{"id":469,"date":"2026-05-05T12:50:48","date_gmt":"2026-05-05T03:50:48","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=469"},"modified":"2026-05-05T13:31:05","modified_gmt":"2026-05-05T04:31:05","slug":"rm-01-%e7%ac%ac%e4%b8%80%e7%ab%a0-%e5%86%8d%e7%94%9f%e5%8c%bb%e7%99%82%e3%81%ae%e6%a6%82%e8%a6%81","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=469","title":{"rendered":"RM-01 \u7b2c\u4e00\u7ae0 \u518d\u751f\u533b\u7642\u306e\u6982\u8981"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"RM-01 \u7b2c\u4e00\u7ae0 \u518d\u751f\u533b\u7642\u306e\u6982\u8981\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/teyhOyetZYE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6NDcwLCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzA1XC9STS0wMS1cdTdiMmNcdTRlMDBcdTdhZTAtXHU1MThkXHU3NTFmXHU1MzNiXHU3NjQyXHUzMDZlXHU2OTgyXHU4OTgxLnBkZiIsImluZGV4IjoxfQ\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"470\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u518d\u751f\u533b\u7642\u306e\u73fe\u72b6\u3068\u5c55\u671b\uff1a\u6280\u8853\u9769\u65b0\u3001\u898f\u5236\u3001\u304a\u3088\u3073\u5e02\u5834\u52d5\u5411\u306b\u95a2\u3059\u308b\u5305\u62ec\u7684\u30d6\u30ea\u30fc\u30d5\u30a3\u30f3\u30b0<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30fb\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u672c\u8cc7\u6599\u306f\u3001\u518d\u751f\u533b\u7642\uff08Regenerative Medicine\uff09\u306e\u5b9a\u7fa9\u3001\u6b74\u53f2\u7684\u9032\u5c55\u3001\u7d30\u80de\u751f\u7269\u5b66\u306e\u57fa\u790e\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3001\u304a\u3088\u3073\u7523\u696d\u30fb\u898f\u5236\u306e\u52d5\u5411\u3092\u5305\u62ec\u7684\u306b\u6982\u8aac\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u306f\u3001\u5f93\u6765\u306e\u533b\u85ac\u54c1\u3084\u533b\u7642\u6a5f\u5668\u3067\u306f\u6cbb\u7642\u304c\u56f0\u96e3\u3067\u3042\u3063\u305f\u75be\u60a3\u306b\u5bfe\u3057\u3001\u7d30\u80de\u3001\u907a\u4f1d\u5b50\u3001\u7d44\u7e54\u5de5\u5b66\u3092\u99c6\u4f7f\u3057\u3066\u640d\u50b7\u3057\u305f\u7d44\u7e54\u3084\u81d3\u5668\u306e\u6a5f\u80fd\u3092\u5fa9\u5143\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u65b0\u305f\u306a\u533b\u7642\u5206\u91ce\u3067\u3042\u308b\u30022006\u5e74\u306eiPS\u7d30\u80de\u306e\u6a39\u7acb\u30012014\u5e74\u306e\u4e16\u754c\u521d\u306eiPSC\u7531\u6765\u7d30\u80de\u79fb\u690d\u3092\u7d4c\u3066\u3001\u73fe\u5728\u306f\u5b9f\u7528\u5316\u30fb\u7523\u696d\u5316\u306e\u6bb5\u968e\u3078\u3068\u79fb\u884c\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001CRISPR-Cas9\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u85ac\uff08Casgevy\u00ae\u7b49\uff09\u306e\u627f\u8a8d\u3084\u3001HLA\u30d0\u30f3\u30af\u306b\u3088\u308b\u4ed6\u5bb6\u7d30\u80de\u6cbb\u7642\u306e\u9032\u5c55\u306f\u3001\u4eca\u5f8c\u306e\u666e\u53ca\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\u3002\u5e02\u5834\u898f\u6a21\u306f2034\u5e74\u307e\u3067\u306b5.5\u5146\u7c73\u30c9\u30eb\u3092\u8d85\u3048\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u304a\u308a\uff08CAGR 31.27%\uff09\u3001\u9ad8\u85ac\u4fa1\u3084\u88fd\u9020\u30b3\u30b9\u30c8\u3001\u898f\u5236\u306e\u6700\u9069\u5316\u3068\u3044\u3063\u305f\u8ab2\u984c\u3092\u62b1\u3048\u3064\u3064\u3082\u3001\u6025\u901f\u306a\u62e1\u5927\u3092\u7d9a\u3051\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u518d\u751f\u533b\u7642\u306e\u5b9a\u7fa9\u3068\u69cb\u6210\u8981\u7d20<\/h2>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u306f\u3001\u6a5f\u80fd\u4e0d\u5168\u306b\u9665\u3063\u305f\u7d44\u7e54\u3084\u81d3\u5668\u3092\u4fee\u5fa9\u30fb\u518d\u751f\u30fb\u7f6e\u63db\u3059\u308b\u305f\u3081\u306e\u591a\u9762\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1.1 \u5206\u985e\u3068\u624b\u6cd5<\/h3>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u306f\u4e3b\u306b\u4ee5\u4e0b\u306e3\u3064\u306e\u4e3b\u8981\u6280\u8853\u3001\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d30\u80de\u6cbb\u7642\uff08Cell Therapy\uff09\uff1a<\/strong> \u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u6295\u4e0e\u30fb\u79fb\u690d\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u6cbb\u7642\uff08Gene Therapy\uff09\uff1a<\/strong> \u907a\u4f1d\u5b50\u6539\u5909\u3084\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305f\u9001\u9054\u3002<\/li>\n\n\n\n<li><strong>\u7d44\u7e54\u5de5\u5b66\uff08Tissue Engineering\uff09\uff1a<\/strong> \u7d30\u80de\u3001\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\uff08\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9\uff09\u3001\u751f\u7406\u6d3b\u6027\u56e0\u5b50\u3092\u7d44\u307f\u5408\u308f\u305b\u30013\u6b21\u5143\u7684\u306a\u7d44\u7e54\u3092\u69cb\u7bc9\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1.2 \u6295\u4e0e\u5f62\u614b<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ex vivo\uff08\u4f53\u5916\u51e6\u7406\uff09\uff1a<\/strong> \u4f53\u5916\u3067\u7d30\u80de\u3092\u6539\u5909\u30fb\u57f9\u990a\u3057\u305f\u5f8c\u306b\u4f53\u5185\u306b\u623b\u3059\u3002<\/li>\n\n\n\n<li><strong>In vivo\uff08\u4f53\u5185\u76f4\u63a5\u6295\u4e0e\uff09\uff1a<\/strong> \u6838\u9178\u533b\u85ac\u3084mRNA\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\uff08RNP\u7b49\uff09\u3092\u76f4\u63a5\u4f53\u5185\u306b\u6295\u4e0e\u3059\u308b\u30022025\u5e74\u4ee5\u964d\u3001\u65e5\u672c\u56fd\u5185\u3067\u3082\u6cd5\u898f\u5236\u306e\u5bfe\u8c61\u304c\u62e1\u5927\u3055\u308c\u308b\u898b\u901a\u3057\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u6b74\u53f2\u7684\u5909\u9077\u3068\u4e3b\u8981\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3<\/h2>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u306e\u767a\u5c55\u306f\u3001\u57fa\u790e\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u5fdc\u7528\u3078\u3068\u7740\u5b9f\u306b\u9032\u5c55\u3057\u3066\u304d\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 \u521d\u671f\u304b\u3089ES\u7d30\u80de\u306e\u767b\u5834\u307e\u3067<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1956\u5e74\uff1a<\/strong> E. Donnall Thomas\u306b\u3088\u308b\u4e16\u754c\u521d\u306e\u9aa8\u9ac4\u79fb\u690d\uff08\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306e\u539f\u70b9\uff09\u3002<\/li>\n\n\n\n<li><strong>1975\u5e74\uff1a<\/strong> Howard Green\u3089\u306b\u3088\u308b\u57f9\u990a\u8868\u76ae\u6280\u8853\u306e\u78ba\u7acb\uff08\u88fd\u54c1\u4f8b\uff1aEpicel\u00ae\u3001\u65e5\u672c\u3067\u306fJ-TEC\u306b\u3088\u308b\u81ea\u5bb6\u57f9\u990a\u8868\u76ae\uff09\u3002<\/li>\n\n\n\n<li><strong>1981\u5e74\uff1a<\/strong> \u30de\u30a6\u30b9ES\u7d30\u80de\u306e\u6a39\u7acb\uff08Evans, Kaufman, Martin\uff09\u3002<\/li>\n\n\n\n<li><strong>1998\u5e74\uff1a<\/strong> James Thomson\u306b\u3088\u308b\u30d2\u30c8ES\u7d30\u80de\u306e\u6a39\u7acb\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 iPS\u7d30\u80de\u3068\u8fd1\u5e74\u306e\u9032\u5c55<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>2006-2007\u5e74\uff1a<\/strong> \u5c71\u4e2d\u4f38\u5f25\u3089\u306b\u3088\u308b\u30de\u30a6\u30b9\u30fb\u30d2\u30c8iPS\u7d30\u80de\u306e\u6a39\u7acb\uff082012\u5e74\u30ce\u30fc\u30d9\u30eb\u8cde\uff09\u3002<\/li>\n\n\n\n<li><strong>2014\u5e74\uff1a<\/strong> \u4e16\u754c\u521d\u3068\u306a\u308biPSC\u7531\u6765\u7db2\u819c\u8272\u7d20\u4e0a\u76ae\uff08RPE\uff09\u79fb\u690d\u306e\u5b9f\u65bd\uff08\u9ad8\u6a4b\u653f\u4ee3\u3089\uff09\u3002<\/li>\n\n\n\n<li><strong>2023\u5e74\uff1a<\/strong> CRISPR\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u85ac\u300cCasgevy\u00ae\u300d\u306e\u627f\u8a8d\uff08FDA\u3001MHRA\uff09\u3002<\/li>\n\n\n\n<li><strong>2026\u5e74\uff08\u4e88\u6e2c\uff09\uff1a<\/strong> \u4e16\u754c\u521d\u306eiPSC\u7531\u6765\u88fd\u54c1\uff08\u30a2\u30e0\u30b7\u30d7\u30ed\u00ae\u3001\u30ea\u30cf\u30fc\u30c8\u00ae\u7b49\uff09\u306e\u627f\u8a8d\u898b\u8fbc\u307f\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u5e79\u7d30\u80de\u306e\u751f\u7269\u5b66\u3068\u4e3b\u8981\u6280\u8853<\/h2>\n\n\n\n<p>\u7d30\u80de\u6cbb\u7642\u306e\u6839\u5e79\u3092\u6210\u3059\u5e79\u7d30\u80de\u306f\u3001\u81ea\u5df1\u8907\u88fd\u80fd\uff08Self-renewal\uff09\u3068\u591a\u5206\u5316\u80fd\uff08Potency\uff09\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 \u5206\u5316\u80fd\u306b\u3088\u308b\u5206\u985e<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u5206\u985e<\/td><td>\u540d\u79f0<\/td><td>\u7279\u5fb4\u30fb\u7d30\u80de\u4f8b<\/td><\/tr><tr><td><strong>\u5168\u80fd\u6027 (Totipotent)<\/strong><\/td><td>\u5168\u80fd\u6027\u5e79\u7d30\u80de<\/td><td>\u53d7\u7cbe\u5375\u3002\u3059\u3079\u3066\u306e\u7d30\u80de\u304a\u3088\u3073\u80ce\u76e4\u306b\u5206\u5316\u53ef\u80fd\u3002<\/td><\/tr><tr><td><strong>\u591a\u80fd\u6027 (Pluripotent)<\/strong><\/td><td>\u591a\u80fd\u6027\u5e79\u7d30\u80de<\/td><td>ES\u7d30\u80de\u3001iPS\u7d30\u80de\u3002\u4e09\u80da\u8449\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u5206\u5316\u53ef\u80fd\u3002<\/td><\/tr><tr><td><strong>\u591a\u80fd\u6027 (Multipotent)<\/strong><\/td><td>\u591a\u5206\u5316\u80fd\u5e79\u7d30\u80de<\/td><td>\u4f53\u6027\u5e79\u7d30\u80de\uff08HSC\u3001MSC\uff09\u3002\u7279\u5b9a\u306e\u7cfb\u7d71\u306e\u7d30\u80de\u306b\u5206\u5316\u53ef\u80fd\u3002<\/td><\/tr><tr><td><strong>\u5358\u80fd\u6027 (Unipotent)<\/strong><\/td><td>\u5358\u80fd\u6027\u5e79\u7d30\u80de<\/td><td>\u76ae\u819a\u5e79\u7d30\u80de\u3001\u7b4b\u8089\u5e79\u7d30\u80de\u3002\u7279\u5b9a\u306e\u5358\u4e00\u7a2e\u306e\u7d30\u80de\u306e\u307f\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">3.2 \u5e79\u7d30\u80de\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u591a\u80fd\u6027\u30b3\u30a2\u56e0\u5b50\uff1a<\/strong> Oct3\/4, Sox2, Nanog\u304c\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5c71\u4e2d\u56e0\u5b50\uff1a<\/strong> Oct3\/4, Sox2, Klf4, c-Myc\u3002\u3053\u308c\u3089\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u4f53\u7d30\u80de\u3092\u521d\u671f\u5316\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30cb\u30c3\u30c1\uff08\u5fae\u5c0f\u74b0\u5883\uff09\uff1a<\/strong> \u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM\uff09\u3084\u5468\u56f2\u306e\u7d30\u80de\u3001\u9178\u7d20\u6fc3\u5ea6\u306a\u3069\u304c\u5e79\u7d30\u80de\u306e\u6319\u52d5\u3092\u5de6\u53f3\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 \u9020\u8840\u5e79\u7d30\u80de\uff08HSC\uff09\u3068\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HSC\uff1a<\/strong> \u9aa8\u9ac4\u79fb\u690d\u3084\u907a\u4f1d\u5b50\u6539\u5909\u306b\u3088\u308b\u96e3\u75c5\u6cbb\u7642\uff08ADA\u6b20\u640d\u75c7\u7b49\uff09\u306b\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><strong>MSC\uff1a<\/strong> \u8102\u80aa\u3084\u9aa8\u9ac4\u304b\u3089\u63a1\u53d6\u3002\u708e\u75c7\u6291\u5236\u3084\u514d\u75ab\u8abf\u6574\u80fd\u3092\u6301\u3061\u3001GvHD\uff08\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff09\u3084\u30af\u30ed\u30fc\u30f3\u75c5\u763b\u5b54\u306a\u3069\u306e\u6cbb\u7642\uff08\u88fd\u54c1\u4f8b\uff1a\u30c6\u30e0\u30bb\u30eb\u00ae\u3001\u30a2\u30ed\u30d5\u30a3\u30bb\u30eb\u00ae\uff09\u306b\u5229\u7528\u3055\u308c\u308b\u3002Caplan(2017)\u306f\u3001\u3053\u308c\u3089\u3092\u300cMedicinal Signaling Cells\uff08\u85ac\u7406\u7684\u4fe1\u53f7\u9001\u9054\u7d30\u80de\uff09\u300d\u3068\u518d\u5b9a\u7fa9\u3059\u308b\u3053\u3068\u3092\u63d0\u5531\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u6b21\u4e16\u4ee3\u6cbb\u7642\u6280\u8853<\/h2>\n\n\n\n<p>\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306f\u3001\u518d\u751f\u533b\u7642\u3092\u5358\u306a\u308b\u7d30\u80de\u7f6e\u63db\u304b\u3089\u3001\u75be\u60a3\u306e\u6839\u672c\u539f\u56e0\u3092\u4fee\u6b63\u3059\u308b\u6cbb\u7642\u3078\u3068\u9032\u5316\u3055\u305b\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">4.1 \u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR-Cas9\uff1a<\/strong> \u7c21\u4fbf\u304b\u3064\u9ad8\u52b9\u7387\u306a\u7de8\u96c6\u3092\u53ef\u80fd\u306b\u3057\u305f\uff082020\u5e74\u30ce\u30fc\u30d9\u30eb\u8cde\uff09\u3002NHEJ\uff08\u975e\u76f8\u540c\u672b\u7aef\u7d50\u5408\uff09\u3084HDR\uff08\u76f8\u540c\u7d44\u63db\u3048\u4fee\u5fa9\uff09\u306e\u6a5f\u69cb\u3092\u5229\u7528\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30d9\u30fc\u30b9\u7de8\u96c6\uff08Base Editing\uff09\uff1a<\/strong> DNA\u3092\u4e8c\u672c\u9396\u5207\u65ad\u305b\u305a\u306b\u3001\u7279\u5b9a\u306e\u5869\u57fa\u3092\u7f6e\u63db\u3059\u308b\uff08C\u2192T, A\u2192G\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30d7\u30e9\u30a4\u30e0\u7de8\u96c6\uff08Prime Editing\uff09\uff1a<\/strong> \u9006\u8ee2\u5199\u9175\u7d20\u3092\u7528\u3044\u3001\u633f\u5165\u30fb\u6b20\u5931\u30fb\u7f6e\u63db\u3092\u7cbe\u5bc6\u306b\u884c\u3046\u300c\u30b5\u30fc\u30c1\u30fb\u30a2\u30f3\u30c9\u30fb\u30ea\u30d7\u30ec\u30fc\u30b9\u300d\u6280\u8853\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4.2 \u9001\u9054\uff08\u30c7\u30ea\u30d0\u30ea\u30fc\uff09\u6280\u8853<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\uff1a<\/strong> AAV\uff08\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\uff09\u304c\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09\u3084\u773c\u75be\u60a3\u3067\u4e3b\u6d41\uff08Luxturna\u00ae\u7b49\uff09\u3002<\/li>\n\n\n\n<li><strong>\u975e\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\uff1a<\/strong> LNP\uff08\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff09\u304cmRNA\u9001\u9054\u306a\u3069\u3067\u6d3b\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u7523\u696d\u5316\u3068\u5e02\u5834\u52d5\u5411<\/h2>\n\n\n\n<p>\u518d\u751f\u533b\u7642\u306f\u3001\u5927\u898f\u6a21\u306a\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3084\u88fd\u9020\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u69cb\u7bc9\u3092\u4f34\u3046\u5de8\u5927\u7523\u696d\u3078\u3068\u6210\u9577\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">5.1 \u81ea\u5bb6\uff08Autologous\uff09 vs \u4ed6\u5bb6\uff08Allogeneic\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u81ea\u5bb6\uff1a<\/strong> \u60a3\u8005\u81ea\u8eab\u306e\u7d30\u80de\u3092\u4f7f\u7528\u3002\u62d2\u7d76\u53cd\u5fdc\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u304c\u3001\u30b3\u30b9\u30c8\u304c\u9ad8\u304f\u500b\u5225\u88fd\u9020\u304c\u5fc5\u8981\u3002<\/li>\n\n\n\n<li><strong>\u4ed6\u5bb6\uff1a<\/strong> \u5065\u5eb7\u306a\u30c9\u30ca\u30fc\u306e\u7d30\u80de\u3092\u4f7f\u7528\u3002\u300cOff-the-shelf\uff08\u65e2\u88fd\u54c1\uff09\u300d\u3068\u3057\u3066\u306e\u5927\u91cf\u4f9b\u7d66\u304c\u53ef\u80fd\u3060\u304c\u3001HLA\u9069\u5408\u6027\u306b\u3088\u308b\u62d2\u7d76\u53cd\u5fdc\u304c\u8ab2\u984c\u3002CiRA Foundation\u7b49\u306f\u3001\u4e3b\u8981\u306aHLA\u578b\u3092\u7db2\u7f85\u3059\u308biPS\u7d30\u80de\u30b9\u30c8\u30c3\u30af\u3092\u69cb\u7bc9\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">5.2 \u5e02\u5834\u898f\u6a21\u3068\u7d4c\u6e08\u7684\u5f71\u97ff<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5e02\u5834\u4e88\u6e2c\uff1a<\/strong> 2025\u5e74\u306e516.5\u5104\u7c73\u30c9\u30eb\u304b\u3089\u30012034\u5e74\u306b\u306f5,555.8\u5104\u7c73\u30c9\u30eb\u3078\u6210\u9577\uff08CAGR 31.27%\uff09\u3002<\/li>\n\n\n\n<li><strong>\u85ac\u4fa1\u306e\u8ab2\u984c\uff1a<\/strong> \u6975\u3081\u3066\u9ad8\u984d\u306a\u85ac\u4fa1\u304c\u793e\u4f1a\u4fdd\u969c\u5236\u5ea6\u306e\u8ca0\u62c5\u3068\u306a\u3063\u3066\u3044\u308b\u3002\n<ul class=\"wp-block-list\">\n<li>Casgevy\u00ae\uff1a\u7d04220\u4e07\u7c73\u30c9\u30eb<\/li>\n\n\n\n<li>Hemgenix\u00ae\uff1a\u7d04350\u4e07\u7c73\u30c9\u30eb<\/li>\n\n\n\n<li>Zolgensma\u00ae\uff1a\u7d04212\u4e07\u7c73\u30c9\u30eb<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u898f\u5236\u306e\u67a0\u7d44\u307f\u3068\u5b9f\u7528\u5316\u306e\u8ab2\u984c<\/h2>\n\n\n\n<p>\u5404\u56fd\u306f\u518d\u751f\u533b\u7642\u306e\u7279\u6027\u306b\u5408\u308f\u305b\u305f\u67d4\u8edf\u306a\u898f\u5236\u3092\u5c0e\u5165\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6.1 \u65e5\u672c\u306e\u898f\u5236\u3068\u300c\u51fa\u53e3\u6a5f\u80fd\u300d<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u85ac\u6a5f\u6cd5\uff1a<\/strong> 2014\u5e74\u3001\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u300c\u6761\u4ef6\u53ca\u3073\u671f\u9650\u4ed8\u627f\u8a8d\u5236\u5ea6\u300d\u3092\u65b0\u8a2d\u3002\u6709\u52b9\u6027\u304c\u63a8\u5b9a\u3055\u308c\u308c\u3070\u3001\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3057\u305f\u4e0a\u3067\u65e9\u671f\u627f\u8a8d\u304c\u53ef\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u6761\u4ef6\u671f\u9650\u4ed8\u627f\u8a8d\u306e\u51fa\u53e3\uff1a<\/strong> 2024\u5e747\u6708\u3001\u30cf\u30fc\u30c8\u30b7\u30fc\u30c8\u00ae\u306e\u672c\u627f\u8a8d\u304c\u4e0d\u627f\u8a8d\u3068\u306a\u308a\u3001\u6761\u4ef6\u4ed8\u627f\u8a8d\u306e\u51fa\u53e3\u6a5f\u80fd\u304c\u521d\u3081\u3066\u767a\u52d5\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">6.2 \u8ab2\u984c<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u88fd\u9020\u7ba1\u7406\uff08CMC\uff09\uff1a<\/strong> \u54c1\u8cea\u306e\u4e00\u8cab\u6027\u3068\u3001\u81ea\u52d5\u5316\u30fb\u4f4e\u30b3\u30b9\u30c8\u5316\u306e\u4e21\u7acb\u304c\u6025\u52d9\u3002CMO\/CDMO\u3078\u306e\u59d4\u8a17\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u627f\u8a8d\u64a4\u9000\u306e\u30ea\u30b9\u30af\uff1a<\/strong> Glybera\u00ae\u3084Zynteglo\u00ae\u306e\u3088\u3046\u306b\u3001\u627f\u8a8d\u5f8c\u3082\u7d4c\u6e08\u7684\u7406\u7531\u3084\u9700\u8981\u4e0d\u8db3\u3067\u5e02\u5834\u304b\u3089\u64a4\u9000\u3059\u308b\u30b1\u30fc\u30b9\u304c\u898b\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027\uff1a<\/strong> \u9577\u671f\u7684\u306a\u751f\u7740\u3001\u816b\u760d\u5f62\u6210\u30ea\u30b9\u30af\u3001\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u306a\u3069\u306e\u76e3\u8996\u304c\u5fc5\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7. 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