n\n\n\n<p>CGT\u306f\u3001\u304b\u3064\u3066\u4e0d\u6cbb\u3068\u3055\u308c\u305f\u8840\u6db2\u30fb\u514d\u75ab\u75be\u60a3\u3092\u300c\u5b8c\u6cbb\u300d\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u6069\u6075\u3092\u5e83\u304f\u793e\u4f1a\u306b\u5c4a\u3051\u308b\u305f\u3081\u306b\u306f\u3001\u6280\u8853\u7684\u306a\u9769\u65b0\uff08iPSC\u6d3b\u7528\u3001\u81ea\u52d5\u88fd\u9020\u7b49\uff09\u306b\u3088\u308b\u30b3\u30b9\u30c8\u4f4e\u6e1b\u3068\u3001\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u76e3\u8996\u4f53\u5236\u306e\u78ba\u7acb\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002\u7279\u306b\u3001\u85ac\u4fa1\u7b97\u5b9a\u3068\u533b\u7642\u7d4c\u6e08\u7684\u6301\u7d9a\u53ef\u80fd\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u3001\u4eca\u5f8c\u306e\u533b\u7642\u30b7\u30b9\u30c6\u30e0\u5168\u4f53\u306b\u304a\u3051\u308b\u5927\u304d\u306a\u8ad6\u70b9\u3068\u306a\u308b\u3060\u308d\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u8840\u6db2\u75be\u60a3\u30fb\u514d\u75ab\u75be\u60a3\u306b\u304a\u3051\u308b\u7d30\u80de\u907a\u4f1d\u5b50\u6cbb\u7642\uff08CGT\uff09\u306e\u73fe\u72b6\u3068\u5c55\u671b \u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc \u672c\u8cc7\u6599\u306f\u3001\u8840\u6db2\u5185\u79d1\u3001\u514d\u75ab\u79d1\u3001\u304a\u3088\u3073\u816b\u760d\u5185\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u7d30\u80de\u907a\u4f1d\u5b50\u6cbb\u7642\uff08CGT\uff09\u306e\u6025\u901f\u306a\u9032\u6b69\u3001\u4e3b\u8981\u306a\u88fd\u54c1\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3001\u304a\u3088\u3073\u76f4\u9762\u3057 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