{"id":826,"date":"2025-08-10T11:12:14","date_gmt":"2025-08-10T02:12:14","guid":{"rendered":"https:\/\/rmnw.jp\/?p=826"},"modified":"2025-09-11T14:59:36","modified_gmt":"2025-09-11T05:59:36","slug":"d34-%e5%b0%8b%e5%b8%b8%e6%80%a7%e7%97%a4%e7%98%a1%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8bv1-0","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/?p=826","title":{"rendered":"D33.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66\u3000\u5c0b\u5e38\u6027\u75e4\u7621\u3000V1.0"},"content":{"rendered":"\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/09\/D33.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u5c0b\u5e38\u6027\u75e4\u7621-V1.0.mp3\"><\/audio><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"D33.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66 \u5c0b\u5e38\u6027\u75e4\u7621 V1.0\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/GkzdYOkKnMA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n<a href=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/09\/D33.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u5c0b\u5e38\u6027\u75e4\u7621-V1.0.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\" data-toolbar=\"bottom\" data-toolbar-fixed=\"on\">D33.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u5c0b\u5e38\u6027\u75e4\u7621-V1.0<\/a>\n\n\n<h1 class=\"wp-block-heading\">\u5c0b\u5e38\u6027\u75e4\u7621\uff08\u306b\u304d\u3073\uff09<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u75ab\u5b66\uff08\u65e5\u672c\u304a\u3088\u3073\u4e16\u754c\uff09<\/h2>\n\n\n\n<p>\u5c0b\u5e38\u6027\u75e4\u7621\uff08\u306b\u304d\u3073\uff09\u306f\u601d\u6625\u671f\u3092\u4e2d\u5fc3\u306b\u975e\u5e38\u306b\u983b\u5ea6\u306e\u9ad8\u3044\u76ae\u819a\u75be\u60a3\u3067\u3059\u3002\u4e16\u754c\u7684\u306b\u306f<strong>\u6709\u75c5\u7387\u7d049.4%\u3068\u63a8\u5b9a\u3055\u308c\u3001\u75be\u75c5\u5168\u4f53\u306e\u4e2d\u3067\u3082\u7b2c8\u4f4d\u3068\u3055\u308c\u308b\u307b\u3069\u4e00\u822c\u7684\u3067\u3059<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25597339\/#:~:text=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u7279\u306b\u601d\u6625\u671f\u5f8c\u534a\u306e\u9752\u5c11\u5e74\u3067\u591a\u304f\u307f\u3089\u308c\u3001\u7537\u6027\u3067\u306f\u5973\u6027\u3088\u308a\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25597339\/#:~:text=Acne%20is%20estimated%20to%20affect,the%20exception%20of%20specific%20populations\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u65e5\u672c\u306b\u304a\u3044\u3066\u3082\u75ab\u5b66\u8abf\u67fb\u3067\u4e2d\u5b663\u5e74\u751f\uff08\u7d0415\u6b73\uff09\u6642\u306e\u6709\u75c5\u7387\u304c87.3%\u3068\u30d4\u30fc\u30af\u306b\u9054\u3057\u3001\u601d\u6625\u671f\u3092\u7d42\u3048\u308b\u307e\u3067\u306b95%\u4ee5\u4e0a\u304c\u767a\u75c7\u3059\u308b<\/strong>\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/dermatol\/130\/8\/130_1811\/_article\/-char\/ja\/#:~:text=%E6%8A%84%E9%8C%B2\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u5e73\u5747\u767a\u75c7\u5e74\u9f62\u306f\u7537\u5b5013.3\u6b73\u30fb\u5973\u5b5012.7\u6b73\u3067\u3001\u65e5\u672c\u4eba\u306e<strong>\u751f\u6daf\u7f79\u60a3\u7387\u306f\u7d0495%\u306b\u3082\u53ca\u3073\u307e\u3059<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/dermatol\/130\/8\/130_1811\/_article\/-char\/ja\/#:~:text=%E6%8A%84%E9%8C%B2\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u601d\u6625\u671f\u306e\u4e00\u904e\u6027\u75be\u60a3\u3068\u6349\u3048\u3089\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u6210\u4eba\u4ee5\u964d\u3082\u7d0415%\u306e\u5973\u6027\u304c\u75e4\u7621\u306b\u60a9\u3080\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u300120\uff5e30\u4ee3\u4ee5\u964d\u306e\u300c\u5927\u4eba\u30cb\u30ad\u30d3\u300d\u3082\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002\u307e\u305f\u75e4\u7621\u306fQOL\uff08\u751f\u6d3b\u306e\u8cea\uff09\u306b\u5927\u304d\u306a\u5f71\u97ff<\/strong>\u3092\u4e0e\u3048\u3046\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9\u3084\u81ea\u5df1\u8a55\u4fa1\u306e\u4f4e\u4e0b\u3001\u91cd\u75c7\u4f8b\u3067\u306f\u3046\u3064\u50be\u5411\u306e\u4e00\u56e0\u3068\u3082\u306a\u308a\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u300c\u9752\u6625\u306e\u30b7\u30f3\u30dc\u30eb\u300d\u3068\u3057\u3066\u8efd\u8996\u3055\u308c\u304c\u3061\u306a\u9762\u304c\u3042\u308a\u3001\u5b9f\u969b\u306b\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3059\u308b\u60a3\u8005\u306f\u5168\u4f53\u306e<strong>10\uff5e16%\u7a0b\u5ea6\u306b\u7559\u307e\u308b<\/strong>\u3068\u306e\u8abf\u67fb\u3082\u3042\u308a\u307e\u3059<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/dermatol\/130\/8\/130_1811\/_article\/-char\/ja\/#:~:text=%E6%8A%84%E9%8C%B2\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u3057\u304b\u3057\u8fd1\u5e74\u3001<strong>\u8efd\u75c7\u4f8b\u3067\u3082\u7622\u75d5\u3092\u6b8b\u3059\u53ef\u80fd\u6027<\/strong>\u3084<strong>\u65e9\u671f\u6cbb\u7642\u306b\u3088\u308b\u7622\u75d5\u4e88\u9632<\/strong>\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3001\u75e4\u7621\u3092\u653e\u7f6e\u305b\u305a\u9069\u5207\u306b\u6cbb\u7642\u3059\u308b\u91cd\u8981\u6027\u304c\u5553\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c5\u56e0\u3068\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n\n\n\n<p><strong>\u5c0b\u5e38\u6027\u75e4\u7621\u306e\u767a\u75c7\u306b\u306f\u8907\u6570\u306e\u8981\u56e0\u304c\u8907\u96d1\u306b\u95a2\u4e0e<\/strong>\u3057\u307e\u3059\u3002\u4e3b\u306a\u75c5\u56e0\u56e0\u5b50\u306f\u4ee5\u4e0b\u306e4\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u76ae\u8102\u306e\u904e\u5270\u5206\u6ccc<\/strong>\uff08\u8102\u817a\u306e\u6d3b\u52d5\u4ea2\u9032\uff09<\/li>\n\n\n\n<li><strong>\u6bdb\u5305\u6f0f\u6597\u90e8\u306e\u89d2\u5316\u7570\u5e38<\/strong>\uff08\u6bdb\u7a74\u306e\u3064\u307e\u308a\u3001\u9762\u76b0\u3008\u30b3\u30e1\u30c9\u3009\u5f62\u6210\uff09<\/li>\n\n\n\n<li><strong>\u30a2\u30af\u30cd\u83cc\uff08Cutibacterium acnes\uff09\u306e\u5897\u6b96<\/strong><\/li>\n\n\n\n<li><strong>\u708e\u75c7\u53cd\u5fdc<\/strong>\uff08\u81ea\u7136\u514d\u75ab\u30fb\u7372\u5f97\u514d\u75ab\u306e\u6d3b\u6027\u5316\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u601d\u6625\u671f\u306b\u306f\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff08\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff09\u306e\u5897\u52a0\u306b\u3088\u308a\u76ae\u8102\u817a\u304c\u80a5\u5927\u3057\u3001<strong>\u76ae\u8102\u5206\u6ccc\u304c\u4ea2\u9032<\/strong>\u3057\u307e\u3059\u3002\u76ae\u8102\u91cf\u306e\u5897\u52a0\u304a\u3088\u3073\u7d44\u6210\u5909\u5316\uff08\u904a\u96e2\u8102\u80aa\u9178\u306e\u5897\u52a0\u306a\u3069\uff09\u306f\u3001\u6bdb\u5305\u5185\u3067\u306eC. acnes\u5897\u6b96\u3092\u52a9\u9577\u3057\u3001\u307e\u305f\u904e\u5270\u306a\u76ae\u8102\u306f\u6bdb\u7a74\u306e\u5185\u5074\u306e\u89d2\u8cea\u3092\u80a5\u539a\u3055\u305b\u3066<strong>\u6bdb\u5305\u6f0f\u6597\u90e8\u306e\u9589\u585e\uff08\u89d2\u6813\u5f62\u6210\uff09\u3092\u62db\u304d\u307e\u3059\u3002\u3053\u3046\u3057\u3066\u5f62\u6210\u3055\u308c\u308b\u9762\u76b0\uff08\u30b3\u30e1\u30c9\u3001\u3044\u308f\u3086\u308b\u300c\u767d\u30cb\u30ad\u30d3\u300d\u300c\u9ed2\u30cb\u30ad\u30d3\u300d\uff09\u306f\u75e4\u7621\u306e\u521d\u767a\u75c5\u5909\u3067\u3042\u308a\u3001\u975e\u708e\u75c7\u6027\u75c5\u5909\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001C. acnes\uff08\u65e7\u79f0Propionibacterium acnes\u3001\u3044\u308f\u3086\u308b\u30a2\u30af\u30cd\u83cc\uff09\u306f\u76ae\u819a\u5e38\u5728\u306e\u5acc\u6c17\u6027\u30b0\u30e9\u30e0\u967d\u6027\u687f\u83cc\u3067\u3001\u76ae\u8102\u3092\u6804\u990a\u6e90\u3068\u3057\u3066\u6bdb\u5305\u5185\u3067\u5897\u6b96\u3057\u3001\u904a\u96e2\u8102\u80aa\u9178\u3084\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u7523\u751f\u3057\u3066\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u3092\u8a98\u5c0e<\/strong>\u3057\u307e\u3059\u3002C. acnes\u306f\u8868\u76ae\u89d2\u5316\u7d30\u80de\u3084\u76ae\u8102\u817a\u7d30\u80de\u306eTLR2\u30fbTLR4\uff08\u30c8\u30eb\u69d8\u53d7\u5bb9\u4f53\uff09\u3092\u523a\u6fc0\u3057\u3001IL-6\u3084IL-8\u306a\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3092\u5f15\u304d\u8d77\u3053\u3059\u307b\u304b\u3001\u597d\u4e2d\u7403\u3092\u6d3b\u6027\u5316\u3057\u3066\u6d3b\u6027\u9178\u7d20\u7523\u751f\u3084\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u653e\u51fa\u3092\u3082\u305f\u3089\u3057\u3001\u5468\u56f2\u7d44\u7e54\u306e\u708e\u75c7\u3068\u7d44\u7e54\u7834\u58ca\u3092\u9032\u884c\u3055\u305b\u307e\u3059\u3002\u3055\u3089\u306bC. acnes\u306fNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u4ecb\u3057\u3066IL-1\u03b2\u7523\u751f\u3082\u8a98\u5c0e\u3057\u3001<strong>\u6bdb\u5305\u5185\u90e8\u3067\u306f\u5fae\u5c0f\u9762\u76b0\u306e\u6bb5\u968e\u304b\u3089\u3059\u3067\u306b\u708e\u75c7\u304c\u59cb\u307e\u3063\u3066\u3044\u308b<\/strong>\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u3063\u3066\u9762\u76b0\u306f<strong>\u7d05\u8272\u4e18\u75b9\u30fb\u81bf\u75b1\u306a\u3069\u306e\u708e\u75c7\u6027\u75c5\u5909<\/strong>\u3078\u9032\u5c55\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30db\u30eb\u30e2\u30f3\u56e0\u5b50<\/strong>\u306f\u76ae\u8102\u5206\u6ccc\u306b\u5f37\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff08\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3084\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff09\u306f\u76ae\u8102\u817a\u306e\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3066\u8102\u8cea\u5408\u6210\u3068\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u6bdb\u5305\u4e0a\u76ae\u306e\u89d2\u5316\u3092\u4fc3\u3059\u3053\u3068\u3067\u75e4\u7621\u306e\u60f9\u8d77\u56e0\u5b50\u3068\u306a\u308a\u307e\u3059\u3002\u6708\u7d4c\u524d\u306b\u60aa\u5316\u3059\u308b\u5973\u6027\u306e\u75e4\u7621\u3067\u306f\u9ec4\u4f53\u671f\u306e\u9ec4\u4f53\u30db\u30eb\u30e2\u30f3\u5909\u52d5\u3084\u76f8\u5bfe\u7684\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u512a\u4f4d\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002\u307e\u305f<strong>\u907a\u4f1d\u7684\u7d20\u56e0<\/strong>\u3082\u7121\u8996\u3067\u304d\u305a\u3001\u5bb6\u65cf\u306b\u91cd\u75c7\u75e4\u7621\u60a3\u8005\u304c\u3044\u308b\u3068\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u74b0\u5883\u56e0\u5b50\u3084\u751f\u6d3b\u7fd2\u6163<\/strong>\u3082\u75e4\u7621\u306e\u5897\u60aa\u8981\u56e0\u3068\u306a\u308a\u3048\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u3001<strong>\u9ad8\u7cd6\u8cea\u8ca0\u8377\u306e\u98df\u4e8b\u3084\u4e73\u88fd\u54c1\u306e\u6442\u53d6<\/strong>\u304c\u75e4\u7621\u60aa\u5316\u306b\u95a2\u9023\u3059\u308b\u3068\u306e\u30c7\u30fc\u30bf\u304c\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9ad8GI\u98df\u3084\u4e73\u88fd\u54c1\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b501\uff08IGF-1\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u3057\u3001IGF-1\u304c\u76ae\u8102\u817a\u3067\u306e\u8102\u8cea\u5408\u6210\u3084\u89d2\u5316\u4ea2\u9032\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5b9f\u969b\u3001\u9ad8GI\u98df\u3092\u63a7\u3048\u305f\u98df\u4e8b\u6307\u5c0e\u3067\u76ae\u75b9\u306e\u6539\u5584\u304c\u307f\u3089\u308c\u305f\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059\uff08\u305f\u3060\u3057\u4e00\u5b9a\u3057\u305f\u7d50\u8ad6\u306b\u306f\u81f3\u3063\u3066\u304a\u3089\u305a\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u753b\u4e00\u7684\u98df\u4e8b\u5236\u9650\u306f\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u305b\u3093\uff09\u3002<strong>\u30b9\u30c8\u30ec\u30b9<\/strong>\u3082\u75e4\u7621\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7761\u7720\u4e0d\u8db3\u3084\u7dca\u5f35\u306b\u3088\u308a\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u304c\u4e71\u308c\u76ae\u8102\u5206\u6ccc\u304c\u5897\u3048\u308b\u3053\u3068\u3001\u307e\u305f\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u76ae\u819a\u306e\u514d\u75ab\u6a5f\u80fd\u304c\u5909\u8abf\u3092\u6765\u3059\u3053\u3068\u304c\u4e00\u56e0\u3067\u3059<a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5302#:~:text=,47\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a>\u3002\u305d\u306e\u307b\u304b<strong>\u5316\u7ca7\u54c1\u985e\uff08\u8102\u6027\u306e\u30d5\u30a1\u30f3\u30c7\u30fc\u30b7\u30e7\u30f3\u306a\u3069\uff09\u306b\u3088\u308b\u6bdb\u7a74\u9589\u585e\uff08\u3044\u308f\u3086\u308b\u9762\u76b0\u6027\u7c83\u7ce0\u75b9, acne cosmetica\uff09\u3001\u9577\u6642\u9593\u306e\u30de\u30b9\u30af\u7740\u7528\u3084\u30d8\u30eb\u30e1\u30c3\u30c8\u30fb\u3042\u3054\u7d10\u306a\u3069\u306b\u3088\u308b\u6a5f\u68b0\u7684\u523a\u6fc0\uff08acne mechanica\uff09\u3082\u767a\u75c7\u30fb\u5897\u60aa\u56e0\u5b50\u3068\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u526f\u814e\u75be\u60a3\u3084\u591a\u56a2\u80de\u6027\u5375\u5de3\u75c7\u5019\u7fa4(PCOS)\u306a\u3069\u5185\u5206\u6ccc\u75be\u60a3<\/strong>\u304c\u80cc\u666f\u306b\u3042\u308b\u5834\u5408\u3082\u3042\u308a\u3001\u601d\u6625\u671f\u3092\u904e\u304e\u305f\u91cd\u75c7\u4f8b\u3084\u6708\u7d4c\u7570\u5e38\u30fb\u591a\u6bdb\u3092\u4f34\u3046\u5973\u6027\u3067\u306f\u30db\u30eb\u30e2\u30f3\u691c\u67fb\u3092\u542b\u3081\u9451\u5225\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u81e8\u5e8a\u5206\u985e\u3068\u91cd\u75c7\u5ea6\u30b9\u30b1\u30fc\u30eb<\/h2>\n\n\n\n<p><strong>\u75e4\u7621\u306e\u81e8\u5e8a\u578b<\/strong>\u306f\u5927\u304d\u304f<strong>\u975e\u708e\u75c7\u6027\u75c5\u5909\uff08\u9762\u76b0\uff09\u3068\u708e\u75c7\u6027\u75c5\u5909<\/strong>\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002\u975e\u708e\u75c7\u6027\u75c5\u5909\u306e\u9762\u76b0\u306b\u306f\u6bdb\u7a74\u306e\u9589\u585e\u3057\u305f<strong>\u767d\u8272\u9762\u76b0\uff08\u30db\u30ef\u30a4\u30c8\u30d8\u30c3\u30c9\uff09\u3068\u3001\u5185\u5bb9\u7269\u304c\u9178\u5316\u3057\u3066\u9ed2\u8272\u70b9\u3068\u306a\u3063\u305f\u9ed2\u8272\u9762\u76b0\uff08\u30d6\u30e9\u30c3\u30af\u30d8\u30c3\u30c9\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u708e\u75c7\u6027\u75c5\u5909\u306b\u306f\u4e18\u75b9\uff08\u8d64\u30cb\u30ad\u30d3\uff09<\/strong>\u3001<strong>\u81bf\u75b1\uff08\u9ec4\u30cb\u30ad\u30d3\uff09<\/strong>\u3001\u3055\u3089\u306b\u91cd\u5ea6\u306e<strong>\u7d50\u7bc0\u30fb\u56a2\u816b<\/strong>\u304c\u3042\u308a\u3001\u91cd\u75c7\u306b\u306a\u308b\u307b\u3069\u75c5\u5909\u304c\u771f\u76ae\u6df1\u5c64\u306b\u53ca\u3073\u7622\u75d5\u5f62\u6210\u3092\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u75e4\u7621\u306e<strong>\u91cd\u75c7\u5ea6\u8a55\u4fa1<\/strong>\u3068\u3057\u3066\u3001\u65e5\u672c\u3068\u6d77\u5916\u3067\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001<strong>\u9854\u9762\u306e\u708e\u75c7\u6027\u76ae\u75b9\u6570<\/strong>\u306b\u3082\u3068\u3065\u304f\u91cd\u75c7\u5ea6\u5224\u5b9a\u57fa\u6e96\uff08\u85e4\u7530\u533b\u5927\u30fb\u6797\u4f38\u548c\u3089\u306e\u57fa\u6e96\uff09\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u76ae\u819a\u79d1\u5c02\u9580\u533b\u306e\u7d4c\u9a13\u7684\u5224\u65ad\u3068\u75c5\u5909\u6570\u3068\u306e\u76f8\u95a2\u304b\u3089\u5c0e\u304b\u308c\u305f\u57fa\u6e96\u3067\u3001<strong>\u7247\u5074\u9854\u9762\u306b\u304a\u3051\u308b\u4e18\u75b9\uff0b\u81bf\u75b1\u306e\u6570<\/strong>\u3067\u6b21\u306e\u3088\u3046\u306b4\u6bb5\u968e\u306b\u5206\u985e\u3057\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8efd\u75c7<\/strong>\uff1a\u708e\u75c7\u6027\u76ae\u75b9 0\uff5e5\u500b\uff08\u7247\u5074\u9854\u9762\uff09 \u2013 \u4e3b\u306b\u9762\u76b0\u304c\u4e2d\u5fc3\u3067\u3001\u4e18\u75b9\u306f\u5c11\u6570\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u7b49\u75c7<\/strong>\uff1a\u708e\u75c7\u6027\u76ae\u75b9 6\uff5e20\u500b \u2013 \u4e18\u75b9\u30fb\u81bf\u75b1\u304c\u591a\u6570\u307f\u3089\u308c\u308b\u304c\u3001\u7d50\u7bc0\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u91cd\u75c7<\/strong>\uff1a\u708e\u75c7\u6027\u76ae\u75b9 21\uff5e50\u500b \u2013 \u4e18\u75b9\u30fb\u81bf\u75b1\u306b\u52a0\u3048\u3001<strong>\u7d50\u7bc0\u6027\u75c5\u5909<\/strong>\uff08\u786c\u7d50\uff09\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u6700\u91cd\u75c7<\/strong>\uff1a\u708e\u75c7\u6027\u76ae\u75b9 51\u500b\u4ee5\u4e0a \u2013 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Assessment\uff09\u3068\u3044\u3063\u305f5\u6bb5\u968e\u8a55\u4fa1\uff08\u30af\u30ea\u30a2\uff5e\u91cd\u75c7\uff09\u306a\u3069\u304c\u4f7f\u308f\u308c\u307e\u3059\u3002\u6b27\u5dde\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u5b9f\u7528\u4e0a\u3001\u300c\u9762\u76b0\u4e3b\u4f53\u300d\u300c\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u4e18\u75b9\u81bf\u75b1\u4e3b\u4f53\u300d\u300c\u91cd\u5ea6\u4e18\u75b9\u81bf\u75b1\u307e\u305f\u306f\u4e2d\u7b49\u5ea6\u7d50\u7bc0\u4e3b\u4f53\u300d\u300c\u91cd\u5ea6\u7d50\u7bc0\u30fb\u51dd\u96c6\u6027\u75e4\u7621\u300d\u306e4\u5206\u985e\u3092\u63d0\u793a\u3057\u3001\u305d\u308c\u305e\u308c\u306b\u5fdc\u3058\u305f\u6cbb\u7642\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u91cd\u75c7\u5ea6\u5224\u5b9a\u306f\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u5b9a\u3059\u308b\u4e0a\u3067\u91cd\u8981\u3067\u3042\u308a\u3001\u52a0\u3048\u3066\u60a3\u8005\u306e\u5fc3\u7406\u793e\u4f1a\u7684\u306a\u8ca0\u62c5<\/strong>\uff08\u4f8b\uff1a\u81ea\u5df1\u8a55\u4fa1\u3084\u5bfe\u4eba\u95a2\u4fc2\u3078\u306e\u5f71\u97ff\uff09\u3082\u8003\u616e\u3057\u3066\u7dcf\u5408\u7684\u306b\u5224\u65ad\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 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href=\"https:\/\/www.dermatol.or.jp\/uploads\/uploads\/files\/guideline\/zasou2023.pdf#:~:text=%E3%81%97%E3%81%9F%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E7%97%A4%E7%98%A1%E9%A1%9E%E4%BC%BC%E7%96%BE%E6%82%A3%E3%81%A8%E3%81%97%E3%81%A6%E9%91%91%E5%88%A5%E3%81%8C%E5%BF%85%E8%A6%81%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%20%E6%B2%BB%E7%99%82%E6%96%B9%E9%87%9D%E3%81%8C%E7%95%B0%E3%81%AA%E3%82%8B%E9%85%92%E7%9A%B6%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E3%82%82%EF%BC%8C%E6%9C%AC%E3%82%AC%E3%82%A4%E3%83%89%E3%83%A9%E3%82%A4%E3%83%B3%E3%81%AE%20%E4%B8%AD%E3%81%A7%E6%89%B1%E3%81%86%E3%81%93%E3%81%A8%E3%81%A8%E3%81%97%E3%81%9F%EF%BC%8E%E3%81%9D%E3%81%AE%E5%BE%8C%EF%BC%8C%E3%82%A2%E3%83%80%E3%83%91%E3%83%AC%E3%83%B3%200\" target=\"_blank\" rel=\"noreferrer noopener\">dermatol.or.jp<\/a>\u3002\u9152\u76b6\u306f30\u4ee3\u4ee5\u964d\u306b\u597d\u767a\u3059\u308b\u9854\u9762\u7d05\u6f6e\u3068\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3092\u4f34\u3046\u75be\u60a3\u3067\u3001\u4e00\u898b\u3059\u308b\u3068\u75e4\u7621\u3068\u540c\u69d8\u306b\u4e18\u75b9\u3084\u81bf\u75b1\u3092\u5448\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u9152\u76b6\u306b\u306f\u9762\u76b0\u304c\u51fa\u73fe\u3057\u306a\u3044<\/strong>\u3053\u3068\u3001\u597d\u767a\u5e74\u9f62\u304c\u9ad8\u3044\u3053\u3068\u3001\u9f3b\u3084\u982c\u306e\u3073\u307e\u3093\u6027\u767a\u8d64\u3092\u4f34\u3046\u3053\u3068\u306a\u3069\u3067\u75e4\u7621\u3068\u9451\u5225\u3067\u304d\u307e\u3059\u3002\u6b21\u306b<strong>\u6bdb\u5305\u708e<\/strong>\u3082\u9451\u5225\u306b\u6319\u304c\u308a\u307e\u3059\u3002\u6bdb\u5305\u708e\u306f\u30d6\u30c9\u30a6\u7403\u83cc\u306a\u3069\u306b\u3088\u308b\u6bdb\u56a2\u306e\u5c40\u6240\u611f\u67d3\u3067\u3001\u81bf\u75b1\u304c\u6bdb\u7a74\u306b\u4e00\u81f4\u3057\u3066\u591a\u767a\u3057\u307e\u3059\u3002\u4e00\u898b\u30cb\u30ad\u30d3\u306b\u4f3c\u307e\u3059\u304c<strong>\u540c\u8cea\u306e\u81bf\u75b1\u304c\u5747\u4e00\u306b\u5206\u5e03\u3057\u3001\u9762\u76b0\u306f\u4f34\u308f\u306a\u3044<\/strong>\u70b9\u3067\u533a\u5225\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3067\u751f\u3058\u308b<strong>\u30b9\u30c6\u30ed\u30a4\u30c9\u3056\u7621<\/strong>\uff08\u4e00\u69d8\u306a\u7d05\u8272\u4e18\u75b9\u304c\u53e3\u56f2\u3084\u4f53\u5e79\u306b\u591a\u767a\uff09\u3082\u9451\u5225\u3057\u307e\u3059\u3002\u601d\u6625\u671f\u3067\u306f<strong>\u30de\u30e9\u30bb\u30c1\u30a2\u6bdb\u5305\u708e<\/strong>\uff08\u30de\u30e9\u30bb\u30c1\u30a2\u771f\u83cc\u306b\u3088\u308b\u6bdb\u5b54\u6027\u4e18\u75b9\uff09\u3082\u80cc\u4e2d\u306e\u30cb\u30ad\u30d3\u3068\u8aa4\u8a8d\u3055\u308c\u3084\u3059\u3044\u3067\u3059\u304c\u3001\u3053\u3061\u3089\u3082<strong>\u5747\u4e00\u306a\u6bdb\u5b54\u4e00\u81f4\u6027\u306e\u7d05\u8272\u4e18\u75b9\u30fb\u81bf\u75b1\u3067\u3001\u75d2\u307f\u3092\u4f34\u3046<\/strong>\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u9854\u9762\u3067\u306f<strong>\u6241\u5e73\u75a3\u8d05\uff08\u5e73\u3089\u306a\u30a4\u30dc\uff09\u304c\u984d\u306b\u591a\u767a\u3059\u308b\u3068\u30cb\u30ad\u30d3\u8de1\u3068\u7d1b\u3089\u308f\u3057\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u89e6\u8a3a\u3067\u89d2\u8cea\u5897\u6b96\u3092\u611f\u3058\u308b\u70b9\u3084\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u7279\u6709\u306e\u7dda\u72b6\u914d\u5217\uff08\u722a\u3067\u63bb\u3044\u305f\u65b9\u5411\u306b\u6cbf\u3063\u3066\u4e26\u3076\uff09\u306a\u3069\u3067\u9451\u5225\u3067\u304d\u307e\u3059\u3002\u91cd\u75c7\u7d50\u7bc0\u304c\u591a\u6570\u307f\u3089\u308c\u308b\u5834\u5408\u306f\u81bf\u76ae\u75c7<\/strong>\uff08\u30a2\u30af\u30cd\u3068\u306f\u5225\u500b\u306e\u91cd\u75c7\u76ae\u819a\u611f\u67d3\u75c7\uff09\u3084**hidradenitis suppurativa\uff08\u5316\u81bf\u6027\u6c57\u817a\u708e\uff09**\u3082\u8003\u616e\u3057\u307e\u3059\u3002\u5f8c\u8005\u306f\u814b\u7aa9\u3084\u9f20\u5f84\u90e8\u306e\u6c57\u817a\u90e8\u4f4d\u306b\u75db\u307f\u3092\u4f34\u3046\u81bf\u760d\u3068\u763b\u5b54\u3092\u5f62\u6210\u3059\u308b\u75be\u60a3\u3067\u3001\u90e8\u4f4d\u304c\u7570\u306a\u308a\u7d4c\u904e\u3082\u6162\u6027\u7684\u3067\u3042\u308b\u70b9\u3067\u9451\u5225\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5<\/h2>\n\n\n\n<p>\u5c0b\u5e38\u6027\u75e4\u7621\u306e\u6cbb\u7642\u306f\u3001<strong>\u75c7\u72b6\u306e\u91cd\u75c7\u5ea6\u3068\u75c5\u5909\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u3066<\/strong>\u6bb5\u968e\u7684\u306b\u884c\u3044\u307e\u3059\u3002\u57fa\u672c\u539f\u5247\u306f\u3001<strong>\u9762\u76b0\u3068\u708e\u75c7\u306e\u53cc\u65b9\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068<\/strong>\u3001\u304a\u3088\u3073<strong>\u8907\u6570\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068<\/strong>\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u6cbb\u7642\u6cd5\u3092\u5916\u7528\u7642\u6cd5\u30fb\u5185\u670d\u7642\u6cd5\u30fb\u7269\u7406\u7642\u6cd5\u30fb\u7f8e\u5bb9\u7684\u6cbb\u7642\u306b\u5206\u3051\u3066\u8ff0\u3079\u307e\u3059\u3002<\/p>\n\n\n\n<h3 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noopener\">dermatol.or.jp<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u7c73\u56fd<\/strong>\u3067\u306f<strong>\u7c73\u56fd\u76ae\u819a\u79d1\u5b66\u4f1a\uff08AAD\uff09\u304c2016\u5e74\u306b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u767a\u8868\u3057\u3066\u304a\u308a\u3001\u57fa\u672c\u7684\u306a\u65b9\u5411\u6027\u306f\u65e5\u672c\u3068\u540c\u69d8\u3067\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u5916\u7528\u30ec\u30c1\u30ce\u30a4\u30c9\uff0bBPO\u3092\u3042\u3089\u3086\u308b\u91cd\u75c7\u5ea6\u306e\u57fa\u790e\u306b\u636e\u3048\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u5916\u7528\u30fb\u7d4c\u53e3\u6297\u83cc\u85ac\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3044\u3046\u65b9\u91dd\u3067\u3059\u3002\u52a0\u3048\u3066\u7279\u5fb4\u7684\u306a\u306e\u306f\u5973\u6027\u306e\u6210\u4eba\u75e4\u7621\u306b\u5bfe\u3059\u308b\u6297\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u7642\u6cd5\u306e\u6d3b\u7528<\/strong>\u3067\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u4e2d\u7b49\u75c7\u4ee5\u4e0a\u306e\u5973\u6027\u306b\u5bfe\u3057\u7d4c\u53e3\u907f\u598a\u85ac\u3084\u30b9\u30d4\u30ed\u30ce\u30e9\u30af\u30c8\u30f3\u5185\u670d\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u6761\u4ef6\u4ed8\u304d\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a4\u30bd\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u306b\u3064\u3044\u3066\u306f\u91cd\u75c7\u4f8b\u3078\u306e\u5f37\u3044\u63a8\u5968\u3068\u3068\u3082\u306b\u3001\u598a\u5a20\u5bfe\u7b56\uff08iPLEDGE\u30d7\u30ed\u30b0\u30e9\u30e0\uff09\u306e\u9075\u5b88\u304c\u660e\u8a18\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305fAAD\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f<strong>\u65b0\u898f\u5916\u7528\u85ac<\/strong>\u306b\u3082\u8a00\u53ca\u3057\u3066\u304a\u308a\u3001\u4f8b\u3068\u3057\u3066<strong>\u65b0\u3057\u3044\u5916\u7528\u6297\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u5264\u3067\u3042\u308b\u30af\u30e9\u30b9\u30b3\u30c6\u30ed\u30f3<\/strong>\u3092\u6319\u3052\u300112\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u306b\u4f7f\u7528\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39761150\/#:~:text=sebaceous%20glands%20by%20androgens%20play,invaluable%20guides%20for%20patients%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\uff082020\u5e74\u306b\u7c73\u56fdFDA\u627f\u8a8d\uff09\u3002\u98df\u4e8b\u6307\u5c0e\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u9ad8\u7cd6\u8cea\u98df\u30fb\u4e73\u88fd\u54c1\u6442\u53d6\u3068\u75e4\u7621\u60aa\u5316\u306e\u95a2\u9023\u306f\u793a\u5506\u3055\u308c\u308b\u304c\u3001\u6cbb\u7642\u3068\u3057\u3066\u7279\u5b9a\u306e\u98df\u4e8b\u5236\u9650\u3092\u63a8\u5968\u3059\u308b\u3060\u3051\u306e\u6839\u62e0\u306f\u306a\u3044\u300d\u3068\u3057\u3001\u73fe\u6642\u70b9\u3067\u306f\u753b\u4e00\u7684\u306a\u98df\u4e8b\u7642\u6cd5\u306f\u52e7\u3081\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u3088\u3046\u306bAAD\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304d\u3064\u3064\u3001\u60a3\u8005\u4e00\u4eba\u3072\u3068\u308a\u306e\u72b6\u6cc1\u306b\u5fdc\u3058\u305f\u67d4\u8edf\u306a\u6cbb\u7642\u9078\u629e\u3092\u652f\u6301\u3059\u308b\u5185\u5bb9\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u6b27\u5dde<\/strong>\u3067\u306f2016\u5e74\u306b<strong>\u6b27\u5dde\u76ae\u819a\u79d1\u30fb\u6027\u75c5\u5b66\u4f1a(EADV)\u306a\u3069\u304c\u4e2d\u5fc3\u3068\u306a\u308aS3\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u66f4\u65b0\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5185\u5bb9\u3082\u6982\u306d\u7c73\u56fd\u30fb\u65e5\u672c\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u56fa\u5b9a\u51e6\u65b9\u306eBPO\uff0b\u30af\u30ea\u30f3\u30c0\u30de\u30a4\u30b7\u30f3\u5408\u5264\u3084BPO\uff0b\u30a2\u30c0\u30d1\u30ec\u30f3\u5408\u5264\u3092\u8efd\u4e2d\u7b49\u5ea6\u75e4\u7621\u306e\u7b2c\u4e00\u9078\u629e\u3068\u3057\u3066\u5f37\u304f\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u6297\u83cc\u85ac\u8010\u6027\u3078\u306e\u61f8\u5ff5\u304b\u3089\u3001\u300c\u6297\u83cc\u85ac\u306e\u5916\u7528\u5358\u72ec\u7642\u6cd5\u306f\u63a8\u5968\u3057\u306a\u3044\u300d\u3053\u3068\u3092\u660e\u78ba\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u6b27\u5dde\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u524d\u8ff0\u306e\u3088\u3046\u306b\u91cd\u75c7\u5ea6\u30924\u5206\u985e\u3057\u3066\u304a\u308a\u3001\u4f8b\u3048\u3070\u91cd\u5ea6\u4e18\u75b9\u81bf\u75b1\u578b\uff5e\u4e2d\u7b49\u5ea6\u7d50\u7bc0\u578b<\/strong>\u306b\u306f\u300c<strong>\u7d4c\u53e3\u6297\u83cc\u85ac\uff0b\u5916\u7528\u30ec\u30c1\u30ce\u30a4\u30c9\uff0bBPO<\/strong>\u300d\u306e\u4f75\u7528\u7642\u6cd5\u3092\u63a8\u5968\u3057\u3001<strong>\u91cd\u5ea6\u7d50\u7bc0\u56a2\u816b\u578b\uff08\u51dd\u96c6\u6027\u75e4\u7621\uff09\u306b\u306f\u7d4c\u53e3\u30a4\u30bd\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5358\u72ec\u7642\u6cd5\u3092\u6700\u3082\u5f37\u304f\u63a8\u5968<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u60a3\u8005\u306e<strong>\u5fc3\u7406\u7684\u5074\u9762<\/strong>\u3078\u306e\u914d\u616e\u3082\u52e7\u544a\u3055\u308c\u3066\u304a\u308a\u3001QOL\u8a55\u4fa1\u7968\u306e\u6d3b\u7528\u3084\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u7cbe\u795e\u79d1\u7684\u4ecb\u5165\u3082\u884c\u3046\u3088\u3046\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u5404\u56fd\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3044\u305a\u308c\u3082\u3001\u300c<strong>\u30ec\u30c1\u30ce\u30a4\u30c9\uff0b\u904e\u9178\u5316\u30d9\u30f3\u30be\u30a4\u30eb<\/strong>\u3092\u57fa\u672c\u306b\u3001\u75c7\u72b6\u306b\u5fdc\u3058\u3066\u6297\u83cc\u85ac\u30fb\u30db\u30eb\u30e2\u30f3\u5264\u30fb\u30a4\u30bd\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u300d\u3068\u3044\u3046\u73fe\u4ee3\u306e\u6a19\u6e96\u6cbb\u7642\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6700\u65b0\u7814\u7a76\u52d5\u5411\uff08\u75c5\u56e0\u30fb\u6cbb\u7642\u306e\u65b0\u5c55\u958b\uff09<\/h2>\n\n\n\n<p>\u75e4\u7621\u306e\u5206\u91ce\u3067\u306f\u3001\u75c5\u614b\u89e3\u660e\u3084\u65b0\u898f\u6cbb\u7642\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u8fd1\u5e74\u98db\u8e8d\u7684\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b<strong>\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411<\/strong>\u3092\u3044\u304f\u3064\u304b\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u75e4\u7621\u30ef\u30af\u30c1\u30f3\u30fb\u6297\u83cc\u7642\u6cd5\u306e\u65b0\u5c55\u958b<\/strong>: <strong>C. acnes\u3092\u6a19\u7684\u3068\u3059\u308b\u30ef\u30af\u30c1\u30f3\u958b\u767a<\/strong>\u306f\u9577\u5e74\u306e\u5922\u3067\u3057\u305f\u304c\u3001\u8fd1\u5e74\u5177\u4f53\u5316\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u6821\uff08UCSD\uff09\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001<strong>C. acnes\u304c\u7523\u751f\u3059\u308b\u9175\u7d20\uff08\u30cf\u30ea\u30e4\u30eb\u30ed\u30cb\u30c0\u30fc\u30bc\uff09\u306e\u7279\u5b9a\u578b\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3<\/strong>\u3092\u958b\u767a\u3057\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067<strong>\u7d0450%\u306e\u75c7\u72b6\u8efd\u6e1b<\/strong>\u3068\u3044\u3046\u6709\u671b\u306a\u7d50\u679c\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30ef\u30af\u30c1\u30f3\u306f\u76ae\u819a\u306e\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3092\u5206\u89e3\u3059\u308bC. acnes\u7531\u6765\u9175\u7d20\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u6291\u3048\u308b\u72d9\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u88fd\u85ac\u5927\u624b\u306e<strong>\u30b5\u30ce\u30d5\u30a3\u793e<\/strong>\u304c\u5225\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u958b\u767a\u3057\u305f**\u75e4\u7621\u30ef\u30af\u30c1\u30f3\u306e\u81e8\u5e8a\u8a66\u9a13\uff08\u7b2cI\/II\u76f8\uff09<strong>\u3092\u9032\u3081\u3066\u304a\u308a\u30012024\u5e74\u306b\u958b\u59cb\u3055\u308c\u305f\u8a66\u9a13\u3067\u7d04400\u4eba\u306e\u4e2d\u7b49\u75c7\uff5e\u91cd\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u4e2d\u3067\u3059<a href=\"https:\/\/www.livescience.com\/health\/medicine-drugs\/acne-vaccine-experimental-shot-for-common-skin-condition-reaches-clinical-trials-heres-what-you-need-to-know#:~:text=Sanofi%20is%20conducting%20what%27s%20known,of%20pimples%20on%20their%20face\" target=\"_blank\" rel=\"noreferrer noopener\">livescience.com<\/a>\u3002\u3053\u306e\u30ef\u30af\u30c1\u30f3\u306fmRNA\u30ef\u30af\u30c1\u30f3\u6280\u8853\u3092\u7528\u3044\u305f\u3082\u306e\u3068\u3055\u308c\u3001\u7279\u5b9a\u306e\u30a2\u30af\u30cd\u83cc\u682a\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u75e4\u7621\u306e\u6539\u5584\u3092\u76ee\u6307\u3057\u307e\u3059<a href=\"https:\/\/www.livescience.com\/health\/medicine-drugs\/acne-vaccine-experimental-shot-for-common-skin-condition-reaches-clinical-trials-heres-what-you-need-to-know#:~:text=In%20this%20case%2C%20the%20target,primary%20bacterium%20associated%20with%20acne\" target=\"_blank\" rel=\"noreferrer noopener\">livescience.com<\/a>\u3002\u5b9f\u7528\u5316\u306b\u306f\u306a\u304a\u6570\u5e74\uff5e10\u5e74\u898f\u6a21\u306e\u6642\u9593\u3092\u8981\u3057\u307e\u3059\u304c\u3001\u5c06\u6765\u30ef\u30af\u30c1\u30f3\u3067\u30cb\u30ad\u30d3\u3092\u4e88\u9632\u30fb\u6cbb\u7642\u3067\u304d\u308b\u53ef\u80fd\u6027\u306f\u73fe\u5b9f\u5473\u3092\u5e2f\u3073\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u6297\u83cc\u6cbb\u7642\u306e\u65b0\u5c55\u958b\u3068\u3057\u3066\u3001\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8\u7642\u6cd5\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30af\u30cd\u83cc\u306b\u611f\u67d3\u3057\u5897\u6b96\u3059\u308b<\/strong>C. acnes\u30d5\u30a1\u30fc\u30b8\uff08\u30a6\u30a4\u30eb\u30b9\uff09**\u3092\u5229\u7528\u3057\u3001\u6297\u751f\u5264\u8010\u6027\u83cc\u3082\u542b\u3081\u30a2\u30af\u30cd\u83cc\u3092\u9078\u629e\u7684\u306b\u6b7b\u6ec5\u3055\u305b\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u8a66\u9a13\u7ba1\u5185\u3084\u30de\u30a6\u30b9\u3067\u52b9\u679c\u304c\u793a\u3055\u308c\u59cb\u3081\u3066\u304a\u308a\u3001\u4eca\u5f8c\u6297\u751f\u7269\u8cea\u306b\u4ee3\u308f\u308b\u6cbb\u7642\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u65b0\u898f\u306e\u5916\u7528\u85ac\u30fb\u7d4c\u53e3\u85ac<\/strong>: \u5f93\u6765\u306e\u6cbb\u7642\u85ac\u3068\u306f\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u3092\u6301\u3064\u65b0\u85ac\u3082\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u30af\u30e9\u30b9\u30b3\u30c6\u30ed\u30f3\uff08\u5546\u54c1\u540dWinlevi\uff09\u306f2020\u5e74\u306b\u7c73\u56fdFDA\u304c\u627f\u8a8d\u3057\u305f\u4e16\u754c\u521d\u306e\u5916\u7528\u6297\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u85ac<\/strong>\u3067\u3059<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39761150\/#:~:text=sebaceous%20glands%20by%20androgens%20play,invaluable%20guides%20for%20patients%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u76ae\u8102\u817a\u306e\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u3092\u7af6\u5408\u7684\u306b\u906e\u65ad\u3057\u3001\u76ae\u8102\u7523\u751f\u3068\u708e\u75c7\u3092\u6291\u5236\u3057\u307e\u3059\u300212\u6b73\u4ee5\u4e0a\u306e\u7537\u5973\u306e\u75e4\u7621\u306b\u9069\u5fdc\u304c\u3042\u308a\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u708e\u75c7\u76ae\u75b9\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3068\u76ae\u8102\u91cf\u4f4e\u4e0b\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u5916\u7528\u5264\u3067\u3042\u308a\u306a\u304c\u3089\u5168\u8eab\u3078\u306e\u30db\u30eb\u30e2\u30f3\u5f71\u97ff\u306f\u6700\u5c0f\u9650\u3067\u3001\u5b89\u5168\u6027\u306e\u9ad8\u3055\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u672a\u627f\u8a8d\u3067\u3059\u304c\u3001\u5c06\u6765\u7684\u306b\u5c0e\u5165\u3055\u308c\u308c\u3070<strong>\u5f93\u6765\u306e\u30ec\u30c1\u30ce\u30a4\u30c9\u3084BPO\u306b\u6b21\u3050\u7b2c3\u306e\u5916\u7528\u85ac<\/strong>\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u7d4c\u53e3\u85ac\u3067\u306f\u524d\u8ff0\u306e<strong>\u30b5\u30ec\u30b5\u30a4\u30af\u30ea\u30f3<\/strong>\u3084<strong>\u65b0\u898f\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u7cfb<\/strong>\u306a\u3069\u3001\u8010\u6027\u83cc\u554f\u984c\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306e\u6297\u83cc\u85ac\u958b\u767a\u304c\u7d9a\u3044\u3066\u3044\u307e\u3059\u3002\u6297\u83cc\u85ac\u4ee5\u5916\u306b\u3082<strong>\u30cb\u30c8\u30ea\u30eb\u30aa\u30ad\u30b7\u30c9\uff08NO\uff09\u653e\u51fa\u88fd\u5264<\/strong>\u306a\u3069\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070SB204\u30b2\u30eb\u306fNO\u3092\u653e\u51fa\u3057\u3066\u6297\u83cc\u30fb\u6297\u708e\u75c7\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u5916\u7528\u5264\u3067\u3001\u7b2cIII\u76f8\u8a66\u9a13\u307e\u3067\u9032\u307f\u307e\u3057\u305f\u3002\u7d50\u679c\u306f\u4e00\u90e8\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u672a\u9054\u3067\u3057\u305f\u304c\u3001\u4eca\u306a\u304a\u6539\u826f\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001<strong>3\u5264\u914d\u5408\u306e\u56fa\u5b9a\u51e6\u65b9<\/strong>\u3082\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u30022023\u5e74\u306b\u306f\u7c73\u56fd\u3067<strong>\u30a2\u30c0\u30d1\u30ec\u30f30.15%\uff0bBPO3.1%\uff0b\u30af\u30ea\u30f3\u30c0\u30de\u30a4\u30b7\u30f31.2%\u914d\u5408\u30b2\u30eb<\/strong>\uff08IDP-126\uff09\u304c\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u5ea6\u306e\u5857\u5e03\u3067\u9762\u76b0\u30fb\u83cc\u30fb\u708e\u75c7\u306e\u3059\u3079\u3066\u306b\u5bfe\u51e6\u3067\u304d\u308b\u51e6\u65b9\u3067\u3042\u308a\u3001\u6cbb\u7642\u306e\u7c21\u4fbf\u3055\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u65b0\u77e5\u898b<\/strong>: \u75e4\u7621\u306e\u708e\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7406\u89e3\u3082\u6df1\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b<strong>\u81ea\u7136\u514d\u75ab\u3068\u7372\u5f97\u514d\u75ab\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af<\/strong>\u304c\u6ce8\u76ee\u3055\u308c\u3001C. acnes\u306b\u5bfe\u3059\u308b<strong>Th17\u7d30\u80de<\/strong>\u3084<strong>Th1\/Th17\u6df7\u5408\u53cd\u5fdc<\/strong>\u304c\u91cd\u75c7\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001\u75e4\u7621\u75c5\u5909\u90e8\u3067\u306fIL-17\u3084TNF-\u03b1\u306a\u3069\u304c\u9ad8\u767a\u73fe\u3057\u3001\u708e\u75c7\u3092\u5897\u5e45\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u65e2\u5b58\u306e**\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08\u4f8b\uff1a\u6297IL-17\u6297\u4f53\u3084\u6297TNF-\u03b1\u6297\u4f53\uff09**\u3092\u91cd\u75c7\u75e4\u7621\u306b\u5fdc\u7528\u3067\u304d\u306a\u3044\u304b\u3068\u3044\u3046\u8a66\u307f\u3082\u6563\u898b\u3055\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u51dd\u96c6\u6027\u5ea7\u7621\uff08Acne conglobata\uff09\u306b\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\uff08\u6297TNF-\u03b1\uff09\u304c\u594f\u52b9\u3057\u305f\u75c7\u4f8b\u5831\u544a\u3084\u3001\u5c0b\u5e38\u6027\u75e4\u7621\u60a3\u8005\u306b\u30a6\u30b9\u30c6\u30ad\u30cc\u30de\u30d6\uff08\u6297IL-12\/23\uff09\u3092\u6295\u4e0e\u3057\u90e8\u5206\u5bdb\u89e3\u3092\u5f97\u305f\u4f8b\u306a\u3069\u304c\u6587\u732e\u4e0a\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u751f\u7269\u5b66\u7684\u88fd\u5264\u306f\u8cbb\u7528\u3084\u526f\u4f5c\u7528\u306e\u70b9\u3067\u5b89\u6613\u306b\u9069\u7528\u3067\u304d\u305a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u6a19\u7684\u3092\u7d5e\u3063\u305f\u4f4e\u5206\u5b50\u85ac\u3084\u30da\u30d7\u30c1\u30c9\u6cbb\u7642\u306a\u3069\u304c\u6a21\u7d22\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u76ae\u819a\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3068\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9<\/strong>: \u76ae\u819a\u306e\u5e38\u5728\u83cc\u53e2\u304c\u75e4\u7621\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3082\u30db\u30c3\u30c8\u306a\u7814\u7a76\u9818\u57df\u3067\u3059\u3002C. acnes\u81ea\u4f53\u306b\u306f\u8907\u6570\u306e\u83cc\u682a\uff08\u30d5\u30a1\u30fc\u30b8\u30bf\u30a4\u30d7\u3001\u907a\u4f1d\u5b50\u30af\u30e9\u30b9\u30bf\u30fc\uff09\u304c\u3042\u308a\u3001<strong>\u75e4\u7621\u60a3\u8005\u306b\u591a\u3044\u6bd2\u6027\u682a<\/strong>\u3068<strong>\u5065\u5eb7\u306a\u76ae\u819a\u306b\u591a\u3044\u5171\u751f\u682a<\/strong>\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u5c06\u6765\u7684\u306b\u306f\u60a3\u8005\u3054\u3068\u306e\u76ae\u819a\u5fae\u751f\u7269\u53e2\u30d0\u30e9\u30f3\u30b9\u3092\u89e3\u6790\u3057\u3001<strong>\u6709\u76ca\u83cc\u3092\u5897\u3084\u3057\u3066\u6709\u5bb3\u83cc\u3092\u6e1b\u3089\u3059\u6cbb\u7642<\/strong>\uff08\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u5916\u7528\u306a\u3069\uff09\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u7d4c\u53e3\u6442\u53d6\u3059\u308b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u4e73\u9178\u83cc\u306a\u3069\uff09\u3082\u5168\u8eab\u306e\u708e\u75c7\u3092\u8efd\u6e1b\u3057\u3046\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u3001\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\u306b\u3088\u308b\u75e4\u7621\u6cbb\u7642\u52b9\u679c\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u306fC. acnes\u304c\u7523\u751f\u3059\u308b<strong>\u7269\u8cea\uff08\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3084\u9175\u7d20\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u963b\u5bb3\u85ac<\/strong>\u306e\u7814\u7a76\u3082\u9032\u884c\u4e2d\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u76ae\u819a\u5e38\u5728\u83cc\u3092\u7dad\u6301\u3057\u3064\u3064\u3001\u30cb\u30ad\u30d3\u306e\u539f\u56e0\u3068\u306a\u308b\u6bd2\u6027\u56e0\u5b50\u3060\u3051\u3092\u6291\u3048\u308b\u65b0\u3057\u3044\u30b3\u30f3\u30bb\u30d7\u30c8\u306e\u6cbb\u7642\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u65b0\u6280\u8853<\/strong>: \u30c7\u30d0\u30a4\u30b9\u9762\u3067\u306f\u3001<strong>\u96c6\u675f\u8d85\u97f3\u6ce2<\/strong>\u3084<strong>\u9ad8\u5468\u6ce2\u306b\u3088\u308b\u76ae\u8102\u817a\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0<\/strong>\u3001<strong>\u4f4e\u51fa\u529b\u96fb\u6d41<\/strong>\u306b\u3088\u308b\u76ae\u8102\u817a\u6291\u5236\u306a\u3069\u30e6\u30cb\u30fc\u30af\u306a\u8a66\u307f\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001AI\uff08\u4eba\u5de5\u77e5\u80fd\uff09\u3092\u7528\u3044\u305f<strong>\u75e4\u7621\u753b\u50cf\u89e3\u6790<\/strong>\u3082\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u3067\u64ae\u5f71\u3057\u305f\u808c\u5199\u771f\u3092AI\u304c\u5206\u6790\u3057\u3001\u30cb\u30ad\u30d3\u306e\u6570\u3084\u91cd\u75c7\u5ea6\u3092\u81ea\u52d5\u8a55\u4fa1\u3057\u3066\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3092\u63d0\u6848\u3059\u308b\u30a2\u30d7\u30ea\u3082\u7814\u7a76\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u60a3\u8005\u304c\u81ea\u5206\u306e\u30cb\u30ad\u30d3\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u306a\u304c\u3089\u533b\u5e2b\u3068\u30c7\u30fc\u30bf\u5171\u6709\u3057\u3066\u6cbb\u7642\u306b\u6d3b\u304b\u3059\u3001\u3068\u3044\u3063\u305f<strong>\u9060\u9694\u533b\u7642\uff0bAI\u8a3a\u65ad<\/strong>\u306e\u5f62\u3082\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u5c0b\u5e38\u6027\u75e4\u7621\u306e\u9818\u57df\u3067\u306f<strong>\u5f93\u6765\u6cbb\u7642\u306e\u6539\u826f<\/strong>\uff08\u65e2\u5b58\u85ac\u306e\u6700\u9069\u306a\u7d44\u307f\u5408\u308f\u305b\u3084\u65b0\u88fd\u5264\u958b\u767a\uff09\u3068<strong>\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u5275\u51fa<\/strong>\uff08\u30ef\u30af\u30c1\u30f3\u30fb\u5fae\u751f\u7269\u7642\u6cd5\u30fb\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306a\u3069\uff09\u304c\u4e26\u884c\u3057\u3066\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u75e4\u7621\u306f\u82e5\u5e74\u8005\u4e2d\u5fc3\u306e\u75be\u60a3\u3067\u3042\u308a\u60a3\u8005\u6570\u3082\u975e\u5e38\u306b\u591a\u3044\u305f\u3081\u3001\u305d\u306e\u30a4\u30f3\u30d1\u30af\u30c8\u306f\u5927\u304d\u304f\u3001\u7814\u7a76\u958b\u767a\u306e\u95a2\u5fc3\u3082\u9ad8\u3044\u5206\u91ce\u3067\u3059\u3002\u4eca\u5f8c\u3001\u8010\u6027\u83cc\u3084\u526f\u4f5c\u7528\u306e\u61f8\u5ff5\u3092\u514b\u670d\u3057\u3064\u3064<strong>\u5b89\u5168\u3067\u6839\u672c\u7684\u306a\u6cbb\u7642<\/strong>\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>References:<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25597339\/#:~:text=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/dermatol\/130\/8\/130_1811\/_article\/-char\/ja\/#:~:text=%E6%8A%84%E9%8C%B2\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a><a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5302#:~:text=,47\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a><a href=\"https:\/\/www.dermatol.or.jp\/uploads\/uploads\/files\/guideline\/zasou2023.pdf#:~:text=%E3%81%97%E3%81%9F%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E7%97%A4%E7%98%A1%E9%A1%9E%E4%BC%BC%E7%96%BE%E6%82%A3%E3%81%A8%E3%81%97%E3%81%A6%E9%91%91%E5%88%A5%E3%81%8C%E5%BF%85%E8%A6%81%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%20%E6%B2%BB%E7%99%82%E6%96%B9%E9%87%9D%E3%81%8C%E7%95%B0%E3%81%AA%E3%82%8B%E9%85%92%E7%9A%B6%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E3%82%82%EF%BC%8C%E6%9C%AC%E3%82%AC%E3%82%A4%E3%83%89%E3%83%A9%E3%82%A4%E3%83%B3%E3%81%AE%20%E4%B8%AD%E3%81%A7%E6%89%B1%E3%81%86%E3%81%93%E3%81%A8%E3%81%A8%E3%81%97%E3%81%9F%EF%BC%8E%E3%81%9D%E3%81%AE%E5%BE%8C%EF%BC%8C%E3%82%A2%E3%83%80%E3%83%91%E3%83%AC%E3%83%B3%200\" target=\"_blank\" rel=\"noreferrer noopener\">dermatol.or.jp<\/a><a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E5%B0%8B%E5%B8%B8%E6%80%A7%E7%97%A4%E7%98%A1#:~:text=%E3%80%8E%E5%B0%8B%E5%B8%B8%E6%80%A7%E7%97%A4%E7%98%A1%E6%B2%BB%E7%99%82%E3%82%AC%E3%82%A4%E3%83%89%E3%83%A9%E3%82%A4%E3%83%B32017%E3%80%8F%EF%BC%88%E6%97%A5%E6%9C%AC%E7%9A%AE%E8%86%9A%E7%A7%91%E5%AD%A6%E4%BC%9A%EF%BC%89%E3%81%A7%E3%81%AF%E5%85%88%E3%81%AB%E8%BF%B0%E3%81%B9%E3%81%9F%E9%80%9A%E3%82%8A%E6%8A%97%E8%8F%8C%E8%96%AC%E3%81%AF%E6%8A%97%E8%8F%8C%E8%96%AC%E4%BB%A5%E5%A4%96%E3%81%A8%E3%81%AE%E4%BD%B5%E7%94%A8%E3%81%8C%E6%9D%A1%E4%BB%B6%E3%81%A7%E3%81%82%E3%82%8B%E3%81%8C%E3%80%81%E6%8E%A8%E5%A5%A8%E5%BA%A6%E3%82%92%E7%A4%BA%E3%81%99%E3%80%82%E5%A4%96%E7%94%A8%E6%8A%97%E8%8F%8C%E8%96%AC%E3%81%A7%E3%81%AF%E7%82%8E%E7%97%87%E6%80%A7%E7%9A%AE%E7%96%B9%E3%81%AB%E3%80%81%E5%A4%96%20%E7%94%A8%E6%8A%97%E8%8F%8C%E8%96%AC%EF%BC%88%E3%82%AF%E3%83%AA%E3%83%B3%E3%83%80%E3%83%9E%E3%82%A4%E3%82%B7%E3%83%B3%E3%80%81%E3%83%8A%E3%82%B8%E3%83%95%E3%83%AD%E3%82%AD%E3%82%B5%E3%82%B7%E3%83%B3%E3%80%81%E3%82%AA%E3%82%BC%E3%83%8E%E3%82%AD%E3%82%B5%E3%82%B7%E3%83%B3%EF%BC%89%E3%82%92%E5%BC%B7%E3%81%8F%E6%8E%A8%E5%A5%A8%E3%81%99%E3%82%8B\" target=\"_blank\" rel=\"noreferrer noopener\">ja.wikipedia.org<\/a><a href=\"https:\/\/www.dermatol.or.jp\/uploads\/uploads\/files\/guideline\/zasou2023.pdf#:~:text=%E6%96%BD%E8%A1%93%20CQ16%20%E7%82%8E%E7%97%87%E6%80%A7%E7%9A%AE%E7%96%B9%E3%81%AB%E3%82%B1%E3%83%9F%E3%82%AB%E3%83%AB%E3%83%94%E3%83%BC%E3%83%AA%E3%83%B3%E3%82%B0%E3%81%AF%E6%9C%89%E5%8A%B9%E3%81%8B%EF%BC%9F%20C1%E3%81%AA%E3%81%84%E3%81%97C2%20%E7%82%8E%E7%97%87%E6%80%A7%E7%9A%AE%E7%96%B9%E3%81%AB%EF%BC%8C%E6%A8%99%E6%BA%96%E6%B2%BB%E7%99%82%E3%81%8C%E7%84%A1%E5%8A%B9%E3%81%82%E3%82%8B%E3%81%84%E3%81%AF%E5%AE%9F%E6%96%BD%E3%81%A7%E3%81%8D%E3%81%AA%E3%81%84%E5%A0%B4,%E5%90%88%E3%81%AB%E3%82%B0%E3%83%AA%E3%82%B3%E3%83%BC%E3%83%AB%E9%85%B8%E3%81%82%E3%82%8B%E3%81%84%E3%81%AF%E3%82%B5%E3%83%AA%E3%83%81%E3%83%AB%E9%85%B8%E3%83%9E%E3%82%AF%E3%83%AD%E3%82%B4%E3%83%BC%E3%83%AB%E3%81%AB%20%E3%82%88%E3%82%8B%E3%82%B1%E3%83%9F%E3%82%AB%E3%83%AB%E3%83%94%E3%83%BC%E3%83%AA%E3%83%B3%E3%82%B0%E3%82%92%E9%81%B8%E6%8A%9E%E8%82%A2%E3%81%AE%E4%B8%80%E3%81%A4%E3%81%A8%E3%81%97%E3%81%A6%E6%8E%A8%E5%A5%A8%E3%81%99%20%E3%82%8B%EF%BC%8E%E4%BD%86%E3%81%97%EF%BC%8C%E4%BF%9D%E9%99%BA%E9%81%A9%E7%94%A8%E5%A4%96%E3%81%A7%E3%81%82%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AB%E9%85%8D%E6%85%AE%E3%81%99%E3%82%8B%E5%BF%85%E8%A6%81%E3%81%8C%E3%81%82%E3%82%8B%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">dermatol.or.jp<\/a><a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5302#:~:text=trifarotene%2C%20alitretinoin%2C%20and%20bexarotene%20,increasing%20exposure%20within%20the%20pilosebaceous\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a><a href=\"https:\/\/www.dermatol.or.jp\/uploads\/uploads\/files\/guideline\/zasou2023.pdf#:~:text=%E7%B6%AD%E6%8C%81%E7%99%82%E6%B3%95%E3%81%A7%E5%86%8D%E7%99%BA%E3%81%97%E3%81%9F%E7%82%8E%E7%97%87%E6%80%A7%E7%9A%AE%E7%96%B9%E3%81%8C%E5%9F%BA%E6%BA%96%E3%81%AE%E5%8D%8A%E6%95%B0%E6%9C%AA%E6%BA%80%E3%81%A7%20%E3%81%82%E3%81%A3%E3%81%9F%E5%A0%B4%E5%90%88%E3%81%AB%E7%B6%AD%E6%8C%81%E7%99%82%E6%B3%95%E6%88%90%E5%8A%9F%E3%81%A8%E5%88%A4%E5%AE%9A%E3%81%97%E3%81%9F%E7%B5%90%E6%9E%9C%EF%BC%8C16%20%E9%80%B1%E7%9B%AE%E3%81%A7%20%E3%82%A2%E3%83%80%E3%83%91%E3%83%AC%E3%83%B3%200,75%EF%BC%85%E3%81%A7%E3%81%82%E3%81%A3%20%E3%81%9F%E3%81%AE%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%EF%BC%8C%E3%82%B2%E3%83%AB%E5%9F%BA%E5%89%A4%E7%BE%A4%E3%81%A7%E3%81%AF%2054%EF%BC%85%E3%81%A7%E3%81%82%E3%81%A3%E3%81%9F%EF%BC%8E%E3%81%BE%E3%81%9F%EF%BC%8C\" target=\"_blank\" rel=\"noreferrer noopener\">dermatol.or.jp<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39761150\/#:~:text=sebaceous%20glands%20by%20androgens%20play,invaluable%20guides%20for%20patients%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.livescience.com\/health\/medicine-drugs\/acne-vaccine-experimental-shot-for-common-skin-condition-reaches-clinical-trials-heres-what-you-need-to-know#:~:text=Sanofi%20is%20conducting%20what%27s%20known,of%20pimples%20on%20their%20face\" target=\"_blank\" rel=\"noreferrer noopener\">livescience.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u5c0b\u5e38\u6027\u75e4\u7621\uff08\u306b\u304d\u3073\uff09 \u75ab\u5b66\uff08\u65e5\u672c\u304a\u3088\u3073\u4e16\u754c\uff09 \u5c0b\u5e38\u6027\u75e4\u7621\uff08\u306b\u304d\u3073\uff09\u306f\u601d\u6625\u671f\u3092\u4e2d\u5fc3\u306b\u975e\u5e38\u306b\u983b\u5ea6\u306e\u9ad8\u3044\u76ae\u819a\u75be\u60a3\u3067\u3059\u3002\u4e16\u754c\u7684\u306b\u306f\u6709\u75c5\u7387\u7d049.4%\u3068\u63a8\u5b9a\u3055\u308c\u3001\u75be\u75c5\u5168\u4f53\u306e\u4e2d\u3067\u3082\u7b2c8\u4f4d\u3068\u3055\u308c\u308b\u307b\u3069\u4e00\u822c\u7684\u3067\u3059pubmed.ncbi.n [&hellip;]","protected":false},"author":1,"featured_media":827,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[38],"tags":[],"class_list":["post-826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-38"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/rmnw.jp\/wp-content\/uploads\/2025\/08\/image-43.png?fit=1024%2C768&ssl=1","jetpack_sharing_enabled":true,"jetpack_likes_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=826"}],"version-history":[{"count":5,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/826\/revisions"}],"predecessor-version":[{"id":1124,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/826\/revisions\/1124"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/media\/827"}],"wp:attachment":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}