{"id":487,"date":"2026-05-05T13:40:22","date_gmt":"2026-05-05T04:40:22","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=487"},"modified":"2026-05-05T13:40:24","modified_gmt":"2026-05-05T04:40:24","slug":"rm05-%e7%ac%ac%e4%ba%94%e7%ab%a0-%e7%9a%ae%e8%86%9a%e7%a7%91%e3%83%bb%e5%bd%a2%e6%88%90%e5%a4%96%e7%a7%91%e3%83%bb%e7%be%8e%e5%ae%b9%e5%a4%96%e7%a7%91","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=487","title":{"rendered":"RM05. \u7b2c\u4e94\u7ae0 \u76ae\u819a\u79d1\u30fb\u5f62\u6210\u5916\u79d1\u30fb\u7f8e\u5bb9\u5916\u79d1"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM05. \u7b2c\u4e94\u7ae0 \u76ae\u819a\u79d1\u30fb\u5f62\u6210\u5916\u79d1\u30fb\u7f8e\u5bb9\u5916\u79d1\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/bIqctytd0B0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6NDg4LCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9STTA1Li1cdTdiMmNcdTRlOTRcdTdhZTAtXHU3NmFlXHU4MTlhXHU3OWQxXHUzMGZiXHU1ZjYyXHU2MjEwXHU1OTE2XHU3OWQxXHUzMGZiXHU3ZjhlXHU1YmI5XHU1OTE2XHU3OWQxLnBkZiIsImluZGV4IjoxfQ\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"488\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u76ae\u819a\u79d1\u30fb\u5f62\u6210\u5916\u79d1\u30fb\u7f8e\u5bb9\u5916\u79d1\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\uff1a\u6280\u8853\u52d5\u5411\u3068\u81e8\u5e8a\u5fdc\u7528\u306e\u5305\u62ec\u7684\u30d6\u30ea\u30fc\u30d5\u30a3\u30f3\u30b0<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u76ae\u819a\u79d1\u304a\u3088\u3073\u5f62\u6210\u30fb\u7f8e\u5bb9\u5916\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306f\u30011970\u5e74\u4ee3\u306e\u57f9\u990a\u8868\u76ae\u6280\u8853\u306e\u78ba\u7acb\u4ee5\u6765\u3001\u76ee\u899a\u307e\u3057\u3044\u767a\u5c55\u3092\u9042\u3052\u3066\u304d\u305f\u3002\u73fe\u5728\u3001\u305d\u306e\u5fdc\u7528\u7bc4\u56f2\u306f\u91cd\u75c7\u71b1\u50b7\u3084\u96e3\u6cbb\u6027\u6f70\u760d\u306a\u3069\u306e\u6551\u547d\u30fb\u518d\u5efa\u533b\u7642\u304b\u3089\u3001\u8131\u6bdb\u75c7\uff08AGA\uff09\u3084\u7622\u75d5\u6cbb\u7642\u3068\u3044\u3063\u305f\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u5411\u4e0a\u3092\u76ee\u6307\u3059\u9818\u57df\u3001\u3055\u3089\u306b\u306f\u907a\u4f1d\u6027\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u3078\u3068\u62e1\u5927\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p><strong>\u4e3b\u8981\u306a\u6210\u679c\u3068\u52d5\u5411\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u78ba\u7acb\u3055\u308c\u305f\u6280\u8853\uff1a<\/strong> \u81ea\u5bb6\u57f9\u990a\u8868\u76ae\uff08CEA\uff09\u306f\u91cd\u75c7\u71b1\u50b7\u6cbb\u7642\u306b\u304a\u3044\u3066\u6a19\u6e96\u5316\u3055\u308c\u3001\u65e5\u672c\u521d\u306e\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u300c\u30b8\u30a7\u30a4\u30b9\uff08JACE\uff09\u300d\u3068\u3057\u3066\u5b9a\u7740\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u907a\u4f1d\u6027\u8868\u76ae\u6c34\u75b1\u75c7\uff08DEB\uff09\u306b\u5bfe\u3059\u308b\u5916\u7528\u907a\u4f1d\u5b50\u6cbb\u7642\u85ac\u300c\u30f4\u30a3\u30b8\u30e5\u30d9\u30c3\u30af\uff08Vyjuvek\uff09\u300d\u306e\u767b\u5834\u306f\u3001\u96e3\u75c5\u6cbb\u7642\u306e\u65b0\u305f\u306a\u30d1\u30e9\u30c0\u30a4\u30e0\u3092\u793a\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u666e\u53ca\u3059\u308b\u4f4e\u4fb5\u8972\u6cbb\u7642\uff1a<\/strong> \u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff08PRP\uff09\u7642\u6cd5\u3084\u8102\u80aa\u7531\u6765\u5e79\u7d30\u80de\uff08ADSC\uff09\u3092\u7528\u3044\u305f\u6cbb\u7642\u304c\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u304c\u3001\u8abf\u88fd\u306e\u6a19\u6e96\u5316\u3084\u6301\u7d9a\u7684\u306a\u6709\u52b9\u6027\u306e\u691c\u8a3c\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6b21\u4e16\u4ee3\u6280\u8853\u306e\u53f0\u982d\uff1a<\/strong> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08\u7d30\u80de\u5916\u5c0f\u80de\uff1aEV\uff09\u3078\u306e\u95a2\u5fc3\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u304c\u3001\u54c1\u8cea\u7ba1\u7406\u3068\u898f\u5236\u9075\u5b88\u306e\u5fb9\u5e95\u304c\u5f37\u304f\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ac\u30d0\u30ca\u30f3\u30b9\u306e\u91cd\u8981\u6027\uff1a<\/strong> \u79d1\u5b66\u7684\u6839\u62e0\uff08\u30a8\u30d3\u30c7\u30f3\u30b9\uff09\u306e\u30ec\u30d9\u30eb\u306b\u5fdc\u3058\u305f\u9069\u5207\u306a\u60c5\u5831\u63d0\u4f9b\u3068\u3001\u672a\u627f\u8a8d\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u898f\u5236\u5f53\u5c40\u306e\u76e3\u8996\uff08FDA\u306e\u8b66\u544a\u66f8\u306a\u3069\uff09\u304c\u3001\u60a3\u8005\u306e\u5b89\u5168\u78ba\u4fdd\u306b\u304a\u3044\u3066\u4e0d\u53ef\u6b20\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u518d\u751f\u533b\u7642\u306e\u6b74\u53f2\u7684\u5909\u9077\u3068\u4e3b\u8981\u88fd\u54c1<\/h2>\n\n\n\n<p>\u76ae\u819a\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306f\u3001\u7d30\u80de\u57f9\u990a\u6280\u8853\u306e\u9032\u5316\u3068\u5171\u306b\u6b69\u3093\u3067\u304d\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1.1 \u6b74\u53f2\u7684\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1975\u5e74\uff1a<\/strong> Howard Green\u3068James G. Rheinwald\u304c\u30013T3-J2\u7d30\u80de\u3092\u30d5\u30a3\u30fc\u30c0\u30fc\u7d30\u80de\u3068\u3057\u3066\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u30d2\u30c8\u8868\u76ae\u7d30\u80de\u306e\u9023\u7d9a\u57f9\u990a\u6cd5\u3092\u78ba\u7acb\u3002<\/li>\n\n\n\n<li><strong>1981\u5e74\uff1a<\/strong> O&#8217;Connor\u3089\u306b\u3088\u308a\u3001\u81ea\u5bb6\u57f9\u990a\u8868\u76ae\u3092\u7528\u3044\u305f\u71b1\u50b7\u6cbb\u7642\u306e\u6210\u529f\u304c\u5831\u544a\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>1988\u5e74\uff1a<\/strong> \u7c73\u56fd\u306b\u3066\u300cEpicel\uff08\u30a8\u30d4\u30bb\u30eb\uff09\u300d\u304cFDA\u3088\u308a\u4eba\u9053\u7684\u30c7\u30d0\u30a4\u30b9\u9069\u7528\uff08HUD\/HDE\uff09\u3068\u3057\u3066\u627f\u8a8d\u3002<\/li>\n\n\n\n<li><strong>2007\u5e74\uff1a<\/strong> \u65e5\u672c\u521d\u306e\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u3068\u3057\u3066\u3001\u682a\u5f0f\u4f1a\u793e\u30b8\u30e3\u30d1\u30f3\u30fb\u30c6\u30a3\u30c3\u30b7\u30e5\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\uff08J-TEC\uff09\u306e\u81ea\u5bb6\u57f9\u990a\u8868\u76ae\u300c\u30b8\u30a7\u30a4\u30b9\uff08JACE\uff09\u300d\u304c\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u3092\u53d6\u5f97\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1.2 \u4e3b\u8981\u306a\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u88fd\u54c1\u540d<\/td><td>\u533a\u5206<\/td><td>\u4e3b\u306a\u9069\u5fdc\u75c7<\/td><td>\u6982\u8981<\/td><\/tr><tr><td><strong>\u30b8\u30a7\u30a4\u30b9 (JACE)<\/strong><\/td><td>\u81ea\u5bb6\u57f9\u990a\u8868\u76ae<\/td><td>\u91cd\u75c7\u71b1\u50b7\u3001\u5148\u5929\u6027\u5de8\u5927\u8272\u7d20\u6027\u6bcd\u6591\u3001\u767d\u6591<\/td><td>\u60a3\u8005\u81ea\u8eab\u306e\u76ae\u819a\u304b\u3089\u8868\u76ae\u7d30\u80de\u3092\u57f9\u990a\u30fb\u30b7\u30fc\u30c8\u5316\u3057\u305f\u3082\u306e\u3002<\/td><\/tr><tr><td><strong>\u30d5\u30a3\u30d6\u30e9\u30b9\u30c8 (Fiblast)<\/strong><\/td><td>\u6210\u9577\u56e0\u5b50\u88fd\u5264<\/td><td>\u8925\u7621\u3001\u76ae\u819a\u6f70\u760d<\/td><td>\u30c8\u30e9\u30d5\u30a7\u30eb\u30df\u30f3\uff08bFGF\uff09\u3092\u7528\u3044\u305f\u88fd\u5264\u3002<\/td><\/tr><tr><td><strong>\u30f4\u30a3\u30b8\u30e5\u30d9\u30c3\u30af (Vyjuvek)<\/strong><\/td><td>\u907a\u4f1d\u5b50\u6cbb\u7642\u7528\u88fd\u54c1<\/td><td>\u907a\u4f1d\u6027\u8868\u76ae\u6c34\u75b1\u75c7 (DEB)<\/td><td>HSV-1\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u3066COL7A1\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3059\u308b\u5916\u7528\u30b8\u30a7\u30eb\u3002<\/td><\/tr><tr><td><strong>\u30a2\u30d7\u30ea\u30b0\u30e9\u30d5 (Apligraf)<\/strong><\/td><td>\u540c\u7a2e\u57f9\u990a\u76ae\u819a<\/td><td>\u96e3\u6cbb\u6027\u6f70\u760d<\/td><td>\u725b\u30b3\u30e9\u30fc\u30b2\u30f3\u3068\u30d2\u30c8\u7d30\u80de\u304b\u3089\u69cb\u6210\u3002\u7c73\u56fdFDA\u627f\u8a8d\u6e08\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u9818\u57df\u5225\u306e\u81e8\u5e8a\u5fdc\u7528\u3068\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 \u91cd\u75c7\u71b1\u50b7\u3068\u96e3\u6cbb\u6027\u6f70\u760d<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u91cd\u75c7\u71b1\u50b7\uff1a<\/strong> \u53d7\u50b7\u9762\u7a4d\uff08TBSA\uff09\u304c\u5e83\u7bc4\u56f2\uff0830%\u4ee5\u4e0a\uff09\u306b\u53ca\u3076\u5834\u5408\u3001\u6551\u547d\u306e\u305f\u3081\u306bJACE\u304c\u4e0d\u53ef\u6b20\u3068\u306a\u308b\u3002Baux\u6307\u6570\u306a\u3069\u3092\u7528\u3044\u305f\u4e88\u5f8c\u4e88\u6e2c\u306b\u304a\u3044\u3066\u3001\u57f9\u990a\u8868\u76ae\u306e\u5c0e\u5165\u306f\u751f\u5b58\u7387\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u96e3\u6cbb\u6027\u6f70\u760d\u30fb\u8925\u7621\uff1a<\/strong> \u300cTIME\uff08Tissue, Infection, Moisture, Edge\uff09\u300d\u30b3\u30f3\u30bb\u30d7\u30c8\u306b\u57fa\u3065\u304f\u30c7\u30d6\u30ea\u30fc\u30c9\u30de\u30f3\u7b49\u306e\u5275\u9762\u74b0\u5883\u8abf\u6574\u304c\u524d\u63d0\u3068\u306a\u308b\u3002bFGF\u88fd\u5264\u3001PRP\u3001\u81ea\u5bb6\u57f9\u990a\u771f\u76ae\u3001\u3042\u308b\u3044\u306f\u30a2\u30d7\u30ea\u30b0\u30e9\u30d5\u7b49\u306e\u88fd\u54c1\u304c\u7528\u3044\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 \u8131\u6bdb\u75c7\uff08AGA\uff09\u3068\u767d\u6591\u6cbb\u7642<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGA\uff1a<\/strong> PRP\u7642\u6cd5\u304c\u76db\u3093\u306b\u884c\u308f\u308c\u3066\u304a\u308a\u3001PDGF\u3084VEGF\u7b49\u306e\u6210\u9577\u56e0\u5b50\u306b\u3088\u308b\u767a\u6bdb\u4fc3\u9032\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001L-PRP\uff08\u767d\u8840\u7403\u542b\u6709\uff09\u3068LP-PRP\uff08\u767d\u8840\u7403\u9664\u53bb\uff09\u306e\u6bd4\u8f03\u3084\u6295\u4e0e\u9593\u9694\u306e\u6700\u9069\u5316\u306a\u3069\u3001\u6a19\u6e96\u5316\u306b\u5411\u3051\u305f\u8b70\u8ad6\u304c\u7d9a\u3044\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5c0b\u5e38\u6027\u767d\u6591\uff1a<\/strong> \u5149\u7dda\u7642\u6cd5\u3084JAK\u963b\u5bb3\u85ac\u306b\u52a0\u3048\u3001J-TEC\u304c\u5c55\u958b\u3059\u308b\u57f9\u990a\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6df7\u5165\u81ea\u5bb6\u57f9\u990a\u8868\u76ae\u306a\u3069\u306e\u5916\u79d1\u7684\u518d\u751f\u533b\u7642\u304c\u3001\u85ac\u7269\u7642\u6cd5\u62b5\u6297\u6027\u306e\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u8272\u7d20\u518d\u751f\u7387\uff0870\uff5e90%\uff09\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 \u7622\u75d5\u30fb\u30b1\u30ed\u30a4\u30c9\u3068\u7f8e\u5bb9\u5916\u79d1<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ADSC\/SVF\uff1a<\/strong> \u8102\u80aa\u7531\u6765\u5e79\u7d30\u80de\uff08ADSC\uff09\u3084\u57fa\u8cea\u7d30\u80de\u753b\u5206\uff08SVF\uff09\u3092\u7528\u3044\u305f\u6cbb\u7642\u3001\u3042\u308b\u3044\u306f\u3053\u308c\u3089\u3092\u8102\u80aa\u79fb\u690d\u306b\u4ed8\u52a0\u3059\u308bCAL\uff08Cell-Assisted 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