{"id":274,"date":"2026-03-20T15:39:32","date_gmt":"2026-03-20T06:39:32","guid":{"rendered":"https:\/\/rmnw.jp\/teams\/?p=274"},"modified":"2026-04-07T22:18:40","modified_gmt":"2026-04-07T13:18:40","slug":"x02-%e5%86%8d%e7%94%9f%e5%8c%bb%e7%99%82%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e7%9a%ae%e4%b8%8bprp%e7%99%82%e6%b3%95%e3%81%ab%e3%82%88%e3%82%8b-%e8%86%9d%e3%83%bb%e9%a0%b8%e9%83%a8%e3%83%bb%e8%82%a9","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/teams\/?p=274","title":{"rendered":"X02.\u518d\u751f\u533b\u7642\u3068\u3057\u3066\u306e\u76ae\u4e0bPRP\u7642\u6cd5\u306b\u3088\u308b \u819d\u30fb\u9838\u90e8\u30fb\u80a9\u75db\u6cbb\u7642"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"X02.\u518d\u751f\u533b\u7642\u3068\u3057\u3066\u306e\u76ae\u4e0bPRP\u7642\u6cd5\u306b\u3088\u308b \u819d\u30fb\u9838\u90e8\u30fb\u80a9\u75db\u6cbb\u7642\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/u-lzn4ZK-A8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n\t\t<div class=\"wppdfemb-frame-container-1\" style=\"-webkit-overflow-scrolling:auto;\">\n\t\t\t<iframe class=\"pdfembed-iframe nonfullscreen wppdf-emb-iframe-1\"\n\t\t\t\tsrc=\"https:\/\/rmnw.jp\/teams\/?pdfemb-data=eyJwZGZJRCI6Mjc1LCJ1cmwiOiJodHRwczpcL1wvcm1udy5qcFwvdGVhbXNcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjZcLzAzXC9YMDIuXHU1MThkXHU3NTFmXHU1MzNiXHU3NjQyXHUzMDY4XHUzMDU3XHUzMDY2XHUzMDZlXHU3NmFlXHU0ZTBiUFJQXHU3NjQyXHU2Y2Q1XHUzMDZiXHUzMDg4XHUzMDhiLVx1ODE5ZFx1MzBmYlx1OTgzOFx1OTBlOFx1MzBmYlx1ODBhOVx1NzVkYlx1NmNiYlx1NzY0Mi5wZGYiLCJpbmRleCI6MX0\"\n\t\t\t\t\t\t\t\tdata-pdf-id=\"275\"\n\t\t\t\tdata-pdf-index=\"1\"\n\t\t\t\tstyle=\"border:none;width:100%;max-width:100%;height:100vh;\"\n\t\t\t\tscrolling=\"yes\">\n\t\t\t<\/iframe>\n\t\t<\/div>\n\n\t\t\n\n\n<h1 class=\"wp-block-heading\">\u518d\u751f\u533b\u7642\u3068\u3057\u3066\u306e\u76ae\u4e0bPRP\u7642\u6cd5\uff1a\u819d\u30fb\u9838\u90e8\u30fb\u80a9\u75db\u6cbb\u7642\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u77e5\u898b\u3068\u5c55\u671b<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30b5\u30de\u30ea\u30fc<\/h2>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u819d\u30fb\u9838\u90e8\u30fb\u80a9\u306e\u75db\u307f\u306f\u3001\u708e\u75c7\u3001\u5909\u6027\u3001\u5fae\u5c0f\u640d\u50b7\u306b\u3088\u308b\u5c40\u6240\u7d44\u7e54\u969c\u5bb3\u3060\u3051\u3067\u306a\u304f\u3001\u672b\u68a2\u304a\u3088\u3073\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u611f\u4f5c\u3001\u795e\u7d4c\u514d\u75ab\u76f8\u4e92\u4f5c\u7528\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u305f\u591a\u9762\u7684\u306a\u75c5\u614b\u3092\u6709\u3057\u3066\u3044\u308b\u3002\u81ea\u5df1\u8840\u7531\u6765\u306e\u8840\u5c0f\u677f\u6fc3\u7e2e\u88fd\u5264\u3092\u7528\u3044\u308bPRP\uff08Platelet-Rich Plasma\uff09\u7642\u6cd5\u306f\u3001\u653e\u51fa\u3055\u308c\u308b\u6210\u9577\u56e0\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u4ecb\u3057\u3066\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u514d\u75ab\u8abf\u7bc0\u3001\u7d44\u7e54\u4fee\u5fa9\u306e\u518d\u8abf\u6574\u3092\u4fc3\u3059\u518d\u751f\u533b\u7642\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u672c\u8cc7\u6599\u3067\u306f\u3001\u7279\u306b\u300c\u6d45\u5c64PRP\uff08\u76ae\u4e0b\u8102\u80aa\u3001\u6d45\u7b4b\u819c\u3001\u3042\u308b\u3044\u306f\u6d45\u5c64\u30fb\u4e2d\u9593\u5c64\u306e\u7b4b\u819c\u9593\u30fb\u795e\u7d4c\u5468\u56f2\u3078\u306e\u6295\u4e0e\uff09\u300d\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u305d\u306e\u81e8\u5e8a\u7684\u6574\u7406\u3092\u884c\u3046\u3002\u73fe\u72b6\u3001\u9ad8\u54c1\u8cea\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u95a2\u7bc0\u5185\u3084\u8171\u5468\u56f2\u3078\u306e\u6ce8\u5165\u306b\u504f\u5728\u3057\u3066\u304a\u308a\u3001\u7d14\u7c8b\u306a\u76ae\u4e0b\u6295\u4e0e\u306b\u3088\u308b\u6cbb\u7642\u6839\u62e0\u306f\u9650\u5b9a\u7684\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7b4b\u819c\u306e\u4fb5\u5bb3\u53d7\u5bb9\u652f\u914d\u306e\u8c4a\u5bcc\u3055\u3084\u3001\u672b\u68a2\u795e\u7d4c\u75db\u306b\u5bfe\u3059\u308b\u795e\u7d4c\u5468\u56f2\u6295\u4e0e\uff08perineural PRP\uff09\u306e\u6709\u52b9\u6027\u3092\u793a\u3059\u5831\u544a\u3082\u3042\u308a\u3001\u75bc\u75db\u5165\u529b\u306e\u518d\u8abf\u6574\u3092\u72d9\u3046\u4ecb\u5165\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f\u6982\u306d\u826f\u597d\u3067\u3042\u308b\u304c\u3001\u507d\u85ac\uff08\u30d7\u30e9\u30bb\u30dc\uff09\u3068\u6bd4\u8f03\u3057\u3066\u8efd\u5fae\u301c\u4e2d\u7b49\u5ea6\u306e\u5408\u4f75\u75c7\uff08\u75bc\u75db\u5897\u60aa\u3001\u816b\u8139\u7b49\uff09\u304c\u767a\u751f\u3059\u308b\u983b\u5ea6\u306f\u7121\u8996\u3067\u304d\u305a\uff08NNH=11\uff09\u3001\u9069\u5207\u306a\u9069\u5fdc\u9078\u629e\u3068\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002\u65e5\u672c\u306b\u304a\u3044\u3066\u306f\u300c\u518d\u751f\u533b\u7642\u7b49\u5b89\u5168\u6027\u78ba\u4fdd\u6cd5\u300d\u306e\u67a0\u7d44\u307f\u306b\u57fa\u3065\u3044\u305f\u53b3\u683c\u306a\u904b\u7528\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u6162\u6027\u75bc\u75db\u306e\u75c5\u614b\u751f\u7406\u3068\u5206\u985e<\/h2>\n\n\n\n<p>\u6162\u6027\u75bc\u75db\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u3001\u56fd\u969b\u75bc\u75db\u5b66\u4f1a\uff08IASP\uff09\u304c\u5b9a\u7fa9\u3059\u308b3\u3064\u306e\u75bc\u75db\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5206\u985e\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4fb5\u5bb3\u53d7\u5bb9\u6027\u75bc\u75db (Nociceptive pain):<\/strong>\u00a0\u5b9f\u969b\u306e\u7d44\u7e54\u640d\u50b7\u3084\u708e\u75c7\uff08\u71b1\u3001\u816b\u308c\u7b49\uff09\u306b\u53cd\u5fdc\u3057\u3066\u751f\u3058\u308b\u3002<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db (Neuropathic pain):<\/strong>\u00a0\u8eab\u4f53\u611f\u899a\u4f53\u7cfb\u306e\u640d\u50b7\u3084\u75be\u60a3\uff08\u3057\u3073\u308c\u3001\u96fb\u6483\u75db\u7b49\uff09\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u3002<\/li>\n\n\n\n<li><strong>\u975e\u4fb5\u5bb3\u53ef\u5851\u6027\u75bc\u75db (Nociplastic pain):<\/strong>\u00a0\u4fb5\u5bb3\u53d7\u5bb9\u306e\u5909\u5316\u306b\u3088\u308a\u3001\u660e\u3089\u304b\u306a\u7d44\u7e54\u640d\u50b7\u3084\u795e\u7d4c\u640d\u50b7\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u751f\u3058\u308b\u75db\u899a\u5897\u5e45\u72b6\u614b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u611f\u4f5c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u672b\u68a2\u611f\u4f5c:<\/strong>\u00a0\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\uff08PGE2\u3001TNF\u3001IL-1\u3001IL-6\u7b49\uff09\u3084TRP\u30c1\u30e3\u30cd\u30eb\uff08TRPV1\u3001TRPA1\uff09\u3092\u4ecb\u3057\u305f\u4fb5\u5bb3\u53d7\u5bb9\u5668\u306e\u8208\u596e\u6027\u5897\u5927\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u67a2\u611f\u4f5c:<\/strong>\u00a0\u810a\u9ac4\u30fb\u8133\u306b\u304a\u3051\u308b\u53ef\u5851\u7684\u5909\u5316\u3002NMDA\u53d7\u5bb9\u4f53\u306e\u95a2\u4e0e\u3084\u7d4c\u6642\u7684\u52a0\u91cd\uff08temporal summation\uff09\u306b\u3088\u308a\u3001\u308f\u305a\u304b\u306a\u523a\u6fc0\u3067\u3082\u5f37\u3044\u75db\u307f\u3068\u3057\u3066\u5897\u5e45\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. PRP\u7642\u6cd5\u306e\u751f\u7269\u5b66\u7684\u57fa\u76e4\u3068\u88fd\u5264\u7279\u6027<\/h2>\n\n\n\n<p>PRP\u306f\u81ea\u5df1\u8840\u304b\u3089\u62bd\u51fa\u3055\u308c\u305f\u8840\u5c0f\u677f\u6fc3\u7e2e\u88fd\u5264\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u8981\u7d20\u3092\u4ecb\u3057\u3066\u5c40\u6240\u306e\u5fae\u5c0f\u74b0\u5883\u3092\u8abf\u6574\u3059\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u306a\u6210\u9577\u56e0\u5b50\u3068\u4f5c\u7528<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u6210\u9577\u56e0\u5b50<\/td><td>\u4e3b\u306a\u5f79\u5272<\/td><\/tr><tr><td><strong>PDGF<\/strong><\/td><td>\u8840\u5c0f\u677f\u7531\u6765\u6210\u9577\u56e0\u5b50\u3002\u7d30\u80de\u5897\u6b96\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3002<\/td><\/tr><tr><td><strong>TGF-\u03b2<\/strong><\/td><td>\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u5897\u6b96\u56e0\u5b50\u3002\u7d44\u7e54\u4fee\u5fa9\u3001\u514d\u75ab\u6291\u5236\u3002<\/td><\/tr><tr><td><strong>VEGF<\/strong><\/td><td>\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u3002\u8840\u7ba1\u65b0\u751f\u3092\u5f37\u529b\u306b\u63a8\u9032\u3002<\/td><\/tr><tr><td><strong>EGF \/ IGF-1<\/strong><\/td><td>\u4e0a\u76ae\u6210\u9577\u56e0\u5b50 \/ \u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50\u3002\u7d30\u80de\u306e\u5206\u5316\u30fb\u5897\u6b96\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d44\u6210\u306b\u3088\u308b\u5206\u985e<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LR-PRP (Leukocyte-Rich):<\/strong>\u00a0\u767d\u8840\u7403\u3092\u591a\u304f\u542b\u3080\u3002\u521d\u671f\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u8a98\u5c0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>LP-PRP (Leukocyte-Poor):<\/strong>\u00a0\u767d\u8840\u7403\u3092\u6975\u529b\u6392\u9664\u3002\u95a2\u7bc0\u75c7\uff08OA\uff09\u306a\u3069\u3067\u306f\u708e\u75c7\u3092\u6291\u3048\u308b\u305f\u3081\u3053\u3061\u3089\u304c\u512a\u5148\u3055\u308c\u308b\u50be\u5411\u306b\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u88fd\u5264\u306e\u6a19\u6e96\u5316\u6307\u6a19\uff08MIBO\u6e96\u62e0\uff09<\/h3>\n\n\n\n<p>\u9ad8\u54c1\u8cea\u306a\u7814\u7a76\u30fb\u6cbb\u7642\u306e\u305f\u3081\u306b\u306f\u3001\u8840\u5c0f\u677f\u6fc3\u5ea6\u3001\u767d\u8840\u7403\u542b\u91cf\u3001\u6d3b\u6027\u5316\u306e\u6709\u7121\uff08CaCl\u2082\u7b49\uff09\u3001\u6295\u4e0e\u91cf\uff08dose\uff09\u306a\u3069\u306e\u60c5\u5831\u3092\u900f\u660e\u5316\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\uff08PAW\u5206\u985e\u3001DEPA\u5206\u985e\u7b49\u306e\u6d3b\u7528\uff09\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u90e8\u4f4d\u5225\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u6982\u6cc1<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u819d\u95a2\u7bc0\uff08\u819dOA\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IA-PRP (\u95a2\u7bc0\u5185\u6295\u4e0e):<\/strong>\u00a0\u30e1\u30bf\u89e3\u6790\u3067\u306f\u75bc\u75db\uff08VAS\uff09\u3084\u6a5f\u80fd\u6539\u5584\uff08WOMAC\uff09\u3092\u652f\u6301\u3059\u308b\u5831\u544a\u304c\u591a\u3044\u304c\u3001\u9ad8\u54c1\u8cea\u306aRCT\uff08RESTORE\u8a66\u9a13\u7b49\uff09\u3067\u306f\u30d7\u30e9\u30bb\u30dc\uff08\u751f\u7406\u98df\u5869\u6c34\uff09\u3068\u306e\u6709\u610f\u5dee\u304c\u51fa\u306a\u3044\u7d50\u679c\uff08\u75bc\u75db\u5dee -0.4\/10\u70b9\uff09\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3:<\/strong>\u00a0ACR\/AF\u3084OARSI\u306f\u300c\u5f37\u3044\u53cd\u5bfe\u300d\u304b\u3089\u300c\u63a8\u5968\u3057\u306a\u3044\u300d\u306e\u7acb\u5834\u3002AAOS\u306f\u300c\u9650\u5b9a\u7684\u63a8\u5968\u300d\u3002ESSKA-ICRS\u306fKL\u5206\u985e0-III\u306e\u75c7\u4f8b\u306b\u5bfe\u3057\u3001\u4fdd\u5b58\u7642\u6cd5\u7121\u52b9\u5f8c\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u300c\u9069\u5207\u300d\u3068\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u9838\u90e8<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u690e\u9593\u95a2\u7bc0 (Facet joint):<\/strong>\u00a0\u5c0f\u898f\u6a21RCT\u306b\u304a\u3044\u3066\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u6295\u4e0e\u3068\u6982\u306d\u540c\u7b49\u306e\u6539\u5584\u52b9\u679c\uff08\u6700\u59276\u30f6\u6708\uff09\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u75db:<\/strong>\u00a0\u5927\u5f8c\u982d\u795e\u7d4c\u5468\u56f2\u3078\u306ePRP\u6295\u4e0e\u306f\u5b89\u5168\u3067\u5b9f\u65bd\u53ef\u80fd\u3067\u3042\u308b\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u660e\u78ba\u306a\u6709\u610f\u5dee\u3092\u793a\u3059\u306b\u306f\u81f3\u3063\u3066\u3044\u306a\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u80a9\u95a2\u7bc0<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8171\u677f\u8171\u75c7:<\/strong>\u00a0\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u306e\u6bd4\u8f03\u3067\u512a\u4f4d\u6027\u3092\u793a\u3059\u5831\u544a\u304c\u3042\u308b\u4e00\u65b9\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3067\u306f\u5dee\u304c\u51fa\u306a\u3044\u8a66\u9a13\u3082\u3042\u308a\u3001\u7570\u8cea\u6027\u304c\u5927\u304d\u3044\u3002<\/li>\n\n\n\n<li><strong>\u51cd\u7d50\u80a9:<\/strong>\u00a0\u30b9\u30c6\u30ed\u30a4\u30c9\u6bd4\u8f03\u30e1\u30bf\u89e3\u6790\u3067\u6709\u52b9\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6a19\u6e96\u7684\u306a\u7406\u5b66\u7642\u6cd5\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u524d\u63d0\u3068\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u76ae\u4e0b\u30fb\u6d45\u5c64PRP\u6295\u4e0e\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u6848<\/h2>\n\n\n\n<p>\u6d45\u5c64PRP\u306f\u3001\u5358\u306a\u308b\u300c\u76ae\u819a\u3078\u306e\u6ce8\u5165\u300d\u3067\u306f\u306a\u304f\u3001\u795e\u7d4c\u5468\u56f2\u3084\u7b4b\u819c\u3092\u6a19\u7684\u3068\u3057\u305f\u7cbe\u5bc6\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u63a1\u8840\u30fb\u524d\u51e6\u7406:<\/strong>\u00a018-21G\u91dd\u3092\u7528\u3044\u300120-60mL\u3092\u63a1\u8840\u3002\u9589\u9396\u7cfb\u6a5f\u5668\u3067\u7121\u83cc\u7684\u306b\u51e6\u7406\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u88fd\u5264\u5316:<\/strong>\u00a0\u30c7\u30d0\u30a4\u30b9\u898f\u5b9a\u306b\u5f93\u3044\u9060\u5fc3\u5206\u96e2\u3002\u767d\u8840\u7403\u542b\u6709\u91cf\uff08LR\/LP\uff09\u3092\u610f\u8b58\u3057\u3066\u8a2d\u8a08\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6d3b\u6027\u5316:<\/strong>\u00a0\u539f\u5247\u3068\u3057\u3066in vivo\uff08\u4f53\u5185\uff09\u3067\u306e\u81ea\u7136\u6d3b\u6027\u5316\u3092\u512a\u5148\u3059\u308b\u304c\u3001\u76ee\u7684\u306b\u5fdc\u3058\u3066CaCl\u2082\u306e\u4f7f\u7528\u3092\u691c\u8a0e\u3059\u308b\u3002\u5c40\u6240\u9ebb\u9154\u85ac\u3068\u306e\u6df7\u548c\u306f\u907f\u3051\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8d85\u97f3\u6ce2\u30ac\u30a4\u30c9\u4e0b\u6ce8\u5165:<\/strong>\u00a0\u6a19\u6e96\u7684\u306a\u624b\u6cd5\u3068\u3057\u3066\u63a8\u5968\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u795e\u7d4c\u5468\u56f2:<\/strong>\u00a01\u90e8\u4f4d\u3042\u305f\u308a1-3mL\u3092\u5206\u5272\u6ce8\u5165\u3002<\/li>\n\n\n\n<li><strong>\u76ae\u4e0b\u301c\u7b4b\u819c\u9593:<\/strong>\u00a0\u75bc\u75db\u9818\u57df\u3078\u6247\u72b6\u306b\u5206\u5272\u6295\u4e0e\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e8b\u5f8c\u8a55\u4fa1:<\/strong>\u00a04-12\u9031\u3067\u75bc\u75db\uff08MCID\uff09\u3001\u6a5f\u80fd\u3001\u7761\u7720\u3001\u85ac\u5264\u4f7f\u7528\u91cf\u306e\u5909\u5316\u3092\u5224\u5b9a\u3059\u308b\u3002<\/li>\n<\/ol>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u5b89\u5168\u6027\u3068\u65e5\u672c\u306e\u5236\u5ea6\u7684\u67a0\u7d44\u307f<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u91cd\u8981\u30c7\u30fc\u30bf<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NNH (Number Needed to Harm) = 11:<\/strong>\u00a0\u819dOA\u306b\u5bfe\u3059\u308bPRP\u6ce8\u5c04\u306b\u304a\u3044\u3066\u300111\u4eba\u306b1\u4eba\u306e\u5272\u5408\u3067\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u591a\u3044\u8efd\u5fae\u301c\u4e2d\u7b49\u5ea6\u306e\u5408\u4f75\u75c7\uff08\u4e00\u904e\u6027\u306e\u75bc\u75db\u5897\u60aa\u7b49\uff09\u304c\u767a\u751f\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7981\u5fcc:<\/strong>\u00a0\u6d3b\u52d5\u6027\u611f\u67d3\u3001\u91cd\u5ea6\u306e\u8840\u5c0f\u677f\u6a5f\u80fd\u7570\u5e38\u3001\u60aa\u6027\u816b\u760d\uff08\u6700\u8fd1\u306e\u75c7\u4f8b\uff09\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u4e2d\uff08\u51fa\u8840\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u5fc5\u8981\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u65e5\u672c\u306e\u6cd5\u5236\u5ea6<\/h3>\n\n\n\n<p>\u81ea\u5df1PRP\u7642\u6cd5\u306f\u300c\u518d\u751f\u533b\u7642\u7b49\u5b89\u5168\u6027\u78ba\u4fdd\u6cd5\u300d\u306e\u67a0\u7d44\u307f\uff08\u591a\u304f\u306f\u7b2cIII\u7a2e\uff09\u3067\u904b\u7528\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u63d0\u4f9b\u8a08\u753b\u306e\u5c4a\u51fa:<\/strong>\u00a0\u539a\u751f\u52b4\u50cd\u7701\u3078\u306e\u5c4a\u51fa\u3068\u8a8d\u5b9a\u518d\u751f\u533b\u7642\u7b49\u59d4\u54e1\u4f1a\u306b\u3088\u308b\u5be9\u67fb\u304c\u5fc5\u9808\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8:<\/strong>\u00a0\u5229\u76ca\u3060\u3051\u3067\u306a\u304f\u3001\u4e0d\u78ba\u5b9f\u6027\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u306e\u5426\u5b9a\u7684\u7d50\u679c\u3001\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u3001\u8cbb\u7528\uff08\u81ea\u8cbb\u8a3a\u7642\uff09\u306b\u3064\u3044\u3066\u66f8\u9762\u3067\u8aac\u660e\u3057\u540c\u610f\u3092\u5f97\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7121\u83cc\u6027\u78ba\u4fdd:<\/strong>\u00a0\u9589\u9396\u7cfb\u6a5f\u5668\u306e\u4f7f\u7528\u3068\u3001\u65bd\u8a2d\u5185SOP\uff08\u6a19\u6e96\u4f5c\u696d\u624b\u9806\u66f8\uff09\u306e\u6574\u5099\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u60a3\u8005\u9078\u629e\u306e\u6700\u9069\u5316\uff08\u6cbb\u7642\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\uff09<\/h2>\n\n\n\n<p>\u6d45\u5c64PRP\u304c\u63a8\u5968\u3055\u308c\u308b\u60a3\u8005\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3001\u300c\u518d\u751f\u300d\u3088\u308a\u3082\u300c\u5165\u529b\u306e\u518d\u8abf\u6574\u300d\u3092\u5fc5\u8981\u3068\u3059\u308b\u5c64\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9069\u683c\u5019\u88dc:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u89e6\u8a3a\u306b\u3088\u308b\u6d45\u5c64\u306e\u518d\u73fe\u75db\u304c\u5f37\u3044\u3002<\/li>\n\n\n\n<li>\u795e\u7d4c\u8d70\u884c\u306b\u4e00\u81f4\u3057\u305f\u707c\u71b1\u75db\u3084\u3057\u3073\u308c\u3001\u30a2\u30ed\u30c7\u30a3\u30cb\u30a2\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u753b\u50cf\u4e0a\u306e\u91cd\u75c7\u5ea6\u3068\u75db\u307f\u306e\u7a0b\u5ea6\u304c\u4e56\u96e2\u3057\u3066\u304a\u308a\u3001\u611f\u4f5c\u512a\u4f4d\u304c\u7591\u308f\u308c\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u306a\u5c64:<\/strong>\n<ul class=\"wp-block-list\">\n<li>nociplastic\uff08\u975e\u4fb5\u5bb3\u53ef\u5851\u6027\uff09\u75bc\u75db\u304c\u512a\u4f4d\u306a\u5e83\u7bc4\u75db\u3001\u7761\u7720\u969c\u5bb3\u3001\u5f37\u3044\u75b2\u52b4\u3092\u4f34\u3046\u75c7\u4f8b\u3002\u3053\u308c\u3089\u306b\u306f\u904b\u52d5\u7642\u6cd5\u3084\u8a8d\u77e5\u884c\u52d5\u7684\u4ecb\u5165\u306e\u4f75\u7528\u304c\u671b\u307e\u3057\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7. \u672a\u89e3\u6c7a\u306e\u8ab2\u984c\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/h2>\n\n\n\n<p>\u73fe\u5728\u3001\u7d14\u7c8b\u306a\u76ae\u4e0b\u5358\u72ec\u6295\u4e0e\u306b\u3088\u308bPRP\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u305f\u53b3\u683c\u306a\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167RCT\u306f\u5b58\u5728\u3057\u306a\u3044\uff080\u4ef6\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6700\u9069\u5316\u554f\u984c:<\/strong>\u00a0\u300c\u3069\u306e\u7d44\u6210\u306ePRP\u3092\u3001\u3069\u306e\u6a19\u7684\u306b\u3001\u3069\u306e\u7a0b\u5ea6\u306e\u9593\u9694\u3067\u300d\u6295\u4e0e\u3059\u308b\u306e\u304c\u6700\u3082\u8cbb\u7528\u5bfe\u52b9\u679c\u304c\u9ad8\u3044\u304b\u3068\u3044\u3046\u6a19\u6e96\u5316\u304c\u6025\u52d9\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u85ac\u7406\u5b66\u7684\u691c\u8a3c:<\/strong>\u00a0\u76ae\u4e0b\u6295\u4e0e\u3055\u308c\u305f\u6210\u9577\u56e0\u5b50\u304c\u5c40\u6240\u5fae\u5c0f\u74b0\u5883\u306b\u3069\u306e\u7a0b\u5ea6\u306e\u6642\u9593\u6b8b\u5b58\u3057\u3001\u30ea\u30f3\u30d1\u8def\u79fb\u884c\u3092\u4ecb\u3057\u3066\u3069\u3046\u4f5c\u7528\u3059\u308b\u304b\u3092\u3001\u751f\u4f53\u30de\u30fc\u30ab\u30fc\u3084\u753b\u50cf\u7b49\u3067\u5b9a\u91cf\u5316\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6b21\u5143\u30a2\u30a6\u30c8\u30ab\u30e0:<\/strong>\u00a0\u75bc\u75db\u5f37\u5ea6\u3060\u3051\u3067\u306a\u304f\u3001\u611f\u4f5c\u6307\u6a19\uff08CSI\uff09\u3001\u795e\u7d4c\u6a5f\u80fd\uff08\u8d85\u97f3\u6ce2\u306b\u3088\u308b\u795e\u7d4c\u816b\u5927\u306e\u8a55\u4fa1\u7b49\uff09\u3001QOL\u3092\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3059\u308b\u7814\u7a76\u8a2d\u8a08\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u518d\u751f\u533b\u7642\u3068\u3057\u3066\u306e\u76ae\u4e0bPRP\u7642\u6cd5\uff1a\u819d\u30fb\u9838\u90e8\u30fb\u80a9\u75db\u6cbb\u7642\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u77e5\u898b\u3068\u5c55\u671b \u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30b5\u30de\u30ea\u30fc \u6162\u6027\u7684\u306a\u819d\u30fb\u9838\u90e8\u30fb\u80a9\u306e\u75db\u307f\u306f\u3001\u708e\u75c7\u3001\u5909\u6027\u3001\u5fae\u5c0f\u640d\u50b7\u306b\u3088\u308b\u5c40\u6240\u7d44\u7e54\u969c\u5bb3\u3060\u3051\u3067\u306a\u304f\u3001\u672b\u68a2\u304a\u3088\u3073\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u611f\u4f5c\u3001\u795e\u7d4c\u514d\u75ab\u76f8\u4e92 [&hellip;]","protected":false},"author":1,"featured_media":276,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[18,20],"tags":[],"class_list":["post-274","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rmnw","category-20"],"jetpack_featured_media_url":"https:\/\/rmnw.jp\/teams\/wp-content\/uploads\/2026\/03\/image-1.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=274"}],"version-history":[{"count":2,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/274\/revisions"}],"predecessor-version":[{"id":413,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/posts\/274\/revisions\/413"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=\/wp\/v2\/media\/276"}],"wp:attachment":[{"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rmnw.jp\/teams\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}