{"id":774,"date":"2025-08-08T14:51:26","date_gmt":"2025-08-08T05:51:26","guid":{"rendered":"https:\/\/rmnw.jp\/?p=774"},"modified":"2025-09-04T13:51:46","modified_gmt":"2025-09-04T04:51:46","slug":"d23-%e3%83%a1%e3%83%a9%e3%83%8b%e3%83%b3%e8%89%b2%e7%b4%a0%e6%80%a7%e7%96%be%e6%82%a3%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e5%8c%85%e6%8b%ac%e7%9a%84%e3%82%ac%e3%82%a4%e3%83%89v1-0","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/?p=774","title":{"rendered":"D22.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66\u3000\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u3000V2.0"},"content":{"rendered":"\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/09\/D21.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u8840\u7ba1\u816b\u304a\u3088\u3073\u8840\u7ba1\u7570\u5e38-V1.0-1.mp3\"><\/audio><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"D22 \u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66 \u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3 V2 0\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/xtd5Z4Bjg6c?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n<a href=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/08\/D22.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3-V2.0.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\" data-toolbar=\"bottom\" data-toolbar-fixed=\"on\">D22.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3-V2.0<\/a>\n\n\n<h1 class=\"wp-block-heading\">\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9a\u7fa9\u3068\u6982\u8981<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u3068\u306f\u3001\u76ae\u819a\u306e\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u7570\u5e38\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u8272\u7d20\u6591\u30fb\u8272\u7d20\u6c88\u7740\u306e\u7dcf\u79f0\u3067\u3042\u308b\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u76ae\u819a\u306e\u8272\u8abf\u3092\u6c7a\u5b9a\u3059\u308b\u8272\u7d20\u3067\u3042\u308a\u3001\u7a2e\u3005\u306e\u8981\u56e0\u3067\u7523\u751f\u30fb\u5206\u5e03\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u5c40\u6240\u7684\u306a\u8336\u8910\u8272\u304b\u3089\u9ed2\u8272\u306e\u6591\u3092\u5f62\u6210\u3059\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=Melasma%20,3\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306b\u306f\u3001<strong>\u809d\u6591<\/strong>\uff08\u304b\u3093\u3071\u3093\uff09\u3084<strong>\u8001\u4eba\u6027\u8272\u7d20\u6591<\/strong>\uff08\u65e5\u5149\u9ed2\u5b50\uff09\u3001<strong>\u96c0\u5375\u6591<\/strong>\uff08\u305d\u3070\u304b\u3059\uff09\u3001<strong>\u5f8c\u5929\u6027\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9<\/strong>\uff08ADM\u3001\u3044\u308f\u3086\u308b\u30db\u30ea\u6bcd\u6591\uff09\u3001<strong>\u592a\u7530\u6bcd\u6591<\/strong>\u3001<strong>\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740<\/strong>\uff08PIH\uff09\u306a\u3069\u304c\u542b\u307e\u308c\u308b\u3002\u3044\u305a\u308c\u3082\u826f\u6027\u306e\u8272\u7d20\u6027\u75c5\u5909\u3067\u3042\u308b\u304c\u3001\u7f8e\u5bb9\u7684\u89b3\u70b9\u304b\u3089\u554f\u984c\u3068\u306a\u308a\u3084\u3059\u304f\u3001\u60a3\u8005\u306eQOL\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3082\u591a\u3044<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Epidemiology\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u8272\u8abf\u306f\u75c5\u5909\u306b\u3088\u3063\u3066\u69d8\u3005\u3067\u3001\u8868\u76ae\u5185\u306b\u30e1\u30e9\u30cb\u30f3\u304c\u5897\u52a0\u3059\u308b\u5834\u5408\u306f\u8910\u8272\u8abf\u3001\u771f\u76ae\u5185\u306b\u6c88\u7740\u3059\u308b\u5834\u5408\u306f\u9752\u7070\u8272\u8abf\u3092\u5448\u3059\u308b\u3002\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u306e\u6df1\u9054\u5ea6\u306fWood\u706f\u691c\u67fb\u306a\u3069\u3067\u5224\u5225\u3067\u304d\u3001\u8868\u76ae\u5185\u306e\u8272\u7d20\u6591\u306f\u7d2b\u5916\u7dda\u7167\u5c04\u4e0b\u3067\u6fc3\u304f\u898b\u3048\u3001\u771f\u76ae\u5185\u306e\u3082\u306e\u306f\u5909\u5316\u3057\u306a\u3044<a href=\"https:\/\/dermnetnz.org\/topics\/wood-lamp-skin-examination#:~:text=A%20Wood%20lamp%20for%20skin,examination%20may%20reveal\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u672c\u7ae0\u3067\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u5404\u75be\u60a3\u306e\u7279\u5fb4\u3068\u305d\u306e\u75ab\u5b66\u3001\u6210\u56e0\u3001\u8a3a\u65ad\u304a\u3088\u3073\u6cbb\u7642\u306b\u3064\u3044\u3066\u6700\u65b0\u306e\u77e5\u898b\u306b\u57fa\u3065\u304d\u5305\u62ec\u7684\u306b\u89e3\u8aac\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75ab\u5b66<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u767a\u75c7\u983b\u5ea6\u3084\u597d\u767a\u96c6\u56e3\u306f\u75be\u60a3\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u809d\u6591<\/strong>: \u5973\u6027\u306b\u5727\u5012\u7684\u306b\u591a\u304f\u3001\u7537\u5973\u6bd4\u306f\u304a\u3088\u305d9:1\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Melasma%20is%20much%20more%20common,and%20histologic%20picture%20is%20identical\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u7279\u306b\u598a\u5a20\u3084\u7d4c\u53e3\u907f\u598a\u85ac\u670d\u7528\u3092\u5951\u6a5f\u306b\u767a\u75c7\u30fb\u5897\u60aa\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u598a\u5a66\u306e15\u201350%\u306b\u809d\u6591\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u3082\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Age\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u597d\u767a\u5e74\u9f62\u306f20\u201340\u4ee3\u306e\u5973\u6027\u3067\u3001\u601d\u6625\u671f\u4ee5\u524d\u306e\u767a\u75c7\u306f\u307e\u308c\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Age\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u4eba\u7a2e\u7684\u306b\u306f\u8272\u7d20\u306e\u6fc3\u3044\u808c\u30bf\u30a4\u30d7\uff08Fitzpatrick III\u4ee5\u4e0a\uff09\u306e\u4eba\u306b\u591a\u304f\u3001\u30e9\u30c6\u30f3\u7cfb\u3084\u30a2\u30b8\u30a2\u7cfb\u3067\u9ad8\u983b\u5ea6\u3067\u3042\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=Genetic%20predisposition%20is%20also%20a,4\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Race\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u5730\u57df\u306b\u3088\u3063\u3066\u6709\u75c5\u7387\u306b\u5dee\u304c\u3042\u308a\u3001\u6771\u5357\u30a2\u30b8\u30a2\u3067\u306f\u4e00\u822c\u4eba\u53e3\u306e\u7d0440%\u306e\u5973\u6027\u306b\u307f\u3089\u308c\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Melasma%20is%20very%20common%2C%20affecting,11%2C%2012%2C%2013\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u4e00\u65b9\u3001\u6b27\u7c73\u306e\u767d\u4eba\u3067\u306f\u6709\u75c5\u7387\u306f\u3084\u3084\u4f4e\u3044\u304c\u3001\u305d\u308c\u3067\u3082\u7c73\u56fd\u3067\u306f500\u4e07\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u304c\u3044\u308b\u3068\u63a8\u8a08\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=US%20frequency\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u8001\u4eba\u6027\u8272\u7d20\u6591\uff08\u65e5\u5149\u9ed2\u5b50\uff09<\/strong>: \u4e2d\u9ad8\u5e74\u4ee5\u964d\u306e\u4eba\u53e3\u306b\u6975\u3081\u3066\u983b\u7e41\u306b\u307f\u3089\u308c\u308b\u5149\u8001\u5316\u5fb4\u5019\u3067\u3042\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=lentigo,darker%20than\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a><a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=Epidemiology\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u767d\u4eba\u3067\u306f60\u6b73\u4ee5\u4e0a\u306e90%\u8fd1\u304f\u306b\u5b58\u5728\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3001\u65e5\u672c\u4eba\u3092\u542b\u3080\u30a2\u30b8\u30a2\u4eba\u3067\u308240\u4ee3\u4ee5\u964d\u3067\u9854\u9762\u3084\u624b\u80cc\u306b\u9ad8\u7387\u306b\u51fa\u73fe\u3059\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=Prevalence\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u7537\u5973\u5dee\u306f\u5c0f\u3055\u3044\u304c\u3001\u5973\u6027\u306f\u7f8e\u5bb9\u4e0a\u306e\u95a2\u5fc3\u304b\u3089\u53d7\u8a3a\u7387\u304c\u9ad8\u304f\u3001\u7d71\u8a08\u4e0a\u5973\u6027\u60a3\u8005\u306e\u65b9\u304c\u591a\u304f\u5831\u544a\u3055\u308c\u308b\u50be\u5411\u304c\u3042\u308b<a href=\"https:\/\/www.jaad.org\/article\/S0190-9622(24)02178-9\/fulltext#:~:text=Results%3A%2027,III%2C%20versus\" target=\"_blank\" rel=\"noreferrer noopener\">jaad.org<\/a>\u3002\u82e5\u5e74\u8005\u3067\u3082\u5f37\u3044\u7d2b\u5916\u7dda\u66dd\u9732\u6b74\u304c\u3042\u308c\u3070\u751f\u3058\u3046\u308b\u304c\u3001\u901a\u5e38\u306f\u9577\u5e74\u306e\u6162\u6027\u7684\u306a\u65e5\u5149\u66dd\u9732\u306e\u84c4\u7a4d\u306b\u3088\u308a\u4e2d\u5e74\u671f\u4ee5\u964d\u306b\u767a\u751f\u3059\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,more%20often%20can%20present%20during\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a><a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=The%20best%20way%20to%20prevent,developing%20ephelides%20and%20solar%20lentigines\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u96c0\u5375\u6591\uff08\u305d\u3070\u304b\u3059\uff09<\/strong>: \u907a\u4f1d\u7684\u7d20\u56e0\u306b\u3088\u308b\u5c0f\u578b\u306e\u8272\u7d20\u6591\u3067\u3001\u5e7c\u5c11\u671f\u304b\u3089\u65e5\u5149\u66dd\u9732\u90e8\u306b\u591a\u6570\u51fa\u73fe\u3059\u308b\u3002\u7279\u306b\u8272\u767d\u3067\u8d64\u6bdb\u3092\u4f34\u3046\u3088\u3046\u306a\u767d\u4eba\u7cfb\u3067\u306f\u975e\u5e38\u306b\u4e00\u822c\u7684\u3067\u3042\u308a\u3001<strong>MC1R<\/strong>\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u95a2\u9023\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=Who%20gets%20ephelides%3F\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=Ephelides%20arise%20on%20an%20individual%27s,than%203%20mm%20in%20diameter\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u65e5\u672c\u4eba\u3092\u542b\u3080\u6771\u30a2\u30b8\u30a2\u4eba\u3067\u3082\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u304c\u3001\u6b27\u7c73\u4eba\u307b\u3069\u591a\u304f\u306f\u306a\u3044\u3002\u6027\u5dee\u306f\u306a\u304f\u3001\u5c0f\u5150\u671f\u306b\u5897\u3048\u601d\u6625\u671f\u307e\u3067\u62e1\u5927\u3059\u308b\u304c\u3001\u6210\u4eba\u4ee5\u964d\u306f\u76ee\u7acb\u305f\u306a\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,discrete%20hyperpigmented%20macule%20that%20is\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a><a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,by%20exposure%20to%20sunlight%2C%20and\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u51ac\u5b63\u306b\u8272\u304c\u8584\u304f\u306a\u308a\u590f\u5b63\u306b\u6fc3\u304f\u306a\u308b\u5b63\u7bc0\u5909\u52d5\u304c\u7279\u5fb4\u3067\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=Brown%20spots%20and%20freckles%20on,both%20are%20generally%20the%20same\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20are%20the%20clinical%20features,of%20ephelides\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u5f8c\u5929\u6027\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08ADM\/Hori\u6bcd\u6591\uff09<\/strong>: \u601d\u6625\u671f\u4ee5\u964d\u306e\u6210\u4eba\u3001\u3068\u304f\u306b\u4e2d\u5e74\u671f\u306e\u30a2\u30b8\u30a2\u4eba\u5973\u6027\u306b\u597d\u767a\u3059\u308b\u3068\u3055\u308c\u308b<a href=\"https:\/\/karger.com\/cde\/article\/14\/3\/368\/821832\/A-Report-of-Unusual-Case-of-Acquired-Dermal#:~:text=There%20is%20a%20rare%20acquired,aged%20Asian\" target=\"_blank\" rel=\"noreferrer noopener\">karger.com<\/a>\u3002\u982c\u90e8\u3092\u4e2d\u5fc3\u306b\u5de6\u53f3\u5bfe\u79f0\u6027\u306b\u7070\u9752\u8272\u301c\u8336\u8910\u8272\u306e\u5c0f\u6591\u70b9\u304c\u591a\u6570\u51fa\u73fe\u3059\u308b\u306e\u304c\u5178\u578b\u3067\u3042\u308b\uff08\u5148\u5929\u6027\u3067\u306f\u306a\u304f<strong>\u5f8c\u5929\u6027<\/strong>\u3067\u3042\u308b\u70b9\u304c\u592a\u7530\u6bcd\u6591\u3068\u7570\u306a\u308b\uff09\u3002\u65e5\u672c\u4eba\u3084\u6771\u6d0b\u4eba\u306b\u591a\u304f\u5831\u544a\u3055\u308c\u3001\u7537\u6027\u3088\u308a\u5973\u6027\u306b\u591a\u3044\u50be\u5411\u304c\u3042\u308b\u304c\u660e\u78ba\u306a\u75ab\u5b66\u7d71\u8a08\u306f\u9650\u5b9a\u7684\u3067\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevus%20of%20Ota%20is%20much,a%20form%20of%20acquired%20melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u592a\u7530\u6bcd\u6591<\/strong>: \u6771\u6d0b\u4eba\u306b\u7279\u6709\u306e\u5148\u5929\u6027\u306e\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5897\u6b96\u75c7\u3067\u3001\u65e5\u672c\u4eba\u3067\u306f\u7d040.2\u20130.6%\u306b\u307f\u3089\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevi%20of%20Ota%20and%20Ito,naevi%20are%20uncommon%20in%20Caucasians\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u51fa\u751f\u6642\u304b\u3089\u3042\u308b\u5834\u5408\u304c\u534a\u6570\u3060\u304c\u3001\u601d\u6625\u671f\u307e\u3067\u306b\u8272\u8abf\u304c\u6fc3\u304f\u306a\u308a\u660e\u3089\u304b\u306b\u306a\u308b\u4f8b\u3082\u591a\u3044<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevus%20of%20Ota%20is%20much,a%20form%20of%20acquired%20melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u4e09\u53c9\u795e\u7d4c\u7b2c1\u30fb2\u679d\u9818\u57df\uff08\u773c\u306e\u5468\u56f2\u3001\u984d\u3001\u982c\uff09\u306b\u7247\u5074\u6027\u306b\u751f\u3058\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u773c\u7403\u306e\u5f37\u819c\u304c\u9752\u7070\u8272\u306b\u8272\u7d20\u6c88\u7740\u3059\u308b\u3053\u3068\u3082\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,shoulder%20girdle\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevus%20of%20Ota\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u5973\u6027\u60a3\u8005\u304c\u7537\u6027\u306e\u7d045\u500d\u3068\u5727\u5012\u7684\u306b\u591a\u3044<a href=\"https:\/\/emedicine.medscape.com\/article\/1058580-overview#:~:text=Epidemiology%20emedicine,of%20Ota%20in%20the\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u767d\u4eba\u3084\u9ed2\u4eba\u3067\u306f\u307e\u308c\u3060\u304c\u3001\u30a2\u30b8\u30a2\u4eba\u3084\u4e00\u90e8\u30a2\u30d5\u30ea\u30ab\u7cfb\u3067\u9ad8\u983b\u5ea6\u306b\u307f\u3089\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1058580-overview#:~:text=Epidemiology%20emedicine,of%20Ota%20in%20the\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\uff08PIH\uff09<\/strong>: \u76ae\u819a\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u3059\u3079\u3066\u306e\u4eba\u7a2e\u30fb\u5e74\u9f62\u3067\u767a\u751f\u3057\u3046\u308b\u304c\u3001\u305d\u306e\u7a0b\u5ea6\u306f\u76ae\u819a\u30bf\u30a4\u30d7\u306b\u3088\u308a\u7570\u306a\u308b\u3002\u8272\u7d20\u6c88\u7740\u306f\u8272\u9ed2\u306e\u4eba\u307b\u3069\u76ee\u7acb\u3061\u3084\u3059\u304f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6d3b\u6027\u304c\u9ad8\u3044\u808c\u8cea\u3067\u306f\u8efd\u5fae\u306a\u708e\u75c7\u3067\u3082\u8272\u7d20\u6c88\u7740\u3092\u6b8b\u3057\u3084\u3059\u3044<a href=\"https:\/\/dermnetnz.org\/topics\/pigmentation-disorders#:~:text=Post,skinned%20individuals%2C%20or\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u30cb\u30ad\u30d3\u3084\u5916\u50b7\u3001\u6e7f\u75b9\u306a\u3069\u306e\u75be\u60a3\u65e2\u5f80\u306e\u3042\u308b\u90e8\u4f4d\u306b\u751f\u3058\u308b\u4e8c\u6b21\u7684\u306a\u73fe\u8c61\u3067\u3042\u308a\u3001\u57fa\u790e\u75be\u60a3\u306e\u983b\u5ea6\u306b\u6e96\u3058\u3066\u82e5\u5e74\u301c\u4e2d\u5e74\u3067\u3088\u304f\u307f\u3089\u308c\u308b\u3002\u7537\u5973\u5dee\u306f\u306a\u304f\u3001\u4f8b\u3048\u3070\u30cb\u30ad\u30d3\u5f8c\u306e\u8272\u7d20\u6c88\u7740\u306f\u82e5\u5e74\u7537\u6027\u306b\u3082\u9ad8\u7387\u306b\u307f\u3089\u308c\u308b\u3002\u7d2b\u5916\u7dda\u66dd\u9732\u306fPIH\u3092\u5897\u60aa\u3055\u305b\u308b\u74b0\u5883\u56e0\u5b50\u3067\u3042\u308a\u3001\u65e5\u713c\u3051\u306b\u3088\u3063\u3066\u8272\u7d20\u6c88\u7740\u306f\u4e00\u5c64\u6fc3\u304f\u9577\u5f15\u304f\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0a\u306e\u3088\u3046\u306b\u3001\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306f\u4eba\u7a2e\u7684\u80cc\u666f\u3084\u5e74\u9f62\u3001\u6027\u5225\u3001\u74b0\u5883\u56e0\u5b50\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u308b\u3002\u305d\u308c\u305e\u308c\u306e\u75be\u60a3\u306e\u6d41\u884c\u7279\u6027\u3092\u8e0f\u307e\u3048\u3001\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u96c6\u56e3\u3067\u306f\u4e88\u9632\u3068\u65e9\u671f\u5bfe\u7b56\u304c\u91cd\u8981\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c5\u56e0\u3068\u767a\u75c7\u6a5f\u5e8f<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f<strong>\u7d2b\u5916\u7dda\uff08UV\uff09<\/strong>\u3001<strong>\u30db\u30eb\u30e2\u30f3<\/strong>\u3001<strong>\u708e\u75c7<\/strong>\u3001<strong>\u907a\u4f1d\u7d20\u56e0<\/strong>\u306a\u3069\u69d8\u3005\u306a\u56e0\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u3002\u75be\u60a3\u3054\u3068\u306b\u4e3b\u56e0\u306f\u7570\u306a\u308b\u304c\u3001\u591a\u304f\u306e\u5834\u5408\u3053\u308c\u3089\u304c\u8907\u5408\u7684\u306b\u4f5c\u7528\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d2b\u5916\u7dda:<\/strong>\u3000UV\u306f\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u6700\u3082\u91cd\u8981\u306a\u74b0\u5883\u56e0\u5b50\u3067\u3042\u308b\u3002\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u8868\u76ae\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u304b\u3089<strong>\u03b1-\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3<\/strong>\uff08\u03b1-MSH\uff09\u3084<strong>\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1<\/strong>\u306a\u3069\u306e\u56e0\u5b50\u304c\u653e\u51fa\u3055\u308c\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u5897\u52a0\u3059\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=The%20most%20important%20factor%20in,in%20melasma%20lesions%2C%20and%20these\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Sunscreens%20that%20primarily%20block%20UV,7\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u307e\u305fUV\u306b\u3088\u308b\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u7523\u751f\u3084\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u3082\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3092\u9ad8\u3081\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=The%20most%20important%20factor%20in,in%20melasma%20lesions%2C%20and%20these\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u9577\u6ce2\u9577\u306e<strong>\u53ef\u8996\u5149<\/strong>\u3082\u8272\u7d20\u6c88\u7740\u3092\u8d77\u3053\u3057\u3046\u308b\u3053\u3068\u304c\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u6ce2\u9577415nm\u524d\u5f8c\u306e\u53ef\u8996\u5149\u7dda\u304c\u6570\u30f6\u6708\u6301\u7d9a\u3059\u308b\u8272\u7d20\u6c88\u7740\u3092\u8a98\u767a\u3059\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=can%20cause%20peroxidation%20of%20lipids,7\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u3057\u305f\u304c\u3063\u3066UVA\/UVB\u3060\u3051\u3067\u306a\u304f\u53ef\u8996\u5149\u3092\u906e\u65ad\u3059\u308b\u906e\u5149\u3082\u809d\u6591\u306a\u3069\u306e\u7ba1\u7406\u306b\u306f\u91cd\u8981\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=finding%2C%20photoprotection%20against%20VL%20is,6%20months%20in%20the%20iron\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=either%20iron%20oxide%20or%20large,issue%20represented%20by%20white%20turbidity28\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u30db\u30eb\u30e2\u30f3:<\/strong>\u3000\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u306a\u3069\u306e\u6027\u30db\u30eb\u30e2\u30f3\u306f\u30e1\u30e9\u30cb\u30f3\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u809d\u6591\u304c\u598a\u5a20\u3084\u7d4c\u53e3\u907f\u598a\u85ac\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30fb\u30d7\u30ed\u30b2\u30b9\u30c8\u30fc\u30b2\u30f3\uff09\u3067\u8a98\u767a\u30fb\u5897\u60aa\u3059\u308b\u3053\u3068\u3084\u3001\u809d\u6591\u90e8\u4f4d\u3067\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=A%20direct%20relationship%20with%20female,form%20of%20melasma%20known%20as\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Hormonal%20influences%20play%20a%20role,estrogen%20do%20not%2C%20implicates%20progesterone\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u598a\u5a20\u4e2d\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30fb\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u30fbMSH\u304c\u5897\u52a0\u3057\u809d\u6591\u304c\u73fe\u308c\u3084\u3059\u304f\u306a\u308b\uff08\u300c\u598a\u5a20\u30de\u30b9\u30af\u300d\uff09\u304c\u3001\u5206\u5a29\u5f8c\u3084\u30d4\u30eb\u4e2d\u6b62\u5f8c\u306b\u81ea\u7136\u6d88\u9000\u3059\u308b\u4f8b\u3082\u3042\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=Pregnant%20women%20often%20get%20melasma%2C,3\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u4e00\u65b9\u3001\u7537\u6027\u306e\u809d\u6591\u3067\u306f\u30db\u30eb\u30e2\u30f3\u7570\u5e38\u306f\u660e\u3089\u304b\u3067\u306a\u304f\u3001\u305d\u306e\u6a5f\u5e8f\u306f\u672a\u89e3\u660e\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=A%20direct%20relationship%20with%20female,form%20of%20melasma%20known%20as\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u307e\u305f<strong>\u7532\u72b6\u817a\u6a5f\u80fd\u7570\u5e38<\/strong>\u3084<strong>\u30b9\u30c8\u30ec\u30b9<\/strong>\u306b\u3088\u308bACTH\/MSH\u5897\u52a0\u3082\u8272\u7d20\u6c88\u7740\u306b\u95a2\u4e0e\u3057\u3046\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=with%20intense%20sun%20exposure%20are,4\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u4f8b\u3048\u3070Addison\u75c5\uff08\u6162\u6027\u526f\u814e\u4e0d\u5168\uff09\u3067\u306f\u5168\u8eab\u306e\u8272\u7d20\u6c88\u7740\uff08\u7279\u306b\u6469\u64e6\u90e8\u4f4d\u306e\u9ed2\u305a\u307f\uff09\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7:<\/strong>\u3000\u76ae\u819a\u306e\u708e\u75c7\u53cd\u5fdc\u5f8c\u306b\u306f\u8272\u7d20\u6c88\u7740\u307e\u305f\u306f\u8131\u8272\u7d20\u304c\u6b8b\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u708e\u75c7\u306b\u4f34\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5206\u6ccc\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u9178\u5316\u3001\u526f\u814e\u76ae\u8cea\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u306a\u3069\u3067\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u4ea2\u9032\u3059\u308b\u305f\u3081\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=The%20most%20important%20factor%20in,in%20melasma%20lesions%2C%20and%20these\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u7279\u306b\u771f\u76ae\u4e0a\u5c64\u306e\u708e\u75c7\u3067\u57fa\u5e95\u819c\u304c\u969c\u5bb3\u3055\u308c\u308b\u3068\u30e1\u30e9\u30cb\u30f3\u304c\u771f\u76ae\u306b\u6f0f\u51fa\u3057\uff08<strong>\u8272\u7d20\u5931\u8abf<\/strong>\uff09\u3001\u771f\u76ae\u5185\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u8caa\u98df\u3055\u308c\u3066<strong>\u30e1\u30e9\u30ce\u30d5\u30a1\u30fc\u30b8<\/strong>\u3092\u5f62\u6210\u3059\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Epidermal%20PIH%20involves%20increased%20melanin,are%20evident%20in%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=epidermis,evident%20in%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u3053\u308c\u304c\u9077\u5ef6\u3059\u308b\u771f\u76ae\u578bPIH\u306e\u539f\u56e0\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001\u6fc0\u3057\u3044\u708e\u75c7\u3067\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u7834\u58ca\u3055\u308c\u708e\u75c7\u5f8c<strong>\u767d\u6591<\/strong>\uff08\u8131\u8272\u7d20\u6591\uff09\u3068\u306a\u308b\u3053\u3068\u3082\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u7d20\u56e0:<\/strong>\u3000\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3084\u5206\u5e03\u306e\u500b\u4eba\u5dee\u306b\u306f\u907a\u4f1d\u7684\u80cc\u666f\u304c\u5927\u304d\u304f\u5bc4\u4e0e\u3059\u308b\u3002\u96c0\u5375\u6591\u3067\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\u306e\u907a\u4f1d\u30d1\u30bf\u30fc\u30f3\u304c\u793a\u5506\u3055\u308c\u3001MC1R\u907a\u4f1d\u5b50\u591a\u578b\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=Genetics\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u809d\u6591\u3082\u5bb6\u65cf\u6b74\u3092\u6709\u3059\u308b\u60a3\u8005\u304c\u534a\u6570\u306b\u306e\u307c\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=ochronosis%20is%20very%20frequently%20caused,2\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=A%20genetic%20predisposition%20is%20a,under%20similar%20conditions%20did%20not\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u592a\u7530\u6bcd\u6591\u3067\u306f\u76ae\u819a\u306e\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u5c40\u6240\u7684\u306b\u5897\u751f\u3059\u308b\u539f\u56e0\u3068\u3057\u3066\u80da\u767a\u751f\u671f\u306e\u795e\u7d4c\u5824\u7d30\u80de\u306e\u79fb\u884c\u7570\u5e38\u304c\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u4e00\u90e8\u3067<strong>GNAQ<\/strong>\u3084<strong>GNA11<\/strong>\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=How%20does%20dermal%20melanocytosis%20arise%2C,and%20who%20is%20at%20risk\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u8272\u7d20\u6027\u75be\u60a3\u306e\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u3084\u7d30\u80de\u5185\u7d4c\u8def\uff08\u4f8b\u3048\u3070<strong>c-kit\u53d7\u5bb9\u4f53<\/strong>\u3084<strong>\u5e79\u7d30\u80de\u56e0\u5b50<\/strong>\u306e\u95a2\u4e0e\u306a\u3069\uff09\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=known%20to%20induce%20increased%20production,melasma%20are%20doomed%20to%20fail\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=contribute%20to%20increased%20melanin%20production,melasma%20are%20doomed%20to%20fail\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u4eca\u5f8c\u3053\u308c\u3089\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u3082\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0a\u306e\u3088\u3046\u306b\u3001\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306f\u5358\u4e00\u306e\u539f\u56e0\u3067\u306a\u304f<strong>\u591a\u56e0\u5b50\u6027<\/strong>\u306e\u75c5\u614b\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u809d\u6591\u306f\u300c\u8868\u76ae\u306e\u904e\u5270\u306a\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u300d\u306b\u52a0\u3048\u300c\u771f\u76ae\u306e\u5149\u8001\u5316\u5909\u5316\uff08\u5f3e\u6027\u7dda\u7dad\u306e\u5909\u6027\u3084\u8840\u7ba1\u62e1\u5f35\uff09\u300d\u3082\u95a2\u4e0e\u3059\u308b\u8907\u96d1\u306a\u72b6\u614b\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Based%20on%20accumulated%20knowledge%2C%20it%E2%80%99s,the%20underlying%20pathophysiology%20of%20melasma\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5b9f\u969b\u3001\u809d\u6591\u75c5\u5909\u90e8\u3067\u306f\u5149\u8001\u5316\u306e\u6307\u6a19\u3067\u3042\u308b<strong>\u65e5\u5149\u5f3e\u6027\u75c7<\/strong>\u3084\u8840\u7ba1\u65b0\u751f\uff08VEGF\u306e\u904e\u5270\u767a\u73fe\uff09\u3082\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=angiogenic%20factors%2C%20including%20basic%20fibroblast,after%20extended%20UV%20exposure%2039\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Previous%20studies%20have%20reported%20a,recognized%20for%20its%20ability%20to\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3057\u305f\u304c\u3063\u3066\u6cbb\u7642\u306b\u969b\u3057\u3066\u306f\u3001\u3053\u308c\u3089\u75c5\u56e0\u30fb\u75c5\u614b\u3092\u8e0f\u307e\u3048\u3066\u5305\u62ec\u7684\u306b\u5bfe\u51e6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3b\u306a\u75be\u60a3\u306e\u5206\u985e\u3068\u7279\u5fb4<\/h2>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u4ee3\u8868\u7684\u306a\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u75c5\u5909\u306e\u7279\u5fb4\u3068\u81e8\u5e8a\u6240\u898b\u3092\u8ff0\u3079\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u809d\u6591\uff08Melasma\uff09<\/h3>\n\n\n\n<p><img decoding=\"async\" alt=\"https:\/\/dermnetnz.org\/topics\/melasma-images\" src=\"blob:https:\/\/chatgpt.com\/f8aab3ef-c642-48cf-a4ef-a33af6052c51\"> \u56f3: \u9854\u9762\u306b\u898b\u3089\u308c\u308b\u809d\u6591\u3002\u5de6\u53f3\u5bfe\u79f0\u306e\u8910\u8272\u6591\u304c\u982c\u90e8\u3092\u4e2d\u5fc3\u306b\u51fa\u73fe\u3057\u3066\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Melasma%20is%20much%20more%20common,and%20histologic%20picture%20is%20identical\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Age\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u809d\u6591\u306f\u601d\u6625\u671f\u4ee5\u964d\u306e\u5973\u6027\u306b\u597d\u767a\u3059\u308b\u5f8c\u5929\u6027\u306e\u8272\u7d20\u6c88\u7740\u6591\u3067\u3001\u984d\u3001\u982c\u9aa8\u90e8\u3001\u4e0a\u53e3\u5507\u3001\u9f3b\u306a\u3069\u306b<strong>\u5730\u56f3\u72b6<\/strong>\u306e\u5883\u754c\u4e0d\u660e\u77ad\u306a\u6de1\u8910\u8272\u301c\u6fc3\u8910\u8272\u306e\u6591\u3068\u3057\u3066\u73fe\u308c\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=The%20symptoms%20of%20melasma%20are,5\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a><a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=or%20mandibular,5\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u5de6\u53f3\u5bfe\u79f0\u306b\u751f\u3058\u308b\u306e\u304c\u5178\u578b\u3067\u3042\u308a\u3001\u7279\u306b<strong>Centrofacial\u578b<\/strong>\uff08\u984d\u30fb\u9f3b\u30fb\u4e0a\u53e3\u5507\u30fb\u982c\u30fb\u984e\uff09\u3001<strong>\u982c\u9aa8\u578b<\/strong>\uff08\u4e21\u982c\u9aa8\u90e8\uff09\u3001<strong>\u4e0b\u984e\u578b<\/strong>\uff08\u4e0b\u984e\u6cbf\u3044\uff09\u306e3\u30d1\u30bf\u30fc\u30f3\u306b\u5206\u985e\u3055\u308c\u308b<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=,5\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u81ea\u899a\u75c7\u72b6\u306f\u306a\u304f\u3001\u7f8e\u5bb9\u4e0a\u306e\u60a9\u307f\u4ee5\u5916\u306e\u81e8\u5e8a\u7684\u554f\u984c\u3092\u751f\u3058\u306a\u3044<a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=The%20symptoms%20of%20melasma%20are,5\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a>\u3002\u809d\u6591\u306e\u8272\u8abf\u306f\u4e00\u69d8\u3067\u306f\u306a\u304f\u3001\u8868\u76ae\u5185\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u304c\u4e3b\u306e\u5834\u5408\u306f\u5883\u754c\u660e\u77ad\u306a\u8336\u8272\u6591\u3060\u304c\u3001\u771f\u76ae\u306b\u3082\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u3092\u4f34\u3046\u5834\u5408\u306f\u7070\u8272\u8abf\u3092\u5e2f\u3073\u308b\u3002\u5f93\u6765\u306fWood\u706f\u3067\u5897\u5f37\u3059\u308b\u3082\u306e\u3092\u8868\u76ae\u578b\u3001\u305d\u3046\u3067\u306a\u3044\u3082\u306e\u3092\u771f\u76ae\u578b\u3001\u4e21\u65b9\u306e\u6240\u898b\u3092\u793a\u3059\u3082\u306e\u3092\u6df7\u5408\u578b\u3068\u5206\u985e\u3057\u3066\u3044\u305f\u304c\u3001\u5b9f\u969b\u306b\u306f\u6df7\u5408\u578b\u304c\u591a\u3044<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/koshohin\/47\/2\/47_470203\/_pdf\/-char\/ja#:~:text=%E3%81%97%E3%81%BF%E3%81%AE%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0%E3%81%8B%E3%82%89%E6%B2%BB%E7%99%82%E3%81%BE%E3%81%A7%20,%E7%B5%84%E7%B9%94%E6%9F%93%E8%89%B2%E3%81%AB%E3%82%88%E3%82%8A%E7%9C%9F%E7%9A%AE%E3%81%AB%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u8fd1\u5e74\u3001\u514d\u75ab\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u304b\u3089\u809d\u6591\u3067\u306f\u771f\u76ae\u306b\u30e1\u30e9\u30cb\u30f3\u306f\u3055\u307b\u3069\u6c88\u7740\u305b\u305a\u3001<strong>\u771f\u76ae\u306e\u5f3e\u6027\u7dda\u7dad\u5909\u6027<\/strong>\u3068<strong>\u8840\u7ba1\u62e1\u5f35<\/strong>\u3053\u305d\u304c\u809d\u6591\u7279\u6709\u306e\u75c5\u7406\u6240\u898b\u3068\u6307\u6458\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/koshohin\/47\/2\/47_470203\/_pdf\/-char\/ja#:~:text=%E3%81%97%E3%81%BF%E3%81%AE%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0%E3%81%8B%E3%82%89%E6%B2%BB%E7%99%82%E3%81%BE%E3%81%A7%20,%E7%B5%84%E7%B9%94%E6%9F%93%E8%89%B2%E3%81%AB%E3%82%88%E3%82%8A%E7%9C%9F%E7%9A%AE%E3%81%AB%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u809d\u6591\u306f\u6162\u6027\u7684\u306b\u7d4c\u904e\u3057\u3001\u590f\u306b\u60aa\u5316\u30fb\u51ac\u306b\u8efd\u5feb\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3002\u81ea\u7136\u6d88\u9000\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u304c\u518d\u767a\u3082\u3057\u3084\u3059\u304f\u3001\u6cbb\u7642\u5f8c\u3082\u7d2b\u5916\u7dda\u5bfe\u7b56\u306a\u3069\u306e\u9577\u671f\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8001\u4eba\u6027\u8272\u7d20\u6591\uff08\u65e5\u5149\u9ed2\u5b50\u3001Solar Lentigo\uff09<\/h3>\n\n\n\n<p>\u8001\u4eba\u6027\u8272\u7d20\u6591\u306f\u4e2d\u9ad8\u5e74\u306e\u5149\u66dd\u9732\u90e8\u4f4d\u306b\u751f\u3058\u308b\u826f\u6027\u306e\u8272\u7d20\u6591\u3067\u3001\u4fd7\u306b\u300c\u8001\u4eba\u6591\u300d\u3084\u300c\u65e5\u5149\u6591\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u3002\u5927\u304d\u3055\u306f\u6570mm\u304b\u30891\u20132cm\u3068\u69d8\u3005\u3067\u3001\u5f62\u3082\u5186\u5f62\uff5e\u985e\u5186\u5f62\u3060\u304c\u6642\u306b\u4e0d\u6574\u5f62\u3067\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20are%20the%20clinical%20features,of%20solar%20lentigines\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8272\u306f\u6de1\u8910\u8272\u304b\u3089\u9ed2\u8910\u8272\u3067\u5747\u4e00\u3001\u5883\u754c\u306f\u6bd4\u8f03\u7684\u306f\u3063\u304d\u308a\u3057\u3066\u304a\u308a\u3001\u8868\u9762\u306f\u5e73\u5766\u3067\u6642\u306b\u3056\u3089\u3064\u304d\u3092\u611f\u3058\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20are%20the%20clinical%20features,of%20solar%20lentigines\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u9854\u9762\uff08\u984d\u30fb\u982c\uff09\u3084\u624b\u306e\u7532\u3001\u524d\u8155\u306a\u3069\u9577\u5e74\u65e5\u306b\u5f53\u305f\u3063\u3066\u304d\u305f\u90e8\u4f4d\u306b\u591a\u767a\u3057\u3001\u51ac\u3067\u3082\u8272\u306f\u6d88\u9000\u3057\u306a\u3044\uff08\u96c0\u5375\u6591\u3068\u306e\u9451\u5225\u70b9\uff09<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=Brown%20spots%20and%20freckles%20on,both%20are%20generally%20the%20same\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20are%20lentigines%3F\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u7d44\u7e54\u5b66\u7684\u306b\u306f\u8868\u76ae\u57fa\u5e95\u5c64\u306e\u30e1\u30e9\u30cb\u30f3\u5897\u52a0\u304a\u3088\u3073<strong>\u8868\u76ae\u306e\u80a5\u539a<\/strong>\uff08\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u3068\u68d8\u7d30\u80de\u5c64\u306e\u914d\u5217\u7570\u5e38\uff09\u3092\u4f34\u3044\u3001\u3057\u3070\u3057\u3070\u57fa\u5e95\u5c64\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5897\u751f\u3082\u307f\u3089\u308c\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,Unlike%20ephelides%20or\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a><a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=predominantly%20involving%20the%20basal%20cell,be%20influenced%20by%20sun%20exposure\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u771f\u76ae\u306b\u306f\u3057\u3070\u3057\u3070\u65e5\u5149\u5f3e\u6027\u5909\u6027\u304c\u898b\u3089\u308c\u3001\u6162\u6027\u7684UV\u969c\u5bb3\u306e\u6240\u898b\u3067\u3042\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,Unlike%20ephelides%20or\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u8001\u4eba\u6027\u8272\u7d20\u6591\u305d\u306e\u3082\u306e\u306f\u826f\u6027\u3060\u304c\u3001\u9577\u5e74\u306e\u7d2b\u5916\u7dda\u66dd\u9732\u304c\u539f\u56e0\u3067\u3042\u308b\u70b9\u3067<strong>\u5149\u7dda\u89d2\u5316\u75c7<\/strong>\uff08\u65e5\u5149\u89d2\u5316\u75c7\uff09\u306a\u3069\u306e\u524d\u304c\u3093\u75c5\u5909\u3068\u5171\u901a\u306e\u80cc\u666f\u3092\u6301\u3064\u3002\u307e\u305f\u5883\u754c\u4e0d\u6574\u30fb\u8272\u8abf\u4e0d\u5747\u4e00\u306a\u5b64\u7acb\u6027\u306e\u8001\u4eba\u6027\u8272\u7d20\u6591\u306f<strong>\u60aa\u6027\u9ed2\u8272\u816b<\/strong>\u3084**\u65e5\u5149\u6027\u9ed2\u5b50\u69d8\u96c0\u5375\u6591\uff08\u30ec\u30f3\u30c1\u30b4\u30fb\u30de\u30e9\u30a4\u30cb\u30e3\uff09**\u3068\u306e\u9451\u5225\u3092\u8981\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20is%20the%20differential%20diagnosis,for%20freckles%20and%20solar%20lentigines\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u3057\u305f\u304c\u3063\u3066\u4e0d\u6574\u306a\u8272\u7d20\u6591\u3067\u306f\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc\u3084\u5fc5\u8981\u306b\u5fdc\u3058\u751f\u691c\u3067\u9451\u5225\u8a3a\u65ad\u3092\u884c\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u96c0\u5375\u6591\uff08\u305d\u3070\u304b\u3059\u3001Ephelides\uff09<\/h3>\n\n\n\n<p>\u96c0\u5375\u6591\u306f\u5c0f\u5150\u671f\u304b\u3089\u751f\u3058\u308b\u6563\u5728\u6027\u306e\u5c0f\u3055\u306a\u8272\u7d20\u6591\u3067\u3001\u76f4\u5f841\uff5e3mm\u7a0b\u5ea6\u306e\u6de1\u8910\u8272\u6591\u304c\u9854\u9762\uff08\u7279\u306b\u9f3b\u30fb\u982c\uff09\u3084\u80a9\u30fb\u80cc\u4e2d\u306e\u4e0a\u90e8\u306b\u591a\u767a\u3059\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,as%20a%20person%20reaches%20adulthood\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a><a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,by%20exposure%20to%20sunlight%2C%20and\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u5f37\u304f\u3001\u8272\u767d\u3067\u8d64\u6bdb\u306e\u4eba\u306b\u9855\u8457\u3067\u3042\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,as%20a%20person%20reaches%20adulthood\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u6625\u304b\u3089\u590f\u306b\u304b\u3051\u3066\u7d2b\u5916\u7dda\u3067\u8272\u8abf\u304c\u6fc3\u304f\u306a\u308a\u6570\u3082\u5897\u3048\u308b\u304c\u3001\u51ac\u5b63\u306b\u306f\u304b\u306a\u308a\u8584\u308c\u308b\uff08\u5b8c\u5168\u306b\u6d88\u5931\u306f\u3057\u306a\u3044\uff09<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=Brown%20spots%20and%20freckles%20on,both%20are%20generally%20the%20same\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20are%20the%20clinical%20features,of%20ephelides\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6570\u306f\u6b63\u5e38\u3060\u304c\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u4ea2\u9032\u3057\u3001\u57fa\u5e95\u5c64\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u306e\u5897\u52a0\u3068\u3057\u3066\u73fe\u308c\u308b<a href=\"https:\/\/www.unboundmedicine.com\/5minute\/view\/5-Minute-Clinical-Consult\/1688528\/all\/Lentigo_and_Freckles__Ephelides_#:~:text=,skin%20and%20elongation%20of%20the\" target=\"_blank\" rel=\"noreferrer noopener\">unboundmedicine.com<\/a>\u3002\u601d\u6625\u671f\u4ee5\u964d\u306f\u65b0\u751f\u304c\u6e1b\u308a\u3001\u6210\u4eba\u306b\u306a\u308b\u3068\u76ee\u7acb\u305f\u306a\u304f\u306a\u308b\u3053\u3068\u3082\u591a\u3044\u3002\u96c0\u5375\u6591\u81ea\u4f53\u306f\u826f\u6027\u3067\u5065\u5eb7\u4e0a\u554f\u984c\u306f\u306a\u3044\u304c\u3001\u7f8e\u5bb9\u7684\u95a2\u5fc3\u304b\u3089\u82e5\u5e74\u3067\u6cbb\u7642\u3092\u5e0c\u671b\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5f8c\u5929\u6027\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08ADM, Hori\u6bcd\u6591\uff09<\/h3>\n\n\n\n<p>ADM\u306f<strong>Hori\u3089\u304c\u63d0\u5531\u3057\u305f acquired dermal melanocytosis<\/strong> \u306e\u3053\u3068\u3067\u3001\u65e5\u672c\u4eba\u3092\u542b\u3080\u6771\u6d0b\u4eba\u5973\u6027\u306e\u4e21\u982c\u90e8\u306b\u5f8c\u5929\u7684\u306b\u51fa\u73fe\u3059\u308b\u7070\u9752\u8272\uff5e\u6de1\u8910\u8272\u306e\u70b9\u72b6\u6591\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11211861\/#:~:text=,and%20may%2C%20in\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.medicaljournals.se\/acta\/content\/html\/10.2340\/00015555-1282#:~:text=Acquired%20dermal%20melanocytosis%20,most%20frequently%20occurring%20on\" target=\"_blank\" rel=\"noreferrer noopener\">medicaljournals.se<\/a>\u3002\u592a\u7530\u6bcd\u6591\u3068\u985e\u4f3c\u3059\u308b\u771f\u76ae\u5185\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5897\u6b96\u75c7\u3060\u304c\u3001<strong>\u601d\u6625\u671f\uff5e\u6210\u4eba\u671f<\/strong>\u306b\u751f\u3058\u308b\u70b9\u3001<strong>\u4e21\u5074\u5bfe\u79f0<\/strong>\u306b\u73fe\u308c\u308b\u70b9\u3067\u7570\u306a\u308b\uff08\u592a\u7530\u6bcd\u6591\u306f\u7247\u5074\u6027\u304c\u591a\u3044\uff09\u3002\u75c5\u5909\u306f\u4e3b\u306b\u4e21\u5074\u982c\u9aa8\u90e8\u306b\u9650\u5c40\u3059\u308b\u304c\u3001\u6642\u306b\u984d\u3084\u9f3b\u306b\u3082\u53ca\u3076\u3002\u76f4\u5f84\u6570mm\u5927\u306e\u5c0f\u6591\u70b9\u304c\u6563\u5728\u3057\u3001\u5883\u754c\u306f\u6bd4\u8f03\u7684\u9bae\u660e\u3067\u3042\u308b\u3002\u8272\u8abf\u306f\u7070\u9752\u8272\u301c\u6de1\u9752\u8910\u8272\u3067\u3001\u771f\u76ae\u306b\u5b58\u5728\u3059\u308b\u30e1\u30e9\u30cb\u30f3\u306b\u3088\u308b<strong>\u771f\u76ae\u578b\u306e\u8272<\/strong>\u3092\u5448\u3059\u308b\u3002\u5973\u6027\u306b\u591a\u304f\u3001\u4e2d\u5e74\u4ee5\u964d\u306b\u76ee\u7acb\u3063\u3066\u304f\u308b\u50be\u5411\u304c\u3042\u308b\u3002\u539f\u56e0\u306f\u660e\u3089\u304b\u3067\u306a\u3044\u304c\u3001\u601d\u6625\u671f\u4ee5\u964d\u306e\u5973\u6027\u30db\u30eb\u30e2\u30f3\u3084\u65e5\u5149\u66b4\u9732\u304c\u8a98\u56e0\u3068\u306e\u6307\u6458\u3082\u3042\u308b\u3002ADM\u81ea\u4f53\u306f\u826f\u6027\u3067\u3042\u308b\u304c\u3001<strong>\u8499\u53e4\u6591<\/strong>\u3084\u592a\u7530\u6bcd\u6591\u306e\u9045\u767a\u578b\u5909\u7570\u3068\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u5206\u985e\u4e0a\u3084\u3084\u63fa\u308c\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u592a\u7530\u6bcd\u6591 (Nevus of Ota)<\/h3>\n\n\n\n<p>\u592a\u7530\u6bcd\u6591\u306f\u4e09\u53c9\u795e\u7d4c\u7b2c1\u30fb2\u679d\u9818\u57df\u306b\u6cbf\u3063\u3066\u751f\u3058\u308b\u9752\u9ed2\u3044\u8272\u7d20\u6591\u3067\u3042\u308b\u3002\u51fa\u751f\u6642\u307e\u305f\u306f\u4e73\u5e7c\u5150\u671f\u306b\u51fa\u73fe\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u601d\u6625\u671f\u307e\u3067\u306b\u660e\u3089\u304b\u306b\u306a\u308b\u30b1\u30fc\u30b9\u3082\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevus%20of%20Ota%20is%20much,a%20form%20of%20acquired%20melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u5358\u5074\u6027\u306b\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u4e21\u5074\u6027\u306e\u4f8b\u3082\u7d045\u201310%\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u773c\u5468\u56f2\u3001\u984d\u3001\u3053\u3081\u304b\u307f\u3001\u982c\u3001\u9f3b\u306a\u3069\u306b\u8272\u7d20\u6591\u304c\u5206\u5e03\u3057\u3001\u5f37\u819c\u3084\u773c\u7403\u7d50\u819c\u3001\u53e3\u8154\u7c98\u819c\u306b\u8272\u7d20\u6c88\u7740\u3092\u4f34\u3046\u3053\u3068\u3082\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,shoulder%20girdle\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevus%20of%20Ota\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8272\u8abf\u306f\u9752\u7d2b\u8272\uff5e\u7070\u9ed2\u8272\u3067\u3001\u6591\u306e\u5927\u304d\u3055\u306f\u4e0d\u898f\u5247\u3002\u601d\u6625\u671f\u306b\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3067\u8272\u304c\u6fc3\u304f\u306a\u308b\u5834\u5408\u304c\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,35%20has%20rarely%20been\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u771f\u76ae\u6df1\u5c64\u306b\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u7d30\u80de\uff08\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\uff09\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3001\u7d2b\u5916\u7dda\u306e\u5f71\u97ff\u306f\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=It%20is%20not%20known%20why,not%20reach%20deep%20dermal%20melanocytes\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u300250%\u4ee5\u4e0a\u306f\u51fa\u751f\u6642\u304b\u3089\u5b58\u5728\u3059\u308b\u305f\u3081\u6bcd\u6591\u3068\u547c\u3070\u308c\u308b\u304c\u3001\u6210\u4eba\u3057\u3066\u304b\u3089\u6fc3\u304f\u306a\u308a\u6c17\u4ed8\u304f\u4f8b\u3082\u591a\u3044\u3002\u592a\u7530\u6bcd\u6591\u306e\u5408\u4f75\u75c7\u3068\u3057\u3066\u3001\u75c5\u5909\u90e8\u306e\u773c\u306b<strong>\u7dd1\u5185\u969c<\/strong>\u304c\u751f\u3058\u308b\u983b\u5ea6\u304c\u82e5\u5e72\u9ad8\u3044\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u3001\u773c\u79d1\u30d5\u30a9\u30ed\u30fc\u304c\u63a8\u5968\u3055\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,with%20a%20nevus%20of%20Ota\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u307e\u305f\u7a00\u306a\u304c\u3089\u767d\u4eba\u3067\u592a\u7530\u6bcd\u6591\u304b\u3089<strong>\u60aa\u6027\u9ed2\u8272\u816b<\/strong>\u3092\u751f\u3058\u305f\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u5909\u5316\u306b\u306f\u6ce8\u610f\u3092\u8981\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,with%20a%20nevus%20of%20Ota\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740 (Post-inflammatory hyperpigmentation, PIH)<\/h3>\n\n\n\n<p>PIH\u306f\u5148\u884c\u3059\u308b\u76ae\u819a\u708e\u75c7\u304c\u6cbb\u7652\u3057\u305f\u90e8\u4f4d\u306b\u4e8c\u6b21\u7684\u306b\u6b8b\u308b\u8272\u7d20\u6c88\u7740\u3067\u3042\u308a\u3001\u75c5\u540d\u3068\u3044\u3046\u3088\u308a\u75c7\u5019\u3067\u3042\u308b\u3002\u539f\u56e0\u306f\u591a\u5c90\u306b\u308f\u305f\u308a\u3001\u30cb\u30ad\u30d3\u3001\u5916\u50b7\u3001\u71b1\u50b7\u3001\u63a5\u89e6\u76ae\u819a\u708e\u3001\u6e7f\u75b9\u3001\u866b\u523a\u3055\u308c\u3001\u5316\u5b66\u85ac\u54c1\u306b\u3088\u308b\u523a\u6fc0\u306a\u3069\u69d8\u3005\u3067\u3042\u308b\u3002\u8272\u7d20\u6c88\u7740\u306e\u7a0b\u5ea6\u306f\u708e\u75c7\u306e\u91cd\u75c7\u5ea6\u3068\u500b\u4eba\u306e\u76ae\u819a\u30bf\u30a4\u30d7\u306b\u4f9d\u5b58\u3059\u308b\u3002\u8868\u76ae\u306b\u30e1\u30e9\u30cb\u30f3\u304c\u5897\u52a0\u3059\u308b\u5834\u5408\u306f\u5883\u754c\u660e\u77ad\u306a\u8336\u8272\u301c\u9ed2\u8910\u8272\u306e\u6591\u3068\u306a\u308a\u3001\u6bd4\u8f03\u7684\u6d45\u5728\u6027\u3067\u3042\u308b\u305f\u3081\u6570\u30f6\u6708\u3067\u6b21\u7b2c\u306b\u8584\u308c\u308b\u3053\u3068\u304c\u591a\u3044<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Also%20see%20Surgical%20Care%20%2C,28%2C%20and%20Medication\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=The%20treatment%20of%20postinflammatory%20hyperpigmentation,part%20of%20any%20therapeutic%20regimen\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u4e00\u65b9\u3001\u708e\u75c7\u306b\u3088\u308a\u57fa\u5e95\u819c\u304c\u7834\u58ca\u3055\u308c\u30e1\u30e9\u30cb\u30f3\u304c\u771f\u76ae\u5185\u3078\u843d\u3061\u8fbc\u3080\u3068\u3001\u771f\u76ae\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u8caa\u98df\u3055\u308c\u9752\u7070\u8272\u306e\u4e0d\u660e\u77ad\u306a\u6591\u3068\u306a\u308b\uff08\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff09\u3002\u3053\u306e<strong>\u771f\u76ae\u578bPIH<\/strong>\u306f\u6d88\u9000\u306b\u975e\u5e38\u306b\u9577\u3044\u6642\u9593\u3092\u8981\u3057\u3001\u5b8c\u5168\u306b\u306f\u6d88\u3048\u306a\u3044\u3053\u3068\u3082\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Epidermal%20PIH%20involves%20increased%20melanin,are%20evident%20in%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=epidermis,evident%20in%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002PIH\u306f\u3068\u308a\u308f\u3051\u8272\u7d20\u6c88\u7740\u3057\u3084\u3059\u3044\u808c\u8cea\uff08\u8272\u9ed2\u306e\u808c\u3084\u30a2\u30b8\u30a2\u30fb\u30a2\u30d5\u30ea\u30ab\u7cfb\uff09\u3067\u554f\u984c\u3068\u306a\u308a\u3084\u3059\u304f\u3001\u30cb\u30ad\u30d3\u8de1\u3084\u50b7\u8de1\u306e\u8272\u7d20\u6c88\u7740\u304c\u9577\u5e74\u6b8b\u308b\u30b1\u30fc\u30b9\u304c\u5c11\u306a\u304f\u306a\u3044\u3002\u6cbb\u7642\u305b\u305a\u3068\u3082\u5f90\u3005\u306b\u6539\u5584\u3059\u308b\u50be\u5411\u306f\u3042\u308b\u304c\u3001\u7f8e\u5bb9\u76ee\u7684\u3067\u6cbb\u7642\u3092\u5e0c\u671b\u3059\u308b\u60a3\u8005\u3082\u591a\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u305d\u306e\u4ed6\u306e\u8272\u7d20\u6591<\/h3>\n\n\n\n<p><strong>\u6241\u5e73\u6bcd\u6591<\/strong>\uff08\u30ab\u30d5\u30a7\u30aa\u30ec\u6591\uff09\u306f\u5883\u754c\u660e\u77ad\u306a\u5747\u4e00\u6de1\u8910\u8272\u306e\u6241\u5e73\u306a\u6bcd\u6591\u3067\u3001\u751f\u6765\u307e\u305f\u306f\u5e7c\u5c11\u6642\u304b\u3089\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u5358\u767a\u306e\u5834\u5408\u306f\u7f8e\u5bb9\u4e0a\u4ee5\u5916\u554f\u984c\u306a\u3044\u304c\u3001\u591a\u767a\u3059\u308b\u5834\u5408\u306f<strong>\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\u2160\u578b<\/strong>\u306a\u3069\u306e\u75c7\u5019\u3092\u793a\u5506\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u5e7c\u5c11\u671f\u304b\u3089\u5b58\u5728\u3059\u308b\u8336\u8910\u8272\u6591\u3068\u3057\u3066\u306f\u4ed6\u306b<strong>\u4f0a\u85e4\u6bcd\u6591<\/strong>\uff08\u80a9\u5cf0\u90e8\u306b\u751f\u3058\u308b\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff09\u3084<strong>\u8272\u7d20\u6027\u6bcd\u6591<\/strong>\uff08\u3044\u308f\u3086\u308b\u30db\u30af\u30ed\uff09\u306a\u3069\u3082\u9451\u5225\u306b\u6319\u304c\u308b\u3002\u307e\u305f<strong>\u30d9\u30c3\u30ab\u30fc\u6bcd\u6591<\/strong>\u306f\u9752\u5e74\u671f\u7537\u6027\u306b\u767a\u751f\u3059\u308b\u4e0d\u6574\u5f62\u306e\u8272\u7d20\u6591\u3067\u3001\u6709\u6bdb\u6027\u3067\u76ae\u819a\u80a5\u539a\u3092\u4f34\u3046\uff08\u30e1\u30e9\u30cb\u30f3\u306e\u307f\u306a\u3089\u305a\u8868\u76ae\u80a5\u539a\u3084\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3082\u95a2\u4e0e\uff09\u305f\u3081\u3001\u3084\u3084\u7279\u6b8a\u306a\u5b58\u5728\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u5148\u5929\u6027\u30fb\u9650\u5c40\u6027\u306e\u8272\u7d20\u6591\u3082\u7f8e\u5bb9\u76ee\u7684\u3067\u6cbb\u7642\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u304c\u3001\u672c\u7ae0\u3067\u306f\u4e3b\u306b\u5f8c\u5929\u6027\u3067\u6c4e\u767a\u6027\u306e\u3082\u306e\u3092\u4e2d\u5fc3\u306b\u8ff0\u3079\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u9451\u5225\u8a3a\u65ad\u3068\u8a3a\u65ad\u6cd5<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306f\u57fa\u672c\u7684\u306b<strong>\u8996\u8a3a<\/strong>\u3067\u8a3a\u65ad\u53ef\u80fd\u3060\u304c\u3001\u985e\u4f3c\u306e\u75c5\u5909\u3084\u60aa\u6027\u75c5\u5909\u3068\u306e\u9451\u5225\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u307e\u305a<strong>\u75c5\u5909\u306e\u5206\u5e03<\/strong>\u3084<strong>\u5f62\u614b<\/strong>\u3001<strong>\u60a3\u8005\u80cc\u666f<\/strong>\u304b\u3089\u3042\u308b\u7a0b\u5ea6\u306e\u9451\u5225\u306f\u53ef\u80fd\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u809d\u6591\u306f\u5973\u6027\u306e\u9854\u9762\u4e21\u5074\u5bfe\u79f0\u306e\u6de1\u8910\u8272\u6591\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001\u8001\u4eba\u6027\u8272\u7d20\u6591\u306f\u5c40\u6240\u7684\u306a\u6fc3\u8910\u8272\u6591\u3067\u5883\u754c\u9bae\u660e\u3001\u96c0\u5375\u6591\u306f\u5c0f\u5150\u304b\u3089\u51fa\u73fe\u3059\u308b\u5c0f\u6591\u70b9\u3001\u591a\u767a\u809d\u6591\u69d8\u306e\u7070\u9752\u8272\u6591\u3067\u601d\u6625\u671f\u4ee5\u964d\u306a\u3089ADM\u3001\u3068\u3044\u3063\u305f\u5177\u5408\u306b\u81e8\u5e8a\u50cf\u3067\u304b\u306a\u308a\u5224\u5225\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9451\u5225\u30dd\u30a4\u30f3\u30c8\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u809d\u6591 vs \u4ed6\u306e\u9854\u9762\u8272\u7d20\u6591:<\/strong>\u3000\u809d\u6591\u306f\u6de1\u3044\u5730\u56f3\u72b6\u3067\u5883\u754c\u304c\u3084\u3084\u4e0d\u9bae\u660e\u3060\u304c\u3001\u8001\u4eba\u6027\u8272\u7d20\u6591\u306f\u6fc3\u8272\u3067\u5883\u754c\u660e\u77ad\u306a\u70b9\u304c\u591a\u3044\u3002\u307e\u305fRiehl\u9ed2\u76ae\u75c7\uff08\u5316\u7ca7\u54c1\u76ae\u819a\u708e\u5f8c\u306e\u8272\u7d20\u6c88\u7740\uff09\u3084\u85ac\u5264\u6027\u809d\u6591\u69d8\u8272\u7d20\u6c88\u7740\uff08\u4f8b: \u30df\u30ce\u30b5\u30a4\u30af\u30ea\u30f3\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\uff09\u3082\u982c\u90e8\u306e\u8272\u7d20\u6c88\u7740\u3092\u6765\u3059\u305f\u3081\u9664\u5916\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Other%20skin%20conditions%20resulting%20in,These%20include\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u809d\u6591\u306fWood\u706f\u3067\u4e00\u90e8\u5897\u5f37\uff08\u8868\u76ae\u6210\u5206\uff09\u3057\u4e00\u90e8\u4e0d\u5909\uff08\u771f\u76ae\u6210\u5206\uff09\u3068\u3044\u3046\u6df7\u5408\u578b\u304c\u591a\u3044<a href=\"https:\/\/dermnetnz.org\/topics\/wood-lamp-skin-examination#:~:text=,white%20%28or%20sometimes\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u4e00\u65b9\u3001\u5916\u56e0\u6027\u306e<strong>\u30aa\u30af\u30ed\u30ce\u30fc\u30b7\u30b9<\/strong>\uff08\u9577\u671f\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u4f7f\u7528\u306b\u3088\u308b\u9ed2\u8272\u5909\uff09\u306f\u9752\u9ed2\u304f\u4e0d\u898f\u5247\u306a\u8272\u8abf\u3092\u5448\u3057\u3001\u65e2\u5f80\u3067\u9451\u5225\u3059\u308b\u3002\u809d\u6591\u3068ADM\/Hori\u6bcd\u6591\u306e\u9451\u5225\u3082\u91cd\u8981\u3067\u3042\u308b\u3002ADM\u306f\u7070\u9752\u8272\u306e\u5c0f\u6591\u70b9\u304c\u6563\u5728\u3057\u3001\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc\u3067\u306f\u771f\u76ae\u30e1\u30e9\u30cb\u30f3\u306b\u3088\u308b<strong>\u9752\u8272\u306e\u70b9\u72b6\u69cb\u9020<\/strong>\u304c\u89b3\u5bdf\u3055\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8944292\/#:~:text=,P%3C0.001%29%2C%20regular%20pigment\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u809d\u6591\u3067\u306f\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc\u3067\u8336\u8272\u301c\u7070\u8272\u306e\u5747\u4e00\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u69d8\u30d1\u30bf\u30fc\u30f3\uff08\u6bdb\u7a74\u3092\u56f2\u3080\u3088\u3046\u306a\u7db2\u76ee\u72b6\u8272\u7d20\u6c88\u7740\uff09\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8944292\/#:~:text=,P%3C0.001%29%2C%20regular%20pigment\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u6df7\u5728\u4f8b\u3067\u306f\u4e21\u8005\u306e\u6210\u5206\u304c\u4f75\u5b58\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8001\u4eba\u6027\u8272\u7d20\u6591 vs \u60aa\u6027\u75c5\u5909:<\/strong>\u3000\u5883\u754c\u304c\u4e0d\u6574\u3067\u307e\u3060\u3089\u306a\u8272\u7d20\u6591\u306f\u3001\u9ad8\u9f62\u8005\u3067\u306f<strong>\u65e5\u5149\u89d2\u5316\u75c7<\/strong>\u3084<strong>\u60aa\u6027\u9ed2\u8272\u816b<\/strong>\uff08\u7279\u306b\u9854\u9762\u306e\u5e73\u5766\u578b\u3067\u3042\u308b<strong>\u60aa\u6027\u9ed2\u5b50\u578b\u9ed2\u8272\u816b<\/strong>\uff09\u3092\u9451\u5225\u3059\u308b\u3002\u76ae\u819a\u93e1\uff08\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc\uff09\u306f\u6709\u7528\u3067\u3001\u8001\u4eba\u6027\u8272\u7d20\u6591\u3067\u306f\u5747\u4e00\u306a\u8272\u7d20\u7db2\u3084\u3056\u3089\u3064\u3044\u305f\u8868\u9762\u304c\u898b\u3089\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3067\u306f\u4e0d\u898f\u5247\u306a\u7db2\u76ee\u7834\u58ca\u3084<strong>\u507d\u7db2\u76ee<\/strong>\u3001\u9ed2\u70b9\/\u30b0\u30ed\u30d6\u30eb\u306a\u3069\u306e\u6240\u898b\u304c\u51fa\u73fe\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=What%20is%20the%20differential%20diagnosis,for%20freckles%20and%20solar%20lentigines\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u7591\u308f\u3057\u3044\u6240\u898b\uff08\u30b5\u30a4\u30ba&gt;6mm\u3001\u8272\u3080\u3089\u3001\u5f62\u306e\u975e\u5bfe\u79f0\u6027\u3001\u5883\u754c\u4e0d\u6574\u306e\u3044\u308f\u3086\u308bABCDE\u6240\u898b\uff09\u304c\u3042\u308c\u3070<strong>\u76ae\u819a\u751f\u691c<\/strong>\u306b\u3088\u308b\u7d44\u7e54\u8a3a\u65ad\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u96c0\u5375\u6591 vs \u592a\u7530\u6bcd\u6591\/ADM:<\/strong>\u3000\u96c0\u5375\u6591\u306f\u8868\u76ae\u6027\u3067\u5b63\u7bc0\u306b\u3088\u308b\u5909\u52d5\u304c\u3042\u308b\u70b9\u3067\u3001\u6301\u7d9a\u6027\u306e\u771f\u76ae\u6027\u6591\u70b9\u3067\u3042\u308b\u592a\u7530\u6bcd\u6591\u3084ADM\u3068\u7570\u306a\u308b\u3002\u81e8\u5e8a\u7684\u306b\u306f\u96c0\u5375\u6591\u306f\u5e7c\u5c11\u671f\u304b\u3089\u3042\u308a\u3001\u6de1\u8d64\u8910\u8272\u3067\u3084\u3084\u6563\u5e03\u7bc4\u56f2\u304c\u5e83\u3044\u3002\u4e00\u65b9ADM\u306f\u6210\u4eba\u306b\u306a\u3063\u3066\u304b\u3089\u751f\u3058\u3001\u7070\u8272\u304c\u304b\u3063\u305f\u8272\u8abf\u3067\u982c\u9aa8\u90e8\u4e2d\u5fc3\u306b\u9650\u5c40\u3059\u308b\u3002\u592a\u7530\u6bcd\u6591\u306f\u7247\u5074\u6027\u3067\u3088\u308a\u6fc3\u3044\u9752\u8272\u3092\u5448\u3057\u3001\u773c\u306e\u8272\u7d20\u6c88\u7740\u3082\u624b\u304c\u304b\u308a\u306b\u306a\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,shoulder%20girdle\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u771f\u76ae\u306e\u9752\u8272\u6591:<\/strong>\u3000\u592a\u7530\u6bcd\u6591\u3084ADM\u4ee5\u5916\u306b\u3082\u771f\u76ae\u306b\u30e1\u30e9\u30cb\u30f3\u304c\u5b58\u5728\u3059\u308b\u75c5\u5909\u306b<strong>\u9752\u8272\u6bcd\u6591<\/strong>\uff08blue nevus\uff09\u304c\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Other%20skin%20conditions%20resulting%20in,These%20include\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u3053\u308c\u306f\u5c0f\u578b\u3067\u5b64\u7acb\u6027\u306e\u9752\u9ed2\u3044\u4e18\u75b9\/\u7d50\u7bc0\u3068\u3057\u3066\u73fe\u308c\u308b\u6bcd\u6591\u7d30\u80de\u6bcd\u6591\u306e\u4e00\u7a2e\u3067\u3001\u5e83\u7bc4\u56f2\u306b\u53ca\u3076\u592a\u7530\u6bcd\u6591\u3068\u306f\u81e8\u5e8a\u7684\u306b\u533a\u5225\u3067\u304d\u308b\u3002\u307e\u305f\u3001\u56fa\u5b9a\u85ac\u75b9\u5f8c\u3084\u6297\u30de\u30e9\u30ea\u30a2\u85ac\u5185\u670d\u306b\u3088\u308b\u7070\u8272\u306e\u8272\u7d20\u6c88\u7740\u6591\u3001\u30ea\u30d5\u30ad\u30f3\u52b9\u679c\u306b\u3088\u308b\u523a\u9752\u69d8\u6c88\u7740\u306a\u3069\u3001<strong>\u85ac\u5264\u6027<\/strong>\u30fb<strong>\u5916\u56e0\u6027<\/strong>\u306e\u771f\u76ae\u30e1\u30e9\u30cb\u30f3\u69d8\u6c88\u7740\u3082\u9451\u5225\u306b\u8003\u3048\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Other%20skin%20conditions%20resulting%20in,These%20include\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8a3a\u65ad\u306b\u7528\u3044\u3089\u308c\u308b<strong>\u88dc\u52a9\u691c\u67fb<\/strong>\u3068\u3057\u3066\u306f\u3001\u524d\u8ff0\u306e<strong>Wood\u706f\u691c\u67fb<\/strong>\u304c\u3042\u308b\u3002\u3053\u308c\u306f\u9577\u6ce2\u9577UV\uff08365nm\uff09\u3092\u5f53\u3066\u3066\u8868\u76ae\u306e\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u3092\u5f37\u8abf\u3059\u308b\u691c\u67fb\u3067\u3001\u809d\u6591\u306e\u8868\u5728\u6210\u5206\u306e\u8a55\u4fa1\u306b\u53e4\u304f\u304b\u3089\u4f7f\u308f\u308c\u3066\u304d\u305f<a href=\"https:\/\/dermnetnz.org\/topics\/wood-lamp-skin-examination#:~:text=A%20Wood%20lamp%20for%20skin,examination%20may%20reveal\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u307e\u305f<strong>\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc<\/strong>\uff08\u76ae\u819a\u93e1\u691c\u67fb\uff09\u306f\u975e\u4fb5\u8972\u7684\u306b\u8272\u7d20\u6591\u306e\u69cb\u9020\u3092\u8a73\u7d30\u306b\u89b3\u5bdf\u3067\u304d\u3001\u809d\u6591\u3067\u306f\u6bdb\u5b54\u5468\u56f2\u306e\u7db2\u76ee\u72b6\u8336\u8272\u73ed\u3001ADM\u3067\u306f\u9752\u3044\u70b9\u72b6\u69cb\u9020\u3001\u8001\u4eba\u6591\u3067\u306f\u5fae\u7d30\u306a\u9846\u7c92\u72b6\u30d1\u30bf\u30fc\u30f3\u3084\u7db2\u76ee\u72b6\u69cb\u9020\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3067\u3042\u308c\u3070\u4e0d\u5747\u4e00\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3084\u30d6\u30eb\u30fc\u30db\u30ef\u30a4\u30c8\u30f4\u30a7\u30fc\u30eb\u306a\u3069\u304c\u898b\u3089\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8944292\/#:~:text=,P%3C0.001%29%2C%20regular%20pigment\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<strong>\u75c5\u7406\u7d44\u7e54\u691c\u67fb<\/strong>\u306f\u57fa\u672c\u7684\u306b\u7f8e\u5bb9\u76ee\u7684\u306e\u8272\u7d20\u6591\u3067\u306f\u884c\u308f\u306a\u3044\u304c\u3001\u9451\u5225\u56f0\u96e3\u306a\u5834\u5408\uff08\u4f8b: \u60aa\u6027\u306e\u5426\u5b9a\uff09\u3084\u6cbb\u7642\u62b5\u6297\u4f8b\u3067\u7d44\u7e54\u5b66\u7684\u6df1\u9054\u5ea6\u3092\u78ba\u8a8d\u3057\u305f\u3044\u5834\u5408\u306b\u884c\u3046\u3002\u7d44\u7e54\u3067\u306f\u30e1\u30e9\u30cb\u30f3\u306f<strong>Fontana-Masson\u67d3\u8272<\/strong>\u3067\u9ed2\u8272\u306b\u67d3\u307e\u308b\u305f\u3081\u3001\u305d\u308c\u306b\u3088\u308a\u8868\u76ae\u57fa\u5e95\u5c64\u304b\u771f\u76ae\u304b\u306e\u5206\u5e03\u304c\u660e\u78ba\u306b\u306a\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=If%20a%20history%20of%20preceding,the%20epidermis%20and%2For%20the%20dermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Staining%20of%20the%20biopsy%20specimen,the%20epidermis%20and%2For%20the%20dermis\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u305f\u3060\u3057\u901a\u5e38\u306e\u8a3a\u7642\u3067\u306f\u3001\u81e8\u5e8a\u6240\u898b\u3068\u5fc5\u8981\u306b\u5fdc\u3058\u305f\u975e\u4fb5\u8972\u691c\u67fb\u3067\u8a3a\u65ad\u304c\u78ba\u5b9a\u3057\u3001\u7d44\u7e54\u691c\u67fb\u307e\u3067\u884c\u3046\u306e\u306f\u307e\u308c\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306f\u3001<strong>\u5916\u7528\u7642\u6cd5<\/strong>\u30fb<strong>\u5185\u670d\u7642\u6cd5<\/strong>\u30fb<strong>\u30ec\u30fc\u30b6\u30fc\u3084\u5149\u6cbb\u7642<\/strong>\u30fb<strong>\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\u30fb<strong>\u8907\u5408\u7684\u6cbb\u7642<\/strong>\u306a\u3069\u591a\u5c90\u306b\u308f\u305f\u308b\u3002\u75be\u60a3\u3068\u8272\u7d20\u306e\u6df1\u9054\u5ea6\u306b\u5fdc\u3058\u3066\u4f7f\u3044\u5206\u3051\u3001\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u4ee5\u4e0b\u306b\u5404\u6cbb\u7642\u6cd5\u306e\u6982\u8981\u3092\u8ff0\u3079\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5916\u7528\u7642\u6cd5\uff08\u6f02\u767d\u5264\u30fb\u5857\u5e03\u85ac\uff09<\/h3>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u6291\u5236\u3084\u89d2\u8cea\u5265\u8131\u3092\u76ee\u7684\u3068\u3057\u305f\u5916\u7528\u85ac\u306f\u8272\u7d20\u6c88\u7740\u6cbb\u7642\u306e\u57fa\u672c\u3067\u3042\u308b\u3002\u4ee3\u8868\u7684\u306a\u85ac\u5264\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3 (HQ):<\/strong> \u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u4f5c\u7528\u3092\u6301\u3064\u4ee3\u8868\u7684\u306a\u6f02\u767d\u5264\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Topical%20skin,Along%20with\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30e1\u30e9\u30cb\u30f3\u751f\u5408\u6210\u306e\u5f8b\u901f\u9175\u7d20\u3067\u3042\u308b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u90e8\u4f4d\u306b\u4f5c\u7528\u3057\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u5f62\u6210\u3068\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3092\u6291\u5236\u3059\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Topical%20skin,Along%20with\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u307e\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u5c0f\u5668\u5b98\u3092\u7834\u58ca\u3057\u3066\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6570\u81ea\u4f53\u3092\u6e1b\u3089\u3059\u52b9\u679c\u3082\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=decades%20as%20benchmark%20in%20the,3\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u6fc3\u5ea62\uff5e5%\u306e\u30af\u30ea\u30fc\u30e0\u3068\u3057\u3066\u809d\u6591\u3084PIH\u306b\u5e83\u304f\u7528\u3044\u3089\u308c\u3001\u7d044\u301c8\u9031\u9593\u3067\u8272\u8abf\u6539\u5584\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u30824%HQ\u5916\u7528\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u6bd4\u3079\u6709\u610f\u306a\u6539\u5584\u52b9\u679c\u3092\u793a\u3057\u300138%\u306e\u60a3\u8005\u3067\u8272\u7d20\u6591\u304c\u5b8c\u5168\u6d88\u9000\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=and%205,several%20reports%20of%20exogenous%20ochronosis\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305f\u3060\u3057\u523a\u6fc0\u6027\u304c\u5f37\u304f\u3001\u7d05\u6591\u3084\u63a5\u89e6\u76ae\u819a\u708e\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308b\u3002\u307e\u305f\u9577\u671f\u9023\u7528\u306b\u3088\u308a\u7a00\u306b<strong>\u5916\u56e0\u6027\u30aa\u30af\u30ed\u30ce\u30fc\u30b7\u30b9<\/strong>\uff08\u9752\u9ed2\u3044\u8272\u7d20\u6c88\u7740\u75c7\uff09\u3092\u751f\u3058\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u3001\u6cbb\u7642\u671f\u9593\u306f\u901a\u5e38\u9023\u7d9a6\u30f6\u6708\u4ee5\u5185\u3068\u3057\u3001\u52b9\u679c\u4e0d\u5341\u5206\u306a\u5834\u5408\u306f\u4f11\u85ac\u671f\u9593\u3092\u8a2d\u3051\u308b\u3002\u65e5\u672c\u3067\u306f\u6fc3\u5ea6\u304c2%\u307e\u3067\u306e\u3082\u306e\u306f\u4e00\u822c\u7528\u533b\u85ac\u54c1\u3068\u3057\u3066\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u3002\u6b27\u7c73\u3067\u306f\u6fc3\u5ea6\u9ad8\u3044HQ\u306f\u533b\u5e2b\u51e6\u65b9\u306e\u307f\u8a31\u53ef\u3055\u308c\u3066\u3044\u308b\u56fd\u3082\u3042\u308b\u3002\u307e\u305fHQ\u306e\u767a\u304c\u3093\u6027\u306b\u3064\u3044\u3066\u52d5\u7269\u5b9f\u9a13\u3067\u306e\u8b70\u8ad6\u304c\u3042\u308b\u304c\u3001\u30d2\u30c8\u3067\u306e\u660e\u78ba\u306a\u767a\u304c\u3093\u5831\u544a\u306f\u306a\u3044<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=melasma%20patient%20groups%20applied%20with,hydroquinone%20use%20were%20also%20raised34\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3 (\u30ec\u30c1\u30ce\u30a4\u30f3\u9178):<\/strong> \u30d3\u30bf\u30df\u30f3A\u8a98\u5c0e\u4f53\u306e\u4e00\u7a2e\u3067\u8868\u76ae\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4fc3\u9032\u4f5c\u7528\u3092\u6301\u3064\u30020.05\u301c0.1%\u30af\u30ea\u30fc\u30e0\u3092\u591c\u9593\u5857\u5e03\u3059\u308b\u3053\u3068\u3067\u89d2\u8cea\u306e\u5265\u96e2\u3068\u30e1\u30e9\u30cb\u30f3\u6392\u51fa\u3092\u4fc3\u3057\u3001\u307e\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u79fb\u884c\u3082\u963b\u5bb3\u3059\u308b\u3068\u3055\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Topical%20retinoids%20have%20shown%20their,side%20effects%2C%20including%20erythema%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5358\u72ec\u3067\u3082\u4e00\u5b9a\u306e\u6de1\u8272\u5316\u52b9\u679c\u304c\u3042\u308b\u304c\u3001\u52b9\u679c\u767a\u73fe\u307e\u3067\u306b\u6570\u30f6\u6708\u3092\u8981\u3059\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=of%20melanosome%2C%20and%20allow%20trans,therapeutic%20option38\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u526f\u4f5c\u7528\u3068\u3057\u3066\u5857\u5e03\u90e8\u4f4d\u306e\u7d05\u6591\u30fb\u843d\u5c51\u30fb\u523a\u6fc0\u611f\u304c\u983b\u767a\u3057\u3001\u808c\u8cea\u306b\u3088\u3063\u3066\u306f\u4f7f\u7528\u7d99\u7d9a\u304c\u96e3\u3057\u3044\u5834\u5408\u3082\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=period%2C%20Griffiths%20et%20al,therapeutic%20option%2058\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305d\u306e\u305f\u3081\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u306f\u5358\u72ec\u3088\u308a\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3068\u306e\u4f75\u7528\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u306e\u914d\u5408\uff08\u5f8c\u8ff0\u306e\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u30af\u30ea\u30fc\u30e0\uff09\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30a2\u30bc\u30e9\u30a4\u30f3\u9178:<\/strong> \u7a40\u985e\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u304b\u3089\u5408\u6210\u3055\u308c\u308b\u81ea\u7136\u7531\u6765\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u300220%\u30af\u30ea\u30fc\u30e0\u304c\u809d\u6591\u3084PIH\u306b\u6709\u52b9\u3068\u3055\u308c\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306b\u5339\u6575\u3059\u308b\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u3082\u3042\u308b<a href=\"https:\/\/www.droracle.ai\/articles\/144240\/treatment-of-melasma#:~:text=What%20is%20the%20recommended%20treatment,for%20the%20treatment%20of\" target=\"_blank\" rel=\"noreferrer noopener\">droracle.ai<\/a>\u3002\u4f5c\u7528\u6a5f\u5e8f\u306f\u904e\u5270\u306a\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u9078\u629e\u7684\u306a\u5897\u6b96\u6291\u5236\u30fb\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u4f4e\u4e0b\u3067\u3042\u308a\u3001\u6b63\u5e38\u76ae\u819a\u306b\u306f\u5f71\u97ff\u304c\u5c11\u306a\u3044\u3068\u3055\u308c\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38099013\/#:~:text=Review%20pubmed,acid%20receive%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u523a\u6fc0\u611f\u306a\u3069\u526f\u4f5c\u7528\u306f\u6bd4\u8f03\u7684\u5c11\u306a\u304f\u3001\u598a\u5a20\u4e2d\u306b\u3082\u4f7f\u7528\u53ef\u80fd\u306a\u5b89\u5168\u6027\u304c\u30e1\u30ea\u30c3\u30c8\u3067\u3042\u308b\u3002\u305f\u3060\u3057\u5373\u52b9\u6027\u306f\u5f37\u304f\u306a\u304f\u30013\u30f6\u6708\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3066\u5f90\u3005\u306b\u52b9\u679c\u304c\u73fe\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53:<\/strong> \u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u81ea\u4f53\u306f\u4e0d\u5b89\u5b9a\u3060\u304c\u3001\u305d\u306e\u8a98\u5c0e\u4f53\uff08\u30ea\u30f3\u9178Mg\u30a2\u30b9\u30b3\u30eb\u30d3\u30eb\u306a\u3069\uff09\u306f\u76ae\u819a\u6d78\u900f\u5f8c\u306b\u30d3\u30bf\u30df\u30f3C\u306b\u5909\u63db\u3055\u308c\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u9084\u5143\u4f5c\u7528\u3084\u6297\u9178\u5316\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u3002\u5358\u72ec\u3067\u306f\u8272\u7d20\u6591\u3092\u5287\u7684\u306b\u8584\u304f\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u304c\u3001\u4ed6\u306e\u6cbb\u7642\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u76f8\u4e57\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u5e02\u8ca9\u306e\u7f8e\u767d\u5316\u7ca7\u54c1\u306b\u3082\u914d\u5408\u3055\u308c\u3001\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u5916\u7528\u5264:<\/strong> \u30b3\u30a6\u30b8\u9178\uff08\u9eb9\u7531\u6765\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\uff09\u3084\u30a2\u30eb\u30d6\u30c1\u30f3\uff08\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u914d\u7cd6\u4f53\uff09\u30014-n-\u30d6\u30c1\u30eb\u30ec\u30be\u30eb\u30b7\u30ce\u30fc\u30eb\uff08\u65b0\u3057\u3044\u7f8e\u767d\u6210\u5206<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=In%20another%20perspective%2C%20these%20safety,were%20proposed%20as%20alternative%20agents35\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\uff09\u3001\u30ea\u30b3\u30ea\u30b9\uff08\u7518\u8349\uff09\u7531\u6765\u306e\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3001\u6700\u8fd1\u3067\u306f<strong>\u30b7\u30b9\u30c6\u30a2\u30df\u30f3<\/strong>\u30af\u30ea\u30fc\u30e0\uff08\u30e1\u30e9\u30cb\u30f3\u524d\u99c6\u4f53\u306e\u4ee3\u8b1d\u62ee\u6297\u5264\uff09\u306a\u3069\u591a\u6570\u306e\u7f8e\u767d\u5916\u7528\u5264\u304c\u5b58\u5728\u3059\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=In%20another%20perspective%2C%20these%20safety,were%20proposed%20as%20alternative%20agents35\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u3089\u306f\u5358\u5264\u3067\u306fHQ\u307b\u3069\u306e\u5f37\u529b\u306a\u52b9\u679c\u306f\u306a\u3044\u304c\u3001\u76ae\u819a\u523a\u6fc0\u304c\u5c11\u306a\u304f\u9577\u671f\u4f7f\u7528\u306b\u5411\u304f\u305f\u3081\u3001\u7dad\u6301\u7642\u6cd5\u3084HQ\u9577\u671f\u4f7f\u7528\u304c\u96e3\u3057\u3044\u4f8b\u3067\u4ee3\u66ff\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3002\u307e\u305f<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178<\/strong>\u306e\u5916\u7528\u5264\u3082\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u6291\u5236\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Despite%20the%20relatively%20good%20safety,strategies%20have%20been%20employed%20to\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u7642\u6cd5 (TCC):<\/strong> \u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3+\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3+\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u3084\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u7b49\uff09\u306e3\u5264\u3092\u6df7\u5408\u3057\u305f\u5916\u7528\u30af\u30ea\u30fc\u30e0\u306f\u3001\u809d\u6591\u6cbb\u7642\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3068\u3055\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u3067\u708e\u75c7\u3092\u6291\u3048\u3064\u3064\u3001HQ\u3068\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u3067\u76f8\u4e57\u7684\u306b\u6f02\u767d\u52b9\u679c\u3092\u9ad8\u3081\u308b\u51e6\u65b9\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u7c73\u56fd\u3067\u5e02\u8ca9\u306eTri-Luma\u00ae\uff08HQ4%+\u30c8\u30ec\u30c1\u30ce\u30a4\u30f30.05%+\u30d5\u30eb\u30aa\u30b7\u30ce\u30ed\u30f30.01%\uff09\u304c\u6709\u540d\u3067\u3001\u65e5\u672c\u3067\u3082\u8abf\u5408\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u306f\u5358\u5264\u5916\u7528\u3088\u308a\u6709\u52b9\u6027\u304c\u9ad8\u304f\u3001\u7d048\u9031\u9593\u7a0b\u5ea6\u306e\u4f7f\u7528\u3067\u809d\u6591\u304c\u5927\u304d\u304f\u6539\u5584\u3059\u308b\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/www.droracle.ai\/articles\/149175\/what-is-the-best-treatment-for-melasma#:~:text=What%20is%20the%20best%20treatment,a%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">droracle.ai<\/a>\u3002\u305f\u3060\u3057\u30b9\u30c6\u30ed\u30a4\u30c9\u542b\u6709\u306e\u305f\u3081\u9577\u671f\u9023\u7528\u306f\u907f\u3051\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5185\u670d\u7642\u6cd5\uff08\u7d4c\u53e3\u85ac\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff09<\/h3>\n\n\n\n<p>\u5168\u8eab\u7684\u306b\u4f5c\u7528\u3057\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u3092\u6539\u5584\u3059\u308b\u85ac\u5264\u3082\u7528\u3044\u3089\u308c\u308b\u3002\u4ee3\u8868\u4f8b\u306f\u4ee5\u4e0b\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178 (TXA):<\/strong> \u672c\u6765\u306f\u6297\u30d7\u30e9\u30b9\u30df\u30f3\u85ac\uff08\u6b62\u8840\u5264\uff09\u3067\u3042\u308b\u304c\u3001\u809d\u6591\u3078\u306e\u6709\u52b9\u6027\u304c\u767a\u898b\u3055\u308c\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=,TXA\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6d3b\u6027\u5316\u306b\u95a2\u308f\u308b\u30d7\u30e9\u30b9\u30df\u30f3\u7cfb\u3092\u6291\u5236\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3084\u8840\u7ba1\u65b0\u751f\u3092\u6291\u3048\u308b\u4f5c\u7528\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=,TXA\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u901a\u5e381\u65e5750mg\u301c2000mg\u3092\u5206\u5272\u7d4c\u53e3\u6295\u4e0e\u3057\u30018\u301c12\u9031\u307b\u3069\u3067\u809d\u6591\u306eMASI\u30b9\u30b3\u30a2\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3068\u306e\u591a\u6570\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=by%20Lajevardi%20et%20al,In%20a\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5916\u7528HQ\u3068\u306e\u4f75\u7528\u3067\u76f8\u4e57\u52b9\u679c\u304c\u5f97\u3089\u308c\u305fRCT\u3082\u3042\u308a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=match%20at%20L424%20by%20Lajevardi,In%20a\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u8fd1\u5e74\u3067\u306f\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\u518d\u767a\u4e88\u9632\u3059\u308b\u8a66\u307f\u3082\u306a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=been%20increasing%20recently%2C%20several%20studies,500%20mg%20per%20day%20along\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u526f\u4f5c\u7528\u306f\u5c11\u306a\u3044\u304c\u3001\u307e\u308c\u306b\u8840\u6813\u50be\u5411\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u6df1\u90e8\u9759\u8108\u8840\u6813\u75c7\u3084\u8133\u6897\u585e\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u306b\u306f\u7981\u5fcc\u3067\u3042\u308b\u3002\u809d\u6591\u306b\u5bfe\u3059\u308bTXA\u5185\u670d\u306f\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u3067\u3082\u63a8\u5968\u3055\u308c\u3066\u304a\u308a\u3001\u7f8e\u5bb9\u76ae\u819a\u79d1\u9818\u57df\u3067\u983b\u7528\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b7\u30b9\u30c6\u30a4\u30f3\u30fb\u30d3\u30bf\u30df\u30f3C:<\/strong> L-\u30b7\u30b9\u30c6\u30a4\u30f3\uff08\u542b\u786b\u30a2\u30df\u30ce\u9178\uff09\u306f\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u7d4c\u8def\u3067\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u7523\u751f\u3092\u52a9\u3051\u3001\u30e1\u30e9\u30cb\u30f3\u3092\u7121\u8272\u5316\u3059\u308b\u65b9\u5411\u306b\u4f5c\u7528\u3059\u308b\u3002\u30d3\u30bf\u30df\u30f3C\u3068\u306e\u4f75\u7528\u3067\u52b9\u679c\u304c\u9ad8\u307e\u308b\u3068\u3055\u308c\u3001\u5e02\u8ca9\u306e\u30b7\u30df\u6539\u5584\u5185\u670d\u85ac\uff08\u4f8b\u3048\u3070\u300c\u30b7\u30ca\u30fc\u30eb\u00ae\u300d\u300c\u30cf\u30a4\u30c1\u30aa\u30fc\u30eb\u00ae\u300d\u306a\u3069\uff09\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u30021\u65e5\u3042\u305f\u308aL-\u30b7\u30b9\u30c6\u30a4\u30f3240mg\u7a0b\u5ea6\u3068\u30d3\u30bf\u30df\u30f3C\u3092\u4f75\u7528\u5185\u670d\u3059\u308b\u3053\u3068\u3067\u3001\u6570\u30f6\u6708\u5f8c\u306b\u8272\u8abf\u6539\u5584\u304c\u307f\u3089\u308c\u305f\u3068\u306e\u5831\u544a\u3082\u3042\u308b<a href=\"https:\/\/brieflands.com\/articles\/jssc-120283.html#:~:text=Although%20it%20presents%20in%200,1\" target=\"_blank\" rel=\"noreferrer noopener\">brieflands.com<\/a>\u3002\u5b89\u5168\u6027\u304c\u9ad8\u3044\u305f\u3081\u3001\u9577\u671f\u306e\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u5185\u670d\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8:<\/strong> \u677e\u8449\u7531\u6765\u306e<strong>\u30d4\u30af\u30ce\u30b8\u30a7\u30ce\u30fc\u30eb<\/strong>\uff08\u30d7\u30ed\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30b8\u30f3\u306e\u6297\u9178\u5316\u4f5c\u7528\uff09\u3084\u3001\u30b7\u30c0\u690d\u7269\u62bd\u51fa\u7269\u306e<strong>\u30dd\u30ea\u30dd\u30c7\u30a3\u30a6\u30e0\u30fb\u30ed\u30a4\u30b3\u30c8\u30e2\u30b9<\/strong>\uff08Heliocare\u00ae\u306a\u3069\u3001\u98f2\u3080\u65e5\u713c\u3051\u6b62\u3081\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u6297\u708e\u75c7\u30fb\u6297\u9178\u5316\u4f5c\u7528\u3067\u809d\u6591\u306b\u88dc\u52a9\u52b9\u679c\u304c\u3042\u308b\u3068\u306e\u5831\u544a\uff09\u3001\u9ad8\u6fc3\u5ea6\u306e\u30d3\u30bf\u30df\u30f3E\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u7d4c\u53e3\u6442\u53d6\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=match%20at%20L467%20have%20been,the%20results%20have%20been%20inconclusive\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=have%20been%20made%20to%20utilize,the%20results%20have%20been%20inconclusive\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u306f\u307e\u3061\u307e\u3061\u3060\u304c\u3001\u4f8b\u3048\u3070\u30d6\u30c9\u30a6\u7a2e\u5b50\u62bd\u51fa\u7269\u306e\u30d7\u30ed\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30b8\u30f3\u30924\u9031\u9593\u5185\u670d\u3057\u809d\u6591\u304c85%\u306e\u60a3\u8005\u3067\u6539\u5584\u3057\u305f\u3068\u306e\u5831\u544a\u3082\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=match%20at%20L604%20Oral%20Tranexamic,formation%20of%20new%20blood%20vessels\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u57fa\u672c\u7684\u306b\u88dc\u52a9\u7684\u624b\u6bb5\u3067\u3042\u308a\u3001\u5358\u72ec\u3067\u5287\u7684\u52b9\u679c\u3092\u671f\u5f85\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ec\u30fc\u30b6\u30fc\u30fb\u5149\u6cbb\u7642<\/h3>\n\n\n\n<p>\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306f\u3001\u9078\u629e\u7684\u5149\u71b1\u4f5c\u7528\u3092\u5229\u7528\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u3092\u7834\u58ca\u30fb\u9664\u53bb\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3002\u6ce2\u9577\u3084\u30d1\u30eb\u30b9\u5e45\u306e\u7570\u306a\u308b\u69d8\u3005\u306a\u6a5f\u5668\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u75c5\u5909\u306b\u5fdc\u3058\u3066\u4f7f\u3044\u5206\u3051\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc (\u30ca\u30ce\u79d2\u30ec\u30fc\u30b6\u30fc):<\/strong> \u4ee3\u8868\u7684\u306a\u8272\u7d20\u75c5\u5909\u6cbb\u7642\u30ec\u30fc\u30b6\u30fc\u3067\u3001<strong>Q-switched\u30eb\u30d3\u30fc\u30ec\u30fc\u30b6\u30fc<\/strong>\uff08694nm\uff09\u3001<strong>Q-switched\u30a2\u30ec\u30ad\u30b5\u30f3\u30c9\u30e9\u30a4\u30c8\u30ec\u30fc\u30b6\u30fc<\/strong>\uff08755nm\uff09\u3001<strong>Q-switched Nd:YAG\u30ec\u30fc\u30b6\u30fc<\/strong>\uff081064nm\/532nm\uff09\u306a\u3069\u304c\u3042\u308b\u3002\u6975\u3081\u3066\u77ed\u3044\u30d1\u30eb\u30b9\uff08\u30ca\u30ce\u79d2=10^-9\u79d2\uff09\u3067\u9ad8\u51fa\u529b\u3092\u7167\u5c04\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u3092\u77ac\u9593\u7684\u306b\u71b1\u7834\u58ca\u3059\u308b\u3002\u8001\u4eba\u6027\u8272\u7d20\u6591\u3084\u96c0\u5375\u6591\u3001\u592a\u7530\u6bcd\u6591\u306a\u3069\u306b\u5358\u767a\u7167\u5c04\u3067\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3057\u3001\u7167\u5c04\u5f8c7\u301c10\u65e5\u3067\u75c2\u76ae\u304c\u53d6\u308c\u8272\u6591\u304c\u8584\u304f\u306a\u308b\u3002\u7279\u306b\u592a\u7530\u6bcd\u6591\u3067\u306f1064nm Q\u30b9\u30a4\u30c3\u30c1YAG\u304c\u7b2c\u4e00\u9078\u629e\u3067\u30015\u301c10\u56de\u7a0b\u5ea6\u306e\u5206\u5272\u7167\u5c04\u3067\u5927\u534a\u304c\u6d88\u9000\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=What%20treatments%20are%20available%20for,melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u96c0\u5375\u6591\u3084\u8001\u4eba\u6027\u8272\u7d20\u6591\u306f1\u56de\u7167\u5c04\u3067\u5927\u304d\u304f\u6539\u5584\u3059\u308b\u304c\u3001\u518d\u767a\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u5f8c\u306f\u4e00\u904e\u6027\u306e\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740(PIH)\u304c10\u301c30%\u7a0b\u5ea6\u306e\u60a3\u8005\u3067\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8853\u5f8c\u306e\u906e\u5149\u3068\u5916\u7528\u7642\u6cd5\u3067\u30b1\u30a2\u3059\u308b\u3002\u307e\u305f\u6fc3\u3044\u53cd\u5fdc\u3092\u8d77\u3053\u3059\u3068\u6c34\u75b1\u3084\u7622\u75d5\u5f62\u6210\u306e\u30ea\u30b9\u30af\u3082\u3042\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u8a2d\u5b9a\u3068\u30a2\u30d5\u30bf\u30fc\u30b1\u30a2\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc:<\/strong> \u8fd1\u5e74\u767b\u5834\u3057\u305f\u6700\u65b0\u306e\u30ec\u30fc\u30b6\u30fc\u3067\u3001\u30d1\u30eb\u30b9\u5e45\u304c\u30d4\u30b3\u79d2\uff0810^-12\u79d2\uff09\u3068\u6975\u3081\u3066\u77ed\u304f\u3001\u30e1\u30e9\u30cb\u30f3\u306b\u5bfe\u3057\u3066<strong>\u5149\u97f3\u97ff\u52b9\u679c<\/strong>\uff08\u885d\u6483\u6ce2\uff09\u3067\u7834\u7815\u3059\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=match%20at%20L169%20%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F,%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc\u306f\u65e2\u5b58\u306eQ\u30b9\u30a4\u30c3\u30c1\uff08\u30ca\u30ce\u79d2\uff09\u30ec\u30fc\u30b6\u30fc\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u7c92\u5b50\u3092\u7d30\u304b\u304f\u7c89\u7815\u3067\u304d\u3001\u523a\u9752\u9664\u53bb\u306a\u3069\u3067\u3082\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u307e\u305f\u71b1\u640d\u50b7\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u8001\u4eba\u6027\u8272\u7d20\u6591\u306b\u5bfe\u3057\u3066\u306f\u6de1\u3044\u8272\u8abf\u306e\u3082\u306e\u306b\u3082\u6709\u52b9\u3067<strong>PIH\u767a\u751f\u7387\u304c\u4f4e\u3044<\/strong>\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=match%20at%20L169%20%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F,%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u809d\u6591\u3078\u306e\u76f4\u63a5\u7167\u5c04\u306f\u4f9d\u7136\u3068\u3057\u3066\u30ea\u30d0\u30a6\u30f3\u30c9\u306e\u61f8\u5ff5\u304c\u3042\u308b\u304c\u3001<strong>\u30c8\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u4f4e\u51fa\u529b\u7167\u5c04\uff09\u3084\u4ed6\u306e\u6cbb\u7642\u306e\u88dc\u52a9\u3068\u3057\u3066\u7528\u3044\u308b\u8a66\u307f\u3082\u884c\u308f\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=match%20at%20L169%20%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F,%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u8907\u6570\u306e\u6ce2\u9577\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642\uff08\u4f8b\u3048\u3070532nm\u30681064nm\u306e\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u7167\u5c04\uff09\u3082\u53ef\u80fd\u3067\u3001\u8868\u76ae\u6591\u3068\u771f\u76ae\u6591\u3092\u540c\u6642\u306b\u6cbb\u7642\u3059\u308b\u3053\u3068\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=match%20at%20L169%20%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F,%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u305f\u3060\u3057\u5168\u3066\u306e\u9762\u3067\u30ca\u30ce\u79d2\u30ec\u30fc\u30b6\u30fc\u3088\u308a\u512a\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u304f<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F%20%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3001\u30b3\u30b9\u30c8\u3082\u9ad8\u3044\u305f\u3081\u3001\u73fe\u5728\u306f\u96e3\u6cbb\u6027\u306e\u809d\u6591\u3084\u523a\u9752\u3001\u518d\u767a\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u75c7\u4f8b\u306b\u9078\u629e\u7684\u306b\u4f7f\u308f\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0:<\/strong> \u672c\u6765Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u306f\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u3067\u30b9\u30dd\u30c3\u30c8\u7684\u306b\u8272\u7d20\u3092\u7834\u58ca\u3059\u308b\u4f7f\u3044\u65b9\u3092\u3059\u308b\u304c\u3001\u809d\u6591\u6cbb\u7642\u3067\u306f<strong>\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0<\/strong>\u3068\u79f0\u3057\u3066\u4f4e\u51fa\u529b\uff08\u4e9c\u71b1\u50b7\u91cf\uff09\u306e1064nmQ\u30b9\u30a4\u30c3\u30c1YAG\u3092\u9854\u5168\u4f53\u306b\u7167\u5c04\u3057\u3001\u5f90\u3005\u306b\u30e1\u30e9\u30cb\u30f3\u3092\u6e1b\u3089\u3059\u65b9\u6cd5\u304c\u53d6\u3089\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=been%20increasing%20recently%2C%20several%20studies,500%20mg%20per%20day%20along\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u90311\u56de\u7a0b\u5ea6\u306e\u7167\u5c04\u309210\u56de\u4ee5\u4e0a\u7e70\u308a\u8fd4\u3059\u3053\u3068\u3067\u809d\u6591\u304c\u8584\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3001\u65e5\u672c\u3067\u3082\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u3001\u30c8\u30fc\u30cb\u30f3\u30b0\u3092\u4e2d\u6b62\u3059\u308b\u3068\u809d\u6591\u304c\u518d\u767a\u30fb\u60aa\u5316\u3059\u308b\u30b1\u30fc\u30b9\uff08<strong>\u30ea\u30d0\u30a6\u30f3\u30c9<\/strong>\uff09\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u614e\u91cd\u306a\u7d4c\u904e\u89b3\u5bdf\u3068\u4e26\u884c\u3057\u305f\u7dad\u6301\u7642\u6cd5\u304c\u5fc5\u8981\u3067\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,hue%20than%20prior%20to%20treatment\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u307e\u305f\u7167\u5c04\u56de\u6570\u304c\u591a\u3044\u3068\u8272\u7d20\u8131\u5931\u3084\u307e\u3060\u3089\u306a\u767d\u6591\u3092\u751f\u3058\u308b\u4f8b\u3082\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>IPL (Intense Pulsed Light):<\/strong> \u7279\u5b9a\u306e\u30ec\u30fc\u30b6\u30fc\u5149\u3067\u306f\u306a\u304f500\u2013700nm\u53f0\u3092\u4e2d\u5fc3\u3068\u3057\u305f<strong>\u5e83\u5e2f\u57df\u306e\u5149<\/strong>\u3092\u30d5\u30a3\u30eb\u30bf\u30fc\u3067\u30ab\u30c3\u30c8\u3057\u3066\u7167\u5c04\u3059\u308b\u6a5f\u5668\u3067\u3001\u300c\u5149\u6cbb\u7642\u300d\u300c\u30d5\u30a9\u30c8\u30d5\u30a7\u30a4\u30b7\u30e3\u30eb\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u3002\u4e3b\u306b\u8001\u4eba\u6027\u8272\u7d20\u6591\u3084\u96c0\u5375\u6591\u306a\u3069\u8868\u76ae\u306e\u6d45\u3044\u8272\u7d20\u6591\u306b\u6709\u52b9\u3067\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u307f\u306a\u3089\u305a\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306b\u3082\u4f5c\u7528\u3059\u308b\u305f\u3081\u3001\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3084\u8d64\u3089\u9854\u306e\u6539\u5584\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5897\u751f\u306b\u3088\u308b\u808c\u8cea\u6539\u5584\u52b9\u679c\u3082\u671f\u5f85\u3067\u304d\u308b\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u306f\u30ec\u30fc\u30b6\u30fc\u3088\u308a\u5f31\u304f\u6570\u56de\u306b\u5206\u3051\u3066\u6cbb\u7642\u3059\u308b\u3002\u7167\u5c04\u5f8c\u306f\u304b\u3055\u3076\u305f\u5f62\u6210\u305b\u305a\u5f90\u3005\u306b\u8584\u304f\u306a\u308b\u305f\u3081\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u304c\u5c11\u306a\u3044\u5229\u70b9\u304c\u3042\u308b\u3002\u305f\u3060\u3057\u809d\u6591\u3078\u306e\u5358\u72ecIPL\u7167\u5c04\u306f\u708e\u75c7\u3092\u8a98\u767a\u3057\u3066\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a<strong>\u7981\u5fcc<\/strong>\u3068\u3055\u308c\u308b\u3002\u4e00\u65b9\u3001\u809d\u6591\u306bIPL\u3092\u5f31\u304f\u5f53\u3066\u308b\u7814\u7a76\u3084\u3001\u809d\u6591\u65e2\u5f80\u306e\u76ae\u819a\u5168\u4f53\u306bIPL\u3092\u65bd\u884c\u3057\u808c\u8cea\u3092\u6539\u5584\u3057\u3066\u518d\u767a\u3057\u306b\u304f\u304f\u3059\u308b\u8a66\u307f\u3082\u3042\u308b\u3002IPL\u306f\u4e00\u5ea6\u306b\u5e83\u7bc4\u56f2\u306e\u6cbb\u7642\u304c\u53ef\u80fd\u3067\u64cd\u4f5c\u3082\u5bb9\u6613\u306a\u305f\u3081\u3001\u7f8e\u5bb9\u30af\u30ea\u30cb\u30c3\u30af\u3067\u5e83\u304f\u666e\u53ca\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u30c7\u30d0\u30a4\u30b9:<\/strong> \u771f\u76ae\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u4fc3\u3059<strong>\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\u30ec\u30fc\u30b6\u30fc<\/strong>\uff08\u30a8\u30eb\u30d3\u30a6\u30e0\u30b0\u30e9\u30b9\u3084CO2\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\uff09\u3084\u3001<strong>RF\uff08\u9ad8\u5468\u6ce2\uff09\u30de\u30a4\u30af\u30ed\u30cb\u30fc\u30c9\u30ea\u30f3\u30b0<\/strong>\u306a\u3069\u3082\u96e3\u6cbb\u6027\u306e\u809d\u6591\u3084\u771f\u76ae\u306e\u8272\u7d20\u6c88\u7740\u306b\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\u30ec\u30fc\u30b6\u30fc\u306f\u76ae\u819a\u306b\u5fae\u5c0f\u306a\u71b1\u640d\u50b7\u30ab\u30e9\u30e0\u3092\u7121\u6570\u306b\u5f62\u6210\u3057\u3001\u5275\u50b7\u6cbb\u7652\u904e\u7a0b\u3067\u8868\u76ae\u306e\u30e1\u30e9\u30cb\u30f3\u3092\u6392\u51fa\u30fb\u771f\u76ae\u3092\u518d\u69cb\u7bc9\u3059\u308b\u3002\u305f\u3060\u3057\u304b\u3055\u3076\u305f\u3068\u767a\u8d64\u306e\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u3084PIH\u30ea\u30b9\u30af\u3082\u3042\u308a\u3001\u809d\u6591\u306b\u306f\u614e\u91cd\u306b\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002\u307e\u305f\u8fd1\u5e74\u3001\u4f4e\u51fa\u529b\u306e<strong>\u5149\u7dda\u529b\u5b66\u7642\u6cd5<\/strong>\uff08Photobiomodulation, \u4f8b\u3048\u3070\u4f4e\u51fa\u529bLED\uff09\u3067\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u52b9\u679c\u3084\u8840\u7ba1\u30fb\u708e\u75c7\u6291\u5236\u52b9\u679c\u3092\u72d9\u3046\u8a66\u307f\u3082\u3042\u308a\u3001\u4e00\u90e8\u3067\u809d\u6591\u6539\u5584\u306b\u6709\u52b9\u3068\u306e\u5831\u544a\u304c\u51fa\u3066\u3044\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38018017\/#:~:text=Photobiomodulation%20for%20melasma%20treatment%3A%20Integrative,PBM%20shows%20potential%20in%20reducing\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0<\/h3>\n\n\n\n<p>\u5316\u5b66\u5265\u96e2\u7642\u6cd5\u306f\u9178\u6027\u85ac\u5264\u3067\u8868\u76ae\u306e\u89d2\u8cea\u3092\u5265\u96e2\u3057\u3001\u8868\u76ae\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4fc3\u9032\u3068\u30e1\u30e9\u30cb\u30f3\u6392\u51fa\u3001\u771f\u76ae\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u518d\u751f\u3092\u56f3\u308b\u6cbb\u7642\u3067\u3042\u308b\u3002\u7528\u3044\u308b\u85ac\u5264\u30fb\u6fc3\u5ea6\u306b\u3088\u308a\u6df1\u9054\u5ea6\u3092\u8abf\u6574\u3067\u304d\u3001\u8272\u7d20\u6027\u75be\u60a3\u306b\u306f\u4e3b\u306b<strong>\u8868\u5c64\u301c\u4e2d\u9593\u5c64\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\u304c\u7528\u3044\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b0\u30ea\u30b3\u30fc\u30eb\u9178 (AHA\u30d4\u30fc\u30ea\u30f3\u30b0):<\/strong> \u30d5\u30eb\u30fc\u30c4\u9178\u3068\u3082\u547c\u3070\u308c\u308b\u03b1-\u30d2\u30c9\u30ed\u30ad\u30b7\u9178\u306e\u4e00\u7a2e\u3067\u3001\u6fc3\u5ea620\u301c70%\u3092\u6570\u5206\u9593\u5857\u5e03\u5f8c\u3001\u4e2d\u548c\u3057\u3066\u5265\u96e2\u3059\u308b\u3002\u8868\u76ae\u89d2\u5c64\u3092\u5747\u4e00\u306b\u5265\u304c\u3057\u3001\u7d042\u301c4\u9031\u9593\u9694\u3067\u7e70\u308a\u8fd4\u3059\u3068\u809d\u6591\u3084PIH\u304c\u5f90\u3005\u306b\u8584\u304f\u306a\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u5358\u72ec\u3067\u3082\u52b9\u679c\u304c\u3042\u308b\u304c\u3001HQ\u3084\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u3068\u306e\u4f75\u7528\u3067\u3088\u308a\u9ad8\u3044\u6539\u5584\u304c\u5f97\u3089\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=topical%20tretinoin%20treatment%20was%20better,skinned%20Indians.%20%5B6\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002AHA\u30d4\u30fc\u30ea\u30f3\u30b0\u306f\u5b89\u5168\u6027\u304c\u9ad8\u304f\u3001\u8272\u7d20\u6c88\u7740\u6cbb\u7642\u306e\u88dc\u52a9\u3068\u3057\u3066\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b5\u30ea\u30c1\u30eb\u9178\u30de\u30af\u30ed\u30b4\u30fc\u30eb (BHA\u30d4\u30fc\u30ea\u30f3\u30b0):<\/strong> \u8102\u6eb6\u6027\u306e\u30b5\u30ea\u30c1\u30eb\u9178\u3092\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306b\u6eb6\u89e3\u3057\u305f\u88fd\u5264\u3067\u3001\u89d2\u8cea\u3078\u306e\u6d78\u900f\u304c\u7a4f\u3084\u304b\u3067\u30e0\u30e9\u306b\u306a\u308a\u306b\u304f\u3044\u3002\u6fc3\u5ea620\u301c30%\u7a0b\u5ea6\u3067\u9854\u5168\u4f53\u306b\u5857\u5e03\u3057\u6570\u5206\u5f8c\u306b\u9664\u53bb\u3059\u308b\u3002\u30cb\u30ad\u30d3\u6cbb\u7642\u3068\u3057\u3066\u666e\u53ca\u3057\u305f\u304c\u3001\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u306e\u6539\u5584\u3084\u809d\u6591\u306e\u30c8\u30fc\u30f3\u30a2\u30c3\u30d7\u306b\u3082\u6709\u7528\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u30b5\u30ea\u30c1\u30eb\u9178\u81ea\u4f53\u306b\u6297\u708e\u75c7\u4f5c\u7528\u3082\u3042\u308a\u3001\u808c\u8cea\u3092\u6574\u3048\u3064\u3064\u8272\u7d20\u6c88\u7740\u3092\u6539\u5584\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30c8\u30ea\u30af\u30ed\u30ed\u9162\u9178 (TCA\u30d4\u30fc\u30ea\u30f3\u30b0):<\/strong> \u6fc3\u5ea6\u306b\u3088\u3063\u3066\u4e2d\u301c\u6df1\u5c64\u307e\u3067\u4f5c\u7528\u53ef\u80fd\u306a\u5265\u96e2\u5264\u300210\u301c20%\u7a0b\u5ea6\u306e\u4f4e\u6fc3\u5ea6TCA\u3092\u7528\u3044\u308c\u3070\u8868\u76ae\u301c\u4e73\u982d\u771f\u76ae\u306b\u4f5c\u7528\u3057\u3001\u809d\u6591\u30fb\u305d\u3070\u304b\u3059\u30fb\u6d45\u3044\u8001\u4eba\u6591\u306e\u6539\u5584\u306b\u7528\u3044\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u30b9\u30dd\u30c3\u30c8\u7684\u306b\u9ad8\u6fc3\u5ea6TCA\u3092\u5857\u5e03\u3059\u308b<strong>\u30b9\u30dd\u30c3\u30c8\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\uff08\u30af\u30ed\u30ed\u9162\u9178\u30b9\u30dd\u30c3\u30c8\u6cd5\uff09\u306f\u3001\u5c0f\u3055\u306a\u8001\u4eba\u6027\u8272\u7d20\u6591\u3084\u305d\u3070\u304b\u3059\u306b\u5bfe\u3057\u3001\u304b\u3055\u3076\u305f\u5f62\u6210\u3092\u7d4c\u30661\u56de\u3067\u9664\u53bb\u3059\u308b\u624b\u6280\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20treatment%20modalities%20include%20use,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u305f\u3060\u3057TCA\u306f\u65bd\u8853\u6df1\u9054\u5ea6\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u304f\u3001\u6fc3\u5ea6\u304c\u9ad8\u3059\u304e\u308b\u3068\u7622\u75d5\u5316\u3084\u8272\u7d20\u8131\u5931\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20treatment%20modalities%20include%20use,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u7279\u306b\u8272\u9ed2\u306e\u60a3\u8005\u3067\u306f\u9ad8\u6fc3\u5ea6TCA\u3084\u6c37\u9162\u9178\u306b\u3088\u308b\u30b9\u30dd\u30c3\u30c8\u6cbb\u7642\u306f<strong>\u7981\u5fcc<\/strong>\u3067\u3042\u308a\u3001\u614e\u91cd\u306a\u9069\u5fdc\u5224\u65ad\u304c\u5fc5\u8981\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20treatment%20modalities%20include%20use,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u30d4\u30fc\u30ea\u30f3\u30b0\u5264:<\/strong> \u4e2d\u6fc3\u5ea6\u4ee5\u4e0a\u306eTCA\u3084\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u7528\u3044\u308b<strong>\u4e2d\u6df1\u5c64\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\u306f\u5f37\u529b\u3060\u304cPIH\u30ea\u30b9\u30af\u3082\u9ad8\u304f\u3001\u8272\u7d20\u6027\u75be\u60a3\u306b\u306f\u901a\u5e38\u7528\u3044\u3089\u308c\u306a\u3044\u3002\u4e00\u65b9\u3001\u4e73\u9178\u3084\u30de\u30f3\u30c7\u30eb\u9178\u306a\u3069\u30de\u30a4\u30eb\u30c9\u306a\u9178\u3092\u7528\u3044\u305f\u8868\u5c64\u30d4\u30fc\u30ea\u30f3\u30b0\u3084\u3001<strong>Jessner\u6db2<\/strong>\uff08\u30b5\u30ea\u30c1\u30eb\u9178+\u4e73\u9178+\u30ec\u30be\u30eb\u30b7\u30f3\uff09\u306a\u3069\u306e\u4f75\u7528\u88fd\u5264\u3082\u3001\u809d\u6591\u6cbb\u7642\u306e\u88dc\u52a9\u3068\u3057\u3066\u4f7f\u308f\u308c\u308b\u5834\u5408\u304c\u3042\u308b\u3002\u7279\u306b<strong>\u6df7\u5408\u6027\u30e1\u30e9\u30cb\u30fc\u5265\u8131\u7642\u6cd5<\/strong>\uff08MPE: Modified Phenol Peel\u304b\u3089\u6d3e\u751f\u3057\u305f\u30de\u30a4\u30eb\u30c9\u306a\u30d4\u30fc\u30ea\u30f3\u30b0\uff09\u306f\u809d\u6591\u306b\u6709\u52b9\u3068\u306e\u5831\u544a\u3082\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0\u306f\u3044\u305a\u308c\u3082<strong>\u6cbb\u7642\u5f8c\u306e\u7d2b\u5916\u7dda\u5bfe\u7b56<\/strong>\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u5265\u96e2\u5f8c\u306e\u76ae\u819a\u306f\u4e00\u6642\u7684\u306b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u65e5\u713c\u3051\u3059\u308b\u3068\u3080\u3057\u308d\u8272\u7d20\u6c88\u7740\u304c\u60aa\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642<\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u8907\u6570\u306e\u6cbb\u7642\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u76f8\u4e57\u52b9\u679c\u3092\u72d9\u3046<strong>\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u7642\u6cd5<\/strong>\u304c\u4e3b\u6d41\u306b\u306a\u308a\u3064\u3064\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=A%20variety%20of%20topical%20treatments,5%5D%20%C2%A0Another\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u5358\u4e00\u7642\u6cd5\u3067\u306f\u9650\u754c\u304c\u3042\u308b\u305f\u3081\u3001\u60a3\u8005\u4e00\u4eba\u3072\u3068\u308a\u306e\u75c5\u614b\u306b\u5408\u308f\u305b\u3066<strong>\u5916\u7528+\u5185\u670d+\u65bd\u8853<\/strong>\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5916\u7528\u85ac\u3068\u5185\u670d\u85ac\u306e\u4f75\u7528:<\/strong> \u4f8b\u3048\u3070\u809d\u6591\u3067\u306f\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3084\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5916\u7528\u3068\u4e26\u884c\u3057\u3066\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u5916\u7528\u306e\u307f\u3088\u308a\u6539\u5584\u304c\u65e9\u304f\u5f37\u3044<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=match%20at%20L424%20by%20Lajevardi,In%20a\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u307e\u305f\u5916\u7528\u85ac\u3067\u3042\u308b\u7a0b\u5ea6\u8584\u304f\u3057\u305f\u4e0a\u3067\u6b8b\u5b58\u3059\u308b\u90e8\u5206\u306b\u65bd\u8853\u3092\u52a0\u3048\u308b\u3068\u3044\u3063\u305f\u6bb5\u968e\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u6709\u52b9\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30ec\u30fc\u30b6\u30fc\/\u5149\u6cbb\u7642\u3068\u5916\u7528\u7642\u6cd5:<\/strong> \u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u524d\u5f8c\u306b\u5916\u7528\u5264\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u3001\u518d\u767a\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4f8b\u3068\u3057\u3066\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0\u3068\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\uff0b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3092\u540c\u6642\u671f\u306b\u884c\u3046\u3068\u3001\u30ec\u30fc\u30b6\u30fc\u5358\u72ec\u3088\u308a\u6709\u610f\u306b\u8272\u7d20\u6c88\u7740\u306e\u6539\u5584\u304c\u826f\u597d\u3060\u3063\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=been%20increasing%20recently%2C%20several%20studies,500%20mg%20per%20day%20along\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30ec\u30fc\u30b6\u30fc\u7167\u5c04\u306b\u3088\u308a\u89d2\u8cea\u306e\u30d0\u30ea\u30a2\u304c\u4e00\u6642\u7684\u306b\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u7167\u5c04\u76f4\u5f8c\u306b\u30d3\u30bf\u30df\u30f3C\u3084\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306e\u5916\u7528\u3092\u884c\u3044\u6d78\u900f\u3092\u9ad8\u3081\u308b\u8a66\u307f\u3082\u3042\u308b\u3002\u307e\u305f\u30d4\u30fc\u30ea\u30f3\u30b0\u5f8c\u306b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u30af\u30ea\u30fc\u30e0\u3092\u5857\u5e03\u3059\u308b\u3068\u3044\u3063\u305f\u7d44\u307f\u5408\u308f\u305b\u3082\u5408\u7406\u7684\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=topical%20tretinoin%20treatment%20was%20better,skinned%20Indians.%20%5B6\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u8907\u6570\u30c7\u30d0\u30a4\u30b9\u306e\u7d44\u307f\u5408\u308f\u305b:<\/strong> \u30ec\u30fc\u30b6\u30fc\u3068IPL\u3001\u3082\u3057\u304f\u306f\u7570\u306a\u308b\u7a2e\u985e\u306e\u30ec\u30fc\u30b6\u30fc\u3092\u4f7f\u3044\u5206\u3051\u308b\u3053\u3068\u3082\u884c\u308f\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Treatment%20of%20a%20melanocytosis%20may,or%20%2047\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u4f8b\u3048\u3070ADM\u3084\u592a\u7530\u6bcd\u6591\u3067\u306fQ\u30b9\u30a4\u30c3\u30c1YAG\u3068\u30eb\u30d3\u30fc\u30ec\u30fc\u30b6\u30fc\u3092\u4f75\u7528\u3057\u3001\u7570\u306a\u308b\u6df1\u3055\u30fb\u7a2e\u985e\u306e\u30e1\u30e9\u30cb\u30f3\u306b\u5bfe\u5fdc\u3059\u308b\u3053\u3068\u304c\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Treatment%20of%20a%20melanocytosis%20may,or%20%2047\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u307e\u305f\u809d\u6591\u3067\u306f\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0\u3068IPL\uff08\u305f\u3060\u3057\u6ce8\u610f\u6df1\u304f\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u809d\u6591\u90e8\u306f\u30c8\u30fc\u30cb\u30f3\u30b0\u3001\u305d\u308c\u4ee5\u5916\u306e\u8272\u3080\u3089\u306fIPL\u3067\u51e6\u7406\u3059\u308b\u306a\u3069\u5de5\u592b\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u306e\u968e\u6bb5\u6226\u7565:<\/strong> \u307e\u305a\u30de\u30a4\u30eb\u30c9\u306a\u65b9\u6cd5\uff08\u5916\u7528\u30fb\u5185\u670d\u30fb\u30d4\u30fc\u30ea\u30f3\u30b0\uff09\u3067\u808c\u5168\u4f53\u306e\u30c8\u30fc\u30f3\u3092\u4e0a\u3052\u3001\u305d\u308c\u3067\u3082\u6b8b\u308b\u9811\u56fa\u306a\u6591\u306b\u5bfe\u3057\u3066\u30b9\u30dd\u30c3\u30c8\u3067\u30ec\u30fc\u30b6\u30fc\u3092\u5f53\u3066\u308b\u3001\u3068\u3044\u3063\u305f<strong>\u6bb5\u968e\u7684\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb<\/strong>\u3082\u63a8\u5968\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u3044\u304d\u306a\u308a\u5f37\u3044\u30ec\u30fc\u30b6\u30fc\u3092\u5f53\u3066\u308b\u3068\u53cd\u5fdc\u6027\u306e\u708e\u75c7\u3084PIH\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u3067\u304d\u308b\u3060\u3051\u808c\u3078\u306e\u8ca0\u62c5\u304c\u5c11\u306a\u3044\u65b9\u6cd5\u304b\u3089\u958b\u59cb\u3057\u3001\u7d4c\u904e\u3092\u898b\u306a\u304c\u3089\u6cbb\u7642\u5f37\u5ea6\u3092\u4e0a\u3052\u3066\u3044\u304f\u306e\u304c\u5b89\u5168\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u306f\u3001\u4e00\u4eba\u3072\u3068\u308a\u7570\u306a\u308b\u75c5\u5909\u30bf\u30a4\u30d7\u306b\u67d4\u8edf\u306b\u5bfe\u5fdc\u3057\u3001\u304b\u3064\u518d\u767a\u9632\u6b62\u306b\u3082\u6709\u7528\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=with%20one%20of%20the%20previously,skinned%20Indians.%20%5B6\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u5b9f\u969b\u306e\u81e8\u5e8a\u3067\u306f\u5916\u7528\u85ac\u30fb\u5185\u670d\u85ac\u30fb\u30ec\u30fc\u30b6\u30fc\u30fb\u30d4\u30fc\u30ea\u30f3\u30b0\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u5305\u62ec\u7684\u306a\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3092\u7d44\u3080\u3053\u3068\u304c\u591a\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6226\u7565\u3068\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u6cbb\u7642\u6226\u7565\u306f\u3001\u75c5\u5909\u306e\u7a2e\u985e\u3001\u5206\u5e03\u3001\u60a3\u8005\u306e\u808c\u8cea\u306a\u3069\u3092\u8003\u616e\u3057\u3066\u7acb\u6848\u3059\u308b\u3002\u4ee5\u4e0b\u306b\u4e3b\u306a\u75be\u60a3\u3054\u3068\u306e\u6cbb\u7642\u65b9\u91dd\u306e\u6982\u7565\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u809d\u6591:<\/strong> \u7b2c\u4e00\u9078\u629e\u306f<strong>\u65e5\u713c\u3051\u6b62\u3081\u3068\u5916\u7528\u7642\u6cd5<\/strong>\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Wavelength%20spectrum%20of%20solar%20irradiation,patients%20with%20melasma%20into%20two\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002UV\u304a\u3088\u3073\u53ef\u8996\u5149\u9632\u5fa1\u306f\u809d\u6591\u6cbb\u7642\u306e\u57fa\u672c\u3067\u3042\u308a\u3001\u9244\u5206\u3092\u542b\u3080\u65e5\u713c\u3051\u6b62\u3081\uff08\u9178\u5316\u9244\u914d\u5408\uff09\u3067\u53ef\u8996\u5149\u3082\u906e\u65ad\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=finding%2C%20photoprotection%20against%20VL%20is,6%20months%20in%20the%20iron\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5916\u7528\u306f\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f34%\u5358\u72ec\u304b\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u30af\u30ea\u30fc\u30e0\u3092\u5c11\u306a\u304f\u3068\u30828\u9031\u9593\u7d99\u7d9a\u3059\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=pigmentation%20in%20the%20clinical%20examination%2C,continuously%2C%20and%20they%20often%20used\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\uff081\u65e5750mg\u301c1,000mg\uff09\u3092\u4f75\u7528\u3059\u308b\u30022\u301c3\u30f6\u6708\u3067\u4e00\u5b9a\u306e\u6539\u5584\u304c\u5f97\u3089\u308c\u306a\u3051\u308c\u3070<strong>\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0<\/strong>\u3092\u691c\u8a0e\u3059\u308b\u3002\u305f\u3060\u3057\u809d\u6591\u306b\u5bfe\u3059\u308b\u30ec\u30fc\u30b6\u30fc\u306f\u518d\u767a\u30ea\u30b9\u30af\u3082\u8aac\u660e\u3057\u3001\u614e\u91cd\u306b\u884c\u3046\u3002\u30c8\u30fc\u30cb\u30f3\u30b0\u306f\u90311\u56de\u309210\u301c20\u56de\u884c\u3044\u5f90\u3005\u306b\u8584\u304f\u3059\u308b\u304c\u3001\u4e26\u884c\u3057\u3066\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3084\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\u3092\u7d99\u7d9a\u3057\u3001\u518d\u71c3\u3092\u9632\u3050<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=been%20increasing%20recently%2C%20several%20studies,500%20mg%20per%20day%20along\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u6cbb\u7642\u7d42\u4e86\u5f8c\u3082\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3092\u9031\u6570\u56de\u5857\u5e03\u3057\u305f\u308a\u3001\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3084\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u914d\u5408\u306e\u5316\u7ca7\u54c1\u3092\u4f7f\u3046\u3002\u809d\u6591\u306f\u6162\u6027\u75be\u60a3\u3067\u3042\u308a\u3001<strong>\u5bdb\u89e3\u7dad\u6301<\/strong>\u306e\u89b3\u70b9\u3067\u9577\u671f\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8001\u4eba\u6027\u8272\u7d20\u6591:<\/strong> \u5358\u767a\u306e\u6fc3\u3044\u75c5\u5909\u306b\u306f<strong>\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642<\/strong>\u304c\u6700\u3082\u901f\u52b9\u6027\u304c\u9ad8\u3044\u3002Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u307e\u305f\u306f\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u3092\u75c5\u5909\u90e8\u306b1\u767a\u7167\u5c04\u3057\u30011\u301c2\u9031\u9593\u306e\u75c2\u76ae\u5f62\u6210\u5f8c\u306b\u75c5\u5909\u304c\u8131\u843d\u3059\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=What%20treatments%20are%20available%20for,melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8272\u7d20\u6591\u304c\u591a\u767a\u3059\u308b\u5834\u5408\u3084\u8584\u3044\u30b7\u30df\u306b\u306f<strong>IPL<\/strong>\u3092\u67081\u56de\u7a0b\u5ea6\u00d7\u6570\u56de\u884c\u3044\u3001\u5f90\u3005\u306b\u8584\u304f\u3059\u308b\u65b9\u6cd5\u3082\u6709\u52b9\u3002\u60a3\u8005\u306e\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u8a31\u5bb9\u5ea6\u3084\u808c\u8cea\u306b\u5408\u308f\u305b\u3066\u9078\u629e\u3059\u308b\u3002\u30ec\u30fc\u30b6\u30fc\u65bd\u8853\u5f8c\u306f\u4e00\u904e\u6027\u306e\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u3092\u9632\u3050\u305f\u3081\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3092\u6570\u9031\u9593\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002\u809d\u6591\u3068\u6df7\u5728\u3059\u308b\u5834\u5408\u3001\u5f37\u3044\u30ec\u30fc\u30b6\u30fc\u306f\u809d\u6591\u3092\u60aa\u5316\u3055\u305b\u3046\u308b\u305f\u3081\u3001\u809d\u6591\u90e8\u5206\u306f\u7167\u5c04\u3092\u907f\u3051\u5225\u9014\u6cbb\u7642\u3059\u308b\u3002\u65e5\u5e38\u7684\u306b\u306fUV\u5bfe\u7b56\u3068\u30d3\u30bf\u30df\u30f3C\u5185\u670d\u306a\u3069\u3067\u65b0\u898f\u306e\u30b7\u30df\u5f62\u6210\u4e88\u9632\u3092\u884c\u3046<a href=\"https:\/\/dermnetnz.org\/topics\/brown-spots-and-freckles#:~:text=will%20reduce%20the%20number%20of,should%20be%20applied%20liberally%20and\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u518d\u767a\u6642\u306b\u306f\u518d\u5ea6\u30ec\u30fc\u30b6\u30fc\u3067\u5bfe\u5fdc\u3067\u304d\u308b\u304c\u3001\u540c\u3058\u7b87\u6240\u306b\u4f55\u5ea6\u3082\u751f\u3058\u308b\u5834\u5408\u306f\u6162\u6027\u7684\u306a\u65e5\u5149\u66dd\u9732\u304c\u539f\u56e0\u306e\u305f\u3081\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6307\u5c0e\u3082\u884c\u3046\u3002<\/li>\n\n\n\n<li><strong>\u96c0\u5375\u6591:<\/strong> \u82e5\u5e74\u8005\u3067\u3042\u3063\u3066\u3082\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306e\u9069\u5fdc\u3068\u306a\u308b\u3002<strong>Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc<\/strong>\uff08532nm or 755nm\uff09\u3067\u9854\u5168\u4f53\u306e\u96c0\u5375\u6591\u3092\u30b9\u30dd\u30c3\u30c8\u7167\u5c04\u3059\u308b\u3068\u30011\u56de\u3067\u5927\u90e8\u5206\u304c\u9664\u53bb\u53ef\u80fd\u3067\u3042\u308b\u3002\u65bd\u8853\u5f8c\u306b\u8272\u7d20\u6c88\u7740\u3092\u9632\u3050\u305f\u3081\u65e5\u713c\u3051\u6b62\u3081\u3092\u53b3\u91cd\u306b\u4f7f\u7528\u3059\u308b\u3002IPL\u3082\u6709\u52b9\u3067\u3001\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u304c\u53d6\u308c\u306a\u3044\u60a3\u8005\u306b\u306fIPL\u30922\u301c3\u56de\u884c\u3046\u9078\u629e\u80a2\u3082\u3042\u308b\u3002\u5916\u7528\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306f\u96c0\u5375\u6591\u306b\u3082\u3042\u308b\u7a0b\u5ea6\u52b9\u679c\u304c\u3042\u308b\u304c\u3001\u30ec\u30fc\u30b6\u30fc\u307b\u3069\u660e\u77ad\u306a\u6539\u5584\u306b\u306f\u6642\u9593\u3092\u8981\u3059\u308b\u3002\u5c0f\u5150\u3067\u306f\u6cbb\u7642\u306f\u614e\u91cd\u306b\u884c\u3046\u304c\u3001\u601d\u6625\u671f\u4ee5\u964d\u3067\u3042\u308c\u3070\u7f8e\u5bb9\u7684\u306b\u6c17\u306b\u3059\u308b\u5834\u5408\u306f\u65bd\u8853\u3057\u3066\u3088\u3044\u3002\u518d\u767a\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u8853\u5f8c\u306eUV\u5bfe\u7b56\u3068\u7dad\u6301\u7684\u306a\u7f8e\u767d\u30b1\u30a2\uff08\u5316\u7ca7\u54c1\u306a\u3069\uff09\u3092\u6307\u5c0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>ADM (\u5f8c\u5929\u6027\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9):<\/strong> \u76ae\u819a\u306e\u6df1\u90e8\uff08\u771f\u76ae\u4e0a\u5c64\uff09\u306b\u5b58\u5728\u3059\u308b\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u7834\u58ca\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u305f\u3081\u3001<strong>\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642<\/strong>\u304c\u4e3b\u3068\u306a\u308b\u3002Q\u30b9\u30a4\u30c3\u30c1YAG\u30ec\u30fc\u30b6\u30fc(1064nm)\u307e\u305f\u306f\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u3092\u4f4e\u51fa\u529b\u3067\u5168\u9854\u306b\u30c8\u30fc\u30cb\u30f3\u30b0\u7684\u306b\u7167\u5c04\u3057\u3001\u3055\u3089\u306b\u6fc3\u3044\u6591\u70b9\u306b\u30b9\u30dd\u30c3\u30c8\u7167\u5c04\u3059\u308b\u65b9\u6cd5\u304c\u3068\u3089\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=What%20treatments%20are%20available%20for,melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8907\u6570\u56de\uff085\u301c10\u56de\uff09\u306e\u65bd\u8853\u304c\u5fc5\u8981\u3067\u3001\u5f90\u3005\u306b\u8584\u304f\u306a\u3063\u3066\u3044\u304f\u3002ADM\u306f\u771f\u76ae\u75c5\u5909\u306e\u305f\u3081\u3001\u8868\u76ae\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u6291\u3048\u3064\u3064\u771f\u76ae\u307e\u3067\u5c4a\u304f1064nm\u304c\u9069\u3059\u308b\u3002<strong>\u8907\u6570\u6ce2\u9577\u306e\u7d44\u5408\u305b<\/strong>\uff08\u4f8b: 532nm\u3067\u8868\u5728\u6210\u5206\u30011064nm\u3067\u6df1\u5728\u6210\u5206\uff09\u3082\u8a66\u307f\u3089\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Treatment%20of%20a%20melanocytosis%20may,or%20%2047\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u30ec\u30fc\u30b6\u30fc\u5f8c\u306f\u4e00\u6642\u7684\u306b\u6fc3\u304f\u898b\u3048\u308b\uff08\u7070\u767d\u8272\u5316\uff09\u5909\u5316\u3092\u7d4c\u3066\u30012\u9031\u9593\u7a0b\u5ea6\u3067\u6539\u5584\u304c\u898b\u3089\u308c\u308b\u3002\u809d\u6591\u3092\u4f75\u767a\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\u6ce8\u610f\u6df1\u304f\u8a55\u4fa1\u3059\u308b\u3002ADM\u306f\u518d\u767a\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u304c\u3001\u4e00\u5ea6\u7834\u58ca\u3055\u308c\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306f\u5f90\u3005\u306b\u6e1b\u5c11\u3059\u308b\u305f\u3081\u3001\u8ffd\u52a0\u6cbb\u7642\u3067\u3055\u3089\u306b\u6539\u5584\u3059\u308b\u3002\u5916\u7528\u7642\u6cd5\u306f\u88dc\u52a9\u7684\u3067\u3001\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\u3082\u4f75\u7528\u3059\u308b\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u306a\u3044\u304c\u3001\u708e\u75c7\u6291\u5236\u76ee\u7684\u3067\u4f75\u7528\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u592a\u7530\u6bcd\u6591:<\/strong> <strong>Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc<\/strong>\u304c\u78ba\u7acb\u3057\u305f\u6cbb\u7642\u6cd5\u3067\u3042\u308a\u30011064nm YAG\u30ec\u30fc\u30b6\u30fc\u3082\u3057\u304f\u306f755nm\u30a2\u30ec\u30ad\u30b5\u30f3\u30c9\u30e9\u30a4\u30c8\u30ec\u30fc\u30b6\u30fc\u3092\u7528\u3044\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=What%20treatments%20are%20available%20for,melanocytosis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u60a3\u90e8\u5168\u4f53\u306b\u30b9\u30dd\u30c3\u30c8\u7167\u5c04\u3057\u3001\u304b\u3055\u3076\u305f\u5f62\u6210\u5f8c\u8272\u8abf\u304c\u8584\u304f\u306a\u308b\u3002\u751f\u5f8c\u65e9\u671f\u304b\u3089\u6cbb\u7642\u53ef\u80fd\u3067\u3001\u5c0f\u5150\u671f\u306e\u65b9\u304c\u30e1\u30e9\u30cb\u30f3\u304c\u5c11\u306a\u304f\u53cd\u5fdc\u304c\u826f\u3044\u3068\u3082\u8a00\u308f\u308c\u308b\u3002\u4e00\u822c\u7684\u306b\u306f\u6570\u56de\uff085\u301c10\u56de\uff09\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u3067\u5927\u304d\u304f\u6539\u5584\u3057\u3001\u5b8c\u5168\u306b\u6d88\u5931\u3059\u308b\u4f8b\u3082\u591a\u3044<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10110811\/#:~:text=Nevus%20of%20Ota%20,1%20to%202%20per%201000\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305f\u3060\u3057\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6b8b\u5b58\u304c\u3042\u308c\u3070\u6210\u4eba\u5f8c\u306b\u518d\u767a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u8ffd\u52a0\u7167\u5c04\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u3082\u3042\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,hue%20than%20prior%20to%20treatment\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u773c\u7403\u5f37\u819c\u306e\u8272\u7d20\u306b\u3064\u3044\u3066\u306f\u30ec\u30fc\u30b6\u30fc\u306e\u5371\u967a\u6027\u304b\u3089\u57fa\u672c\u7684\u306b\u306f\u6cbb\u7642\u305b\u305a\u3001\u30b3\u30f3\u30bf\u30af\u30c8\u30ec\u30f3\u30ba\u3067\u30ab\u30d0\u30fc\u306a\u3069\u5bfe\u75c7\u7642\u6cd5\u3068\u306a\u308b\u3002\u5408\u4f75\u75c7\u3068\u3057\u3066\u3001\u4e00\u6642\u7684\u306a<strong>\u4e00\u904e\u6027\u773c\u5727\u4e0a\u6607<\/strong>\u304c\u7167\u5c04\u773c\u3067\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u773c\u79d1\u7684\u30c1\u30a7\u30c3\u30af\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3002\u592a\u7530\u6bcd\u6591\u306f\u96e3\u6cbb\u3067\u306f\u306a\u3044\u304c\u3001\u5e83\u7bc4\u306a\u5834\u5408\u306b\u306f\u6839\u6c17\u5f37\u3044\u6cbb\u7642\u8a08\u753b\u3068\u60a3\u8005\u306e\u5354\u529b\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740 (PIH):<\/strong> \u539f\u56e0\u75be\u60a3\u306e\u6cbb\u7642\u3068\u4e26\u884c\u3057\u3066\u884c\u3046\u3002\u307e\u305a\u65b0\u305f\u306a\u708e\u75c7\u3092\u8d77\u3053\u3055\u306a\u3044\u3053\u3068\u304c\u91cd\u8981\u3067\u3001\u539f\u56e0\u3068\u306a\u3063\u305f\u30cb\u30ad\u30d3\u3084\u6e7f\u75b9\u306b\u306f\u9069\u5207\u306a\u6cbb\u7642\u3092\u3059\u308b\u3002\u8272\u7d20\u6591\u81ea\u4f53\u306b\u306f<strong>\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528<\/strong>\u3084<strong>\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5916\u7528<\/strong>\u304c\u6709\u52b9\u3067\u3001\u8868\u76ae\u578bPIH\u3067\u306f3\u301c6\u30f6\u6708\u306e\u7d99\u7d9a\u3067\u304b\u306a\u308a\u6539\u5584\u3059\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=A%20variety%20of%20topical%20treatments,of%20salicylic%20acid%20peel%20and\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u771f\u76ae\u578bPIH\u306f\u56f0\u96e3\u3060\u304c\u3001\u9577\u671f\u7684\u306b\u306f\u3084\u3084\u8584\u304f\u306a\u308b\u305f\u3081\u5916\u7528\u7642\u6cd5\u3092\u7d9a\u3051\u308b\u4fa1\u5024\u306f\u3042\u308b\u3002<strong>\u5316\u5b66\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\uff08AHA\u3084\u30b5\u30ea\u30c1\u30eb\u9178\uff09\u3082\u5b89\u5168\u306b\u65bd\u884c\u3067\u304d\u3001\u7279\u306b\u30cb\u30ad\u30d3\u8de1\u306ePIH\u3067\u306f\u30cb\u30ad\u30d3\u6cbb\u7642\u3068\u517c\u306d\u3066\u65bd\u884c\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Topical%20tretinoin%200.1,has%20been%20shown%20to%20be\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\u306fPIH\u5358\u72ec\u3078\u306e\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5c11\u306a\u3044\u304c\u3001\u809d\u6591\u5408\u4f75\u4f8b\u306a\u3069\u3067\u306f\u7528\u3044\u3089\u308c\u308b\u3002\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306f\u614e\u91cd\u3067\u3001\u65e9\u671f\u306b\u5f37\u3044\u30ec\u30fc\u30b6\u30fc\u3092\u5f53\u3066\u308b\u3068\u3055\u3089\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u304b\u306d\u306a\u3044\u3002\u3069\u3046\u3057\u3066\u3082\u6b8b\u5b58\u3059\u308b\u771f\u76ae\u578bPIH\u306b\u306fQ\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u3092\u5f31\u3081\u306b\u5f53\u3066\u8a66\u307f\u308b\u3053\u3068\u3082\u3042\u308b\u304c\u63a8\u5968\u306f\u3055\u308c\u306a\u3044\u3002<strong>\u4e88\u9632<\/strong>\u304c\u6700\u5927\u306e\u6cbb\u7642\u3067\u3042\u308a\u3001\u65b0\u305f\u306a\u50b7\u3084\u708e\u75c7\u3092\u4f5c\u3089\u306a\u3044\u30b9\u30ad\u30f3\u30b1\u30a2\u6307\u5c0e\uff08\u65e5\u713c\u3051\u6b62\u3081\u3001\u4fdd\u6e7f\u3001\u523a\u6fc0\u56de\u907f\uff09\u304c\u809d\u8981\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=improves%20epidermal%20hypermelanosis%2C%20but%20none,part%20of%20any%20therapeutic%20regimen\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u60a3\u8005\u306b\u306f\u6cbb\u7642\u306b\u6642\u9593\u3092\u8981\u3059\u308b\u3053\u3068\uff086\u301c12\u30f6\u6708\uff09\u3092\u5341\u5206\u8aac\u660e\u3057\u3001\u7126\u3089\u305a\u7d99\u7d9a\u3059\u308b\u3088\u3046\u4fc3\u3059<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Also%20see%20Surgical%20Care%20%2C,28%2C%20and%20Medication\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0a\u3001\u75be\u60a3\u3054\u3068\u306b\u6700\u9069\u306a\u6cbb\u7642\u3092\u9078\u629e\u3057\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u308b\u3002\u3044\u305a\u308c\u306e\u5834\u5408\u3082<strong>\u7d2b\u5916\u7dda\u9632\u5fa1<\/strong>\u3068<strong>\u9577\u671f\u7684\u306a\u7d4c\u904e\u89b3\u5bdf<\/strong>\u304c\u91cd\u8981\u3067\u3001\u4e00\u5ea6\u6cbb\u7642\u306b\u6210\u529f\u3057\u3066\u3082\u518d\u767a\u4e88\u9632\u306e\u305f\u3081\u306e\u30b1\u30a2\u3092\u7d9a\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5408\u4f75\u75c7\u3068\u305d\u306e\u7ba1\u7406<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u4f34\u3063\u3066\u8d77\u3053\u308a\u5f97\u308b\u526f\u4f5c\u7528\u30fb\u5408\u4f75\u75c7\u3068\u3001\u305d\u306e\u5bfe\u7b56\u3092\u8ff0\u3079\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740 (PIH):<\/strong> \u524d\u8ff0\u306e\u901a\u308a\u3001\u30ec\u30fc\u30b6\u30fc\u7167\u5c04\u3084\u30d4\u30fc\u30ea\u30f3\u30b0\u5f8c\u306e\u708e\u75c7\u306b\u3088\u3063\u3066\u4e8c\u6b21\u7684\u306b\u8272\u7d20\u6c88\u7740\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u7279\u306b\u808c\u306e\u8272\u304c\u6fc3\u3044\u4eba\u307b\u3069PIH\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u3002\u5bfe\u7b56\u3068\u3057\u3066\u306f<strong>\u4e8b\u524d\u306e\u5916\u7528\u7642\u6cd5<\/strong>\uff08HQ\u3084\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u3067\u30e1\u30e9\u30cb\u30f3\u91cf\u3092\u6e1b\u3089\u3059\uff09\u3084<strong>\u30c6\u30b9\u30c8\u7167\u5c04<\/strong>\u3067\u808c\u53cd\u5fdc\u3092\u78ba\u8a8d\u3057\u3001\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u304b\u3089\u6cbb\u7642\u3092\u59cb\u3081\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u4e07\u4e00PIH\u304c\u8d77\u3053\u3063\u305f\u5834\u5408\u306f\u3001\u901f\u3084\u304b\u306b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3084\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5916\u7528\u3092\u518d\u958b\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3067\u708e\u75c7\u3092\u6291\u3048\u308b\u3002\u307e\u305f\u7d2b\u5916\u7dda\u306b\u5f53\u3066\u306a\u3044\u3088\u3046\u6307\u5c0e\u3059\u308b\u3002PIH\u306f\u591a\u304f\u304c\u6642\u9593\u3068\u3068\u3082\u306b\u6539\u5584\u3059\u308b\u304c\u3001\u771f\u76ae\u307e\u3067\u9054\u3057\u305f\u5834\u5408\u306f\u9577\u5f15\u304f\u3053\u3068\u3092\u8aac\u660e\u3057\u3001\u6839\u6c17\u5f37\u304f\u6cbb\u7642\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8131\u8272\u7d20\u6591\uff08\u767d\u6591\uff09:<\/strong> \u5f37\u529b\u306a\u6cbb\u7642\uff08\u9ad8\u51fa\u529b\u30ec\u30fc\u30b6\u30fc\u3001\u6fc3\u5ea6\u306e\u9ad8\u3044\u30d5\u30a7\u30ce\u30fc\u30eb\/TCA\u30d4\u30fc\u30ea\u30f3\u30b0\u3001\u9577\u671f\u306e\u30e2\u30ce\u30d9\u30f3\u30be\u30f3\u5916\u7528\u306a\u3069\uff09\u306f\u6b63\u5e38\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u7834\u58ca\u3057\u3001\u5c40\u6240\u7684\u306a\u8272\u629c\u3051\uff08\u767d\u6591\uff09\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20treatment%20modalities%20include%20use,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u7279\u306b\u30e2\u30ce\u30d9\u30f3\u30be\u30f3\uff08\u30e2\u30ce\u30d9\u30f3\u30b8\u30eb\u30a8\u30fc\u30c6\u30eb\u30fb\u30aa\u30d6\u30fb\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\uff09\u306f\u5c0b\u5e38\u6027\u767d\u6591\u306e\u6cbb\u7642\u306b\u7528\u3044\u308b\u8131\u8272\u7d20\u5264\u3060\u304c\u3001\u6b63\u5e38\u90e8\u307e\u3067\u8131\u8272\u3057\u5f97\u308b\u305f\u3081\u8272\u7d20\u6c88\u7740\u6cbb\u7642\u306b\u306f<strong>\u7981\u5fcc<\/strong>\u3067\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Patients%20should%20never%20be%20treated,or%20at%20distal%20cutaneous%20sites\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u30ec\u30fc\u30b6\u30fc\u306b\u3088\u308b\u767d\u6591\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u4e00\u90e8\u7834\u58ca\u3067\u3042\u308a\u3001\u591a\u304f\u306f\u6642\u9593\u3068\u3068\u3082\u306b\u5883\u754c\u304c\u307c\u3084\u3051\u76ee\u7acb\u305f\u306a\u304f\u306a\u308b\u3002\u3057\u304b\u3057\u5e83\u7bc4\u306a\u767d\u6591\u304c\u6b8b\u3063\u305f\u5834\u5408\u3001\u6cbb\u7642\u306f\u56f0\u96e3\u3067\u3042\u308b\u3002\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u751f\u304d\u3066\u3044\u308c\u3070<strong>\u30ca\u30ed\u30fc\u30d0\u30f3\u30c9UVB\u7167\u5c04<\/strong>\u3084<strong>\u30a8\u30ad\u30b7\u30de\u30ec\u30fc\u30b6\u30fc<\/strong>\u3067\u518d\u8272\u7d20\u5316\u3092\u56f3\u308b\u3053\u3068\u3082\u3042\u308b\u304c\u3001\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3002\u6700\u7d42\u624b\u6bb5\u3068\u3057\u3066\u306f\u5468\u56f2\u306b\u5408\u308f\u305b\u3066\u3055\u3089\u306b\u8131\u8272\u3059\u308b\uff08\u767d\u6591\u4ee5\u5916\u3092\u6f02\u767d\u3059\u308b\uff09\u9078\u629e\u3082\u3042\u308b\u304c\u3001\u7f8e\u5bb9\u7684\u306b\u8a31\u5bb9\u3067\u304d\u308b\u304b\u614e\u91cd\u306b\u5224\u65ad\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7622\u75d5\u5f62\u6210:<\/strong> \u30ec\u30fc\u30b6\u30fc\u3084\u6df1\u3044\u30d4\u30fc\u30ea\u30f3\u30b0\u306b\u3088\u308b<strong>\u71b1\u50b7<\/strong>\u3084<strong>\u771f\u76ae\u640d\u50b7<\/strong>\u304c\u8d77\u3053\u308b\u3068\u3001\u7622\u75d5\u30fb\u30b1\u30ed\u30a4\u30c9\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u5e78\u3044\u3001\u9069\u5207\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u3067\u884c\u3048\u3070\u8272\u7d20\u6027\u75c5\u5909\u6cbb\u7642\u3067\u7622\u75d5\u3092\u751f\u3058\u308b\u3053\u3068\u306f\u307e\u308c\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u904e\u5ea6\u306a\u91cd\u306d\u6253\u3061\u3084\u4e0d\u9069\u5207\u306a\u8a2d\u5b9a\u306b\u3088\u308a\u6c34\u75b1\u3084\u6f70\u760d\u304c\u3067\u304d\u305f\u5834\u5408\u3001\u305d\u306e\u90e8\u4f4d\u304c\u51f9\u51f8\u72b6\u306e\u7622\u75d5\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u7622\u75d5\u3092\u9632\u3050\u306b\u306f\u3001\u5f37\u3044\u708e\u75c7\u5146\u5019\u304c\u51fa\u305f\u6642\u70b9\u3067\u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3084\u5275\u50b7\u88ab\u8986\u3067\u65e9\u671f\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u4e07\u4e00\u7622\u75d5\u304c\u6b8b\u3063\u305f\u5834\u5408\u3001\u5f8c\u7642\u6cd5\u3068\u3057\u3066<strong>\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\u30ec\u30fc\u30b6\u30fc<\/strong>\u3084<strong>\u5c40\u6240\u30b9\u30c6\u30ed\u30a4\u30c9\u6ce8\u5c04<\/strong>\u306a\u3069\u7622\u75d5\u6cbb\u7642\u304c\u5225\u9014\u5fc5\u8981\u3068\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7d05\u6591\u30fb\u708e\u75c7\u53cd\u5fdc:<\/strong> \u30ec\u30fc\u30b6\u30fc\u76f4\u5f8c\u306e\u7167\u5c04\u90e8\u4f4d\u306f\u4e00\u904e\u6027\u306e\u7d05\u6591\u30fb\u6d6e\u816b\u304c\u751f\u3058\u308b\u3002\u901a\u5e38\u6570\u65e5\u3067\u53ce\u307e\u308b\u304c\u3001\u5f37\u3044\u708e\u75c7\u304c\u9577\u5f15\u304f\u3068\u8272\u7d20\u6c88\u7740\u3084\u7622\u75d5\u306e\u30ea\u30b9\u30af\u3068\u306a\u308b\u305f\u3081\u3001<strong>\u51b7\u5374<\/strong>\u3084<strong>\u30b9\u30c6\u30ed\u30a4\u30c9\u8edf\u818f\u5857\u5e03<\/strong>\u3067\u708e\u75c7\u3092\u901f\u3084\u304b\u306b\u6c88\u9759\u5316\u3055\u305b\u308b\u3002\u307e\u305f\u30d4\u30fc\u30ea\u30f3\u30b0\u5f8c\u306e\u4e00\u6642\u7684\u306a\u76ae\u819a\u306e\u4e7e\u71e5\u30fb\u843d\u5c51\u3084\u8efd\u3044\u523a\u6fc0\u611f\u3082\u3088\u304f\u3042\u308b\u526f\u4f5c\u7528\u3067\u3042\u308a\u3001\u4fdd\u6e7f\u5264\u3084\u5916\u7528\u30b9\u30c6\u30ed\u30a4\u30c9\u3067\u5bfe\u5fdc\u3059\u308b\u3002\u708e\u75c7\u304c\u5f37\u3044\u5834\u5408\u306f\u6cbb\u7642\u9593\u9694\u3092\u5ef6\u3070\u3057\u3001\u808c\u304c\u5341\u5206\u56de\u5fa9\u3057\u3066\u304b\u3089\u6b21\u56de\u6cbb\u7642\u3092\u884c\u3046\u306a\u3069\u8abf\u6574\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u76ae\u819a\u840e\u7e2e\u30fb\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35:<\/strong> \u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3092\u9577\u671f\u306b\u308f\u305f\u3063\u3066\u4f7f\u7528\u3059\u308b\u3068\u3001\u76ae\u819a\u304c\u8584\u304f\u306a\u308a\u6bdb\u7d30\u8840\u7ba1\u304c\u900f\u898b\u3055\u308c\u308b\u6050\u308c\u304c\u3042\u308b\u3002\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u30af\u30ea\u30fc\u30e0\u306a\u3069\u306b\u30b9\u30c6\u30ed\u30a4\u30c9\u304c\u542b\u307e\u308c\u308b\u5834\u5408\u306f\u3001\u6cbb\u7642\u671f\u9593\u30928\u9031\u7a0b\u5ea6\u306b\u7559\u3081\u3001\u305d\u308c\u4ee5\u4e0a\u306f\u4f11\u85ac\u3082\u3057\u304f\u306f\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u7dad\u6301\u7642\u6cd5\u306b\u5207\u308a\u66ff\u3048\u308b\u3002\u307e\u305f\u5f37\u529b\u306a\u30d4\u30fc\u30ea\u30f3\u30b0\u3092\u983b\u56de\u306b\u884c\u3046\u3068\u4e00\u6642\u7684\u306b\u76ae\u819a\u304c\u8584\u304f\u306a\u308a\u3001\u8d64\u3089\u9854\u306e\u3088\u3046\u306b\u306a\u308b\u5834\u5408\u304c\u3042\u308b\u304c\u3001\u3053\u308c\u306f\u65bd\u8853\u9593\u9694\u3092\u9069\u5207\u306b\u3068\u308c\u3070\u6539\u5584\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5168\u8eab\u7684\u526f\u4f5c\u7528:<\/strong> \u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5185\u670d\u3067\u306f\u3054\u304f\u7a00\u306b\u6d88\u5316\u5668\u75c7\u72b6\uff08\u60aa\u5fc3\u306a\u3069\uff09\u3084\u8840\u6813\u50be\u5411\u306e\u4e0a\u6607\u304c\u554f\u984c\u3068\u306a\u308b\u3002\u65e2\u5f80\u6b74\u3092\u78ba\u8a8d\u3057\u3001\u75c7\u72b6\u304c\u51fa\u305f\u3089\u4e2d\u6b62\u3059\u308b\u3002\u307e\u305f\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3C\u306f\u814e\u7d50\u77f3\u3092\u4fc3\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u6c34\u5206\u3092\u5341\u5206\u6442\u53d6\u3055\u305b\u308b\u3002\u3053\u308c\u3089\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u304c\u3001\u60a3\u8005\u306b\u8aac\u660e\u3057\u3066\u304a\u304f\u3053\u3068\u3067\u4e0d\u5b89\u8efd\u6e1b\u306b\u3064\u306a\u304c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0a\u306e\u3088\u3046\u306a\u5408\u4f75\u75c7\u306f\u3001\u9069\u5207\u306a\u4e88\u9632\u3068\u65e9\u671f\u5bfe\u5fdc\u3067\u307b\u3068\u3093\u3069\u56de\u907f\u53ef\u80fd\u3067\u3042\u308b\u3002\u7279\u306bPIH\u3068\u7622\u75d5\u306f\u7f8e\u5bb9\u6cbb\u7642\u306b\u304a\u3044\u3066\u907f\u3051\u305f\u3044\u4e8c\u5927\u526f\u4f5c\u7528\u3067\u3042\u308b\u305f\u3081\u3001\u65bd\u8853\u524d\u306e\u6ce8\u610f\u6df1\u3044\u8a55\u4fa1\u3068\u8853\u5f8c\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u6b20\u304b\u305b\u306a\u3044<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20treatment%20modalities%20include%20use,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=to%20avoid%20necrosis%20or%20blistering,of%20permanent%20depigmentation%20and%20scarring\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411\u3068\u65b0\u6280\u8853<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u6cbb\u7642\u30fb\u75c5\u614b\u89e3\u660e\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u30c8\u30d4\u30c3\u30af\u3092\u7d39\u4ecb\u3059\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc\u306e\u9032\u6b69:<\/strong> \u524d\u8ff0\u306e\u901a\u308a\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc\u306f\u5f93\u6765\u306e\u30ca\u30ce\u79d2\u30ec\u30fc\u30b6\u30fc\u306b\u6bd4\u3079\u30e1\u30e9\u30cb\u30f3\u7c92\u5b50\u3092\u3088\u308a\u5fae\u7d30\u306b\u7834\u7815\u3067\u304d\u3001\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u3082\u8d77\u3053\u308a\u306b\u304f\u3044\u3068\u3044\u3046\u5229\u70b9\u304b\u3089\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=match%20at%20L169%20%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F,%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u65e5\u672c\u3067\u30822020\u5e74\u4ee3\u306b\u5165\u308a\u7f8e\u5bb9\u76ae\u819a\u79d1\u9818\u57df\u3067\u6025\u901f\u306b\u666e\u53ca\u3057\u59cb\u3081\u3066\u304a\u308a\u3001\u7279\u306b\u523a\u9752\u9664\u53bb\u3001\u592a\u7530\u6bcd\u6591\u30fbADM\u3001\u96e3\u6cbb\u6027\u306e\u8001\u4eba\u6027\u8272\u7d20\u6591\u306a\u3069\u3078\u306e\u9069\u5fdc\u304c\u5e83\u304c\u3063\u3066\u3044\u308b\u3002\u809d\u6591\u3078\u306e\u76f4\u63a5\u9069\u5fdc\u306f\u614e\u91cd\u3060\u304c\u3001\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc\u306b<strong>\u30c7\u30e5\u30a2\u30eb\u6ce2\u9577\u30e2\u30fc\u30c9<\/strong>\u3084<strong>\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\u30ec\u30f3\u30ba<\/strong>\u3092\u642d\u8f09\u3057\u3001\u809d\u6591\u3092\u60aa\u5316\u3055\u305b\u305a\u306b\u771f\u76ae\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u52b9\u679c\u3092\u5f97\u308b\u8a66\u307f\u3082\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u4e00\u90e8\u306e\u5831\u544a\u3067\u306f\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u306e\u4f4e\u51fa\u529b\u30d5\u30e9\u30af\u30b7\u30e7\u30ca\u30eb\u7167\u5c04\u304c\u809d\u6591\u306b\u6709\u52b9\u3067\u3042\u3063\u305f\u3068\u3055\u308c\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5f85\u305f\u308c\u308b\u3002\u4eca\u5f8c\u3082\u30d4\u30b3\u79d2\u53f0\u306e\u8d85\u77ed\u30d1\u30eb\u30b9\u30ec\u30fc\u30b6\u30fc\u6280\u8853\u306e\u6539\u826f\u306b\u3088\u308a\u3001\u3088\u308a\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u8272\u7d20\u6591\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u89e3\u6790\u3068\u5206\u5b50\u6a19\u7684:<\/strong> \u8272\u7d20\u6027\u75be\u60a3\u306e\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u3084\u5206\u5b50\u6a5f\u5e8f\u306e\u89e3\u660e\u304c\u9032\u3093\u3067\u3044\u308b\u3002\u4f8b\u3068\u3057\u3066\u592a\u7530\u6bcd\u6591\u30fb\u9752\u8272\u6bcd\u6591\u3067\u306f<strong>GNAQ\/GNA11<\/strong>\u5909\u7570\u304c\u898b\u3064\u304b\u308a\u3001\u3053\u308c\u3089\u306f\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5897\u6b96\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u3068\u8003\u3048\u3089\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=How%20does%20dermal%20melanocytosis%20arise%2C,and%20who%20is%20at%20risk\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u809d\u6591\u306b\u95a2\u3057\u3066\u3082\u3001\u771f\u76ae\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u56e0\u5b50\u3084\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u5e79\u7d30\u80de\u56e0\u5b50\uff08SCF\/c-kit\u7d4c\u8def\uff09\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=known%20to%20induce%20increased%20production,melasma%20are%20doomed%20to%20fail\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u307e\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u5206\u5316\u3084\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u306e\u7814\u7a76\u304b\u3089\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u304c\u6a21\u7d22\u3055\u308c\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070<strong>MITF<\/strong>\uff08\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u30de\u30b9\u30bf\u30fc\u8ee2\u5199\u56e0\u5b50\uff09\u3084<strong>PAR-2<\/strong>\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53-2\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u53d6\u8fbc\u307f\u306b\u95a2\u4e0e\uff09\u306a\u3069\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u8272\u7d20\u6c88\u7740\u3092\u6291\u3048\u308b\u7814\u7a76\u304c\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Previous%20studies%20have%20reported%20a,this%20by%20activating%20the%20microphthalmia\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u6a19\u7684\u7642\u6cd5\u306f\u307e\u3060\u57fa\u790e\u7814\u7a76\u6bb5\u968e\u3060\u304c\u3001\u5c06\u6765\u7684\u306b\u306f\u753b\u671f\u7684\u306a\u5185\u670d\u85ac\u3084\u5916\u7528\u85ac\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5e79\u7d30\u80de\u7642\u6cd5\u30fb\u30a8\u30af\u30bd\u30bd\u30fc\u30e0:<\/strong> \u518d\u751f\u533b\u7642\u306e\u89b3\u70b9\u304b\u3089\u3001<strong>\u5e79\u7d30\u80de<\/strong>\u3084\u305d\u3053\u304b\u3089\u653e\u51fa\u3055\u308c\u308b<strong>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0<\/strong>\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u306e\u8abf\u7bc0\u306b\u306f\u76ae\u819a\u306e\u5fae\u5c0f\u74b0\u5883\u304c\u5f71\u97ff\u3059\u308b\u304c\u3001\u5e79\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u306f\u6297\u708e\u75c7\u4f5c\u7528\u3084\u7d44\u7e54\u4fee\u5fa9\u4fc3\u9032\u4f5c\u7528\u304c\u3042\u308a\u3001\u809d\u6591\u306e\u3088\u3046\u306a\u6162\u6027\u708e\u75c7\u30fb\u8840\u7ba1\u5897\u751f\u3092\u4f34\u3046\u8272\u7d20\u6c88\u7740\u306b\u6709\u7528\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.dravaliani.com\/how-exosomes-may-help-melasma-new-hope-that-is-offering-safe-and-effective-solution-to-a-very-challenging-problem\/#:~:text=,collagen%20synthesis%2C%20and%20modulating%20melanogenesis\" target=\"_blank\" rel=\"noreferrer noopener\">dravaliani.com<\/a>\u3002\u5b9f\u969b\u3001\u30d2\u30c8\u81cd\u5e2f\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u30de\u30a4\u30af\u30ed\u30cb\u30fc\u30c9\u30eb\u3067\u9854\u9762\u306b\u5c0e\u5165\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u5b89\u5168\u306b\u76ae\u819a\u306e\u8272\u8abf\u3084\u8cea\u611f\u304c\u6539\u5584\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06221787#:~:text=Stem%20Cell%20Derived%20Exosomes%20in,free%20therapeutic%20strategy%20in\" target=\"_blank\" rel=\"noreferrer noopener\">clinicaltrials.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12140750\/#:~:text=The%20Efficacy%20of%20Combined%20Exosome,reduction%20and%20skin%20texture%20enhancement\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u307e\u305f\u3001PRP\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\uff09\u7642\u6cd5\u3082\u81ea\u5df1\u7531\u6765\u6210\u9577\u56e0\u5b50\u306e\u52b9\u679c\u3067\u809d\u6591\u6539\u5584\u306b\u4f7f\u308f\u308c\u59cb\u3081\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f<strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u79fb\u690d<\/strong>\u306f\u5c0b\u5e38\u6027\u767d\u6591\u3067\u78ba\u7acb\u3055\u308c\u3064\u3064\u3042\u308b\u304c\u3001\u9006\u306b\u904e\u5270\u306a\u30e1\u30e9\u30cb\u30f3\u3092\u6e1b\u3089\u3059\u65b9\u5411\u3067\u306e\u7d30\u80de\u6cbb\u7642\u3082\u5c06\u6765\u7684\u306a\u7814\u7a76\u30c6\u30fc\u30de\u3068\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u65b0\u898f\u7f8e\u767d\u5264\u30fb\u7d4c\u76ae\u30c7\u30ea\u30d0\u30ea\u30fc\u6280\u8853:<\/strong> \u5f93\u6765\u306e\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306b\u4ee3\u308f\u308b\u5b89\u5168\u3067\u5f37\u529b\u306a\u7f8e\u767d\u5264\u306e\u7814\u7a76\u3082\u6d3b\u767a\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070<strong>\u30c7\u30ab\u30da\u30d7\u30c1\u30c9-12<\/strong>\u3068\u3044\u3046\u4eba\u5de5\u5408\u6210\u30da\u30d7\u30c1\u30c9\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u4f5c\u7528\u304c\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e17\u500d\u5f37\u529b\u3067\u3042\u308a\u306a\u304c\u3089\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6bd2\u6027\u304c\u4f4e\u304f\u3001\u30e1\u30e9asma\u60a3\u8005\u3067\u6709\u52b9\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=hyperpigmentation%20caused%20by%20UV%20radiation,16\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Other%20studies%20suggest%20that%20decapeptide,19\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u307e\u305f<strong>\u30a2\u30ed\u30a8\u30d9\u30e9\u8449\u30a8\u30ad\u30b9<\/strong>\u4e2d\u306e\u30a2\u30ed\u30a4\u30f3\u3001\u7518\u8349\u30a8\u30ad\u30b9\u4e2d\u306e\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306a\u3069\u5929\u7136\u7531\u6765\u306e\u7f8e\u767d\u6210\u5206\u306e\u9ad8\u6fc3\u5ea6\u914d\u5408\u88fd\u5264\u3082\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Depigmenting%20agents%20abound%20in%20a,21\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u7d4c\u76ae\u5438\u53ce\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b<strong>\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0<\/strong>\uff08DDS\uff09\u306e\u5fdc\u7528\u3082\u691c\u8a0e\u3055\u308c\u3066\u304a\u308a\u3001\u30ea\u30dd\u30bd\u30fc\u30e0\u3084\u30de\u30a4\u30af\u30ed\u30cb\u30fc\u30c9\u30eb\u3001\u8d85\u97f3\u6ce2\u5c0e\u5165\u306a\u3069\u3067\u6709\u52b9\u6210\u5206\u3092\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u307e\u3067\u5c4a\u3051\u308b\u6280\u8853\u304c\u7814\u7a76\u4e2d\u3067\u3042\u308b<a href=\"https:\/\/www.dravaliani.com\/how-exosomes-may-help-melasma-new-hope-that-is-offering-safe-and-effective-solution-to-a-very-challenging-problem\/#:~:text=,collagen%20synthesis%2C%20and%20modulating%20melanogenesis\" target=\"_blank\" rel=\"noreferrer noopener\">dravaliani.com<\/a>\u3002\u4f8b\u3048\u3070\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3092\u30de\u30a4\u30af\u30ed\u30b9\u30d5\u30a7\u30a2\u306b\u5c01\u5165\u3057\u305f\u30b2\u30eb\u88fd\u5264\u306f\u5f93\u6765\u3088\u308a\u9ad8\u3044\u7f8e\u767d\u52b9\u679c\u3092\u793a\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=Depigmenting%20agents%20abound%20in%20a,21\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u30fb\u8840\u7ba1\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1:<\/strong> \u809d\u6591\u306e\u75c5\u614b\u306b<strong>\u8840\u7ba1\u62e1\u5f35<\/strong>\u3084<strong>\u708e\u75c7<\/strong>\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u3092\u72d9\u3063\u305f\u65b0\u898f\u6cbb\u7642\u3082\u6a21\u7d22\u3055\u308c\u308b\u3002\u4f8b\u3048\u3070<strong>\u03b2\u906e\u65ad\u85ac\u306e\u5916\u7528<\/strong>\uff08\u8840\u7ba1\u65b0\u751f\u6291\u5236\uff09\u3084<strong>\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u963b\u5bb3\u5264<\/strong>\u306e\u5c40\u6240\u6295\u4e0e\u306a\u3069\u3082\u7814\u7a76\u6bb5\u968e\u306b\u3042\u308b\u3002\u307e\u305f<strong>\u5149\u7dda\u529b\u5b66\u7684\u7642\u6cd5(PDT)\u3067\u30e1\u30e9\u30cb\u30f3\u3067\u306f\u306a\u304f\u708e\u75c7\u7d30\u80de\u3084\u8840\u7ba1\u306b\u50cd\u304d\u304b\u3051\u809d\u6591\u3092\u6cbb\u7642\u3059\u308b\u8a66\u307f\u3082\u5c11\u6570\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u4f4e\u51fa\u529b\u30ec\u30fc\u30b6\u30fc\u3084LED\u306b\u3088\u308b\u30d5\u30a9\u30c8\u30d0\u30a4\u30aa\u30e2\u30b8\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/strong>\u306f\u3001\u708e\u75c7\u3092\u6291\u3048\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u3092\u4fc3\u3059\u3053\u3068\u3067\u809d\u6591\u306b\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38018017\/#:~:text=Photobiomodulation%20for%20melasma%20treatment%3A%20Integrative,PBM%20shows%20potential%20in%20reducing\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u6700\u65b0\u306e\u7814\u7a76\u306f\u30e1\u30e9\u30cb\u30f3\u305d\u306e\u3082\u306e\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u5468\u8fba\u74b0\u5883\uff08\u708e\u75c7\u30fb\u8840\u7ba1\u30fb\u7dda\u7dad\uff09\u3084\u4e0a\u6d41\u306e\u5236\u5fa1\u6a5f\u69cb\uff08\u907a\u4f1d\u5b50\u30fb\u7d30\u80de\u5916\u5c0f\u80de\uff09\u306b\u307e\u3067\u5e83\u304c\u3063\u3066\u3044\u308b\u3002\u8fd1\u3044\u5c06\u6765\u3001\u3053\u308c\u3089\u65b0\u6280\u8853\u306e\u4e00\u90e8\u304c\u5b9f\u7528\u5316\u3055\u308c\u3001\u5f93\u6765\u96e3\u6cbb\u3060\u3063\u305f\u8272\u7d20\u6027\u75be\u60a3\u306b\u3082\u753b\u671f\u7684\u306a\u6cbb\u7642\u304c\u767b\u5834\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9f\u81e8\u5e8a\u3078\u306e\u5fdc\u7528\u3068\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6307\u91dd<\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306f\u3001\u591a\u304f\u306e\u7814\u7a76\u3068\u81e8\u5e8a\u7d4c\u9a13\u306b\u57fa\u3065\u3044\u3066\u4f53\u7cfb\u5316\u3055\u308c\u3066\u304d\u3066\u3044\u308b\u3002\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7dcf\u5408\u7684\u30a2\u30d7\u30ed\u30fc\u30c1:<\/strong> \u4e00\u3064\u306e\u6cbb\u7642\u6cd5\u306b\u56fa\u57f7\u305b\u305a\u3001\u60a3\u8005\u306e\u75c5\u5909\u30bf\u30a4\u30d7\u30fb\u76ae\u819a\u30bf\u30a4\u30d7\u306b\u5408\u308f\u305b\u3066\u8907\u6570\u306e\u624b\u6bb5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=A%20variety%20of%20topical%20treatments,of%20salicylic%20acid%20peel%20and\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002\u4f8b\u3048\u3070\u809d\u6591\u3067\u306f\u65e5\u713c\u3051\u6b62\u3081+\u5916\u7528+\u5185\u670d+\u65bd\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u59cb\u3081\u3001\u7d4c\u904e\u3092\u898b\u306a\u304c\u3089\u8abf\u6574\u3059\u308b\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u3082\u5358\u4e00\u6cbb\u7642\u3088\u308a\u4f75\u7528\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u304c\u591a\u3044<a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=agents%20include%20hydroquinone%2C%20tretinoin%20cream%2C,Kligman%20formula%20of%20hydroquinone%202\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=topical%20tretinoin%20treatment%20was%20better,skinned%20Indians.%20%5B6\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u7acb:<\/strong> \u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3084\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u84c4\u7a4d\u306b\u3088\u308a\u3001\u52b9\u679c\u306e\u78ba\u304b\u306a\u6cbb\u7642\u3068\u305d\u3046\u3067\u306a\u3044\u6cbb\u7642\u304c\u660e\u78ba\u306b\u306a\u308a\u3064\u3064\u3042\u308b\u3002\u4f8b\u3068\u3057\u3066\u809d\u6591\u6cbb\u7642\u3067\u306f\u3001\u300c\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5358\u72ec\u7642\u6cd5\u304a\u3088\u3073\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u7642\u6cd5\uff08HQ+RA+\u30b9\u30c6\u30ed\u30a4\u30c9\uff09\u304c\u4f9d\u7136\u3068\u3057\u3066\u91d1\u6a19\u6e96\u3067\u3042\u308b\u300d\u3053\u3068\u3084\u3001\u300cHQ\u3001\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u3001\u65e5\u713c\u3051\u6b62\u3081\u3001\u30b3\u30a6\u30b8\u9178\u3001\u30a2\u30bc\u30e9\u30a4\u30f3\u9178\u5916\u7528\u306fGrade A\u306e\u63a8\u5968\u3067\u3042\u308b\u300d\u3053\u3068\u304c2023\u5e74\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u793a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38099013\/#:~:text=Review%20pubmed,acid%20receive%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u4e00\u65b9\u3001\u30d3\u30bf\u30df\u30f3C\u3084\u30a2\u30eb\u30d6\u30c1\u30f3\u306a\u3069\u306f\u52b9\u679c\u306f\u3042\u308b\u304c\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306f\u3084\u3084\u52a3\u308b\uff08Grade B\u7a0b\u5ea6\uff09\u3068\u3055\u308c\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38099013\/#:~:text=Review%20pubmed,acid%20receive%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u5185\u670d\u3067\u306f\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u591a\u304f\u306eRCT\u304c\u652f\u6301\u3057\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=by%20Lajevardi%20et%20al,In%20a\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027\u3068\u30ea\u30b9\u30af\u7ba1\u7406:<\/strong> \u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u6709\u52b9\u6027\u3060\u3051\u3067\u306a\u304f\u5b89\u5168\u6027\u3082\u91cd\u8996\u3055\u308c\u308b\u3002\u4f8b\u3048\u3070HQ\u306f\u6709\u52b9\u3067\u306f\u3042\u308b\u304c\u9577\u671f\u4f7f\u7528\u30ea\u30b9\u30af\u304b\u3089\u6b27\u5dde\u3067\u306f\u4e00\u822c\u5316\u7ca7\u54c1\u3078\u306e\u914d\u5408\u304c\u7981\u6b62\u3055\u308c\u3066\u304a\u308a\u3001\u65e5\u672c\u3067\u3082\u6f2b\u7136\u3068\u4f7f\u308f\u305a\u52b9\u679c\u304c\u982d\u6253\u3061\u306b\u306a\u308c\u3070\u4e00\u65e6\u4e2d\u6b62\u3059\u308b\u306a\u3069\u306e\u6307\u91dd\u304c\u5fc5\u8981\u3067\u3042\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=melasma%20patient%20groups%20applied%20with,hydroquinone%20use%20were%20also%20raised34\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30ec\u30fc\u30b6\u30fc\u306b\u3064\u3044\u3066\u3082\u3001\u809d\u6591\u3078\u306e\u5b89\u6613\u306a\u7167\u5c04\u306f\u4e00\u6642\u7684\u6539\u5584\u304c\u3042\u3063\u3066\u3082\u9577\u671f\u7684\u306b\u9006\u52b9\u679c\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u3001\u307e\u305a\u5916\u7528\u3067\u7c98\u308a\u5f37\u304f\u6cbb\u7642\u3057\u3001\u305d\u308c\u3067\u3082\u6b8b\u308b\u5834\u5408\u306e\u307f\u7167\u5c04\u3092\u8003\u616e\u3059\u308b\u306a\u3069\u6bb5\u968e\u7684\u6226\u7565\u304c\u63a8\u5968\u3055\u308c\u308b<a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=,hue%20than%20prior%20to%20treatment\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u306e\u7f8e\u5bb9\u76ae\u819a\u79d1\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff08\u6b63\u5f0f\u306a\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u5b58\u5728\u3057\u306a\u3044\u3082\u306e\u306e\u3001\u5c02\u9580\u5bb6\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\uff09\u306f\u3001\u300c\u5f37\u3044\u6cbb\u7642\u307b\u3069\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u3082\u4e0a\u304c\u308b\u305f\u3081\u3001\u5e38\u306b\u526f\u4f5c\u7528\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u3068\u60a3\u8005\u6559\u80b2\u3092\u884c\u3044\u306a\u304c\u3089\u6cbb\u7642\u3092\u9032\u3081\u308b\u300d\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b<a href=\"https:\/\/sakihifuka.com\/blog\/column\/%E8%82%9D%E6%96%91%E3%82%92%E5%88%B6%E3%81%99%E3%82%8B%E3%81%AB%E3%81%AF%E8%82%9D%E6%96%91%E3%82%92%E8%89%AF%E3%81%8F%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%8B%E3%82%89%E3%80%82\/#:~:text=%E8%82%9D%E6%96%91%E3%82%92%E5%88%B6%E3%81%99%E3%82%8B%E3%81%AB%E3%81%AF%E8%82%9D%E6%96%91%E3%82%92%E8%89%AF%E3%81%8F%E7%9F%A5%E3%82%8B%E3%81%93%E3%81%A8%E3%81%8B%E3%82%89%E3%80%82%20,%E6%97%A5%E5%85%89%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%29%E3%81%A7%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E3%82%92%E5%90%AB%E6%9C%89%E3%81%97%E3%81%9F%E7%95%B0%E5%B8%B8%E8%A7%92%E5%8C%96%E7%B4%B0%E8%83%9E\" target=\"_blank\" rel=\"noreferrer noopener\">sakihifuka.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u60a3\u8005\u6559\u80b2\u3068\u9577\u671f\u7ba1\u7406:<\/strong> \u8272\u7d20\u6027\u75c5\u5909\u306f\u518d\u767a\u3057\u5f97\u308b\u6162\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u60a3\u8005\u306b\u73fe\u5b9f\u7684\u306a\u76ee\u6a19\u8a2d\u5b9a\u3092\u7406\u89e3\u3057\u3066\u3082\u3089\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002\u5b8c\u5168\u306b\u6d88\u3059\u3053\u3068\u304c\u96e3\u3057\u3044\u5834\u5408\u3082\u3042\u308a\u3001<strong>\u6539\u5584\u7387<\/strong>\u3068\u3057\u3066\u76ee\u6a19\u3092\u5171\u6709\u3059\u308b\u3002\u307e\u305f\u6cbb\u7642\u7d42\u4e86\u5f8c\u3082\u65e5\u5e38\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\uff08\u906e\u5149\u30fb\u4fdd\u6e7f\u30fb\u7f8e\u767d\u5264\uff09\u3092\u7d9a\u3051\u308b\u3053\u3068\u3067\u518d\u767a\u3092\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u8aac\u660e\u3059\u308b\u3002\u7279\u306b\u809d\u6591\u306f\u518d\u767a\u304c\u5e38\u3067\u3042\u308a\u3001\u60a3\u8005\u3068\u4e8c\u4eba\u4e09\u811a\u3067<strong>\u7dad\u6301\u7642\u6cd5<\/strong>\u3092\u7d99\u7d9a\u3059\u308b\u59ff\u52e2\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u9650\u754c\u3068\u500b\u5225\u5316\u533b\u7642:<\/strong> \u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u306b\u306f\u500b\u4eba\u5dee\u304c\u5927\u304d\u304f\u3001\u540c\u3058\u6cbb\u7642\u3067\u3082\u52b9\u304f\u4eba\u30fb\u52b9\u304b\u306a\u3044\u4eba\u304c\u3044\u308b\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u96c6\u56e3\u3068\u3057\u3066\u306e\u50be\u5411\u3092\u793a\u3059\u304c\u3001\u5b9f\u81e8\u5e8a\u3067\u306f<strong>\u30c6\u30fc\u30e9\u30fc\u30e1\u30a4\u30c9<\/strong>\u306e\u767a\u60f3\u3067\u3001\u52b9\u679c\u5224\u5b9a\u3068\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3092\u7e70\u308a\u8fd4\u3057\u6700\u9069\u89e3\u3092\u63a2\u308b\u3053\u3068\u306b\u306a\u308b\u3002\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u5f93\u6765\u306e\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u306a\u3044\u96e3\u6cbb\u4f8b\u3082\u304a\u308a\u3001\u305d\u306e\u5834\u5408\u306f\u6700\u65b0\u306e\u6cbb\u9a13\u7684\u6cbb\u7642\uff08\u4f8b\u3048\u3070Cyspera\u00ae\u30af\u30ea\u30fc\u30e0\uff08\u30b7\u30b9\u30c6\u30a2\u30df\u30f3\uff09\u3084\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u306e\u8a66\u7528\u306a\u3069\uff09\u3082\u8003\u616e\u3059\u308b\u3002\u500b\u3005\u306e\u60a3\u8005\u80cc\u666f\uff08\u598a\u5a20\u5e0c\u671b\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3001\u8cbb\u7528\u8ca0\u62c5\u610f\u8b58\uff09\u3082\u8003\u616e\u3057\u3001EBM\uff08\u79d1\u5b66\u7684\u6839\u62e0\uff09\u3068<strong>\u60a3\u8005\u4e2d\u5fc3\u306e\u533b\u7642<\/strong>\u3092\u7d71\u5408\u3057\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7406\u60f3\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u6700\u5f8c\u306b\u3001\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u6cbb\u7642\u306f\u7d76\u3048\u305a\u9032\u6b69\u3057\u3066\u3044\u308b\u5206\u91ce\u3067\u3042\u308b\u3002\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u3067\u3042\u308b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3084\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3082\u3001\u4eca\u5f8c\u3055\u3089\u306b\u52b9\u679c\u7684\u304b\u3064\u5b89\u5168\u306a\u65b0\u85ac\u30fb\u65b0\u6280\u8853\u306b\u7f6e\u304d\u63db\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u533b\u7642\u8005\u306f\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u5e38\u306b\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\u3057\u3064\u3064\u3001\u60a3\u8005\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u5584\u306e\u6cbb\u7642\u8a08\u753b\u3092\u63d0\u4f9b\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308b<a href=\"https:\/\/www.droracle.ai\/articles\/149175\/what-is-the-best-treatment-for-melasma#:~:text=What%20is%20the%20best%20treatment,a%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">droracle.ai<\/a><a href=\"https:\/\/www.droracle.ai\/articles\/149175\/what-is-the-best-treatment-for-melasma#:~:text=A%20systematic%20review%20of%20174,a%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">droracle.ai<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e:<\/strong> \u672c\u7ae0\u3067\u5f15\u7528\u3057\u305f\u6587\u732e\u30fb\u60c5\u5831\u6e90\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Melasma#:~:text=Melasma%20,3\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=US%20frequency\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1068640-overview#:~:text=Melasma%20is%20much%20more%20common,and%20histologic%20picture%20is%20identical\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/naevus-of-ota-ito-hori#:~:text=Naevi%20of%20Ota%20and%20Ito,naevi%20are%20uncommon%20in%20Caucasians\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jslsm\/45\/1\/45_jslsm-45_0007\/_article\/-char\/ja\/#:~:text=%E7%99%BA%E6%8C%AF%E6%99%82%E9%96%93%E3%81%AE%E9%9D%9E%E5%B8%B8%E3%81%AB%E7%9F%AD%E3%81%84%E3%83%94%E3%82%B3%E7%A7%92%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%81%AF%E3%83%A1%E3%83%A9%E3%83%8B%E3%83%B3%E8%89%B2%E7%B4%A0%E6%80%A7%E7%96%BE%E6%82%A3%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E8%80%81%E4%BA%BA%E6%80%A7%E8%89%B2%E7%B4%A0%E6%96%91%E3%81%A7%E3%81%AF%E8%96%84%E3%81%84%E8%89%B2%E8%AA%BF%E3%81%AB%E6%9C%89%E5%8A%B9%E3%81%A7%EF%BC%8C%E3%81%8B%E3%81%A4%E7%82%8E%E7%97%87%E5%BE%8C%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80%E3%81%AE%E7%99%BA%E7%94%9F%E7%8E%87%E3%81%8C%E4%BD%8E%E3%81%84%EF%BC%8E%E3%81%BE%E3%81%9F%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%B2%BB%20%E7%99%82%E3%81%AB%E3%82%82%E8%A3%9C%E5%8A%A9%E7%9A%84%E3%81%AB%E7%94%A8%E3%81%84%E3%82%8B%EF%BC%8E%E3%81%95%E3%82%89%E3%81%AB%E3%81%AF%E9%A1%94%E5%85%A8%E4%BD%93%E3%81%AB%E5%AF%BE%E3%81%97%E3%81%A6%E8%A4%87%E6%95%B0%E3%81%AE%E6%B3%A2%E9%95%B7%E3%82%92%E7%B5%84%E3%81%BF%E5%90%88%E3%82%8F%E3%81%9B%E3%81%9F%E6%89%8B%E6%B3%95%E3%82%82%E5%8F%AF%E8%83%BD%E3%81%A7%E3%81%82%E3%82%8B%EF%BC%8E%E3%81%97%E3%81%8B%E3%81%97%E3%81%AA%E3%81%8C%E3%82%89%E5%85%A8%E3%81%A6%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E5%BE%93%E6%9D%A5%E3%81%AE%E3%83%8A%E3%83%8E%E7%A7%92%E7%99%BA%E6%8C%AFQ%E3%82%B9%E3%82%A4%E3%83%83%E3%83%81%E3%83%AC%E3%83%BC%E3%82%B6%E3%83%BC%E3%82%88%E3%82%8A%E5%84%AA%E3%82%8C%E3%81%A6%E3%81%84%E3%82%8B%E3%82%8F%20%E3%81%91%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84%EF%BC%8E\" target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=Topical%20skin,Along%20with\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11148313\/#:~:text=and%205,several%20reports%20of%20exogenous%20ochronosis\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38099013\/#:~:text=Review%20pubmed,acid%20receive%20grade%20A%20recommendation\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/emedicine.medscape.com\/article\/1069191-overview#:~:text=A%20variety%20of%20topical%20treatments,5%5D%20%C2%A0Another\" target=\"_blank\" rel=\"noreferrer noopener\">emedicine.medscape.com<\/a>\uff08\u4ed6\u3001\u6587\u4e2d\u306b\u793a\u3057\u305f\u5f15\u7528\u7b87\u6240\u3092\u53c2\u7167\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3 \u5b9a\u7fa9\u3068\u6982\u8981 \u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u6027\u75be\u60a3\u3068\u306f\u3001\u76ae\u819a\u306e\u30e1\u30e9\u30cb\u30f3\u6c88\u7740\u7570\u5e38\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u8272\u7d20\u6591\u30fb\u8272\u7d20\u6c88\u7740\u306e\u7dcf\u79f0\u3067\u3042\u308b\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u76ae\u819a\u306e\u8272\u8abf\u3092\u6c7a\u5b9a\u3059\u308b\u8272\u7d20\u3067\u3042\u308a\u3001\u7a2e\u3005\u306e\u8981\u56e0\u3067\u7523\u751f\u30fb\u5206\u5e03\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u5c40\u6240\u7684\u306a\u8336\u8910\u8272\u304b\u3089\u9ed2 [&hellip;]","protected":false},"author":1,"featured_media":775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[38],"tags":[],"class_list":["post-774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-38"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/rmnw.jp\/wp-content\/uploads\/2025\/08\/image-31.png?fit=1024%2C768&ssl=1","jetpack_sharing_enabled":true,"jetpack_likes_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=774"}],"version-history":[{"count":6,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/774\/revisions"}],"predecessor-version":[{"id":1051,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/posts\/774\/revisions\/1051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=\/wp\/v2\/media\/775"}],"wp:attachment":[{"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rmnw.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}