{"id":478,"date":"2026-05-05T13:30:18","date_gmt":"2026-05-05T04:30:18","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=478"},"modified":"2026-05-05T13:30:19","modified_gmt":"2026-05-05T04:30:19","slug":"rm03-%e7%ac%ac3%e7%ab%a0-%e6%95%b4%e5%bd%a2%e5%a4%96%e7%a7%91%e3%83%bb%e3%82%b9%e3%83%9d%e3%83%bc%e3%83%84%e5%8c%bb%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=478","title":{"rendered":"RM03.\u7b2c3\u7ae0 \u6574\u5f62\u5916\u79d1\u30fb\u30b9\u30dd\u30fc\u30c4\u533b\u5b66"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM03.\u7b2c3\u7ae0 \u6574\u5f62\u5916\u79d1\u30fb\u30b9\u30db\u309a\u30fc\u30c4\u533b\u5b66\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/bM1Qzwungdo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6NDc5LCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9STTAzLlx1N2IyYzNcdTdhZTAtXHU2NTc0XHU1ZjYyXHU1OTE2XHU3OWQxXHUzMGZiXHUzMGI5XHUzMGRkXHUzMGZjXHUzMGM0XHU1MzNiXHU1YjY2LnBkZiIsImluZGV4IjoxfQ\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"479\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u6574\u5f62\u5916\u79d1\u30fb\u30b9\u30dd\u30fc\u30c4\u533b\u5b66\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\uff1a\u6700\u65b0\u52d5\u5411\u3068\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u95a2\u3059\u308b\u8981\u7d04\u5831\u544a\u66f8<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u672c\u5831\u544a\u66f8\u306f\u3001\u6574\u5f62\u5916\u79d1\u304a\u3088\u3073\u30b9\u30dd\u30fc\u30c4\u533b\u5b66\u306e\u5206\u91ce\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306e\u73fe\u72b6\u3001\u4e3b\u8981\u306a\u6280\u8853\u3001\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u304a\u3088\u3073\u898f\u5236\u306e\u67a0\u7d44\u307f\u3092\u5305\u62ec\u7684\u306b\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u73fe\u5728\u3001\u3053\u306e\u5206\u91ce\u306f\u5f93\u6765\u306e\u5916\u79d1\u7684\u624b\u6cd5\u304b\u3089\u3001\u7d30\u80de\u6cbb\u7642\u3001\u8840\u5c0f\u677f\u7531\u6765\u56e0\u5b50\u3001\u7d44\u7e54\u5de5\u5b66\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u300c\u30aa\u30fc\u30bd\u30d0\u30a4\u30aa\u30ed\u30b8\u30af\u30b9\uff08Orthobiologics\uff09\u300d\u3078\u3068\u5927\u304d\u304f\u30b7\u30d5\u30c8\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u4e3b\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u75be\u60a3\u52d5\u5411\uff1a<\/strong> \u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\uff08KOA\uff09\u306e\u6f5c\u5728\u60a3\u8005\u6570\u306f2,530\u4e07\u4eba\u306b\u9054\u3057\u3001\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u304a\u3044\u3066\u518d\u751f\u533b\u7642\u306e\u9700\u8981\u304c\u6975\u3081\u3066\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u4e3b\u8981\u6280\u8853\uff1a<\/strong> \u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u3001\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff08PRP\uff09\u3001\u9aa8\u9ac4\u5438\u5165\u6fc3\u7e2e\u6db2\uff08BMAC\uff09\u306b\u52a0\u3048\u3001BEAR\u00ae\u3084MACI\u00ae\u3068\u3044\u3063\u305f\u9769\u65b0\u7684\u306a\u7d44\u7e54\u5de5\u5b66\u88fd\u54c1\u304c\u5e02\u5834\u3092\u727d\u5f15\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u898f\u5236\u3068\u8ab2\u984c\uff1a<\/strong> \u300c\u533b\u85ac\u54c1\u3001\u533b\u7642\u6a5f\u5668\u7b49\u306e\u54c1\u8cea\u3001\u6709\u52b9\u6027\u53ca\u3073\u5b89\u5168\u6027\u306e\u78ba\u4fdd\u7b49\u306b\u95a2\u3059\u308b\u6cd5\u5f8b\uff08\u85ac\u6a5f\u6cd5\uff09\u300d\u306b\u57fa\u3065\u304d\u30012024\u5e74\u304b\u30892025\u5e74\u306b\u304b\u3051\u3066\u65b0\u305f\u306a\u627f\u8a8d\u3084\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u66f4\u65b0\u304c\u4e88\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u904e\u53bb\u306eINFUSE\u00ae\uff08BMP-2\uff09\u306e\u4e8b\u4f8b\u304b\u3089\u3001\u30aa\u30d5\u30e9\u30d9\u30eb\u4f7f\u7528\u306e\u7ba1\u7406\u3068\u900f\u660e\u6027\u306e\u9ad8\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u69cb\u7bc9\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u7684\u6709\u52b9\u6027\uff1a<\/strong> \u591a\u304f\u306e\u30e1\u30bf\u89e3\u6790\u306b\u3088\u308a\u3001PRP\u3084MSC\u304c\u5f93\u6765\u306e\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\uff08HA\uff09\u6cbb\u7642\u3092\u4e0a\u56de\u308b\u75bc\u75db\u6539\u5584\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6a19\u6e96\u5316\uff08MIBO\u7b49\uff09\u304c\u4eca\u5f8c\u306e\u666e\u53ca\u306e\u9375\u3068\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u898f\u5236\u306e\u67a0\u7d44\u307f\u3068\u5e02\u5834\u52d5\u5411<\/h2>\n\n\n\n<p>\u6574\u5f62\u5916\u79d1\u5206\u91ce\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306f\u3001\u53b3\u683c\u306a\u6cd5\u7684\u898f\u5236\u306e\u4e0b\u3067\u9032\u5c55\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u85ac\u6a5f\u6cd5\u306e\u5f71\u97ff\uff1a<\/strong> 2014\u5e7411\u6708\u306e\u65bd\u884c\u4ee5\u6765\u3001\u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u306e\u65e9\u671f\u627f\u8a8d\u5236\u5ea6\u304c\u5c0e\u5165\u3055\u308c\u305f\u30022024\u5e746\u6708\u304b\u30892025\u5e745\u6708\u306b\u304b\u3051\u3066\u3001\u65e2\u5b58\u306e\u67a0\u7d44\u307f\u306e\u66f4\u65b0\u3068\u65b0\u305f\u306a\u627f\u8a8d\u30d7\u30ed\u30bb\u30b9\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u4e3b\u8981\u306a\u627f\u8a8d\u88fd\u54c1\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>MACI\u00ae\uff1a<\/strong> \u81ea\u5bb6\u57f9\u990a\u8edf\u9aa8\u3002FDA\u306b\u3088\u308a2016\u5e74\u306b\u627f\u8a8d\u300218\u301c54\u6b73\u306e\u819d\u8edf\u9aa8\u6b20\u640d\u3092\u5bfe\u8c61\u3068\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>BEAR\u00ae\uff1a<\/strong> \u524d\u5341\u5b57\u976d\u5e2f\uff08ACL\uff09\u4fee\u5fa9\u7528\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9\u30022020\u5e74\u306bFDA\u306eDe Novo\u627f\u8a8d\u3092\u53d6\u5f97\u3002<\/li>\n\n\n\n<li><strong>Osteopore\u00ae\uff1a<\/strong> 3D\u30d7\u30ea\u30f3\u30c8\u6280\u8853\u3092\u7528\u3044\u305fPCL-TCP\u88fd\u306e\u9aa8\u6b20\u640d\u88dc\u586b\u6750\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u518d\u751f\u533b\u7642\u306e\u4e3b\u8981\u306a\u30e2\u30c0\u30ea\u30c6\u30a3\u3068\u6280\u8853<\/h2>\n\n\n\n<p>\u6574\u5f62\u5916\u79d1\u3067\u7528\u3044\u3089\u308c\u308b\u4e3b\u306a\u6cbb\u7642\u624b\u6bb5\u306f\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5206\u985e\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 \u7d30\u80de\u6cbb\u7642 (Cells)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MSC\uff08\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff09\uff1a<\/strong> \u9aa8\u9ac4\u7531\u6765\uff08BM-MSC\uff09\u3001\u8102\u80aa\u7531\u6765\uff08AD-MSC\uff09\u3001\u81cd\u5e2f\u7531\u6765\uff08UC-MSC\uff09\u306a\u3069\u304c\u7528\u3044\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>iPS\u7d30\u80de\uff1a<\/strong> \u65e5\u672c\u3092\u4e2d\u5fc3\u306b\u3001iPS\u7d30\u80de\u7531\u6765\u8edf\u9aa8\uff08hiPS-Cart\uff09\u306e\u81e8\u5e8a\u7814\u7a76\u304c2024\u5e747\u6708\u6642\u70b9\u3067\u9032\u884c\u4e2d\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 \u8840\u6db2\u30fb\u9aa8\u9ac4\u7531\u6765\u56e0\u5b50 (Blood\/Bone Marrow Derived)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PRP\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff09\uff1a<\/strong> \u6210\u9577\u56e0\u5b50\u3092\u653e\u51fa\u3057\u3001\u7d44\u7e54\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u3002Marx\u306e\u63d0\u5531\u306b\u3088\u308c\u3070\u30011,000,000\u500b\/\u00b5L\u4ee5\u4e0a\u306e\u8840\u5c0f\u677f\u6fc3\u5ea6\u304c\u76ee\u5b89\u3068\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>BMAC\uff08\u9aa8\u9ac4\u5438\u5165\u6fc3\u7e2e\u6db2\uff09\uff1a<\/strong> \u5e79\u7d30\u80de\u3068\u6210\u9577\u56e0\u5b50\u306e\u4e21\u65b9\u3092\u542b\u307f\u3001\u9aa8\u58ca\u6b7b\uff08ONFH\uff09\u3084\u507d\u95a2\u7bc0\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 \u7d44\u7e54\u5de5\u5b66\u3068\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9 (Scaffolds)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>3D\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\uff1a<\/strong> \u60a3\u8005\u500b\u5225\u306e\u89e3\u5256\u5b66\u7684\u5f62\u72b6\u306b\u5408\u308f\u305b\u305f\u88dc\u586b\u6750\u306e\u4f5c\u6210\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30e9\u30fc\u30b2\u30f3\u88fd\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9\uff1a<\/strong> BEAR\u00ae\u306e\u3088\u3046\u306b\u3001\u81ea\u5df1\u8840\u3092\u4fdd\u6301\u3057\u3066\u7d44\u7e54\u518d\u751f\u306e\u8db3\u5834\u3068\u306a\u308b\u6280\u8853\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u81e8\u5e8a\u5fdc\u7528\uff1a\u90e8\u4f4d\u5225\u306e\u8a73\u7d30\u5206\u6790<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 \u819d\u95a2\u7bc0\u75be\u60a3<\/h3>\n\n\n\n<p>\u819d\u95a2\u7bc0\u306f\u518d\u751f\u533b\u7642\u306e\u6700\u5927\u306e\u5e02\u5834\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7 (KOA)\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>ROAD\u30b9\u30bf\u30c7\u30a3\u306b\u3088\u308c\u3070\u300140\u6b73\u4ee5\u4e0a\u306e\u6709\u75c5\u7387\u306f\u7537\u602742.6%\u3001\u5973\u602762.4%\u306b\u9054\u3059\u308b\u3002<\/li>\n\n\n\n<li>Kellgren-Lawrence\uff08KL\uff09\u5206\u985e\u30b0\u30ec\u30fc\u30c92\u301c3\u306e\u75c7\u4f8b\u304c\u3001PRP\u3084MSC\u306e\u4e3b\u8981\u306a\u9069\u5fdc\u5bfe\u8c61\u3068\u306a\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u524d\u5341\u5b57\u976d\u5e2f (ACL)\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5f93\u6765\u306e\u518d\u5efa\u8853\uff08BPTB\u6cd5\u7b49\uff09\u306b\u5bfe\u3057\u3001\u81ea\u5df1\u976d\u5e2f\u306e\u6cbb\u7652\u3092\u4fc3\u9032\u3059\u308bBEAR\u00ae\u6cbb\u7642\u304c\u767b\u5834\u3002<\/li>\n\n\n\n<li>BEAR II\u8a66\u9a13\uff08n=100\uff09\u3067\u306f\u3001IKDC\u30b9\u30b3\u30a2\u304a\u3088\u3073\u524d\u65b9\u4e0d\u5b89\u5b9a\u6027\u306e\u6539\u5584\u306b\u304a\u3044\u3066\u3001\u518d\u5efa\u8853\u3068\u540c\u7b49\u306e\u6210\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u534a\u6708\u677f\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8840\u7ba1\u306e\u4e4f\u3057\u3044\u300c\u30db\u30ef\u30a4\u30c8\u30be\u30fc\u30f3\u300d\u306e\u640d\u50b7\u306b\u5bfe\u3057\u3001CMI\uff08Stryker\u793e\uff09\u3084Actifit\u306a\u3069\u306e\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9\u3092\u7528\u3044\u305f\u4fee\u5fa9\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3.2 \u80a1\u95a2\u7bc0\u304a\u3088\u3073\u80a9\u95a2\u7bc0<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5927\u817f\u9aa8\u982d\u58ca\u6b7b (ONFH)\uff1a<\/strong> Hernigou\u3089\u306b\u3088\u308bBMAC\u6cbb\u7642\u306e\u9577\u671f\u6210\u7e3e\u3067\u306f\u3001Stage I\/II\u306e\u65e9\u671f\u75c7\u4f8b\u306b\u304a\u3044\u3066\u300110\u5e74\u5f8c\u306e\u4eba\u5de5\u80a1\u95a2\u7bc0\u7f6e\u63db\u8853\uff08THA\uff09\u3078\u306e\u79fb\u884c\u3092\u5927\u5e45\u306b\u9045\u3089\u305b\u308b\u52b9\u679c\uff0887%\u304c\u56de\u907f\uff09\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8171\u677f\u65ad\u88c2\uff1a<\/strong> PRP\uff08\u7279\u306bLP-PRP\uff09\u306e\u4f75\u7528\u304c\u3001\u518d\u65ad\u88c2\u7387\u306e\u4f4e\u4e0b\u3068\u8853\u5f8c\u75bc\u75db\u306e\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u30e1\u30bf\u89e3\u6790\u7d50\u679c\uff08Hurley, 2021\uff09\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 \u810a\u690e\u75be\u60a3\u3068\u9aa8\u6b20\u640d<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u690e\u9593\u677f\u6027\u8170\u75db\uff1a<\/strong> Mesoblast\u793e\u306eMSC\u88fd\u54c1\uff08rexlemestrocel-L\uff09\u306e\u30d5\u30a7\u30fc\u30baIII\u8a66\u9a13\uff08n=404\uff09\u306b\u304a\u3044\u3066\u3001\u6709\u610f\u306a\u75bc\u75db\u6539\u5584\u52b9\u679c\uff08p=0.008\uff09\u304c\u793a\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li><strong>\u9aa8\u7652\u5408\u4fc3\u9032\uff1a<\/strong> INFUSE\u00ae\uff08rhBMP-2\uff09\u306f\u30012002\u5e74\u306eFDA\u627f\u8a8d\u4ee5\u6765\u3001\u8170\u690e\u524d\u65b9\u56fa\u5b9a\u8853\uff08ALIF\uff09\u306b\u9769\u547d\u3092\u3082\u305f\u3089\u3057\u305f\u304c\u3001\u526f\u4f5c\u7528\u3068\u30aa\u30d5\u30e9\u30d9\u30eb\u4f7f\u7528\u304c\u554f\u984c\u3068\u306a\u3063\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u96c6\u7d04\uff08\u30e1\u30bf\u89e3\u6790\u7d50\u679c\uff09<\/h2>\n\n\n\n<p>\u30bd\u30fc\u30b9\u5185\u3067\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u4e3b\u8981\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u5bfe\u8c61\u75be\u60a3<\/td><td>\u6bd4\u8f03\u5185\u5bb9<\/td><td>\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u7d50\u8ad6<\/td><td>\u51fa\u5178<\/td><\/tr><tr><td><strong>KOA<\/strong><\/td><td>PRP vs \u30d2\u30a2\u30eb\u30ed\u30f3\u9178<\/td><td>18\u4ef6\u306eRCT\u89e3\u6790\u3067\u3001PRP\u304c\u6709\u610f\u306b\u512a\u308b\u75bc\u75db\u6539\u5584\u3092\u793a\u3059<\/td><td>Belk (2021)<\/td><\/tr><tr><td><strong>\u8171\u677f\u65ad\u88c2<\/strong><\/td><td>LP-PRP\u306e\u4f75\u7528<\/td><td>13\u4ef6\u306eRCT\u89e3\u6790\u3067\u3001\u518d\u65ad\u88c2\u7387\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u308b<\/td><td>Hurley (2021)<\/td><\/tr><tr><td><strong>ACL\u4fee\u5fa9<\/strong><\/td><td>BEAR\u00ae vs \u518d\u5efa\u8853<\/td><td>6\u5e74\u9593\u306e\u8ffd\u8de1\u3067\u3001BEAR\u00ae\u304c\u518d\u5efa\u8853\u3068\u540c\u7b49\u306e\u6a5f\u80fd\u7dad\u6301\u3092\u78ba\u8a8d<\/td><td>Fleming (2024)<\/td><\/tr><tr><td><strong>\u690e\u9593\u677f<\/strong><\/td><td>MSC\u6ce8\u5165<\/td><td>3\u30f6\u6708\u6642\u70b9\u3067\u75bc\u75db\u306e\u6709\u610f\u306a\u6539\u5584\u3092\u78ba\u8a8d<\/td><td>Mesoblast PhIII<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u5b89\u5168\u6027\u3068\u6559\u8a13\uff1aINFUSE\u00ae (BMP-2) \u306e\u4e8b\u4f8b<\/h2>\n\n\n\n<p>Medtronic\u793e\u306eINFUSE\u00ae\u306f\u3001\u518d\u751f\u533b\u7642\u306b\u304a\u3051\u308b\u300c\u5149\u3068\u5f71\u300d\u3092\u8c61\u5fb4\u3059\u308b\u4e8b\u4f8b\u3068\u3057\u3066\u8a73\u8ff0\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6210\u529f\u3068\u666e\u53ca\uff1a<\/strong> 2002\u5e74\u306e\u627f\u8a8d\u5f8c\u3001\u9aa8\u878d\u5408\u738794.5%\uff08\u81ea\u5bb6\u9aa888.7%\u306b\u5bfe\u3057\u512a\u4f4d\uff09\u3068\u3044\u3046\u9ad8\u3044\u6210\u7e3e\u3092\u53ce\u3081\u305f\u3002<\/li>\n\n\n\n<li><strong>\u4e0d\u9069\u5207\u306a\u4f7f\u7528\u3068\u8a34\u8a1f\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5168\u4f7f\u7528\u306e\u7d0485%\u304c\u30aa\u30d5\u30e9\u30d9\u30eb\uff08\u627f\u8a8d\u5916\u4f7f\u7528\uff09\u3067\u3042\u3063\u305f\u3002<\/li>\n\n\n\n<li>2008\u5e74\u306e\u516c\u8846\u885b\u751f\u901a\u77e5\u306b\u3088\u308a\u3001\u9838\u690e\u3078\u306e\u4f7f\u7528\u306b\u3088\u308b\u6df1\u523b\u306a\u5408\u4f75\u75c7\uff08\u6c17\u9053\u9589\u585e\u7b49\uff09\u304c\u5831\u544a\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>Medtronic\u793e\u306f\u3001False Claims Act\u9055\u53cd\u7b49\u306b\u3088\u308a\u3001\u7dcf\u984d\u6570\u5104\u30c9\u30eb\u306e\u548c\u89e3\u91d1\u3092\u652f\u6255\u3046\u306b\u81f3\u3063\u305f\uff082011\u5e74\uff1a2.35\u5104\u30c9\u30eb\u30012012\u5e74\uff1a0.85\u5104\u30c9\u30eb\u7b49\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6559\u8a13\uff1a<\/strong> \u518d\u751f\u533b\u7642\u7b49\u88fd\u54c1\u306e\u666e\u53ca\u306b\u306f\u3001\u8ca9\u58f2\u4fc3\u9032\u306e\u900f\u660e\u6027\u3068\u3001\u4e88\u671f\u305b\u306c\u526f\u4f5c\u7528\u306b\u5bfe\u3059\u308b\u53b3\u683c\u306a\u76e3\u8996\u4f53\u5236\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u4eca\u5f8c\u306e\u5c55\u671b\u3068\u6a19\u6e96\u5316<\/h2>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u304c\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u5b9a\u7740\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u6cbb\u7642\u6cd5\u306e\u300c\u6a19\u6e96\u5316\u300d\u304c\u6025\u52d9\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MIBO\u306e\u63a8\u9032\uff1a<\/strong> \u30aa\u30fc\u30bd\u30d0\u30a4\u30aa\u30ed\u30b8\u30af\u30b9\u306b\u304a\u3051\u308b\u6700\u5c0f\u9650\u306e\u60c5\u5831\u5831\u544a\u57fa\u6e96\uff08Minimum Information for Biologics in Orthopaedics\uff09\u306e\u78ba\u7acb\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6b21\u4e16\u4ee3\u6280\u8853\uff1a<\/strong> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08EV\uff09\u3084\u3001\u3088\u308a\u9ad8\u6fc3\u5ea6\u306e\u7d30\u80de\u6295\u4e0e\uff08Superdose\uff09\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>2026\u5e74\u554f\u984c\uff1a<\/strong> \u591a\u304f\u306e\u9032\u884c\u4e2d\u306eRCT\uff08Mautner\u3089\u306eORBI\u8a66\u9a13\u7b49\uff09\u304c2026\u5e744\u6708\u307e\u3067\u306b\u7d50\u679c\u3092\u51fa\u3059\u4e88\u5b9a\u3067\u3042\u308a\u3001\u3053\u306e\u6642\u671f\u304c\u6574\u5f62\u5916\u79d1\u518d\u751f\u533b\u7642\u306e\u8ee2\u63db\u70b9\u3068\u306a\u308b\u3068\u4e88\u6e2c\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u6574\u5f62\u5916\u79d1\u30fb\u30b9\u30dd\u30fc\u30c4\u533b\u5b66\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\uff1a\u6700\u65b0\u52d5\u5411\u3068\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u95a2\u3059\u308b\u8981\u7d04\u5831\u544a\u66f8 \u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc \u672c\u5831\u544a\u66f8\u306f\u3001\u6574\u5f62\u5916\u79d1\u304a\u3088\u3073\u30b9\u30dd\u30fc\u30c4\u533b\u5b66\u306e\u5206\u91ce\u306b\u304a\u3051\u308b\u518d\u751f\u533b\u7642\u306e\u73fe\u72b6\u3001\u4e3b\u8981\u306a\u6280\u8853\u3001\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u304a\u3088\u3073\u898f\u5236 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