{"id":724,"date":"2025-08-08T13:12:08","date_gmt":"2025-08-08T04:12:08","guid":{"rendered":"https:\/\/rmnw.jp\/?p=724"},"modified":"2025-08-29T15:25:36","modified_gmt":"2025-08-29T06:25:36","slug":"d06-%e7%be%8e%e5%ae%b9%e7%9a%ae%e8%86%9a%e7%a7%91%e5%8c%bb%e5%90%91%e3%81%91%e3%83%a1%e3%83%a9%e3%83%8b%e3%83%b3%e5%ad%a6%e3%81%ae%e8%a9%b3%e7%b4%b0%e8%aa%bf%e6%9f%bbv1-0","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/?p=724","title":{"rendered":"D06.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66\u3000\u30e1\u30e9\u30cb\u30f3\u3000V1.1"},"content":{"rendered":"\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/08\/D06.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66-\u30e1\u30e9\u30cb\u30f3-V1.1.mp3\"><\/audio><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"D06 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class=\"wp-block-heading\">\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u7406\u5b66\u3068\u5206\u5b50\u69cb\u9020<\/h2>\n\n\n\n<p><strong>\u30e1\u30e9\u30cb\u30f3\u306e\u7a2e\u985e:<\/strong> \u4eba\u4f53\u306e\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u306b\u306f\u5927\u304d\u304f<strong>\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3<\/strong>\uff08\u9ed2\uff5e\u8910\u8272\u306e\u30e1\u30e9\u30cb\u30f3\uff09\u3068<strong>\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3<\/strong>\uff08\u9ec4\uff5e\u8d64\u8272\u306e\u30e1\u30e9\u30cb\u30f3\uff09\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u6bd4\u7387\u3084\u91cf\u304c\u76ae\u819a\u30fb\u6bdb\u9aea\u30fb\u8679\u5f69\u306e\u8272\u8abf\u3092\u6c7a\u5b9a\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=In%20its%20various%20forms%2C%20melanin,of%20the%20skin%20and%20eye\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u306f\u3055\u3089\u306b\u9ed2\u8272\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u3068\u8336\u8272\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u306b\u7d30\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001<strong>\u795e\u7d4c\u30e1\u30e9\u30cb\u30f3<\/strong>\uff08\u30cb\u30e5\u30fc\u30ed\u30e1\u30e9\u30cb\u30f3\uff09\u3068\u547c\u3070\u308c\u308b\u9ed2\u8272\u9854\u6599\u304c\u8133\u5185\uff08\u4e2d\u8133\u9ed2\u8cea\u3084\u9752\u6591\u6838\uff09\u306b\u3082\u5b58\u5728\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=pheomelanin%20to%20eumelanin%20expression%29\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u3044\u305a\u308c\u3082\u30a2\u30df\u30ce\u9178L-\u30c1\u30ed\u30b7\u30f3\u7531\u6765\u306e\u7a2e\u3005\u306e\u30a4\u30f3\u30c9\u30fc\u30eb\u5316\u5408\u7269\u304c\u91cd\u5408\u3057\u305f\u9ad8\u5206\u5b50\u3067\u3042\u308a\u3001\u5358\u4e00\u306e\u5316\u5b66\u69cb\u9020\u3067\u306f\u306a\u304f\u8907\u96d1\u306a\u30dd\u30ea\u30de\u30fc\u3068\u3057\u3066\u5b58\u5728\u3057\u307e\u3059\u3002\u76ae\u819a\u306e\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u306f<strong>\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0<\/strong>\u3068\u3044\u3046\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u305f\u72b6\u614b\u3067\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u3059<a target=\"_blank\" rel=\"noreferrer noopener\">kitashiro.org<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u5408\u6210\u306b\u95a2\u308f\u308b\u5206\u5b50:<\/strong> 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noopener\">spandidos-publications.com<\/a>\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u5c0f\u80de\u4f53\u3067\u5408\u6210\u3055\u308c\u30b4\u30eb\u30b8\u4f53\u3067\u68b1\u5305\u3055\u308c\u305f\u5f8c\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u819c\u306b\u8f38\u9001\u3055\u308c\u3066\u6a5f\u80fd\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=indispensable%20enzyme%20of%20melanogenesis,coordinates%20this%20system%20not%20only\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u30e1\u30e9\u30cb\u30f3\u306b\u306f\u7d2b\u5916\u7dda\u5438\u53ce\u3084\u30e9\u30b8\u30ab\u30eb\u6d88\u53bb\u4f5c\u7528\u304c\u3042\u308a\u3001\u751f\u4f53\u3092\u6709\u5bb3\u306a\u5149\u7dda\u304b\u3089\u5b88\u308b<strong>\u5149\u9632\u8b77<\/strong>\u6a5f\u80fd\u3092\u679c\u305f\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=the%20final%20product%20of%20complex,The%20present%20review\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=In%20its%20various%20forms%2C%20melanin,of%20the%20skin%20and%20eye\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u4f8b\u3048\u3070\u76ae\u819a\u3067\u306f\u3001\u57fa\u5e95\u5c64\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5185\u306b\u84c4\u7a4d\u3057\u305f\u30e1\u30e9\u30cb\u30f3\u304c\u7d2b\u5916\u7dda\u3092\u5438\u53ce\u30fb\u6563\u4e71\u3057\u3001DNA\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=the%20final%20product%20of%20complex,The%20present%20review\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u307e\u305f\u30e1\u30e9\u30cb\u30f3\u306f\u6d3b\u6027\u9178\u7d20\u7a2e\u306e\u4e2d\u548c\u306b\u3082\u95a2\u4e0e\u3057\u3001\u76ae\u819a\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=the%20final%20product%20of%20complex,The%20present%20review\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u8679\u5f69\u3084\u8108\u7d61\u819c\u306e\u30e1\u30e9\u30cb\u30f3\u3082\u773c\u7403\u5185\u3078\u306e\u904e\u5270\u306a\u5149\u7dda\u4fb5\u5165\u3092\u9632\u304e\u3001\u773c\u3092\u4fdd\u8b77\u3057\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Just%20as%20melanin%20protects%20the,related%20ocular%20issues\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u6bdb\u9aea\u306e\u8272\u3082\u30e1\u30e9\u30cb\u30f3\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u3001\u9ed2\u8272\uff5e\u8336\u8272\u306e\u6bdb\u9aea\u306f\u4e3b\u306b\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u306b\u3088\u308b\u8272\u8abf\u3067\u3001\u8d64\u8272\u6bdb\u306f\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u306e\u5272\u5408\u5897\u52a0\u306b\u3088\u308a\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Hair%20color%20is%20determined%20by,of%20various%20forms%20of%20melanin\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u76ae\u819a\u30fb\u6bdb\u9aea\u30fb\u8679\u5f69\u3078\u306e\u5206\u5e03:<\/strong> \u6b63\u5e38\u76ae\u819a\u3067\u306f\u3001\u8868\u76ae\u57fa\u5e95\u5c64\u306b\u3042\u308b<strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8<\/strong>\uff08\u8272\u7d20\u7d30\u80de\uff09\u304c\u30e1\u30e9\u30cb\u30f3\u3092\u7523\u751f\u3057\u3001\u5468\u56f2\u306e<strong>\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8<\/strong>\u3078\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3092\u4f9b\u7d66\u3057\u3066\u3044\u307e\u3059\u3002\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306f\u8868\u76ae\u7d30\u80de\u5168\u4f53\u306e\u7d048\uff5e10%\u3092\u5360\u3081\u3001\u8868\u76ae\u306e\u5168\u57df\u306b\u307b\u307c\u5747\u4e00\u306b\u5206\u5e03\u3057\u307e\u3059\uff08\u90e8\u4f4d\u306b\u3088\u3063\u3066\u5bc6\u5ea6\u5dee\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u4eba\u7a2e\u9593\u3067\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6570\u81ea\u4f53\u306f\u5927\u5dee\u3042\u308a\u307e\u305b\u3093\uff09<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=are%20the%20melanocytes%2C%20neuroectodermic%20dendritic,The%20process\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a><a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=influence%20of%20the%20neural%20tube,7\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u512a\u4f4d\u306e\u76ae\u819a\u306f\u4e00\u822c\u306b\u8272\u9ed2\u3067\u7d2b\u5916\u7dda\u8010\u6027\u304c\u9ad8\u304f\u3001\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u6bd4\u7387\u306e\u9ad8\u3044\u76ae\u819a\u306f\u8272\u767d\u3067\u3059\u304c\u7d2b\u5916\u7dda\u611f\u53d7\u6027\u304c\u9ad8\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u8272\u767d\u306e\u76ae\u819a\u3067\u306f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u304c\u57fa\u5e95\u5c64\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5185\u30672\uff5e3\u500b\u305a\u3064<strong>\u9846\u7c92\u96c6\u5408\u4f53<\/strong>\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001\u8272\u9ed2\u306e\u76ae\u819a\u3067\u306f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u304c<strong>\u5358\u4e00\u5206\u6563<\/strong>\u3057\u3066\u5927\u91cf\u306b\u84c4\u7a4d\u3057\u3046\u308b\u305f\u3081\u3001\u5f8c\u8005\u3067\u306f\u3088\u308a\u5f37\u3044\u8272\u7d20\u6c88\u7740\u304c\u751f\u3058\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=melanosomes%20in%20the%20basal%20layer,The%20overall%20melanin%20density%20correlates\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=nipples%2C%20vagina%2C%20and%20glans%20of,well%20as%20Fitzpatrick%20skin%20type\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u3088\u3046\u306a\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u5206\u5e03\u3068\u30e1\u30e9\u30cb\u30f3\u91cf\u306e\u5dee\u7570\u304c\u30d5\u30a3\u30c3\u30c4\u30d1\u30c8\u30ea\u30c3\u30af\u306e\u76ae\u819a\u30bf\u30a4\u30d7\uff08I\uff5eVI\uff09\u306e\u9055\u3044\u306b\u3082\u53cd\u6620\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=nipples%2C%20vagina%2C%20and%20glans%20of,well%20as%20Fitzpatrick%20skin%20type\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u8679\u5f69\u3067\u306f\u30e1\u30e9\u30cb\u30f3\u91cf\u304c\u591a\u3044\u3068\u8336\u8910\u8272\uff5e\u9ed2\u8272\u306e\u77b3\u3068\u306a\u308a\u3001\u5c11\u306a\u3044\u3068\u9752\u8272\u3084\u7dd1\u8272\u306b\u898b\u3048\u307e\u3059\u3002\u30e1\u30e9\u30cb\u30f3\u304c\u5c11\u306a\u3044\u8679\u5f69\u3067\u306f\u5149\u969c\u5bb3\uff08\u7729\u5149\u3084\u7d2b\u5916\u7dda\u306b\u3088\u308b\u969c\u5bb3\uff09\u304c\u751f\u3058\u3084\u3059\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Just%20as%20melanin%20protects%20the,related%20ocular%20issues\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u6bdb\u9aea\u3067\u306f\u6bdb\u6bcd\u7d30\u80de\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304b\u3089\u76ae\u8cea\u7d30\u80de\u306b\u4f9b\u7d66\u3055\u308c\u308b\u30e1\u30e9\u30cb\u30f3\u306b\u3088\u308a\u6bdb\u9aea\u8272\u304c\u6c7a\u5b9a\u3057\u3001\u9ed2\u9aea\u30fb\u8336\u9aea\u3067\u306f\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u304c\u4e3b\u4f53\u3001\u91d1\u9aea\u3067\u306f\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u304c\u5c11\u91cf\u3001\u8d64\u6bdb\u3067\u306f\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u304c\u591a\u304f\u542b\u307e\u308c\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Hair%20color%20is%20determined%20by,of%20various%20forms%20of%20melanin\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n\n\n\n<p><strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u8d77\u6e90\u3068\u6a5f\u80fd:<\/strong> \u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306f\u80da\u767a\u751f\u671f\u306b<strong>\u795e\u7d4c\u5824<\/strong>\u7531\u6765\u306e\u524d\u99c6\u7d30\u80de\uff08\u30e1\u30e9\u30ce\u30d6\u30e9\u30b9\u30c8\uff09\u304c\u8868\u76ae\u3084\u6bdb\u5305\u3001\u773c\u306a\u3069\u3078\u904a\u8d70\u30fb\u5206\u5316\u3057\u3066\u751f\u3058\u305f\u7d30\u80de\u3067\u3001\u6a39\u679d\u72b6\u306e\u7a81\u8d77\u3092\u6301\u3064\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Eumelanin%20and%20pheomelanin%20are%20produced,4\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=are%20the%20melanocytes%2C%20neuroectodermic%20dendritic,The%20process\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u76ae\u819a\u3067\u306f\u57fa\u5e95\u5c64\u306b\u4f4d\u7f6e\u3057\u3001\u6a39\u679d\u72b6\u7a81\u8d77\uff08\u30c7\u30f3\u30c9\u30e9\u30a4\u30c8\uff09\u3092\u5468\u56f2\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5c64\u3078\u4f38\u3070\u3057\u3066\u591a\u6570\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3092\u4f9b\u7d66\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Eumelanin%20and%20pheomelanin%20are%20produced,4\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u3067\u4f5c\u3089\u308c\u308b\u76f4\u5f84\u6570\u767enm\u306e\u819c\u7d50\u5408\u5c0f\u80de\u3067\u3001I\u671f\uff08\u672a\u719f\uff09\u304b\u3089IV\u671f\uff08\u6210\u719f\uff09\u307e\u3067\u6bb5\u968e\u7684\u306b\u6210\u719f\u3057\u307e\u3059\u3002\u672a\u719f\u306a\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3067\u306f\u5185\u90e8\u306b\u7dda\u7dad\u72b6\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u304c\u5f62\u6210\u3055\u308c\u308b\u3082\u306e\u306e\u30e1\u30e9\u30cb\u30f3\u306f\u6c88\u7740\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306a\u3069\u5408\u6210\u9175\u7d20\u304c\u53d6\u308a\u8fbc\u307e\u308c\u3066II\u671f\u4ee5\u964d\u306b\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u59cb\u307e\u308a\u3001III\u671f\u3067\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u304c\u5145\u586b\u3055\u308c\u3001IV\u671f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3067\u306f\u5185\u90e8\u304c\u30e1\u30e9\u30cb\u30f3\u3067\u5b8c\u5168\u306b\u9ed2\u304f\u6e80\u305f\u3055\u308c\u305f\u72b6\u614b\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/melanosome#:~:text=Stages%20II%20and%20III%20are,while%20stage%20IV%20melanosomes\" target=\"_blank\" rel=\"noreferrer noopener\">sciencedirect.com<\/a><a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/melanosome#:~:text=Melanosome%20,are%20completely%20filled%20with%20melanin\" target=\"_blank\" rel=\"noreferrer noopener\">sciencedirect.com<\/a>\u3002\u6210\u719f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6a39\u679d\u3092\u4ecb\u3057\u3001\u8868\u76ae\u57fa\u5e95\u5c64\u306e\u7d0430\uff5e40\u500b\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u3068\u8f38\u9001\u30fb\u4f9b\u7d66\u3055\u308c\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Eumelanin%20and%20pheomelanin%20are%20produced,4\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306f\u7d30\u80de\u6838\u4e0a\u65b9\u306b\u5e3d\u5b50\u72b6\u306b\u914d\u5217\u3057\uff08<strong>\u30e1\u30e9\u30cb\u30f3\u30ad\u30e3\u30c3\u30d7<\/strong>\uff09\u3001\u6838\u306eDNA\u3092\u7d2b\u5916\u7dda\u304b\u3089\u906e\u853d\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=round%20membrane,4\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u7d4c\u8def:<\/strong> \u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u3067\u306e\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u904e\u7a0b\u306f<strong>\u30e1\u30e9\u30ce\u30b8\u30a7\u30cd\u30b7\u30b9\uff08melanogenesis\uff09\u3068\u547c\u3070\u308c\u3001\u591a\u6bb5\u968e\u306e\u9175\u7d20\u53cd\u5fdc\u306b\u3088\u3063\u3066\u9032\u884c\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=months%20of%20life%20into%20the,ultraviolet\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u307e\u305a\u30a2\u30df\u30ce\u9178\u306eL-\u30c1\u30ed\u30b7\u30f3\u304c\u30d2\u30c9\u30ed\u30ad\u30b7\u30e9\u30fc\u30bc\u306b\u3088\u308aL-\u30c9\u30fc\u30d1\uff083,4-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\uff09\u306b\u5909\u63db\u3055\u308c\u3001\u6b21\u306b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc<\/strong>\u306e\u4f5c\u7528\u3067\u30c9\u30fc\u30d1\u304c\u9178\u5316\u3055\u308c\u3066<strong>\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3<\/strong>\u3092\u751f\u6210\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=The%20first%20step%20of%20biosynthesis,form%20the%20eumelanin%20or%20pheomelanin\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u6bb5\u968e\u307e\u3067\u306f\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u3068\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u306e\u7d4c\u8def\u306f\u5171\u901a\u3067\u3059\u3002\u305d\u306e\u5f8c\u306e\u5206\u5c90\u3067\u3001\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3\u306b\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u4ed8\u52a0\u3055\u308c\u308b\u7d4c\u8def\u3067\u306f\u30d9\u30f3\u30be\u30c1\u30a2\u30b8\u30f3\u8a98\u5c0e\u4f53\u3092\u7d4c\u3066<strong>\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3<\/strong>\uff08\u8d64\uff5e\u9ec4\u8272\u306e\u8272\u7d20\uff09\u304c\u751f\u6210\u3055\u308c\u3001\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u95a2\u4e0e\u3057\u306a\u3044\u7d4c\u8def\u3067\u306f\u30a4\u30f3\u30c9\u30fc\u30eb\u7cfb\u306e\u4e2d\u9593\u4f53\uff08\u30a4\u30f3\u30c9\u30fc\u30eb-5,6-\u30ad\u30ce\u30f3\u7b49\uff09\u3092\u7d4c\u3066\u9ad8\u5206\u5b50\u306e<strong>\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3<\/strong>\uff08\u8336\uff5e\u9ed2\u8272\u306e\u8272\u7d20\uff09\u3078\u3068\u91cd\u5408\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea1\uff08TRP-1\uff09\u306f\u4e2d\u9593\u4f53\u306e\u30c9\u30fc\u30d1\u30af\u30ed\u30e0\u3092\u30bf\u30a6\u30c8omer\u5316\u3057\u3066\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u5f62\u6210\u3092\u9032\u3081\u3001TRP-2\u306f5,6-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30a4\u30f3\u30c9\u30fc\u30eb-2-\u30ab\u30eb\u30dc\u30f3\u9178\u306e\u8131\u70ad\u9178\u3092\u89e6\u5a92\u3057\u3066\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u306b\u5bc4\u4e0e\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=associated%20to%20the%20Parkinson%20disease,61%2C53\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u3053\u306e\u3088\u3046\u306b\u591a\u6570\u306e\u9175\u7d20\u3068\u53cd\u5fdc\u3092\u7d4c\u3066\u30e1\u30e9\u30cb\u30f3\u304c\u5408\u6210\u30fb\u84c4\u7a4d\u3055\u308c\u308b\u306e\u3067\u3059\uff08\u56f31\u53c2\u7167\uff09\u3002<\/p>\n\n\n\n<p><strong>\u7d2b\u5916\u7dda\u3068\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff:<\/strong> <strong>\u7d2b\u5916\u7dda\uff08UV\uff09\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u523a\u6fc0\u3059\u308b\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3001\u30e1\u30e9\u30ce\u30b8\u30a7\u30cd\u30b7\u30b9\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002UVB\u7167\u5c04\u306f\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u304b\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u3084DNA\u640d\u50b7\u3092\u4ecb\u3057\u3066\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u65b0\u305f\u306a\u30e1\u30e9\u30cb\u30f3\u5408\u6210\uff08\u9045\u5ef6\u578b\u9ed2\u5316\uff09\u3092\u8a98\u5c0e\u3057\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2593890\/#:~:text=,while%20UVB%20induces%20delayed\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002UVA\u7167\u5c04\u3067\u306f\u65e2\u5b58\u306e\u30e1\u30e9\u30cb\u30f3\u3084\u524d\u99c6\u4f53\u306e\u9178\u5316\u306b\u3088\u3063\u3066\u5373\u6642\u578b\u306e\u8272\u7d20\u6697\u5316\uff08\u5373\u6642\u578b\u9ed2\u5316\uff09\u304c\u751f\u3058\u3001\u6570\u6642\u9593\u4ee5\u5185\u306b\u76ae\u819a\u304c\u5c0f\u9ea6\u8272\u306b\u898b\u3048\u308b\u5909\u5316\u3092\u3082\u305f\u3089\u3057\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2593890\/#:~:text=,while%20UVB%20induces%20delayed\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u307e\u305f\u7d2b\u5916\u7dda\u306f\u76ae\u819a\u3067\u30d7\u30ed\u30aa\u30d4\u30aa\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f3\uff08POMC\uff09\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001\u305d\u3053\u304b\u3089\u5207\u308a\u51fa\u3055\u308c\u308b\u03b1-\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08\u03b1-MSH\uff09\u3084ACTH\u304c\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u4e0a\u306eMC1\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3066\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u5408\u6210\u3092\u8a98\u5c0e\u3057\u3001\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3092\u5897\u52a0\u3055\u305b\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=The%20primary%20stimulus%20for%20melanogenesis,in%20pheomelanin%20to%20eumelanin%20expression\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u305f\u3081\u65e5\u5149\u66dd\u9732\u306b\u3088\u308a\u76ae\u819a\u306f\u5f90\u3005\u306b\u8910\u8272\u5316\uff08\u65e5\u713c\u3051\uff09\u3057\u3001\u5149\u4fdd\u8b77\u80fd\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u3068\u3044\u3063\u305f\u6027\u30db\u30eb\u30e2\u30f3<\/strong>\u3082\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306b\u5f71\u97ff\u3057\u3046\u308b\u56e0\u5b50\u3067\u3059\u3002\u598a\u5a20\u3084\u7d4c\u53e3\u907f\u598a\u85ac\u4f7f\u7528\u306b\u4f34\u3044\u8272\u7d20\u6c88\u7740\u304c\u5897\u3059\u3053\u3068\u304c\u3042\u308a\uff08\u5f8c\u8ff0\u306e\u809d\u6591\u3092\u53c2\u7167\uff09\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306fMSH\u306e\u7523\u751f\u3084\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12419#:~:text=oestrogen%20cream%20and%20the%20use,at%20the%20molecular%20level%20by\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a><a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12419#:~:text=the%20induction%20and%20upregulation%20of,new%20treatment%20targets%20for%20melasma\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u3053\u306e\u3088\u3046\u306b\u5185\u7684\u30fb\u5916\u7684\u56e0\u5b50\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u91cf\u306f\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u81e8\u5e8a\u7684\u610f\u7fa9\uff08\u8272\u7d20\u6027\u75be\u60a3\u3068\u30e1\u30e9\u30cb\u30f3\u7570\u5e38\uff09<\/h2>\n\n\n\n<p>\u76ae\u819a\u306e\u30e1\u30e9\u30cb\u30f3\u304c\u904e\u5270\u307e\u305f\u306f\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u3058\u308b\u4ee3\u8868\u7684\u306a\u8272\u7d20\u6027\u75c5\u5909\u30fb\u75be\u60a3\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8001\u4eba\u6027\u8272\u7d20\u6591\uff08Solar Lentigo\uff09:<\/strong> \u4e2d\u9ad8\u5e74\u306e\u5149\u66dd\u9732\u90e8\u4f4d\u306b\u51fa\u73fe\u3059\u308b\u5883\u754c\u660e\u77ad\u306a\u8910\u8272\u6591\u3067\u3001\u3044\u308f\u3086\u308b\u300c\u809d\u6591\uff08\u304b\u3093\u3071\u3093\uff09\u300d\u3068\u6df7\u540c\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u5225\u306e\u75be\u60a3\u3067\u3059\u3002\u75c5\u56e0\u306f\u9577\u5e74\u306b\u308f\u305f\u308b\u65e5\u5149\u66dd\u9732\u306e\u84c4\u7a4d\u306b\u3088\u308b\u3082\u306e\u3067\u3001<strong>\u7d2b\u5916\u7dda\u306b\u3088\u308b\u8868\u76ae\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3084\u8001\u5316\u73fe\u8c61\u306b\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u4ea2\u9032\u3057\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5185\u306b\u8272\u7d20\u304c\u904e\u5270\u306b\u4fdd\u6301\u3055\u308c\u308b<\/strong>\u3053\u3068\u304c\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u307e\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/lentigo-pathology#:~:text=Solar%20lentigines%20are%20benign%20lesions,abnormal%20pigment%20retention%20by%20keratinocytes\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u75c5\u7406\u5b66\u7684\u306b\u306f\u8868\u76ae\u57fa\u5e95\u5c64\u306e\u30e1\u30e9\u30cb\u30f3\u5897\u52a0\u304a\u3088\u3073\u8efd\u5ea6\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5897\u751f\u3001\u8868\u76ae\u7a81\u8d77\u306e\u80a5\u539a\u4f38\u9577\u304c\u307f\u3089\u308c\u307e\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/lentigo-pathology#:~:text=Histologically%2C%20the%20hallmark%20of%20the,elongation%20of%20the%20rete%20ridges\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/lentigo-pathology#:~:text=Histologically%2C%20there%20is%20a%20conspicuous,figure%205\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8001\u4eba\u6027\u8272\u7d20\u6591\u81ea\u4f53\u306f\u826f\u6027\u3067\u3042\u308a\u3001\u60aa\u6027\u5316\u306f\u3057\u307e\u305b\u3093\u304c\u3001\u7f8e\u5bb9\u7684\u89b3\u70b9\u304b\u3089\u6cbb\u7642\uff08\u30ec\u30fc\u30b6\u30fc\u7b49\uff09\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u809d\u6591\uff08Melasma\uff09:<\/strong> \u9854\u9762\uff08\u982c\u90e8\u3084\u984d\u3001\u4e0a\u5507\u306a\u3069\uff09\u306b\u5de6\u53f3\u5bfe\u79f0\u306e\u6de1\u8910\u8272\uff5e\u8910\u8272\u306e\u8272\u7d20\u6591\u304c\u751f\u3058\u308b\u5f8c\u5929\u6027\u76ae\u819a\u75be\u60a3\u3067\u3059\u300220\uff5e40\u4ee3\u5973\u6027\u306b\u597d\u767a\u3057\u3001\u598a\u5a20\u3084\u7d4c\u53e3\u907f\u598a\u85ac\u306b\u3088\u308b\u30db\u30eb\u30e2\u30f3\u5909\u5316\u304c\u8a98\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<strong>\u7d2b\u5916\u7dda\u66dd\u9732\u304c\u767a\u75c7\u30fb\u5897\u60aa\u306e\u4e3b\u56e0\u3067\u3042\u308a\u3001\u907a\u4f1d\u7684\u7d20\u56e0\u3084\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3082\u95a2\u4e0e\u3059\u308b\u591a\u56e0\u5b50\u6027<\/strong>\u306e\u75c5\u614b\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=epidermis%2C%20dermis%20and%20extracellular%20matrix,30\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u75c5\u7406\u5b66\u7684\u306b\u306f\u8868\u76ae\u57fa\u5e95\u5c64\u304b\u3089\u771f\u76ae\u4e0a\u5c64\u306b\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u306e\u5897\u52a0\u304c\u307f\u3089\u308c\u3001\u771f\u76ae\u306b\u306f\u30e1\u30e9\u30cb\u30f3\u3092\u8caa\u98df\u3057\u305f<strong>\u30e1\u30e9\u30ce\u30d5\u30a1\u30fc\u30b8<\/strong>\uff08\u8caa\u98df\u7d30\u80de\uff09\u306e\u5897\u52a0\u3092\u4f34\u3044\u307e\u3059\u3002Wood\u706f\u691c\u67fb\u6240\u898b\u306a\u3069\u304b\u3089\u8868\u76ae\u578b\u30fb\u771f\u76ae\u578b\u30fb\u6df7\u5408\u578b\u306b\u5206\u985e\u3055\u308c\u3001\u8868\u76ae\u578b\u3067\u306f\u30e1\u30e9\u30cb\u30f3\u5897\u52a0\u304c\u8868\u76ae\u5185\u306b\u3068\u3069\u307e\u308b\u306e\u306b\u5bfe\u3057\u3001\u771f\u76ae\u578b\u3067\u306f\u8272\u7d20\u304c\u771f\u76ae\u306b\u6c88\u7740\u3057\u3066\u7070\u8910\u8272\u8abf\u3092\u5448\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12419#:~:text=nerve%20are%20located%20%281%20%29,other%20parts%20is%20not%20obvious\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a><a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12419#:~:text=normal%20skin%20is%20not%20obvious,of%20melasma%20are%20related%20to\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u809d\u6591\u306f\u826f\u6027\u3067\u3059\u304c\u7f8e\u5bb9\u4e0a\u554f\u984c\u3068\u306a\u308a\u3001\u6cbb\u7642\u304c\u96e3\u3057\u3044\u75be\u60a3\u3067\u3082\u3042\u308a\u307e\u3059\uff08\u6cbb\u7642\u6cd5\u306f\u5f8c\u8ff0\uff09\u3002<\/li>\n\n\n\n<li><strong>\u96c0\u5375\u6591\uff08\u30a8\u30d5\u30a7\u30ea\u30b9\u3001\u3044\u308f\u3086\u308b\u300c\u305d\u3070\u304b\u3059\u300d\uff09:<\/strong> \u5c0f\u5150\u671f\u304b\u3089\u601d\u6625\u671f\u306b\u597d\u767a\u3059\u308b\u5c0f\u3055\u306a\u6de1\u8910\u8272\u6591\u70b9\u3067\u3001\u65e5\u5149\u66dd\u9732\u90e8\uff08\u9854\u9762\u3001\u624b\u80cc\u3001\u80a9\u306a\u3069\uff09\u306b\u591a\u767a\u3057\u307e\u3059\u3002\u907a\u4f1d\u7684\u7d20\u56e0\uff08\u8272\u767d\u306e\u808c\u3084\u8d64\u6bdb\u306e\u4eba\u306b\u591a\u3044\uff09\u306b\u52a0\u3048\u7d2b\u5916\u7dda\u306b\u3088\u308b\u8a98\u767a\u3067\u5897\u60aa\u3057\u3001\u590f\u5b63\u306b\u8272\u6fc3\u304f\u306a\u308a\u51ac\u5b63\u306b\u8584\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<strong>\u75c5\u5909\u90e8\u3067\u306f\u57fa\u5e95\u5c64\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306b\u304a\u3051\u308b\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u904e\u5270\u306a\u3060\u3051\u3067\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6570\u81ea\u4f53\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><a href=\"https:\/\/www.rixisdermatology.com\/freckles-ephelides#:~:text=Freckles%2C%20scientifically%20termed%20as%20ephelides%2C,and%20%2036\" target=\"_blank\" rel=\"noreferrer noopener\">rixisdermatology.com<\/a>\u3002\u3059\u306a\u308f\u3061\u300c\u8272\u7d20\u7d30\u80de\u306e\u50cd\u304d\u304c\u6d3b\u767a\u306a\u7d50\u679c\u3068\u3057\u3066\u751f\u3058\u308b\u6591\u70b9\u300d\u3067\u3059\u3002\u7121\u5bb3\u306a\u305f\u3081\u6cbb\u7642\u306e\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5e0c\u671b\u306b\u3088\u308a\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3084\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3067\u8584\u304f\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\uff08Post-inflammatory Hyperpigmentation; PIH\uff09:<\/strong> \u30cb\u30ad\u30d3\u3084\u6e7f\u75b9\u3001\u5916\u50b7\u3001\u71b1\u50b7\u3001\u65bd\u8853\u5f8c\u306a\u3069\u76ae\u819a\u306b\u751f\u3058\u305f<strong>\u708e\u75c7\u3084\u640d\u50b7\u304c\u6cbb\u7652\u3057\u305f\u5f8c\u306b\u6b8b\u308b\u4e8c\u6b21\u7684\u306a\u8272\u7d20\u6c88\u7740<\/strong>\u3067\u3059\u3002\u708e\u75c7\u306b\u3088\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u904a\u96e2\u8102\u80aa\u9178\u306e\u5f71\u97ff\u3067<strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u523a\u6fc0\u3055\u308c\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u304c\u4ea2\u9032\u3057\u3001\u5468\u56f2\u306e\u8868\u76ae\u7d30\u80de\u3078\u904e\u5270\u306b\u30e1\u30e9\u30cb\u30f3\u3092\u4f9b\u7d66\u3059\u308b<\/strong>\u3053\u3068\u3067\u767a\u751f\u3057\u307e\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Postinflammatory%20hyperpigmentation%20follows%20damage%20to,skin%20cells%29%20and%2For%20dermis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u307e\u305f\u708e\u75c7\u304c\u57fa\u5e95\u5c64\u306b\u53ca\u3093\u3067\u7d30\u80de\u969c\u5bb3\u3092\u8d77\u3053\u3059\u3068\u3001\u30e1\u30e9\u30cb\u30f3\u304c\u57fa\u5e95\u819c\u4e0b\u306e\u771f\u76ae\u306b\u6f0f\u51fa\u3057\u3001<strong>\u771f\u76ae\u5185\u306e\u8caa\u98df\u7d30\u80de\uff08\u30e1\u30e9\u30ce\u30d5\u30a1\u30fc\u30b8\uff09\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u6c88\u7740\u3059\u308b<\/strong>\u3053\u3068\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Inflammation%20in%20the%20epidermis%20stimulates,dermal%20melanosis%20or%20pigment%20incontinence\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u8868\u76ae\u5185\u306b\u3068\u3069\u307e\u308b\u8272\u7d20\u6c88\u7740\u306f\u6bd4\u8f03\u7684\u6642\u9593\u3068\u3068\u3082\u306b\u6539\u5584\u3057\u3084\u3059\u3044\u306e\u306b\u5bfe\u3057\u3001\u771f\u76ae\u5185\u306b\u30e1\u30e9\u30cb\u30f3\u304c\u3042\u308b\u5834\u5408\u306f\u7070\u8272\u304c\u304b\u3063\u305f\u8272\u8abf\u3068\u306a\u308a\u6d88\u9000\u306b\u6642\u9593\u3092\u8981\u3057\u307e\u3059\u3002PIH\u306f\u808c\u306e\u8272\u304c\u6fc3\u3044\u4eba\u307b\u3069\u751f\u3058\u3084\u3059\u304f\u3001\u30cb\u30ad\u30d3\u8de1\u306a\u3069\u3068\u3057\u3066\u3057\u3070\u3057\u3070\u554f\u984c\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u65e5\u713c\u3051\uff08tan, tanning\uff09:<\/strong> \u5f37\u3044\u65e5\u5149\u306b\u66dd\u9732\u3057\u305f\u6570\u65e5\u5f8c\u304b\u3089\u76ae\u819a\u304c\u8910\u8272\u5316\u3059\u308b\u73fe\u8c61\u3067\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u76ae\u819a\u306e\u9632\u5fa1\u53cd\u5fdc\u3067\u3059\u3002\u4e0a\u8ff0\u3057\u305f\u3088\u3046\u306b<strong>UVA\u306b\u3088\u308b\u65e2\u5b58\u30e1\u30e9\u30cb\u30f3\u306e\u9178\u5316\u3084\u518d\u5206\u5e03\u306b\u3088\u308b\u5373\u6642\u578b\u306e\u8272\u7d20\u6697\u5316<\/strong>\u3068\u3001<strong>UVB\u306b\u3088\u308b\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30fb\u30e1\u30e9\u30cb\u30f3\u65b0\u751f\u5897\u52a0\u306b\u3088\u308b\u9045\u767a\u578b\u306e\u65e5\u713c\u3051<\/strong>\u306b\u5927\u5225\u3055\u308c\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2593890\/#:~:text=,while%20UVB%20induces%20delayed\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5f8c\u8005\u3067\u306f\u66dd\u9732\u5f8c2\uff5e3\u65e5\u4ee5\u964d\u306b\u30d4\u30fc\u30af\u3068\u306a\u308b\u8910\u8272\u6591\u304c\u51fa\u73fe\u3057\u3001\u6570\u9031\u9593\u6301\u7d9a\u3057\u307e\u3059\u3002\u6162\u6027\u7684\u306a\u65e5\u713c\u3051\u306f\u5149\u8001\u5316\u306e\u4e00\u56e0\u3068\u306a\u308a\u3001\u76ae\u819a\u764c\u767a\u751f\u30ea\u30b9\u30af\u3082\u9ad8\u3081\u308b\u305f\u3081\u3001\u533b\u7642\u8005\u306f\u60a3\u8005\u306b\u5bfe\u3057\u65e5\u713c\u3051\u6b62\u3081\u4f7f\u7528\u306a\u3069\u306e\u5149\u5bfe\u7b56\u6307\u5c0e\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u767d\u6591\uff08Vitiligo\uff09:<\/strong> \u5f8c\u5929\u6027\u306b\u76ae\u819a\u306e\u30e1\u30e9\u30cb\u30f3\u304c\u6d88\u5931\u3059\u308b\u75be\u60a3\u3067\u3001\u5883\u754c\u660e\u77ad\u306a\u8131\u8272\u7d20\u6591\uff08\u767d\u6591\uff09\u304c\u4f53\u8868\u306e\u69d8\u3005\u306a\u90e8\u4f4d\u306b\u51fa\u73fe\u3057\u307e\u3059\u3002\u81ea\u5df1\u514d\u75ab\u6a5f\u5e8f\u306b\u3088\u3063\u3066\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u7834\u58ca\u3055\u308c\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=,immune%20destruction%20of%20melanocytes\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3001\u8131\u8272\u7d20\u75c5\u5909\u306f\u5916\u898b\u4e0a\u76ee\u7acb\u3064\u305f\u3081\u7cbe\u795e\u7684\u82e6\u75db\u3092\u4f34\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u60a3\u90e8\u306f\u65e5\u5149\u306b\u5bfe\u3057\u3066\u7121\u9632\u5099\u3068\u306a\u308b\u305f\u3081\u65e5\u713c\u3051\u3057\u3084\u3059\u304f\u3001\u307e\u305f\u3057\u3070\u3057\u3070\u6bdb\u9aea\u3082\u767d\u6bdb\u5316\u3057\u307e\u3059\u3002\u6cbb\u7642\u306b\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u5916\u7528\u3084\u5c40\u6240\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u3001\u5149\u7642\u6cd5\uff08\u30ca\u30ed\u30fc\u30d0\u30f3\u30c9UVB\u7167\u5c04\uff09\u306a\u3069\u304c\u884c\u308f\u308c\u307e\u3059\u304c\u3001\u518d\u8272\u7d20\u6c88\u7740\u306b\u306f\u6642\u9593\u3092\u8981\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5148\u5929\u6027\u8272\u7d20\u6b20\u4e4f\u75c7\uff08\u767d\u76ae\u75c7\u3001Albinism\uff09:<\/strong> \u751f\u6765\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u3092\u307b\u3068\u3093\u3069\u7523\u751f\u3067\u304d\u306a\u3044\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7dcf\u79f0\u3067\u3059\u3002\u4e2d\u3067\u3082\u4ee3\u8868\u7684\u306a**\u773c\u76ae\u819a\u767d\u76ae\u75c7\uff08oculocutaneous albinism, OCA\uff09**\u3067\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306a\u3069\u306b\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u7d4c\u8def\u306b\u652f\u969c\u3092\u6765\u305f\u3057\u3001\u751f\u6daf\u306b\u308f\u305f\u308a\u76ae\u819a\u30fb\u6bdb\u9aea\u304c\u767d\u8272\uff5e\u6de1\u9ec4\u8272\u3067\u77b3\u5b54\u306f\u8d64\uff5e\u6de1\u8910\u8272\u3092\u5448\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=phenylalanine%20buildup,bound\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u76ae\u819a\u3084\u7db2\u819c\u3067\u306e\u30e1\u30e9\u30cb\u30f3\u6b20\u5982\u306b\u3088\u308a\u65e5\u5149\u306b\u3088\u308b\u5149\u640d\u50b7\u3084\u76ae\u819a\u764c\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u307e\u305f\u773c\u306e\u8272\u7d20\u3082\u4e0d\u8db3\u3059\u308b\u305f\u3081\u5149\u906e\u853d\u304c\u4e0d\u5341\u5206\u3067\u5f37\u3044\u7f9e\u660e\uff08\u307e\u3076\u3057\u3055\uff09\u3084\u8996\u529b\u969c\u5bb3\u3092\u4f34\u3044\u307e\u3059\u3002\u6839\u672c\u7684\u6cbb\u7642\u6cd5\u306f\u306a\u304f\u3001\u7d2b\u5916\u7dda\u9632\u5fa1\u3068\u773c\u79d1\u7684\u30b1\u30a2\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><em>(\u203b\u306a\u304a\u3001\u907a\u4f1d\u6027\u306e\u90e8\u5206\u7684\u306a\u8272\u7d20\u6b20\u4e4f\u3068\u3057\u3066\u3001\u8eab\u4f53\u306e\u4e00\u90e8\u306b\u9650\u5c40\u3057\u305f\u767d\u6591\u3092\u5448\u3059\u308b<strong>\u30d1\u30a4\u30d6\u30a2\u30eb\u30c9\u75c7\uff08piebaldism\uff09\u306a\u3069\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u80da\u767a\u751f\u904e\u7a0b\u306e\u7570\u5e38\u306b\u3088\u308a\u767d\u9aea\u306e\u524d\u9aea\u306a\u3069\u3092\u7279\u5fb4\u3068\u3059\u308bWaardenburg\u75c7\u5019\u7fa4<\/strong>\u3082\u77e5\u3089\u308c\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=Each%20step%20in%20the%20formation,8\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u3089\u306f\u7a00\u306a\u75be\u60a3\u3067\u3059\u304c\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u30fb\u5206\u5e03\u306e\u7570\u5e38\u3068\u3057\u3066\u8208\u5473\u6df1\u3044\u73fe\u8c61\u3067\u3059\u3002\uff09<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7f8e\u5bb9\u65bd\u8853\u3068\u30e1\u30e9\u30cb\u30f3\u306e\u95a2\u4fc2<\/h2>\n\n\n\n<p>\u76ae\u819a\u306e\u8272\u7d20\u6027\u75c5\u5909\u306b\u5bfe\u3059\u308b\u7f8e\u5bb9\u76ae\u819a\u79d1\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u3001\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3001\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0\u3001\u5404\u7a2e\u306e\u7f8e\u767d\u5264\uff08\u5916\u7528\u85ac\uff09\u3001\u7d4c\u53e3\u85ac\u3084\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\uff08\u5c40\u6240\u6ce8\u5c04\u7642\u6cd5\uff09\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u808c\u8cea\uff08\u4eba\u7a2e\u3084\u76ae\u819a\u30bf\u30a4\u30d7\uff09\u306b\u3088\u308b\u53cd\u5fdc\u6027\u306e\u9055\u3044\u3082\u8e0f\u307e\u3048\u3066\u3001\u4ee3\u8868\u7684\u306a\u65bd\u8853\u3068\u30e1\u30e9\u30cb\u30f3\u3068\u306e\u95a2\u4fc2\u3092\u6982\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306b\u3088\u308b\u8272\u7d20\u9664\u53bb<\/h3>\n\n\n\n<p><strong>Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc:<\/strong> Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u306f\u6570\u30ca\u30ce\u79d2\u3068\u3044\u3046\u6975\u3081\u3066\u77ed\u3044\u30d1\u30eb\u30b9\u5e45\u306e\u30ec\u30fc\u30b6\u30fc\u3067\u3001\u30e1\u30e9\u30cb\u30f3\u3092<strong>\u9078\u629e\u7684\u5149\u71b1\u5206\u89e3<\/strong>\uff08Selective Photothermolysis\uff09\u306e\u539f\u7406\u3067\u7834\u58ca\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=risk%20of%20adverse%20effects%20,an%20increasing%20number%20of%20dermatological\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002694nm\uff08\u30eb\u30d3\u30fc\u30ec\u30fc\u30b6\u30fc\uff09\u3001755nm\uff08\u30a2\u30ec\u30ad\u30b5\u30f3\u30c9\u30e9\u30a4\u30c8\u30ec\u30fc\u30b6\u30fc\uff09\u3001532nm\/1064nm\uff08Nd:YAG\u30ec\u30fc\u30b6\u30fc\uff09\u306a\u3069\u304c\u4ee3\u8868\u3067\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3084\u8272\u7d20\u6027\u75c5\u5909\uff08\u30b7\u30df\u3001\u305d\u3070\u304b\u3059\u3001\u592a\u7530\u6bcd\u6591\u3001\u523a\u9752\u306a\u3069\uff09\u306e\u30e1\u30e9\u30cb\u30f3\u306b\u5438\u53ce\u3055\u308c\u3066\u77ac\u9593\u7684\u306b\u9ad8\u71b1\u3092\u767a\u751f\u3055\u305b\u3001\u8272\u7d20\u3092\u5fae\u5c0f\u306a\u7c92\u5b50\u306b\u7834\u7815\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u306f\u5468\u56f2\u7d44\u7e54\u306b\u7121\u5bb3\u306a\u5f62\u3067\u9664\u53bb\u3055\u308c\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u8caa\u98df\u30fb\u6392\u51fa\u304c\u4fc3\u3055\u308c\u307e\u3059\u3002<strong>\u8001\u4eba\u6027\u8272\u7d20\u6591\u3084\u96c0\u5375\u6591\u306e\u6cbb\u7642\u3067\u306f1\uff5e2\u56de\u306e\u7167\u5c04\u3067\u9ad8\u3044\u52b9\u679c<\/strong>\u3092\u793a\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u304c\u8584\u76ae\u72b6\u306e\u75c2\u76ae\u3068\u306a\u3063\u3066\u8131\u843d\u3057\u307e\u3059\u3002\u307e\u305f<strong>\u771f\u76ae\u306e\u7570\u6240\u6027\u30e1\u30e9\u30cb\u30f3\u304c\u539f\u56e0\u306e\u592a\u7530\u6bcd\u6591\u3084ADM<\/strong>\uff08\u5f8c\u5929\u6027\u771f\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff09\u3082Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u3067\u6cbb\u7642\u53ef\u80fd\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=epidermis%2C%20dermis%20and%20extracellular%20matrix,30\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u7279\u306b<strong>Q\u30b9\u30a4\u30c3\u30c1Nd:YAG\u30ec\u30fc\u30b6\u30fc\uff081064nm\uff09\u306f\u30a2\u30b8\u30a2\u4eba\u306e\u8272\u7d20\u6027\u75c5\u5909\u6cbb\u7642\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9<\/strong>\u3068\u3055\u308c\u3001\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306b\u30b7\u30df\u3092\u9664\u53bb\u3067\u304d\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=radiation%2C%20genetic%20factors%20and%20sex,50\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305f\u3060\u3057\u3001\u4e00\u90e8\u306e\u75c5\u5909\uff08\u4f8b\uff1a\u809d\u6591\uff09\u3067\u306f\u30ec\u30fc\u30b6\u30fc\u523a\u6fc0\u306b\u3088\u308a\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\uff08PIH\uff09\u3084\u518d\u767a\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u3001<strong>\u7167\u5c04\u5f8c\u306b\u8272\u7d20\u6c88\u7740\u3084\u8272\u7d20\u8131\u5931\uff08\u4f4e\u8272\u7d20\u6591\uff09\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u8d77\u3053\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059<\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=In%20most%20cases%2C%20the%20pigmented,30\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305d\u306e\u305f\u3081\u809d\u6591\u306b\u5bfe\u3057\u3066\u306f\u4f4e\u51fa\u529b1064nm\u30ec\u30fc\u30b6\u30fc\u3092\u8907\u6570\u56de\u7167\u5c04\u3059\u308b\u300c\u30ec\u30fc\u30b6\u30fc\u30c8\u30fc\u30cb\u30f3\u30b0\u300d\u3068\u3044\u3046\u624b\u6cd5\u304c\u8003\u6848\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4f9d\u7136\u3068\u3057\u3066\u518d\u71c3\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u614e\u91cd\u306a\u9069\u5fdc\u5224\u65ad\u304c\u5fc5\u8981\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=In%20most%20cases%2C%20the%20pigmented,30\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc:<\/strong> \u8fd1\u5e74\u767b\u5834\u3057\u305f<strong>\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc<\/strong>\uff08\u30d4\u30b3\u79d2\u9818\u57df\u306e\u8d85\u77ed\u30d1\u30eb\u30b9\u30ec\u30fc\u30b6\u30fc\uff09\u306f\u3001Q\u30b9\u30a4\u30c3\u30c1\u30ec\u30fc\u30b6\u30fc\u3088\u308a\u3055\u3089\u306b\u77ed\u3044\u30d1\u30eb\u30b9\uff08\u6570\u767e\u30d4\u30b3\u79d2\uff09\u3067<strong>\u5149\u97f3\u97ff\u52b9\u679c<\/strong>\u3092\u767a\u751f\u3055\u305b\u3001\u30e1\u30e9\u30cb\u30f3\u3092\u7269\u7406\u7684\u306b\u632f\u52d5\u30fb\u7834\u7815\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=risk%20of%20adverse%20effects%20,an%20increasing%20number%20of%20dermatological\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u8d85\u77ed\u30d1\u30eb\u30b9\u306b\u3088\u308a\u71b1\u7684\u62e1\u6563\u304c\u6700\u5c0f\u5316\u3055\u308c\u308b\u305f\u3081\u5468\u56f2\u7d44\u7e54\u3078\u306e\u71b1\u30c0\u30e1\u30fc\u30b8\u304c\u5c11\u306a\u304f\u3001PIH\u306a\u3069\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u4f4e\u6e1b\u304c\u671f\u5f85\u3067\u304d\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=risk%20of%20adverse%20effects%20,an%20increasing%20number%20of%20dermatological\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u306f\u5143\u6765\u523a\u9752\u9664\u53bb\u306e\u5206\u91ce\u3067\u5c0e\u5165\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u96e3\u6cbb\u6027\u306e<strong>\u771f\u76ae\u6027\u8272\u7d20\u6591<\/strong>\u3084<strong>ADM<\/strong>\u3001\u5f93\u6765\u306e\u30ca\u30ce\u79d2\u30ec\u30fc\u30b6\u30fc\u3067\u306f\u53d6\u308a\u5207\u308c\u306a\u304b\u3063\u305f\u8584\u3044\u30b7\u30df\u306e\u6cbb\u7642\u306a\u3069\u306b\u3082\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=risk%20of%20adverse%20effects%20,an%20increasing%20number%20of%20dermatological\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=lasers%20%28ruby%2C%20alexandrite%2C%20Nd%3AYAG%20Q,41\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u4f8b\u3048\u3070\u30d4\u30b3\u79d2\u30a2\u30ec\u30ad\u30b5\u30f3\u30c9\u30e9\u30a4\u30c8\u30ec\u30fc\u30b6\u30fc(755nm)\u3084Nd:YAG(532\/1064nm)\u306f\u3001\u30a2\u30b8\u30a2\u4eba\u306e\u809d\u6591\u6cbb\u7642\u3084\u6df1\u5728\u6027\u306e\u8272\u7d20\u75be\u60a3\u306b\u3082\u6709\u7528\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u30d4\u30b3\u79d2\u30ec\u30fc\u30b6\u30fc\u306f\u30e1\u30e9\u30cb\u30f3\u4ee5\u5916\u306b\u808c\u306e\u30ea\u30b8\u30e5\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\uff08\u808c\u8cea\u6539\u5584\uff09\u76ee\u7684\u3067\u3082\u4f7f\u308f\u308c\u59cb\u3081\u3066\u304a\u308a\u3001\u5fae\u5c0f\u306a\u30ec\u30fc\u30b6\u30fc\u8a98\u767a\u7a7a\u5b54\u306b\u3088\u308b<strong>\u771f\u76ae\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u52b9\u679c<\/strong>\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u6642\u306e\u7559\u610f\u70b9\uff08\u808c\u30bf\u30a4\u30d7\u5225\u306e\u53cd\u5fdc\u6027\uff09:<\/strong> \u30ec\u30fc\u30b6\u30fc\u306f\u30e1\u30e9\u30cb\u30f3\u3092\u6a19\u7684\u3068\u3059\u308b\u305f\u3081\u3001\u60a3\u8005\u306e\u76ae\u819a\u30bf\u30a4\u30d7\uff08\u8272\u306e\u6fc3\u3055\uff09\u306b\u3088\u3063\u3066\u5b89\u5168\u6027\u30fb\u6709\u52b9\u6027\u304c\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002<strong>\u8272\u9ed2\u306e\u808c\u3067\u306f\u8868\u76ae\u30e1\u30e9\u30cb\u30f3\u304c\u8c4a\u5bcc\u306a\u305f\u3081\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u591a\u304f\u5438\u53ce\u3057\u3066\u3057\u307e\u3044\u3001\u8868\u76ae\u71b1\u50b7\u3084\u8272\u7d20\u7570\u5e38\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557626\/#:~:text=NCBI%20www,injury%20in%20those%20with\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><\/strong>\u3002\u4e00\u822c\u306b\u30d5\u30a3\u30c3\u30c4\u30d1\u30c8\u30ea\u30c3\u30af\u76ae\u819a\u30bf\u30a4\u30d7III\u4ee5\u4e0a\uff08\u4e2d\u9593\uff5e\u8272\u9ed2\u808c\uff09\u3067\u306f\u4f4e\u51fa\u529b\u304b\u3089\u614e\u91cd\u306b\u7167\u5c04\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u8abf\u6574\u3057\u3001\u6ce2\u9577\u3082<strong>1064nm Nd:YAG\u30ec\u30fc\u30b6\u30fc<\/strong>\u306e\u3088\u3046\u306b\u6df1\u9054\u5ea6\u304c\u9ad8\u304f\u8868\u76ae\u30e1\u30e9\u30cb\u30f3\u3078\u306e\u5438\u53ce\u304c\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u3082\u306e\u3092\u9078\u629e\u3059\u308b\u306a\u3069\u306e\u5de5\u592b\u304c\u5fc5\u8981\u3067\u3059<a href=\"https:\/\/aestheticsbiomedical.com\/blog\/provider-protocols-treating-darker-fitzpatrick-skin-types\/#:~:text=Provider%20Protocols%3A%20Treating%20Darker%20Fitzpatrick,and%20injury%20during%20treatment\" target=\"_blank\" rel=\"noreferrer noopener\">aestheticsbiomedical.com<\/a>\u3002\u9006\u306b\u8272\u767d\u306e\u808c\u3067\u306f\u9ad8\u51fa\u529b\u3067\u3082\u8868\u76ae\u969c\u5bb3\u304c\u8d77\u304d\u306b\u304f\u304f\u52b9\u679c\u3082\u5f97\u3084\u3059\u3044\u3067\u3059\u304c\u3001\u305d\u3082\u305d\u3082\u8272\u7d20\u75c5\u5909\u304c\u30e1\u30e9\u30cb\u30f3\u91cf\u306e\u5c11\u306a\u3044\u8584\u3044\u30b7\u30df\u3067\u3042\u308b\u5834\u5408\u306f\u30ec\u30fc\u30b6\u30fc\u306b\u53cd\u5fdc\u3057\u3065\u3089\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u808c\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u3001\u9069\u5207\u306a\u30ec\u30fc\u30b6\u30fc\u7a2e\u985e\u30fb\u8a2d\u5b9a\u3067\u65bd\u8853\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u307e\u305f\u30ec\u30fc\u30b6\u30fc\u7167\u5c04\u5f8c\u306f\u808c\u304c\u4e00\u6642\u7684\u306b\u708e\u75c7\u72b6\u614b\u306b\u306a\u308b\u305f\u3081\u3001\u5168\u3066\u306e\u60a3\u8005\u3067<strong>\u7d2b\u5916\u7dda\u9632\u5fa1\u3068\u708e\u75c7\u93ae\u9759<\/strong>\u3092\u5fb9\u5e95\u3057\u3001PIH\u4e88\u9632\u3092\u56f3\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0\u3068\u30e1\u30e9\u30cb\u30f3<\/h3>\n\n\n\n<p><strong>\u30b1\u30df\u30ab\u30eb\u30d4\u30fc\u30ea\u30f3\u30b0<\/strong>\u306f\u30b0\u30ea\u30b3\u30fc\u30eb\u9178\u3001\u30b5\u30ea\u30c1\u30eb\u9178\u3001\u30c8\u30ea\u30af\u30ed\u30ed\u9162\u9178(TCA)\u306a\u3069\u306e\u85ac\u5264\u3067\u8868\u76ae\u306e\u89d2\u8cea\u5c64\uff5e\u4e0a\u5c64\u3092\u5265\u96e2\u3055\u305b\u3001\u65b0\u9673\u4ee3\u8b1d\u3092\u4fc3\u3059\u6cbb\u7642\u3067\u3059\u3002<strong>\u8868\u76ae\u306e\u30e1\u30e9\u30cb\u30f3\u3092\u542b\u3080\u5c64\u3092\u524a\u308a\u53d6\u308b\u3053\u3068\u3067\u3001\u6d45\u5728\u6027\u306e\u8272\u7d20\u6591\uff08\u8868\u76ae\u5185\u306e\u30b7\u30df\uff09\u3092\u8584\u304f\u3059\u308b\u52b9\u679c<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u30b0\u30ea\u30b3\u30fc\u30eb\u9178\u3084\u4e73\u9178\u306b\u3088\u308bAHA\u30d4\u30fc\u30ea\u30f3\u30b0\u306f\u809d\u6591\u3084\u304f\u3059\u307f\u6cbb\u7642\u306e\u88dc\u52a9\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3001\u6570\u9031\u9593\u304a\u304d\u306e\u65bd\u8853\u3067\u5f90\u3005\u306b\u8272\u8abf\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u30d4\u30fc\u30ea\u30f3\u30b0\u306b\u3088\u308a\u4ed6\u306e\u7f8e\u767d\u5264\u306e\u6d78\u900f\u304c\u9ad8\u307e\u308b\u5229\u70b9\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067<strong>\u30d4\u30fc\u30ea\u30f3\u30b0\u305d\u306e\u3082\u306e\u304c\u5f37\u3044\u708e\u75c7\u3092\u8d77\u3053\u3059\u3068\u65b0\u305f\u306a\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u3092\u62db\u304f<\/strong>\u6050\u308c\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Chemical%20peels%20%2C%20%2054,it%20by%20injuring%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u6fc3\u5ea6\u3084\u63a5\u89e6\u6642\u9593\u306e\u7ba1\u7406\u3092\u9069\u5207\u306b\u884c\u3044\u3001\u60a3\u8005\u306e\u808c\u8cea\uff08\u7279\u306b\u8272\u9ed2\u306e\u808c\u306f\u8981\u6ce8\u610f\uff09\u306b\u5408\u308f\u305b\u3066\u30de\u30a4\u30eb\u30c9\u306b\u65bd\u8853\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Chemical%20peels%20%2C%20%2054,it%20by%20injuring%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u30d4\u30fc\u30ea\u30f3\u30b0\u5f8c\u3082\u7d2b\u5916\u7dda\u9632\u5fa1\u3092\u5fb9\u5e95\u3057\u3001\u4fdd\u6e7f\u3084\u6297\u708e\u75c7\u30b1\u30a2\u3067\u808c\u306e\u30d0\u30ea\u30a2\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u306b\u8272\u7d20\u6c88\u7740\u6539\u5584\u52b9\u679c\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7f8e\u767d\u5916\u7528\u85ac\uff08\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u30fb\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u30fb\u30a2\u30bc\u30e9\u30a4\u30f3\u9178 \u4ed6\uff09<\/h3>\n\n\n\n<p><strong>\u7f8e\u767d\u5264<\/strong>\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3057\u305f\u308a\u65e2\u5b58\u306e\u8272\u7d20\u3092\u6e1b\u5c11\u3055\u305b\u305f\u308a\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u304a\u308a\u3001\u809d\u6591\u3084PIH\u306a\u3069\u306e\u7b2c\u4e00\u9078\u629e\u6cbb\u7642\u3068\u306a\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u4e3b\u8981\u306a\u7f8e\u767d\u6709\u52b9\u6210\u5206\u3068\u4f5c\u7528\u6a5f\u5e8f\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\uff08HQ\uff09:<\/strong> \u76ae\u819a\u79d1\u9818\u57df\u3067\u53e4\u304f\u304b\u3089\u7528\u3044\u3089\u308c\u308b\u4ee3\u8868\u7684\u306a\u7f8e\u767d\u5264\u3067\u3001<strong>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u7af6\u5408\u7684\u306b\u963b\u5bb3<\/strong>\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30c9\u30fc\u30d1\u304b\u3089\u30e1\u30e9\u30cb\u30f3\u3078\u306e\u5408\u6210\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Hydroquinone%20acts%20as%20a%20skin,6\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u30e1\u30e9\u30cb\u30f3\u524d\u99c6\u4f53\u306e\u69cb\u9020\u985e\u4f3c\u4f53\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u80fd\u529b\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067<strong>\u6a19\u7684\u90e8\u4f4d\u306e\u8272\u7d20\u6c88\u7740\u3092\u5f90\u3005\u306b\u8584\u304f<\/strong>\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Hydroquinone%20acts%20as%20a%20skin,6\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u30024%\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u30af\u30ea\u30fc\u30e0\u304c\u6700\u3082\u5e83\u304f\u4f7f\u308f\u308c\u3001\u809d\u6591\u30fb\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u30fb\u96c0\u5375\u6591\u30fb\u8001\u4eba\u6027\u8272\u7d20\u6591\u306a\u3069\u306b\u6570\u30f6\u6708\u5358\u4f4d\u3067\u7d99\u7d9a\u9069\u7528\u3057\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Hydroquinone%20cream%20is%20the%20standard,mechanism%20of%20action%2C%20methods%20of\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Hydroquinone%20cream%20is%20the%20standard,of%20dyschromia%2C%20such%20as%20in\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u5358\u5264\u3067\u3082\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u304c\u3001<strong>\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\uff08\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\uff09\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u306e\u4f75\u7528<\/strong>\uff08\u30c8\u30ea\u30d7\u30eb\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u7642\u6cd5\uff09\u3067\u52b9\u679c\u5897\u5f37\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Multiple%20studies%20have%20shown%20that,a%20prescription%20by%20a%20dermatologist\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u4e3b\u306a\u526f\u4f5c\u7528\u306f\u523a\u6fc0\u6027\u63a5\u89e6\u76ae\u819a\u708e\u3084\u7d05\u6591\u306a\u3069\u306e\u5c40\u6240\u523a\u6fc0\u75c7\u72b6\u3067\u3042\u308a\u3001\u7a00\u306b\u9577\u671f\u4f7f\u7528\u3067**\u5916\u56e0\u6027\u9ed2\u76ae\u75c7\uff08ochronosis\uff09**\u3068\u547c\u3070\u308c\u308b\u9752\u9ed2\u3044\u8272\u7d20\u6c88\u7740\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3002\u65e5\u672c\u3084EU\u3067\u306f\u9ad8\u6fc3\u5ea6\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u88fd\u5264\u306e\u5e02\u8ca9\u306f\u7981\u6b62\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u533b\u7642\u6a5f\u95a2\u3067\u51e6\u65b9\u306e\u4e0b\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\uff08TXA\uff09:<\/strong> 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href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0923181117305406#:~:text=Tranexamic%20acid%20inhibits%20melanogenesis%20by,the%20plasminogen%2Fplasmin%20pathway%2C%20thereby\" target=\"_blank\" rel=\"noreferrer noopener\">sciencedirect.com<\/a>\u3002\u3055\u3089\u306b\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u306b\u3088\u308a\u3001\u809d\u6591\u75c5\u5909\u90e8\u306b\u307f\u3089\u308c\u308b\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3084\u305d\u308c\u306b\u4f34\u3046\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u3092\u6291\u3048\u308b\u52b9\u679c\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S209669112400061X#:~:text=Tranexamic%20acid%20,angiogenic%20effects\" target=\"_blank\" rel=\"noreferrer noopener\">sciencedirect.com<\/a>\u3002\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306f\u7d4c\u53e3\u6295\u4e0e\uff08\u901a\u5e381\u65e5750mg\uff5e1,000mg\u30922\uff5e3\u30f6\u6708\u4ee5\u4e0a\uff09\u3067\u809d\u6591\u306e\u8272\u8abf\u6539\u5584\u306b\u6709\u52b9\u3068\u3055\u308c\u3001\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u306e\u809d\u6591\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u63a8\u5968\u5ea6A\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f**\u5c40\u6240\u3078\u306e\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\uff08\u5fae\u5c0f\u6ce8\u5c04\uff09**\u3084\u5916\u7528\u3082\u4e00\u5b9a\u306e\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u7d4c\u53e3\u5185\u670d\u304c\u56f0\u96e3\u306a\u5834\u5408\u306e\u4ee3\u66ff\u624b\u6bb5\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/fpsam.2024.0187#:~:text=Intradermal%20Injection%20of%20Tranexamic%20Acid,treatment%2C%20with%20potential%20advantages\" target=\"_blank\" rel=\"noreferrer noopener\">liebertpub.com<\/a>\u3002\u526f\u4f5c\u7528\u306f\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u3067\u3059\u304c\u3001\u7d4c\u53e3\u3067\u306f\u7a00\u306b\u6d88\u5316\u5668\u75c7\u72b6\u3084\u8840\u6813\u50be\u5411\uff08\u57fa\u790e\u75be\u60a3\u306e\u3042\u308b\u60a3\u8005\uff09\u306b\u7559\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a2\u30bc\u30e9\u30a4\u30f3\u9178:<\/strong> \u30cb\u30ad\u30d3\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u7528\u3044\u3089\u308c\u308b\u6210\u5206\u3067\u3059\u304c\u3001<strong>\u7570\u5e38\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306b\u5bfe\u3059\u308b\u9078\u629e\u7684\u306a\u7d30\u80de\u6bd2\u6027<\/strong>\u3092\u6301\u3061\u3001\u7f8e\u767d\u5264\u3068\u3057\u3066\u3082\u6709\u7528\u3067\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=Azelaic%20acid%20inhibits%20the%20synthesis,and%20does%20not%20cause%20depigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u30a2\u30bc\u30e9\u30a4\u30f3\u9178\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306eDNA\u5408\u6210\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9175\u7d20\u3092\u963b\u5bb3\u3057\u3001\u3055\u3089\u306b\u5f31\u3044\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u4f5c\u7528\u3068\u6297\u9178\u5316\u4f5c\u7528\u3082\u793a\u3057\u307e\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=Azelaic%20acid%20inhibits%20the%20synthesis,and%20does%20not%20cause%20depigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3002\u3053\u308c\u306b\u3088\u308a<strong>\u904e\u5270\u306a\u8272\u7d20\u6c88\u7740\u90e8\u4f4d\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3060\u3051\u3092\u6291\u5236<\/strong>\u3057\u3001\u6b63\u5e38\u76ae\u819a\u306e\u8272\u306b\u306f\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u70b9\u304c\u7279\u5fb4\u3067\u3059<a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=Azelaic%20acid%20inhibits%20the%20synthesis,and%20does%20not%20cause%20depigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u300215\uff5e20%\u6fc3\u5ea6\u306e\u30af\u30ea\u30fc\u30e0\u304c\u6b27\u7c73\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u65e5\u672c\u3067\u306f\u533b\u85ac\u54c1\u672a\u627f\u8a8d\u3067\u3059\u304c\u5165\u624b\u53ef\u80fd\uff09\u3002\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u3084\u809d\u6591\u306b\u5bfe\u3057\u3066\u3082\u5b89\u5168\u306b\u4f7f\u7528\u3067\u304d\u308b\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306e\u809d\u6591\u6cbb\u7642\u306a\u3069\u3067\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u4ee3\u66ff\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u7f8e\u767d\u6210\u5206:<\/strong> 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href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=,acetyl%20glucosamine%2C%20soy\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u69d8\u3005\u306a\u6bb5\u968e\u306b\u4f5c\u7528\u3057\u3066\u8272\u7d20\u6c88\u7740\u3092\u6539\u5584\u3059\u308b\u3082\u306e\u3067\u3001\u5e02\u8ca9\u306e\u5316\u7ca7\u54c1\u304b\u3089\u533b\u7642\u6a5f\u95a2\u51e6\u65b9\u307e\u3067\u5e45\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u5358\u5264\u3067\u306f\u52b9\u679c\u304c\u30de\u30a4\u30eb\u30c9\u306a\u3053\u3068\u3082\u591a\u304f\u3001\u8907\u6570\u6210\u5206\u306e\u4f75\u7528\u3084\u30d4\u30fc\u30ea\u30f3\u30b0\u30fb\u30ec\u30fc\u30b6\u30fc\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u76f8\u4e57\u52b9\u679c\u3092\u72d9\u3046\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Topical%20treatments%20for%20postinflammatory%20hyperpigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Chemical%20peels%20%2C%20%2054,it%20by%20injuring%20the%20epidermis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5185\u670d\u7642\u6cd5\u30fb\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\u3068\u5168\u8eab\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/h3>\n\n\n\n<p><strong>\u5185\u670d\u7642\u6cd5:<\/strong> 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href=\"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/4969#:~:text=Efficacy%20and%20Safety%20of%20Tranexamic,routine%20treatment%20modalities%20for%20melasma\" target=\"_blank\" rel=\"noreferrer noopener\">medicaljournalssweden.se<\/a>\uff08\u518d\u767a\u3057\u3084\u3059\u3044\u305f\u3081\u7dad\u6301\u7642\u6cd5\u3082\u691c\u8a0e\u3055\u308c\u307e\u3059\uff09\u3002<\/p>\n\n\n\n<p><strong>\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc:<\/strong> \u7f8e\u5bb9\u9818\u57df\u3067\u3044\u3046\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\u3068\u306f\u3001\u6709\u52b9\u6210\u5206\u3092\u76ae\u5185\u307e\u305f\u306f\u76ae\u4e0b\u306b<strong>\u5c11\u91cf\u305a\u3064\u76f4\u63a5\u6ce8\u5165<\/strong>\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u809d\u6591\u3084\u96e3\u6cbb\u6027\u8272\u7d20\u6591\u306b\u5bfe\u3057\u3066\u3001<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306e\u5c40\u6240\u6ce8\u5c04\uff084 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noopener\">liebertpub.com<\/a>\u3002\u3053\u308c\u306f\u60a3\u90e8\u306b\u9ad8\u6fc3\u5ea6\u306e\u85ac\u5264\u3092\u5c4a\u3051\u3001\u5168\u8eab\u526f\u4f5c\u7528\u3092\u6291\u3048\u306a\u304c\u3089\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6d3b\u52d5\u3092\u5c40\u6240\u7684\u306b\u5236\u5fa1\u3057\u3088\u3046\u3068\u3059\u308b\u8a66\u307f\u3067\u3059\u300210\uff5e14\u65e5\u9593\u9694\u3067\u6570\u56de\u306e\u65bd\u8853\u3092\u884c\u3046\u3053\u3068\u3067\u30e1\u30e9\u30cb\u30f3\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u809d\u6591\u306eMASI\u30b9\u30b3\u30a2\uff08\u809d\u6591\u9762\u7a4d\u91cd\u75c7\u5ea6\u6307\u6570\uff09\u306e\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/fpsam.2024.0187#:~:text=Intradermal%20Injection%20of%20Tranexamic%20Acid,treatment%2C%20with%20potential%20advantages\" target=\"_blank\" rel=\"noreferrer noopener\">liebertpub.com<\/a>\u3002\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\u306e\u5229\u70b9\u306f\u65bd\u8853\u90e8\u4f4d\u306b\u30d4\u30f3\u30dd\u30a4\u30f3\u30c8\u3067\u4f5c\u7528\u3055\u305b\u3089\u308c\u308b\u70b9\u3067\u3059\u304c\u3001\u4e00\u65b9\u3067\u6ce8\u5c04\u306b\u3088\u308b\u75db\u307f\u3084\u5185\u51fa\u8840\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u30d3\u30bf\u30df\u30f3C\u3084\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3092\u5fae\u7d30\u91dd\u3067\u771f\u76ae\u306b\u5c0e\u5165\u3059\u308b\u7f8e\u767d\u30ab\u30af\u30c6\u30eb\u7642\u6cd5<\/strong>\u3082\u4e00\u90e8\u3067\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u52b9\u679c\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7dcf\u3058\u3066\u3001<strong>\u5185\u670d\u30fb\u5916\u7528\u30fb\u30ec\u30fc\u30b6\u30fc\u7b49\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u5305\u62ec\u7684\u306a\u6cbb\u7642<\/strong>\u306e\u4e2d\u3067\u3001\u88dc\u52a9\u7684\u306b\u30e1\u30bd\u30bb\u30e9\u30d4\u30fc\u3092\u53d6\u308a\u5165\u308c\u308b\u30b1\u30fc\u30b9\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u5f8c\u306b\u3001\u7f8e\u5bb9\u76ae\u819a\u79d1\u9818\u57df\u3067\u306f<strong>\u4e88\u9632\u7684\u30b1\u30a2<\/strong>\u3082\u91cd\u8981\u3067\u3059\u3002\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u306e\u904e\u5270\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u65e5\u5e38\u7684\u306a<strong>\u7d2b\u5916\u7dda\u5bfe\u7b56\uff08SPF50+\u306e\u65e5\u713c\u3051\u6b62\u3081\u306e\u5857\u5e03<a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=What%20is%20the%20treatment%20for,postinflammatory%20hyperpigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3084\u906e\u5149)\u3084\u6297\u9178\u5316\u5264\u306e\u4f7f\u7528<\/strong>\u3001\u523a\u6fc0\u6027\u708e\u75c7\u306e\u56de\u907f\u306a\u3069\u3092\u6307\u5c0e\u3057\u307e\u3059\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u79c1\u305f\u3061\u306e\u4f53\u3092\u5b88\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u304c\u3001\u7f8e\u5bb9\u4e0a\u306e\u89b3\u70b9\u3067\u306f\u305d\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u3084\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304d\u3001\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u30e1\u30e9\u30cb\u30f3\u5236\u5fa1\u6cd5\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u304c\u3001\u7f8e\u5bb9\u76ae\u819a\u79d1\u533b\u306b\u6c42\u3081\u3089\u308c\u308b\u30b9\u30ad\u30eb\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e:<\/strong> \u30e1\u30e9\u30cb\u30f3\u306e\u751f\u7406\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=In%20its%20various%20forms%2C%20melanin,of%20the%20skin%20and%20eye\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=nipples%2C%20vagina%2C%20and%20glans%20of,well%20as%20Fitzpatrick%20skin%20type\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.10071#:~:text=Azelaic%20acid%20inhibits%20the%20synthesis,and%20does%20not%20cause%20depigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">spandidos-publications.com<\/a>\u3001\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u6a5f\u69cb<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=The%20first%20step%20of%20biosynthesis,form%20the%20eumelanin%20or%20pheomelanin\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459156\/#:~:text=The%20primary%20stimulus%20for%20melanogenesis,in%20pheomelanin%20to%20eumelanin%20expression\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a>\u3001\u8272\u7d20\u6027\u75be\u60a3\u306b\u95a2\u3059\u308b\u30ec\u30d3\u30e5\u30fc<a href=\"https:\/\/dermnetnz.org\/topics\/lentigo-pathology#:~:text=Solar%20lentigines%20are%20benign%20lesions,abnormal%20pigment%20retention%20by%20keratinocytes\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a><a href=\"https:\/\/www.rixisdermatology.com\/freckles-ephelides#:~:text=Freckles%2C%20scientifically%20termed%20as%20ephelides%2C,and%20%2036\" target=\"_blank\" rel=\"noreferrer noopener\">rixisdermatology.com<\/a><a href=\"https:\/\/dermnetnz.org\/topics\/postinflammatory-hyperpigmentation#:~:text=Postinflammatory%20hyperpigmentation%20follows%20damage%20to,skin%20cells%29%20and%2For%20dermis\" target=\"_blank\" rel=\"noreferrer noopener\">dermnetnz.org<\/a>\u3001\u7f8e\u5bb9\u76ae\u819a\u6cbb\u7642\u306e\u6700\u65b0\u77e5\u898b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258696\/#:~:text=epidermis%2C%20dermis%20and%20extracellular%20matrix,30\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539693\/#:~:text=Hydroquinone%20acts%20as%20a%20skin,6\" target=\"_blank\" rel=\"noreferrer noopener\">ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0923181117305406#:~:text=Tranexamic%20acid%20inhibits%20melanogenesis%20by,the%20plasminogen%2Fplasmin%20pathway%2C%20thereby\" target=\"_blank\" rel=\"noreferrer noopener\">sciencedirect.com<\/a>\u306a\u3069.\uff08\u5404\u5f15\u7528\u53c2\u7167\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"\u30e1\u30e9\u30cb\u30f3: \u751f\u7406\u5b66\u30fb\u5206\u5b50\u69cb\u9020\u304b\u3089\u81e8\u5e8a\u5fdc\u7528\u307e\u3067 \u30e1\u30e9\u30cb\u30f3\u306e\u751f\u7406\u5b66\u3068\u5206\u5b50\u69cb\u9020 \u30e1\u30e9\u30cb\u30f3\u306e\u7a2e\u985e: \u4eba\u4f53\u306e\u30e1\u30e9\u30cb\u30f3\u8272\u7d20\u306b\u306f\u5927\u304d\u304f\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\uff08\u9ed2\uff5e\u8910\u8272\u306e\u30e1\u30e9\u30cb\u30f3\uff09\u3068\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\uff08\u9ec4\uff5e\u8d64\u8272\u306e\u30e1\u30e9\u30cb\u30f3\uff09\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u6bd4\u7387\u3084\u91cf\u304c\u76ae 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