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class=\"wp-block-heading\">2. \u6162\u6027\u524d\u7acb\u817a\u708e\uff08CP\/CPPS\uff09\uff1a\u7e70\u308a\u8fd4\u3059\u75db\u307f\u304b\u3089\u306e\u89e3\u653e<\/h3>\n\n\n\n<p>\u6162\u6027\u524d\u7acb\u817a\u708e\u3001\u3068\u308a\u308f\u3051\u6162\u6027\u9aa8\u76e4\u75db\u75c7\u5019\u7fa4\uff08CPPS\uff09\u306f\u3001\u539f\u56e0\u304c\u7279\u5b9a\u3057\u3065\u3089\u304f\u3001\u591a\u304f\u306e\u7537\u6027\u3092\u6697\u3044\u5f71\u306e\u3088\u3046\u306b\u8ffd\u3044\u8a70\u3081\u308b\u75be\u60a3\u3067\u3059\u3002\u5f93\u6765\u306e\u6297\u83cc\u85ac\u3084\u93ae\u75db\u5264\u306f\u3001\u3042\u304f\u307e\u3067\u300c\u706b\u3092\u6d88\u3059\u300d\u305f\u3081\u306e\u9053\u5177\u306b\u904e\u304e\u305a\u3001\u7d44\u7e54\u306b\u523b\u307e\u308c\u305f\u6df1\u3044\u30c0\u30e1\u30fc\u30b8\u307e\u3067\u306f\u7652\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u75db\u307f\u306e\u5287\u7684\u306a\u7de9\u548c\uff1a<\/strong>\u00a0\u81e8\u5e8a\u30c7\u30fc\u30bf\u3067\u306f\u3001\u75db\u307f\u3092\u793a\u3059VAS\u30b9\u30b3\u30a2\u304c50\uff05\u4ee5\u4e0a\u6e1b\u5c11\u3057\u305f\u3068\u3044\u3046\u9bae\u3084\u304b\u306a\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>QOL\u306e\u5411\u4e0a\uff1a<\/strong>\u00a0\u708e\u75c7\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u3066\u3044\u305f\u65e5\u5e38\u751f\u6d3b\u306e\u8cea\u304c\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u3068\u3068\u3082\u306b\u672c\u6765\u306e\u8f1d\u304d\u3092\u53d6\u308a\u623b\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u300cPRP\u306f\u6162\u6027\u524d\u7acb\u817a\u708e\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u300d<\/p>\n\n\n\n<p><strong>\u5206\u6790\u3068\u30ea\u30d5\u30ec\u30af\u30b7\u30e7\u30f3\uff1a<\/strong>&nbsp;\u306a\u305c\u3001\u5f93\u6765\u306e\u6cbb\u7642\u3067\u6551\u308f\u308c\u306a\u304b\u3063\u305f\u75c7\u4f8b\u306bPRP\u304c\u97ff\u304f\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u305d\u308c\u306f\u3001\u6162\u6027\u524d\u7acb\u817a\u708e\u304c\u708e\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u795e\u7d4c\u7cfb\u3084\u5fc3\u7406\u7684\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3046\u300c\u591a\u56e0\u5b50\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\uff08Multifactorial Mechanisms\uff09\u300d\u3092\u6301\u3063\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002PRP\u306b\u542b\u307e\u308c\u308b<strong>PDGF\u3001TGF-\u03b2\u3001IGF-1\u3001FGF\u3001VEGF<\/strong>\u3068\u3044\u3063\u305f\u591a\u69d8\u306a\u6210\u9577\u56e0\u5b50\u306f\u3001\u8840\u7ba1\u3068\u795e\u7d4c\u3092\u540c\u6642\u306b\u30b1\u30a2\u3057\u3001\u708e\u75c7\u306b\u3088\u3063\u3066\u8352\u308c\u679c\u3066\u305f\u7d44\u7e54\u3092\u591a\u89d2\u7684\u306b\u4fee\u5fa9\u3057\u307e\u3059\u3002\u5358\u306a\u308b\u9664\u83cc\u3084\u93ae\u75db\u3092\u8d85\u3048\u3001\u7d44\u7e54\u74b0\u5883\u3092\u571f\u53f0\u304b\u3089\u6574\u3048\u308b\u3002\u305d\u308c\u3053\u305d\u304c\u3001\u518d\u751f\u533b\u7642\u3060\u3051\u306b\u53ef\u80fd\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u52c3\u8d77\u4e0d\u5168\uff08ED\uff09\uff1a\u85ac\u306b\u983c\u3089\u306a\u3044\u3001\u6839\u672c\u304b\u3089\u306e\u300c\u518d\u751f\u300d<\/h3>\n\n\n\n<p>\u30d0\u30a4\u30a2\u30b0\u30e9\u306b\u4ee3\u8868\u3055\u308c\u308bPDE5\u963b\u5bb3\u85ac\u306f\u78ba\u304b\u306b\u4fbf\u5229\u3067\u3059\u304c\u3001\u305d\u308c\u306f\u4e00\u6642\u7684\u306b\u8840\u6d41\u3092\u4fc3\u3059\u3060\u3051\u306e\u300c\u9b54\u6cd5\u306e\u6756\u300d\u306b\u904e\u304e\u307e\u305b\u3093\u3002\u6756\u304c\u306a\u3051\u308c\u3070\u6b69\u3051\u306a\u3044\u72b6\u614b\u304b\u3089\u3001\u81ea\u5206\u306e\u8db3\u3067\u529b\u5f37\u304f\u7acb\u3061\u4e0a\u304c\u308b\u3002\u305d\u308c\u3092\u53ef\u80fd\u306b\u3059\u308b\u306e\u304cPRP\u7642\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n<ul 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class=\"wp-block-heading\">4. \u7537\u6027\u4e0d\u598a\uff1a\u7cbe\u5b50\u306e\u300c\u8cea\u300d\u3092\u5287\u7684\u306b\u5909\u3048\u308b\u53ef\u80fd\u6027<\/h3>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u3001PRP\u304c\u7cbe\u5b50\u306e\u5f62\u6210\u306b\u307e\u3067\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3001\u533b\u7642\u5f93\u4e8b\u8005\u306e\u9593\u3067\u3082\u9a5a\u304d\u3092\u3082\u3063\u3066\u53d7\u3051\u6b62\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4e0d\u598a\u6cbb\u7642\u3068\u3044\u3048\u3070\u5973\u6027\u5074\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u6ce8\u76ee\u3055\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u7537\u6027\u5074\u306e\u300c\u7a2e\u306e\u8cea\u300d\u3092DNA\u30ec\u30d9\u30eb\u3067\u5411\u4e0a\u3055\u305b\u308b\u9053\u304c\u958b\u304b\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cbe\u5b50\u6fc3\u5ea6\u306e\u5411\u4e0a\uff1a<\/strong>\u00a043%\u30a2\u30c3\u30d7<\/li>\n\n\n\n<li><strong>\u7cbe\u5b50\u904b\u52d5\u7387\u306e\u5411\u4e0a\uff1a<\/strong>\u00a035%\u30a2\u30c3\u30d7<\/li>\n\n\n\n<li><strong>\u7cbe\u5b50DNA\u640d\u50b7\u7387\uff08DFI\uff09\u306e\u4f4e\u4e0b\uff1a<\/strong>\u00a033%\u30c0\u30a6\u30f3<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5206\u6790\u3068\u30ea\u30d5\u30ec\u30af\u30b7\u30e7\u30f3\uff1a<\/strong>&nbsp;\u7279\u7b46\u3059\u3079\u304d\u306f\u3001DFI\uff08DNA\u4e0d\u9023\u7d9a\u5316\u6307\u6570\uff09\u304c33\uff05\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002PRP\u306b\u542b\u307e\u308c\u308bPDGF\u3084VEGF\u306a\u3069\u306e\u6210\u9577\u56e0\u5b50\u304c\u3001\u7cbe\u5b50\u5f62\u6210\u306e\u73fe\u5834\u3067\u3042\u308b\u7cbe\u5de3\u74b0\u5883\u3092\u6574\u3048\u3001\u751f\u547d\u306e\u8a2d\u8a08\u56f3\u3067\u3042\u308bDNA\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u4fee\u5fa9\u30fb\u4fdd\u8b77\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6570\u306f\u3082\u3061\u308d\u3093\u3067\u3059\u304c\u3001\u300c\u751f\u547d\u3068\u3057\u3066\u306e\u5065\u5168\u6027\u300d\u3092\u9ad8\u3081\u308b\u3053\u306e\u6280\u8853\u306f\u3001\u4e0d\u598a\u306b\u60a9\u3080\u30ab\u30c3\u30d7\u30eb\u306b\u3068\u3063\u3066\u3001\u4e16\u4ee3\u3092\u8d85\u3048\u305f\u771f\u306e\u5e0c\u671b\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">5. \u9593\u8cea\u6027\u8180\u80f1\u708e\uff08IC\/BPS\uff09\uff1a\u8180\u80f1\u58c1\u3092\u300c\u5185\u5074\u304b\u3089\u300d\u4f5c\u308a\u76f4\u3059<\/h3>\n\n\n\n<p>\u6fc0\u75db\u3068\u983b\u5c3f\u3002\u9593\u8cea\u6027\u8180\u80f1\u708e\u306e\u60a3\u8005\u69d8\u304c\u62b1\u3048\u308b\u82e6\u75db\u306f\u3001\u60f3\u50cf\u3092\u7d76\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u539f\u56e0\u306e\u4e00\u3064\u306f\u3001\u8180\u80f1\u3092\u5c3f\u306e\u523a\u6fc0\u304b\u3089\u5b88\u308b\u300cGAG\u5c64\uff08\u7c98\u819c\u4fdd\u8b77\u5c64\uff09\u300d\u304c\u5265\u304c\u308c\u843d\u3061\u3066\u3057\u307e\u3046\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9a5a\u7570\u306e\u75bc\u75db\u6539\u5584\uff1a<\/strong>\u00a0<strong>O\u2019Leary-Sant\u30b9\u30b3\u30a2<\/strong>\u3092\u7528\u3044\u305f\u8a55\u4fa1\u3067\u3001\u75bc\u75db\u6539\u5584\u738770%\u3068\u3044\u3046\u9ad8\u3044\u6570\u5024\u3092\u8a18\u9332\u3002<\/li>\n\n\n\n<li><strong>\u5168\u822c\u7684\u75c7\u72b6\u6539\u5584\uff08GRA\uff09\uff1a<\/strong>\u00a0\u60a3\u8005\u306e85%\u304c\u3001\u75c7\u72b6\u306e\u5168\u4f53\u7684\u306a\u597d\u8ee2\u3092\u5b9f\u611f\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5206\u6790\u3068\u30ea\u30d5\u30ec\u30af\u30b7\u30e7\u30f3\uff1a<\/strong>&nbsp;PRP\u306f\u3001\u3053\u306e\u5265\u304c\u308c\u843d\u3061\u305f\u8180\u80f1\u7c98\u819c\u3092\u300c\u5185\u5074\u304b\u3089\u4f5c\u308a\u76f4\u3059\u300d\u5f37\u529b\u306a\u30d0\u30c3\u30af\u30a2\u30c3\u30d7\u3068\u306a\u308a\u307e\u3059\u3002TGF-\u03b2\u3084VEGF\u304c\u7c98\u819c\u306e\u518d\u4e0a\u76ae\u5316\u3092\u4fc3\u3057\u3001\u795e\u7d4c\u904e\u654f\u3092\u93ae\u3081\u308b\u3002\u75db\u307f\u306e\u4fe1\u53f7\u3092\u906e\u65ad\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u75db\u307f\u306e\u300c\u5143\u300d\u3068\u306a\u3063\u3066\u3044\u308b\u7269\u7406\u7684\u306a\u58c1\u3092\u518d\u751f\u3055\u305b\u308b\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3053\u305d\u304c\u3001\u9577\u5e74\u306e\u82e6\u3057\u307f\u304b\u3089\u60a3\u8005\u69d8\u3092\u89e3\u653e\u3059\u308b\u6c7a\u5b9a\u6253\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6. \u5c3f\u5931\u7981\uff08PPI\/SUI\uff09\uff1a93%\u306e\u6539\u5584\u7387\u304c\u793a\u3059\u3001\u624b\u8853\u5f8c\u306e\u5b89\u5fc3<\/h3>\n\n\n\n<p>\u524d\u7acb\u817a\u304c\u3093\u306e\u624b\u8853\u5f8c\u306b\u6b8b\u308b\u5c3f\u5931\u7981\uff08PPI\uff09\u3084\u3001\u5973\u6027\u306b\u591a\u3044\u8179\u5727\u6027\u5c3f\u5931\u7981\uff08SUI\uff09\u3002\u3053\u308c\u307e\u3067\u306f\u300c\u547d\u3092\u6551\u3046\u305f\u3081\u306e\u4ee3\u511f\u300d\u3068\u3057\u3066\u3001\u30d1\u30c3\u30c9\u306e\u4f7f\u7528\u3092\u4f59\u5100\u306a\u304f\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6700\u65b0\u306e\u30c7\u30fc\u30bf\u306f\u305d\u306e\u5e38\u8b58\u3092\u9bae\u3084\u304b\u306b\u5857\u308a\u66ff\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>92.9%\u3068\u3044\u3046\u5727\u5012\u7684\u6539\u5584\u7387\uff1a<\/strong>\u00a0PRP\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u7d0493%\u304c\u3001\u5168\u822c\u7684\u6539\u5584\uff08GRA\uff09\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5ba2\u89b3\u7684\u306a\u6a5f\u80fd\u5f37\u5316\uff1a<\/strong>\u00a0\u5c3f\u6f0f\u308c\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u3092\u793a\u3059\u8179\u5727\u6027\u5c3f\u6f0f\u308c\u70b9\u5727\uff08ALPP\uff09\u304c\u3001<strong>57.5 cmH2O\u304b\u3089126.0 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