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target=\"_blank\" rel=\"noreferrer noopener\">dsr-skincare.jp<\/a>\u3002\u540c\u3058\u304f\u9846\u7c92\u5c64\u306e\u89d2\u5316\u7d30\u80de\u5185\u306b\u306f\u30e9\u30e1\u30e9\u9846\u7c92<\/strong>\uff08\u819c\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0\u9846\u7c92\uff09\u3068\u547c\u3070\u308c\u308b\u5c0f\u80de\u304c\u591a\u6570\u5b58\u5728\u3057\u3001\u5404\u7a2e**\u6975\u6027\u8102\u8cea\uff08\u4e8c\u5c64\u819c\u3092\u5f62\u6210\u3059\u308b\u8102\u8cea\uff09**\u3084\u52a0\u6c34\u5206\u89e3\u9175\u7d20\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3084\u30ea\u30d1\u30fc\u30bc\uff09\u3001\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306a\u3069\u304c\u84c4\u3048\u3089\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=migration%20of%20keratinocytes%20from%20the,undergoes%20complete%20turnover%20every%2028\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<p>\u3084\u304c\u3066\u89d2\u5316\u7d30\u80de\u306f<strong>\u7d42\u672b\u5206\u5316<\/strong>\u306e\u6bb5\u968e\u306b\u5165\u308a\u3001\u7d30\u80de\u6838\u3092\u542b\u3080\u7d30\u80de\u5c0f\u5668\u5b98\u306f\u9175\u7d20\u4f5c\u7528\u306b\u3088\u308a\u5d29\u58ca\u30fb\u6d88\u5931\u3057\u307e\u3059\u3002\u307e\u305f\u7d30\u80de\u8cea\u5185\u306e\u30b1\u30e9\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f<strong>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3<\/strong>\u306b\u3088\u3063\u3066\u51dd\u96c6\u3055\u308c\u3001\u7d30\u80de\u306f\u6241\u5e73\u5316\u3057\u3066\u4e08\u592b\u306a\u69cb\u9020\u3078\u3068\u5909\u5316\u3057\u307e\u3059<a href=\"https:\/\/nationaleczema.org\/blog\/what-is-my-skin-barrier\/#:~:text=for%20filaggrin,prompt%20immune%20responses%20like%20inflammation\" target=\"_blank\" rel=\"noreferrer noopener\">nationaleczema.org<\/a>\u3002\u7d30\u80de\u819c\u306e\u5185\u5074\u3067\u306f<strong>\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3<\/strong>\u3084<strong>\u30ed\u30ea\u30af\u30ea\u30f3<\/strong>\u3001<strong>\u30b9\u30e2\u30fc\u30eb\u30d7\u30ed\u30ea\u30f3\u30ea\u30c3\u30c1\u30d7\u30ed\u30c6\u30a4\u30f3\uff08SPRR\uff09\u3068\u3044\u3063\u305f\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\uff08CE; \u89d2\u8cea\u7d30\u80de\u5305\uff09\u306e\u69cb\u6210\u524d\u99c6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6b21\u3005\u3068\u7d50\u5408\u3057\u3066\u5c64\u677f\u3092\u5f62\u6210\u3057\u307e\u3059<a target=\"_blank\" rel=\"noreferrer 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target=\"_blank\" rel=\"noreferrer noopener\">jci.org<\/a>\u3002\u4ee5\u4e0a\u306e\u5909\u5316\u306b\u3088\u308a\u89d2\u5316\u7d30\u80de\u306f\u89d2\u8cea\u7d30\u80de\uff08\u30b3\u30eb\u30cd\u30aa\u30b5\u30a4\u30c8\uff09\u3068\u3057\u3066\u89d2\u8cea\u5c64\u306b\u7a4d\u5c64\u3057\u3001\u5916\u754c\u306b\u5bfe\u3059\u308b\u30d0\u30ea\u30a2\u3092\u62c5\u3046\u7d42\u672b\u7d30\u80de\u3068\u306a\u308a\u307e\u3059\u3002\u89d2\u8cea\u7d30\u80de\u9593\u306b\u306f\u524d\u8ff0\u306e\u30e9\u30e1\u30e9\u9846\u7c92\u304b\u3089\u653e\u51fa\u3055\u308c\u305f\u8102\u8cea\u304c\u6e80\u305f\u3055\u308c\u3001\u7d30\u80de\u540c\u58eb\u3092\u30e2\u30eb\u30bf\u30eb\uff08\u3057\u3063\u304f\u3044\uff09\u306e\u3088\u3046\u306b\u63a5\u7740\u3057\u3066\u6c34\u5206\u306e\u900f\u904e\u3092\u9632\u3050\u8102\u8cea\u4e8c\u91cd\u5c64<\/strong>\u304c\u69cb\u7bc9\u3055\u308c\u307e\u3059<a href=\"https:\/\/www.jci.org\/articles\/view\/28521#:~:text=activates%20the%20transglutaminase%20,This%20process%20of%20differentiation\" target=\"_blank\" rel=\"noreferrer noopener\">jci.org<\/a>\u3002\u3053\u306e\u3088\u3046\u306b\u89d2\u8cea\u5c64\u306f**\u300c\u30ec\u30f3\u30ac\u3068\u30e2\u30eb\u30bf\u30eb\u300d\u69cb\u9020**\uff08\u30ec\u30f3\u30ac\uff1d\u89d2\u8cea\u7d30\u80de\u3001\u30e2\u30eb\u30bf\u30eb\uff1d\u7d30\u80de\u9593\u8102\u8cea\uff09\u3092\u3068\u308a\u3001\u5f37\u56fa\u306a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u307e\u3059<a href=\"https:\/\/www.jci.org\/articles\/view\/28521#:~:text=activates%20the%20transglutaminase%20,This%20process%20of%20differentiation\" target=\"_blank\" rel=\"noreferrer 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href=\"https:\/\/www.jci.org\/articles\/view\/28521\/figure\/1#:~:text=Epidermal%20keratinocytes%20undergo%20a%20linear,water%20content%20of%20the%20body\" target=\"_blank\" rel=\"noreferrer noopener\">jci.org<\/a>\u8868\u76ae\u306e\u57fa\u5e95\u7d30\u80de\uff08Basal\uff09\u306f\u5206\u88c2\u5897\u6b96\u3057\u3066\u6709\u68d8\u5c64\uff08Spinous\uff09\u3078\u79fb\u884c\u3057\u3001\u9846\u7c92\u5c64\uff08Granular\uff09\u3067\u9846\u7c92\u3084\u8102\u8cea\u5c0f\u80de\u3092\u5f62\u6210\u3057\u306a\u304c\u3089\u7d42\u672b\u5206\u5316\u3057\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u7121\u6838\u5316\u3057\u305f\u89d2\u8cea\u7d30\u80de\uff08Squame\uff09\u304c\u89d2\u8cea\u5c64\uff08Stratum 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noopener\">jci.org<\/a>\u3002<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u76ae\u819a\u30d0\u30ea\u30a2\u306e\u5206\u5b50\u69cb\u6210\u6210\u5206<\/h2>\n\n\n\n<p>\u76ae\u819a\u30d0\u30ea\u30a2\u3092\u652f\u3048\u308b\u89d2\u8cea\u5c64\u306b\u306f\u3001<strong>\u89d2\u8cea\u7d30\u80de\uff08\u30b3\u30eb\u30cd\u30aa\u30b5\u30a4\u30c8\uff09\u3068\u305d\u308c\u3092\u53d6\u308a\u5dfb\u304f\u7d30\u80de\u9593\u8102\u8cea<\/strong>\u3001\u304a\u3088\u3073\u7d30\u80de\u9593\u7d50\u5408\u3084\u5929\u7136\u4fdd\u6e7f\u6210\u5206\u306a\u3069\u69d8\u3005\u306a<strong>\u5206\u5b50\u6210\u5206<\/strong>\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u89d2\u8cea\u7d30\u80de\u3068\u89d2\u8cea\u7d30\u80de\u5305\uff08\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\uff09<\/h3>\n\n\n\n<p>\u89d2\u8cea\u7d30\u80de\u305d\u306e\u3082\u306e\u306f\u3001\u5185\u90e8\u306b\u5927\u91cf\u306e\u30b1\u30e9\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u675f\u3092\u542b\u307f\u3001\u5916\u5074\u306f<strong>\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\uff08CE\uff09\u3068\u547c\u3070\u308c\u308b\u56fa\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6bbb\u3067\u8986\u308f\u308c\u3066\u3044\u307e\u3059<a target=\"_blank\" rel=\"noreferrer noopener\">shiseido.co.jp<\/a><a target=\"_blank\" rel=\"noreferrer noopener\">shiseido.co.jp<\/a>\u3002CE\u306e\u4e3b\u8981\u69cb\u6210\u5206\u306f\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3<\/strong>\u3001<strong>\u30ed\u30ea\u30af\u30ea\u30f3<\/strong>\u3001<strong>\u30a8\u30f3\u30dc\u30d7\u30ec\u30ad\u30f3<\/strong>\u3001<strong>\u30da\u30ea\u30d7\u30ec\u30ad\u30f3<\/strong>\u3001<strong>SPRR\uff08Late Cornified Envelope\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u542b\u3080\uff09\u306a\u3069\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u30ed\u30ea\u30af\u30ea\u30f3\u304c\u89d2\u8cea\u7d30\u80de\u5305\u30bf\u30f3\u30d1\u30af\u306e70\u201385%\u3092\u5360\u3081\u308b\u3068\u3082\u3044\u308f\u308c\u307e\u3059\u3002\u3053\u306eCE\u5f62\u6210\u306b\u306f\u524d\u8ff0\u3057\u305f\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc1\uff08TGM1\uff09\u304c\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3001Ca&lt;sup&gt;2+&lt;\/sup&gt;\u4f9d\u5b58\u7684\u306b\u3053\u308c\u3089\u57fa\u8cea\u30bf\u30f3\u30d1\u30af\u3092\u6b21\u3005\u3068\u5171\u6709\u7d50\u5408\u3067\u67b6\u6a4b\u3057\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=to%20initiate%20the%20processing%20pathway26,envelope%20formation%20during%20terminal%20differentiation\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u3055\u3089\u306bTGM1\u306f\u3001\u9577\u9396\u306e\u03c9-\u30d2\u30c9\u30ed\u30ad\u30b7\u30bb\u30e9\u30df\u30c9<\/strong>\uff08\u5f8c\u8ff0\u3059\u308b\u30bb\u30e9\u30df\u30c9EOS\u306a\u3069\uff09\u3092\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3\u306a\u3069CE\u30bf\u30f3\u30d1\u30af\u306b\u30a8\u30b9\u30c6\u30eb\u7d50\u5408\u3055\u305b\u308b\u89e6\u5a92\u3067\u3082\u3042\u308a\u3001\u89d2\u8cea\u7d30\u80de\u8868\u9762\u306b<strong>\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u8102\u8cea\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\uff08CLE\uff09\u3068\u547c\u3070\u308c\u308b\u8102\u8cea\u306e\u5916\u5c64\u3092\u5f62\u6210\u3057\u307e\u3059<a href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/7\/2271#:~:text=The%20earlier%20phases%20of%20cornified,lipid%20barrier%20is%20a%20characteristic\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a>\u3002\u3053\u306eCLE\u306f\u89d2\u8cea\u7d30\u80de\u3068\u7d30\u80de\u9593\u8102\u8cea\u5c64\u3068\u306e\u5883\u754c\u3092\u63a5\u7740\u3055\u305b\u308b\u201c\u306e\u308a\u201d\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4e00\u5c64\u9ad8\u3081\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30bb\u30e9\u30df\u30c9\u3092\u4e3b\u4f53\u3068\u3059\u308b\u7d30\u80de\u9593\u8102\u8cea\u3082\u5b9f\u306f\u89d2\u8cea\u7d30\u80de\u306e\u5916\u5074\u3092\u8986\u3046CE\u3068\u3044\u3046\u3057\u3063\u304b\u308a\u3057\u305f\u8db3\u5834\u304c\u3042\u3063\u3066\u3053\u305d\u79e9\u5e8f\u3060\u3063\u3066\u7a4d\u5c64\u914d\u7f6e\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u3080\u3057\u308dCE\u3053\u305d\u304c\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4e3b\u5f79<\/strong>\u3068\u3082\u8a00\u308f\u308c\u3066\u3044\u307e\u3059<a target=\"_blank\" rel=\"noreferrer noopener\">shiseido.co.jp<\/a>\u3002\u4e8b\u5b9f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u60a3\u8005\u76ae\u819a\u3067\u306f\u672a\u6210\u719f\u306aCE\u3057\u304b\u6301\u305f\u306a\u3044\u89d2\u8cea\u7d30\u80de\u304c\u591a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001CE\u306e\u6210\u719f\u5ea6\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059<a target=\"_blank\" rel=\"noreferrer 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href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=processing%20of%20profilaggrin%20to%20filaggrin,rich%20proteins\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u305d\u306e\u7d50\u679c\u3001\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u81ea\u5df1\u5207\u65ad\u306b\u5fc5\u8981\u306a\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u8a8d\u8b58\u90e8\u4f4d\u304c\u9732\u51fa\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc14\u306a\u3069\u306e\u9175\u7d20\u306b\u3088\u308b\u5207\u65ad\u304c\u958b\u59cb\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=processing%20of%20profilaggrin%20to%20filaggrin,rich%20proteins\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u4e00\u65b9\u3001\u7d30\u80de\u5185\u306eCa&lt;sup&gt;2+&lt;\/sup&gt;\u30b9\u30c8\u30a2\u3067\u3042\u308b\u5c0f\u80de\u4f53\u7531\u6765\u306eCa&lt;sup&gt;2+&lt;\/sup&gt;\u3082\u30d0\u30ea\u30a2\u8abf\u7bc0\u306b\u91cd\u8981\u3067\u3059\u3002\u5c0f\u80de\u4f53\u30b9\u30c8\u30a2\u306eCa&lt;sup&gt;2+&lt;\/sup&gt;\u304c\u67af\u6e07\u3059\u308b\u3068\u89d2\u5316\u7d30\u80de\u306e<strong>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9<\/strong>\u5fdc\u7b54\u304c\u6d3b\u6027\u5316\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc14\u3084\u30ed\u30ea\u30af\u30ea\u30f3\u306e\u767a\u73fe\u304c\u4fc3\u9032\u3055\u308c\u30e9\u30e1\u30e9\u9846\u7c92\u306e\u5206\u6ccc\u304c\u523a\u6fc0\u3055\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=ER%20Ca2%2B%20depletion%20stimulates%20lamellar,is%20a%20critical%20signal\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a><a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=barrier%20function%20can%20trigger%20LBs,regulator%20in%20keratinocyte%20differ%02entiation%20and\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u3053\u308c\u306f\u8868\u76ae\u30d0\u30ea\u30a2\u306b\u969c\u5bb3\u304c\u751f\u3058\u305f\u969b\u3001\u89d2\u5316\u7d30\u80de\u5185\u30b9\u30c8\u30a2Ca&lt;sup&gt;2+&lt;\/sup&gt;\u306e\u653e\u51fa\u306b\u3088\u3063\u3066\u30d0\u30ea\u30a2\u4fee\u5fa9\u304c\u30b9\u30a4\u30c3\u30c1\u30aa\u30f3\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3067\u3042\u308a\u3001\u5b9f\u969b\u306b\u5916\u7528\u85ac\u3067\u4eba\u5de5\u7684\u306b\u8868\u76ae\u306b\u5fae\u5c0f\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u5909\u5316\u3092\u4e0e\u3048\u308b\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u5f37\u5316\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=Skin%20Barrier%20and%20Calcium%20Vol,a%20strategy%20to%20en%02hance%20permeability\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a><a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=of%20CaSR%20in%20vivo%20by,and%20barrier%20function%20in%20vivo\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002<\/p>\n\n\n\n<p>\u30ab\u30eb\u30b7\u30a6\u30e0\u30b7\u30b0\u30ca\u30eb\u306e\u4e0a\u6d41\u306b\u306f**\u30ab\u30eb\u30b7\u30a6\u30e0\u611f\u77e5\u53d7\u5bb9\u4f53\uff08CaSR\uff09**\u304c\u5b58\u5728\u3057\u307e\u3059\u3002CaSR\u306f\u9846\u7c92\u5c64\u306e\u89d2\u5316\u7d30\u80de\u819c\u4e0a\u306b\u767a\u73fe\u3059\u308bG\u30bf\u30f3\u30d1\u30af\u5171\u5f79\u53d7\u5bb9\u4f53\u3067\u3001\u7d30\u80de\u5916Ca&lt;sup&gt;2+&lt;\/sup&gt;\u6fc3\u5ea6\u306e\u4e0a\u6607\u3092\u691c\u77e5\u3057\u3066\u30db\u30b9\u30db\u30ea\u30d1\u30fc\u30bcC\u7d4c\u8def\uff08IP3\u751f\u6210\uff09\u3092\u6d3b\u6027\u5316\u3057\u3001\u5c0f\u80de\u4f53\u304b\u3089\u306eCa&lt;sup&gt;2+&lt;\/sup&gt;\u653e\u51fa\u3068\u30b9\u30c8\u30a2\u4f5c\u52d5\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u6d41\u5165\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=1,from%20intracellular%20stores%20such%20as\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u3053\u306e\u7d4c\u8def\u306b\u3088\u3063\u3066\u9846\u7c92\u5c64\u89d2\u5316\u7d30\u80de\u306e\u7d30\u80de\u5185Ca&lt;sup&gt;2+&lt;\/sup&gt;\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u6838\u5185\u8ee2\u5199\u56e0\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u524d\u8ff0\u306e\u5206\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u7fa4\uff08TGM1\u3001\u30ed\u30ea\u30af\u30ea\u30f3\u3001\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3\u3001\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3001\u30b1\u30e9\u30c1\u30f3\u306a\u3069\uff09\u306e\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=the%20stratum%20granulosum,synthesis%20of%20differ%02entiation%20specific%20proteins\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u3057\u305f\u304c\u3063\u3066CaSR\u306f\u300c\u8868\u76ae\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u52fe\u914d\u3092\u5bdf\u77e5\u3057\u3066\u89d2\u5316\u7d30\u80de\u306e\u5206\u5316\u30fb\u30d0\u30ea\u30a2\u5f62\u6210\u3092\u53f8\u308b\u30bb\u30f3\u30b5\u30fc\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u304a\u308a\u3001CaSR\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8868\u76ae\u30ab\u30eb\u30b7\u30a6\u30e0\u52fe\u914d\u306e\u6d88\u5931\u3068\u5206\u5316\u30de\u30fc\u30ab\u30fc\u306e\u5927\u5e45\u6e1b\u5c11\u3001\u30e9\u30e1\u30e9\u9846\u7c92\u5206\u6ccc\u4e0d\u5168\u3092\u6765\u3059\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=of%20CaSR%20in%20vivo%20by,and%20barrier%20function%20in%20vivo\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u3068\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u5f62\u6210<\/h3>\n\n\n\n<p><strong>\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\uff08transglutaminase; 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noopener\">mdpi.com<\/a>\u3002TGM1\u306f\u9846\u7c92\u5c64\u3067\u767a\u73fe\u3057\u3001\u7d30\u80de\u7d42\u672b\u5206\u5316\u6642\u306b\u7d30\u80de\u5185Ca&lt;sup&gt;2+&lt;\/sup&gt;\u6fc3\u5ea6\u306e\u4e0a\u6607\u3068\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3066\u6d3b\u6027\u5316\u3057\u3001\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3\u3001\u30ed\u30ea\u30af\u30ea\u30f3\u3001\u30a8\u30f3\u30dc\u30d7\u30ec\u30ad\u30f3\u3001\u30da\u30ea\u30d7\u30ec\u30ad\u30f3\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3001\u30b1\u30e9\u30c1\u30f3\u306a\u3069\u591a\u6570\u306e\u57fa\u8cea\u3092\u6b21\u3005\u3068\u67b6\u6a4b\u3057\u3066\u4e0d\u6eb6\u6027\u306e\u89d2\u8cea\u7d30\u80de\u5305\uff08CE\uff09\u3092\u5f62\u6210\u3057\u307e\u3059<a href=\"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.2018.30.3.265#:~:text=to%20initiate%20the%20processing%20pathway26,envelope%20formation%20during%20terminal%20differentiation\" target=\"_blank\" rel=\"noreferrer noopener\">anndermatol.org<\/a>\u3002\u307e\u305f\u524d\u8ff0\u306e\u3088\u3046\u306bTGM1\u306f\u03c9-\u30d2\u30c9\u30ed\u30ad\u30b7\u30bb\u30e9\u30df\u30c9\u3092CE\u30bf\u30f3\u30d1\u30af\u306b\u7d50\u5408\u3055\u305b\u308b\u6a5f\u80fd\u3082\u6301\u3064\u305f\u3081\u3001TGM1\u6b20\u640d\u3067\u306f\u7d30\u80de\u8868\u9762\u306e\u8102\u8cea\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u5f62\u6210\u304c\u4e0d\u80fd\u3068\u306a\u308a\u30d0\u30ea\u30a2\u4e0d\u5168\u306b\u9665\u308a\u307e\u3059<a href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/7\/2271#:~:text=The%20earlier%20phases%20of%20cornified,lipid%20barrier%20is%20a%20characteristic\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a><a href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/7\/2271#:~:text=corneocyte%20lipid%20envelope%20in%20the,of%20LOR%20with%20KIF%2C%20FLG\" target=\"_blank\" rel=\"noreferrer noopener\">mdpi.com<\/a>\u3002TGM1\u4ee5\u5916\u3067\u306f<strong>TGM3<\/strong>\u3082\u4e3b\u306b\u6bdb\u5305\u4ed8\u5c5e\u5668\u3067\u767a\u73fe\u3057\u307e\u3059\u304c\u4e00\u90e8\u8868\u76ae\u306b\u3082\u5b58\u5728\u3057\u3001\u89d2\u8cea\u7d30\u80de\u540c\u58eb\u306e\u63a5\u7740\u6591\uff08\u30b3\u30eb\u30cd\u30aa\u30c7\u30b9\u30e2\u30bd\u30fc\u30e0\uff09\u306e\u786c\u5316\u3084\u8131\u843d\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002TGM2\u306f\u57fa\u5e95\u5c64\u3067\u767a\u73fe\u3057\u50b7\u5bb3\u6642\u306e\u8868\u76ae\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u306a\u3069\u3001\u5404\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3067\u6a5f\u80fd\u304c\u7570\u306a\u308a\u307e\u3059\u3002TGM1\u767a\u73fe\u306f\u4e0a\u8a18\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3A\u30fbD\u3001\u307e\u305f\u7a2e\u3005\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u8ee2\u5199\u56e0\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u4f8b\u3048\u3070\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306fTGM1\u3084\u30ed\u30ea\u30af\u30ea\u30f3\u306e\u767a\u73fe\u4f4e\u4e0b\u3067\u8efd\u5ea6\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u304c\u8d77\u3053\u308a\u3001\u9006\u306b\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\uff08\u30d3\u30bf\u30df\u30f3A\u8a98\u5c0e\u4f53\uff09\u5916\u7528\u3067TGM1\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3068\u3044\u3063\u305f\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-4\u3084IL-13\u306a\u3069Th2\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09\u306fTGM1\u3084\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3001\u30ed\u30ea\u30af\u30ea\u30f3\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u5f8c\u8ff0\u306e\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3067\u306f\u554f\u984c\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=haptens,Additionally%2C%20loricrin%2C%20and%20involucrin%2C%20which\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5265\u96e2\u3068\u30d0\u30ea\u30a2\u6052\u5e38\u6027<\/h3>\n\n\n\n<p>\u89d2\u8cea\u5c64\u3067\u306f\u3001\u53e4\u3044\u89d2\u8cea\u7d30\u80de\u304c\u6700\u7d42\u7684\u306b\u57a2\u3068\u306a\u3063\u3066\u81ea\u7136\u5265\u96e2\u3059\u308b<strong>\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\uff08\u89d2\u8cea\u5265\u8131\uff09\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u306e\u5265\u8131\u306f\u3001\u89d2\u8cea\u7d30\u80de\u9593\u306e\u63a5\u7740\u88c5\u7f6e\u3067\u3042\u308b\u30b3\u30eb\u30cd\u30aa\u30c7\u30b9\u30e2\u30bd\u30fc\u30e0<\/strong>\u3092\u5206\u89e3\u3059\u308b<strong>\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc<\/strong>\u7fa4\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u3082\u306e\u306f<strong>\u30ab\u30ea\u30af\u30ec\u30a4\u30f3\u95a2\u9023\u30da\u30d7\u30c1\u30c0\u30fc\u30bc<\/strong>\u3068\u3044\u3046\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u7fa4\uff08<strong>KLK5<\/strong>\uff0c<strong>KLK7<\/strong>\u306a\u3069\uff09\u3067\u3001\u89d2\u8cea\u7d30\u80de\u9593\u3067\u30b3\u30eb\u30cd\u30aa\u30c7\u30b9\u30e2\u30b7\u30f3\u306a\u3069\u63a5\u7740\u5206\u5b50\u3092\u5207\u65ad\u3057\u3001\u89d2\u8cea\u7d30\u80de\u3092\u4e00\u679a\u305a\u3064\u5265\u304c\u3057\u3066\u3044\u304d\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002KLK\u306e\u6d3b\u6027\u306f<strong>\u76ae\u819a\u8868\u9762\u306e\u6c34\u5206\u91cf\u3084pH<\/strong>\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u901a\u5e38\u306f\u76ae\u819a\u304c\u6f64\u3063\u3066\u5f31\u9178\u6027\u306b\u4fdd\u305f\u308c\u308b\u3053\u3068\u3067\u904e\u5ea6\u306a\u5265\u96e2\u304c\u8d77\u3053\u3089\u306a\u3044\u3088\u3046\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=Elevated%20skin%20pH%20can%20impact,pH%2C%20while%20an%20acidic%20pH\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5177\u4f53\u7684\u306b\u306f\u89d2\u8cea\u7d30\u80de\u4e2d\u306e<strong>LEKTI<\/strong>\uff08Serine Protease Inhibitor Kazal Type 5; SPINK5\u907a\u4f1d\u5b50\u7523\u7269\uff09\u3068\u547c\u3070\u308c\u308b\u5185\u56e0\u6027\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u304cKLK\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3001\u307e\u305fpH5\u524d\u5f8c\u306e\u74b0\u5883\u4e0b\u3067\u306fKLK\u9175\u7d20\u81ea\u4f53\u306e\u6d3b\u6027\u3082\u5f31\u3044\u305f\u3081\u3067\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3057\u304b\u3057\u76ae\u819a\u304c\u30a2\u30eb\u30ab\u30ea\u6027\u306b\u50be\u3044\u305f\u308a\u4e7e\u71e5\u3057\u305f\u308a\u3059\u308b\u3068\u3001KLK\u306e\u6d3b\u6027\u304c\u4ea2\u9032\u3057\u89d2\u8cea\u5265\u8131\u304c\u4fc3\u9032\u3055\u308c\u3059\u304e\u3066\u30d0\u30ea\u30a2\u304c\u7834\u7dbb\u3059\u308b\u4e00\u56e0\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5b9f\u969b\u3001\u76ae\u819a\u8868\u9762pH\u3092\u5b9f\u9a13\u7684\u306b7\u4ee5\u4e0a\u306b\u4e0a\u6607\u3055\u305b\u308b\u3068KLK5\u304c\u6d3b\u6027\u5316\u3057\u3066\u30de\u30a6\u30b9\u306b\u30a2\u30c8\u30d4\u30fc\u69d8\u76ae\u819a\u708e\u3092\u751f\u3058\u308b\u3053\u3068\u3001KLK7\u304cIL-1\u03b2\u3092\u6d3b\u6027\u5316\u3057\u3066\u708e\u75c7\u3092\u60f9\u8d77\u3059\u308b\u3053\u3068\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u4e00\u65b9\u3067\u3001\u30ab\u30b9\u30d1\u30fc\u30bc14\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u5206\u89e3\uff09\u3001\u30ab\u30eb\u30d1\u30a4\u30f3\u3084\u30ad\u30e3\u30c6\u30d7\u30b7\u30f3\u985e\uff08\u89d2\u8cea\u7d30\u80de\u5305\u5185\u30bf\u30f3\u30d1\u30af\u306e\u51e6\u7406\uff09\u306a\u3069\u3001\u89d2\u8cea\u5c64\u306b\u306f\u8907\u6570\u7a2e\u985e\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u305e\u308c\u304c<strong>\u30d0\u30ea\u30a2\u6052\u5e38\u6027\u7dad\u6301<\/strong>\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u306e\u7570\u5e38\u306f\u9b5a\u9c57\u766c\u3084\u5265\u8131\u6027\u76ae\u819a\u708e\u306a\u3069\u306e\u75c5\u614b\u306b\u3064\u306a\u304c\u308b\u305f\u3081\u3001\u305d\u306e\u5236\u5fa1\u3082\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5916\u7684\u56e0\u5b50\u306b\u3088\u308b\u30d0\u30ea\u30a2\u6a5f\u80fd\u7834\u7dbb\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n\n\n\n<p>\u76ae\u819a\u30d0\u30ea\u30a2\u306f\u5916\u90e8\u74b0\u5883\u304b\u3089\u69d8\u3005\u306a\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<strong>\u7d2b\u5916\u7dda\uff08UV\uff09<\/strong>\u3001<strong>\u4e7e\u71e5\u74b0\u5883<\/strong>\u3001<strong>\u7269\u7406\u30fb\u5316\u5b66\u7684\u523a\u6fc0\u7269<\/strong>\u306a\u3069\u306e\u5916\u7684\u8981\u56e0\u306f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u4e3b\u8981\u306a\u8a98\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d2b\u5916\u7dda\uff08UV\uff09:<\/strong> \u7d2b\u5916\u7dda\u306f\u76ae\u819a\u306b\u591a\u9762\u7684\u306a\u969c\u5bb3\u3092\u4e0e\u3048\u307e\u3059\u304c\u3001\u7279\u306bUVB\uff08\u6ce2\u9577290\u2013320nm\uff09\u306f\u8868\u76ae\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5438\u53ce\u3055\u308c\u3084\u3059\u304f\u3001\u8868\u76ae\u7d30\u80de\u3084\u7d30\u80de\u9593\u8102\u8cea\u306b\u76f4\u63a5\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u307e\u3059\u3002UVB\u7167\u5c04\u306b\u3088\u308a\u89d2\u8cea\u5c64\u3067\u306f**\u5171\u6709\u7d50\u5408\u578b\u30bb\u30e9\u30df\u30c9\uff08\u03c9-\u30d2\u30c9\u30ed\u30ad\u30b7\u30bb\u30e9\u30df\u30c9\uff09<strong>\u306e\u30ec\u30d9\u30eb\u4f4e\u4e0b\u304c\u8d77\u3053\u308a\u3001\u305d\u308c\u306b\u6bd4\u4f8b\u3057\u3066TEWL\uff08\u7d4c\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u304c\u6709\u610f\u306b\u5897\u5927\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/pdfs.semanticscholar.org\/36b1\/627dbb90e43e6f9fd6e238a8d59cffcb3fcd.pdf#:~:text=in%20parallel%20with%20a%20significant,in%20the%20epidermis%20are%20thought\" target=\"_blank\" rel=\"noreferrer noopener\">pdfs.semanticscholar.org<\/a>\u3002\u3053\u308c\u306fUVB\u304c\u89d2\u8cea\u7d30\u80de\u5305\u306b\u7d50\u5408\u3057\u305f\u30bb\u30e9\u30df\u30c9\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30d0\u30ea\u30a2\u306e\u201c\u30e2\u30eb\u30bf\u30eb\u201d\u3092\u640d\u306a\u3046\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5b9f\u969b\u3001UVB\u7167\u5c04\u5f8c\u306e\u76ae\u819a\u3067\u306f\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u6307\u6a19\u3067\u3042\u308b\u89d2\u5c64\u6c34\u5206\u91cf\u304c\u4f4e\u4e0b\u3057\u3001\u9855\u5fae\u93e1\u7684\u306b\u3082\u89d2\u8cea\u7d30\u80de\u306b\u7a7a\u9699\u304c\u751f\u3058\u308b\u306a\u3069\u30d0\u30ea\u30a2\u7834\u7dbb\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059<a href=\"https:\/\/www.uspharmacist.com\/article\/benefits-of-ceramides-in-uv-protection-and-skin-care#:~:text=skin%2C%20and%203%29%20UV,containing%20skincare%20routine\" target=\"_blank\" rel=\"noreferrer noopener\">uspharmacist.com<\/a>\u3002\u307e\u305fUVB\u306f\u8868\u76ae\u7d30\u80de\u306eDNA\u3092\u50b7\u3064\u3051\u3066\u65e5\u713c\u3051\uff08\u30b5\u30f3\u30d0\u30fc\u30f3\uff09\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u306e\u4e8c\u6b21\u7684\u5f71\u97ff\u3067\u89d2\u5316\u7570\u5e38\u3084\u5265\u8131\u4ea2\u9032\u304c\u751f\u3058\u308b\u3053\u3068\u3082\u30d0\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001UVA\uff08320\u2013400nm\uff09\u306f\u771f\u76ae\u307e\u3067\u5230\u9054\u3057\u3066\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\u3092\u5909\u6027\u3055\u305b\u307e\u3059\u304c\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u305d\u306e\u3082\u306e\u3078\u306e\u76f4\u63a5\u5f71\u97ff\u306fUVB\u307b\u3069\u5927\u304d\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057UVA\u3082\u6d3b\u6027\u9178\u7d20\u7a2e\u3092\u767a\u751f\u3055\u305b\u76ae\u819a\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u9ad8\u3081\u3001\u30bb\u30e9\u30df\u30c9\u306e\u904e\u9178\u5316\u5206\u89e3\u306a\u3069\u3067\u9593\u63a5\u7684\u306b\u30d0\u30ea\u30a2\u3092\u4e71\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30d0\u30ea\u30a2\u969c\u5bb3\u3092\u9632\u3050\u306b\u306f\u65e5\u5e38\u7684\u306a<\/strong>\u5149\u9632\u5fa1\uff08\u30b5\u30f3\u30b9\u30af\u30ea\u30fc\u30f3\u5264\u306e\u4f7f\u7528\u3084\u906e\u5149\uff09**\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u8fd1\u5e74\u3067\u306f\u30bb\u30e9\u30df\u30c9\u542b\u6709\u65e5\u713c\u3051\u6b62\u3081\u306a\u3069\u30d0\u30ea\u30a2\u4fdd\u8b77\u52b9\u679c\u3092\u4f75\u305b\u6301\u3064\u88fd\u54c1\u3082\u6709\u7528\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.uspharmacist.com\/article\/benefits-of-ceramides-in-uv-protection-and-skin-care#:~:text=ceramides%20can%20help%20protect%20against,health%20against%20chronic%20sun%20exposure\" target=\"_blank\" rel=\"noreferrer noopener\">uspharmacist.com<\/a><a href=\"https:\/\/www.uspharmacist.com\/article\/benefits-of-ceramides-in-uv-protection-and-skin-care#:~:text=The%20authors%20concluded%20that%20the,overall%20against%20chronic%20sun%20exposure\" target=\"_blank\" rel=\"noreferrer noopener\">uspharmacist.com<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u4e7e\u71e5\u30fb\u4f4e\u6e7f\u5ea6:<\/strong> 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target=\"_blank\" rel=\"noreferrer noopener\">jstage.jst.go.jp<\/a>\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u306f\u901f\u3084\u304b\u306a\u4e7e\u71e5\u3068\u76ae\u819a\u4fdd\u8b77\u5264\u306b\u3088\u308b\u51e6\u7f6e\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u5185\u7684\u8981\u56e0\u306b\u3088\u308b\u30d0\u30ea\u30a2\u6a5f\u80fd\u7834\u7dbb\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n\n\n\n<p>\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306f\u4f53\u5185\u306e\u8981\u56e0\u3001\u3059\u306a\u308f\u3061<strong>\u52a0\u9f62<\/strong>\u3084<strong>\u907a\u4f1d\u7d20\u56e0\u30fb\u75be\u60a3<\/strong>\u306b\u3088\u3063\u3066\u3082\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u52a0\u9f62\uff08\u30a8\u30a4\u30b8\u30f3\u30b0\uff09:<\/strong> 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rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=skin%20,Figure%201\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u306f\u76ae\u8102\u7523\u751f\u4f4e\u4e0b\u306b\u3088\u308b\u8102\u80aa\u9178\u6e1b\u5c11\u3084\u3001\u6c57\u817a\u306esPLA&lt;sub&gt;2&lt;\/sub&gt;\uff08\u30db\u30b9\u30db\u30ea\u30d1\u30fc\u30bcA&lt;sub&gt;2&lt;\/sub&gt;\uff09\u6d3b\u6027\u4f4e\u4e0b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=stratum%20corneum,skin%2C%20at%20least%20in%20mice\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u3055\u3089\u306b\u306f\u8868\u76ae\u306eNHE1\uff08\u30ca\u30c8\u30ea\u30a6\u30e0\u30fb\u6c34\u7d20\u4ea4\u63db\u8f38\u9001\u4f53\uff09\u306e\u767a\u73fe\u4f4e\u4e0b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=Sodium,corneum%20correlates%20positively%20with%20skin\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u767a\u73fe\u4f4e\u4e0b\u306b\u3088\u308bUCA\u6e1b\u5c11<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=skin%20,Figure%201\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u306a\u3069\u8907\u6570\u306e\u8981\u56e0\u3067\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u76ae\u819a\u304c\u30a2\u30eb\u30ab\u30ea\u5316\u3059\u308b\u3068\u89d2\u8cea\u5c64\u306e\u8102\u8cea\u52a0\u5de5\u9175\u7d20\u306e\u6d3b\u6027\u4f4e\u4e0b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=Elevated%20skin%20pH%20can%20impact,pH%2C%20while%20an%20acidic%20pH\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3084\u3001\u524d\u8ff0\u306eKLK5\/7\u306e\u7570\u5e38\u6d3b\u6027\u5316\u306b\u3088\u308b\u89d2\u8cea\u5265\u8131\u30fb\u708e\u75c7\u8a98\u767a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=the%20increased%20skin%20surface%20pH,like\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u5e38\u5728\u83cc\u53e2\u306e\u4e71\u308c\uff08\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u3084\u771f\u83cc\u306e\u5897\u6b96\uff09<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=skin%20pH%20can%20abrogate%20the,is%20rich%20in%20proteases%20with\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u306a\u3069\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u304c\u53ca\u3073\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u9ad8\u9f62\u8005\u3067\u306f<strong>\u76ae\u819a\u306e\u6c34\u5206\u4fdd\u6301\u529b\u4f4e\u4e0b\u3068\u6162\u6027\u76ae\u819a\u708e<\/strong>\uff08\u3044\u308f\u3086\u308b\u300c\u4e7e\u76ae\u75c7\u300d\u3084\u300c\u76ae\u819a\u63bb\u75d2\u75c7\u300d\uff09\u304c\u751f\u3058\u3084\u3059\u304f\u306a\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=Reductions%20in%20stratum%20corneum%20hydration,it%20cannot%20be%20rapidly%20normalized\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u52a0\u9f62\u76ae\u819a\u3067\u306f\u5916\u7684\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u30d0\u30ea\u30a2\u56de\u5fa9\u80fd\u3082\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u4e00\u5ea6\u30d0\u30ea\u30a2\u304c\u7834\u7dbb\u3059\u308b\u3068\u82e5\u5e74\u8005\u3088\u308a\u3082\u4fee\u5fa9\u306b\u6642\u9593\u304c\u304b\u304b\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=As%20mentioned%20above%2C%20permeability%20barrier,atopic%20dermatitis%20and%20contact%20dermatitis\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u305d\u306e\u305f\u3081\u63bb\u7834\u3084\u8efd\u5fae\u306a\u5916\u50b7\u304b\u3089\u6162\u6027\u6e7f\u75b9\u3084\u96e3\u6cbb\u6027\u76ae\u819a\u708e\u306b\u79fb\u884c\u3057\u3084\u3059\u304f\u3001\u3044\u308f\u3086\u308b**\u300c\u6cbb\u308a\u306b\u304f\u3044\u76ae\u819a\u300d<strong>\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=As%20mentioned%20above%2C%20permeability%20barrier,atopic%20dermatitis%20and%20contact%20dermatitis\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u9ad8\u9f62\u8005\u3067\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3084\u63a5\u89e6\u76ae\u819a\u708e\u304c\u5897\u60aa\u3057\u3084\u3059\u3044\u4e00\u56e0\u3082\u3001\u3053\u3046\u3057\u305f\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u52a0\u9f62\u5909\u5316\u306b\u3042\u308a\u307e\u3059\u3002\u5f93\u3063\u3066\u9ad8\u9f62\u306e\u76ae\u819a\u3067\u306f\u82e5\u5e74\u6642\u4ee5\u4e0a\u306b<\/strong>\u4fdd\u6e7f\u30b1\u30a2<strong>\u3084<\/strong>\u4f4e\u523a\u6fc0\u6027\u88fd\u54c1\u306e\u4f7f\u7528**\u3001**\u76ae\u819a\u306e\u9178\u6027\u5ea6\u7dad\u6301\uff08pH\u30b1\u30a2\uff09**\u306a\u3069\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u9ad8\u9f62\u8005\u306b\u9178\u6027\u306e\u4fdd\u6e7f\u5264\uff08pH4\u7a0b\u5ea6\uff09\u30921\u30f6\u6708\u9593\u4f7f\u7528\u3059\u308b\u3068\u3001\u89d2\u8cea\u6c34\u5206\u91cf\u306e\u6539\u5584\u3084\u30d0\u30ea\u30a2\u6a5f\u80fd\u6307\u6a19\u306e\u4e0a\u6607\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7138575\/#:~:text=Studies%20have%20demonstrated%20that%20acidification,0\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u76ae\u819a\u306e\u7a4d\u6975\u7684\u306a\u9178\u6027\u5316\u30fb\u4fdd\u6e7f\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\uff08AD\uff09:<\/strong> 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target=\"_blank\" rel=\"noreferrer noopener\">nationaleczema.org<\/a>\uff08\u65e5\u672c\u4eba\u3067\u308210%\u524d\u5f8c\u3068\u306e\u5831\u544a\u3042\u308a\uff09\u3002\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u4e0d\u8db3\u306f\u524d\u8ff0\u306e\u3088\u3046\u306b\u89d2\u8cea\u5c64\u306e\u4fdd\u6e7f\u529b\u4f4e\u4e0b\u3068pH\u4e0a\u6607\u3001\u89d2\u8cea\u69cb\u9020\u306e\u7de9\u307f\u3092\u62db\u304d\u3001\u7d4c\u76ae\u611f\u4f5c\uff08\u30a2\u30ec\u30eb\u30b2\u30f3\u4fb5\u5165\uff09\u3092\u8a31\u3059\u6839\u672c\u8981\u56e0\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/nationaleczema.org\/blog\/what-is-my-skin-barrier\/#:~:text=for%20filaggrin,prompt%20immune%20responses%20like%20inflammation\" target=\"_blank\" rel=\"noreferrer noopener\">nationaleczema.org<\/a>\u3002\u3055\u3089\u306bAD\u76ae\u819a\u3067\u306f\u89d2\u8cea\u5c64\u30bb\u30e9\u30df\u30c9\uff08\u7279\u306bEOS\u578b\uff09\u306e\u6709\u610f\u306a\u6b20\u4e4f\u304c\u3042\u308a\u3001NMF\u4f4e\u4e0b\u3068\u306e\u76f8\u4e57\u3067\u9855\u8457\u306a\u4e7e\u71e5\u808c\u3068\u306a\u308a\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=of%20antimicrobial%20peptides%20,agents%2C%20sodium%20hypochlorite%2C%20probiotics%2C%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=The%20cornified%20layer%20is%20surrounded,altered%20composition%20in%20AD%20skin\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u52a0\u3048\u3066\u6162\u6027\u7684\u306aTh2\u578b\u708e\u75c7\u304c\u8868\u76ae\u306b\u5b58\u5728\u3059\u308b\u305f\u3081\u3001IL-4\u3084IL-13\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306e\u5206\u5316\u3092\u4e71\u3057\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3084\u30ed\u30ea\u30af\u30ea\u30f3\u3001\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3\u306e\u767a\u73fe\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=haptens,Additionally%2C%20loricrin%2C%20and%20involucrin%2C%20which\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u3088\u3046\u306b<strong>\u907a\u4f1d\u8981\u56e0\uff0b\u74b0\u5883\u8981\u56e0\uff0b\u514d\u75ab\u8981\u56e0<\/strong>\u306e\u8907\u5408\u7684\u4f5c\u7528\u3067\u76ae\u819a\u30d0\u30ea\u30a2\u969c\u5bb3\u304c\u751f\u3058\u3001\u3055\u3089\u306b\u30d0\u30ea\u30a2\u7834\u7dbb\u306b\u3088\u308b\u523a\u6fc0\u6297\u539f\u4fb5\u5165\u304c\u514d\u75ab\u5fdc\u7b54\u3092\u4ea2\u9032\u3055\u305b\u3066\u76ae\u819a\u708e\u3092\u7dad\u6301\u30fb\u5897\u60aa\u3055\u305b\u308b\u3068\u3044\u3046<strong>\u60aa\u5faa\u74b0<\/strong>\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u5b9f\u969b\u3001AD\u60a3\u8005\u3067\u306f\u5065\u5e38\u76ae\u819a\u3068\u6bd4\u3079\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u7570\u5e38\u5897\u6b96\u304c\u307b\u307c\u5e38\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u30d0\u30ea\u30a2\u969c\u5bb3\u306b\u3088\u308b\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u7523\u751f\u4f4e\u4e0b\u3068\u76ae\u819apH\u4e0a\u6607\u304c\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u307e\u3059<a href=\"https:\/\/www.erca.go.jp\/yobou\/zensoku\/sukoyaka\/47\/medical\/medical03.html#:~:text=Image\" target=\"_blank\" rel=\"noreferrer noopener\">erca.go.jp<\/a><a href=\"https:\/\/www.erca.go.jp\/yobou\/zensoku\/sukoyaka\/47\/medical\/medical03.html#:~:text=%E5%90%8C%E6%99%82%E3%81%AB%E3%80%81%E3%82%B9%E3%82%AD%E3%83%B3%E3%82%B1%E3%82%A2%E3%81%AB%E3%82%88%E3%81%A3%E3%81%A6%E3%83%90%E3%83%AA%E3%82%A2%E6%A9%9F%E8%83%BD%E3%82%92%E5%BC%B7%E5%8C%96%E3%81%97%E3%81%BE%E3%81%99%E3%80%82%E3%82%B9%E3%82%AD%E3%83%B3%E3%82%B1%E3%82%A2%E3%81%A8%E3%81%AF%E3%80%81%E7%9A%AE%E8%86%9A%E3%82%92%E3%81%97%E3%81%A3%E3%81%8B%E3%82%8A%E3%81%A8%E4%B8%81%E5%AF%A7%E3%81%AB%E6%B4%97%E3%81%A3%E3%81%A6%E6%B8%85%E6%BD%94%E3%81%AB%E3%81%97%E3%80%81%E7%9A%AE%E8%86%9A%E3%82%92%E4%B9%BE%E7%87%A5%E3%81%8B%E3%82%89%E5%AE%88%E3%82%8B%E3%81%9F%E3%82%81%E3%81%AB%E4%BF%9D%E6%B9%BF%E5%89%A4%E3%82%92%E5%A1%97%E3%82%8B%E3%81%93%E3%81%A8%E3%81%A7%E3%81%99%E3%80%82\" target=\"_blank\" rel=\"noreferrer noopener\">erca.go.jp<\/a>\u3002AD\u6cbb\u7642\u3067\u306f\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u3068\u540c\u6642\u306b**\u30b9\u30ad\u30f3\u30b1\u30a2\uff08\u76ae\u819a\u3092\u6e05\u6f54\u306b\u4fdd\u3061\u4fdd\u6e7f\u3059\u308b\u3053\u3068\uff09**\u3067\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3059<a href=\"https:\/\/www.erca.go.jp\/yobou\/zensoku\/sukoyaka\/47\/medical\/medical03.html#:~:text=%E7%9A%AE%E8%86%9A%E3%81%AE%E7%82%8E%E7%97%87%E3%81%8C%E3%81%82%E3%82%8B%E3%81%A8%E3%81%9D%E3%82%8C%E3%81%AB%E3%81%A8%E3%82%82%E3%81%AA%E3%81%A3%E3%81%A6%E3%83%90%E3%83%AA%E3%82%A2%E6%A9%9F%E8%83%BD%E3%81%8C%E3%82%88%E3%82%8A%E4%BD%8E%E4%B8%8B%E3%81%99%E3%82%8B%E3%80%81%E3%81%A8%E3%81%84%E3%81%86%E6%82%AA%E5%BE%AA%E7%92%B0%E3%81%8C%E8%B5%B7%E3%81%93%E3%82%8A%E3%81%BE%E3%81%99%E3%80%82%E3%81%9D%E3%81%AE%E3%81%9F%E3%82%81%E3%80%81%E3%82%A2%E3%83%88%E3%83%94%E3%83%BC%E6%80%A7%E7%9A%AE%E8%86%9A%E7%82%8E%E3%81%AE%E6%B2%BB%E7%99%82%E3%81%A7%E3%81%AF%E3%80%81\" target=\"_blank\" rel=\"noreferrer noopener\">erca.go.jp<\/a><a href=\"https:\/\/www.erca.go.jp\/yobou\/zensoku\/sukoyaka\/47\/medical\/medical03.html#:~:text=Image\" target=\"_blank\" rel=\"noreferrer noopener\">erca.go.jp<\/a>\u3002\u3053\u308c\u306b\u3088\u308a\u30a2\u30ec\u30eb\u30b2\u30f3\u4fb5\u5165\u3068\u708e\u75c7\u306e\u60aa\u5faa\u74b0\u3092\u65ad\u3061\u5207\u308a\u3001\u85ac\u7269\u6cbb\u7642\u306e\u52b9\u679c\u3082\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5b9f\u969b\u3001<strong>\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u6b63\u5e38\u306b\u4fdd\u3064\u4fdd\u6e7f\u30b9\u30ad\u30f3\u30b1\u30a2\u306fAD\u6cbb\u7642\u306e\u57fa\u672c<\/strong>\u3067\u3042\u308a\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u30b9\u30c6\u30ed\u30a4\u30c9\u306a\u3069\u85ac\u7269\u7642\u6cd5\u3068\u4e26\u3076\u67f1\u3068\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/hc.mochida.co.jp\/skincare\/atopic\/atopic3.html#:~:text=%E4%B9%BE%E7%87%A5%E3%82%92%E9%98%B2%E3%81%8E%E3%80%81%E7%9A%AE%E8%86%9A%E3%81%AE%E3%83%90%E3%83%AA%E3%82%A2%E6%A9%9F%E8%83%BD%E3%82%92%E6%AD%A3%E5%B8%B8%E3%81%AB%E4%BF%9D%E3%81%A4%E3%81%9F%E3%82%81%E3%81%AE%E3%82%B9%E3%82%AD%E3%83%B3%E3%82%B1%E3%82%A2%E3%81%AF%E3%80%81%E3%82%A2%E3%83%88%E3%83%94%E3%83%BC%E6%80%A7%E7%9A%AE%E8%86%9A%E7%82%8E%E3%81%AE%E6%A8%99%E6%BA%96%E6%B2%BB%E7%99%82%E3%81%AE%E3%81%B2%E3%81%A8%E3%81%A4%E3%81%A8%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%E3%80%82%E3%81%BE%E3%81%9F%E3%80%81%E3%82%A2%E3%83%88%E3%83%94%E3%83%BC%E6%80%A7%E7%9A%AE%E8%86%9A%E7%82%8E%E3%81%AF%E3%80%81%E7%97%87%E7%8A%B6%E3%81%AE%E6%94%B9%E5%96%84%E3%81%A8%E6%82%AA%E5%8C%96%E3%82%92%20\" target=\"_blank\" rel=\"noreferrer noopener\">hc.mochida.co.jp<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u75be\u60a3\u30fb\u8981\u56e0:<\/strong> <strong>\u9b5a\u9c57\u766c<\/strong>\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5148\u5929\u6027\u89d2\u5316\u75c7\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u3088\u308a\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u6b20\u640d\u3084TGM1\u6b20\u640d\u3001ABCA12\u8102\u8cea\u8f38\u9001\u4f53\u7570\u5e38\u306a\u3069\u304c\u3042\u308a\u3001\u751f\u6765\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3092\u5448\u3057\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=demonstrated%20that%20multiple%20factors%2C%20including,agents%2C%20sodium%20hypochlorite%2C%20probiotics%2C%20and\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002<strong>\u4e7e\u766c<\/strong>\u3067\u306f\u8868\u76ae\u7d30\u80de\u306e\u904e\u5270\u5897\u6b96\u30fb\u5206\u5316\u4e0d\u5168\u306b\u3088\u308a\u672a\u719f\u306a\u89d2\u8cea\u7d30\u80de\u304c\u84c4\u7a4d\u3057\u3001\u30d0\u30ea\u30a2\u4e0d\u5168\u304b\u3089\u708e\u75c7\u304c\u60aa\u5faa\u74b0\u3057\u3066\u3044\u307e\u3059\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306e\u7570\u5e38\u5206\u5316\u3092\u6b63\u5e38\u5316\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u5916\u7528\u306f\u30d0\u30ea\u30a2\u56de\u5fa9\u306b\u5bc4\u4e0e\u3059\u308b\u6cbb\u7642\u3067\u3059\uff09\u3002<strong>\u63a5\u89e6\u76ae\u819a\u708e<\/strong>\u3084<strong>\u523a\u6fc0\u6027\u76ae\u819a\u708e<\/strong>\u306f\u5916\u7684\u523a\u6fc0\u3067\u751f\u3058\u307e\u3059\u304c\u3001\u500b\u4eba\u5dee\u3068\u3057\u3066\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u3044\u4eba\u306f\u767a\u75c7\u3057\u3084\u3059\u304f\u3001\u305d\u3053\u306b\u514d\u75ab\u53cd\u5fdc\u304c\u52a0\u308f\u308b\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u76ae\u819a\u708e\u3068\u3057\u3066\u56fa\u5b9a\u5316\u3057\u307e\u3059\u3002\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u308b<strong>\u76ae\u819a\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0<\/strong>\uff08\u5e38\u5728\u83cc\u53e2\uff09\u306e\u4e71\u308c\u3082\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u95a2\u4fc2\u304c\u6df1\u3044\u3067\u3059\u3002\u76ae\u819a\u5e38\u5728\u83cc\u306f\u75c5\u539f\u83cc\u306e\u6392\u9664\u3084\u76ae\u819a\u514d\u75ab\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7279\u306b\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306e\u7570\u5e38\u5897\u6b96\u306fAD\u3084\u3056\u7621\u306a\u3069\u69d8\u3005\u306a\u76ae\u819a\u75c5\u614b\u3092\u60aa\u5316\u3055\u305b\u307e\u3059<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5911439\/#:~:text=It%20has%20also%20recently%20been,4%20%2C%2035%2C43\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30d0\u30ea\u30a2\u969c\u5bb3\u304c\u3042\u308b\u3068\u5e38\u5728\u83cc\u53e2\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u304f\u3001\u9006\u306b\u7279\u5b9a\u83cc\u306e\u7570\u5e38\u5897\u6b96\u304c\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u3055\u3089\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u60aa\u5faa\u74b0\u3082\u8d77\u3053\u308a\u5f97\u307e\u3059\u3002\u4ee5\u4e0a\u306e\u3088\u3046\u306b\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u306f\u5185\u7684\u30fb\u5916\u7684\u56e0\u5b50\u306b\u3088\u308b<strong>\u7834\u7dbb\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong>\u304c\u591a\u5c90\u306b\u308f\u305f\u308b\u305f\u3081\u3001\u305d\u306e\u6539\u5584\u306b\u306f\u5305\u62ec\u7684\u306a\u5bfe\u5fdc\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 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noopener\">nationaleczema.org<\/a>\u3002\u6d17\u6d44\u5f8c\u306f\u6642\u9593\u3092\u304a\u304b\u305a\u306b\u4fdd\u6e7f\u5264\u3092\u5168\u8eab\u306b\u5857\u5e03\u3057\u307e\u3059\u3002\u4fdd\u6e7f\u5264\u306f\u89d2\u8cea\u5c64\u306b\u6c34\u5206\u3092\u88dc\u7d66\u30fb\u4fdd\u6301\u3057\u3001\u3055\u3089\u306b\u6cb9\u5206\u3067\u30d5\u30bf\u3092\u3057\u3066\u6c34\u5206\u84b8\u767a\u3092\u9632\u3050\u76ee\u7684\u3067\u7528\u3044\u307e\u3059<a href=\"https:\/\/www.erca.go.jp\/yobou\/zensoku\/sukoyaka\/47\/medical\/medical03.html#:~:text=Image\" target=\"_blank\" rel=\"noreferrer 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noopener\">disease.jp.lilly.com<\/a>\u3002\u60a3\u8005\u306e\u76ae\u819a\u72b6\u614b\u306b\u5408\u308f\u305b\u3066\u6700\u9069\u306a\u57fa\u5264\u30fb\u6210\u5206\u3092\u9078\u629e\u3057\u3001<strong>\u5165\u6d74\u5f8c\u306a\u3069\u76ae\u819a\u304c\u6f64\u3063\u3066\u3044\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u5857\u5e03\u3059\u308b<\/strong>\u3068\u6d78\u900f\u52b9\u679c\u304c\u9ad8\u307e\u308a\u307e\u3059<a href=\"https:\/\/disease.jp.lilly.com\/atopic-dermatitis\/treatment#:~:text=%E5%A4%B1%E3%82%8F%E3%82%8C%E3%81%9F%E7%9A%AE%E8%86%9A%E3%81%AE%E3%83%90%E3%83%AA%E3%82%A2%E6%A9%9F%E8%83%BD%E3%82%92%E5%9B%9E%E5%BE%A9%E3%83%BB%E7%B6%AD%E6%8C%81%E3%81%99%E3%82%8B%E3%81%9F%E3%82%81%E3%81%AB%E3%80%81%E4%BF%9D%E6%B9%BF%E5%89%A4%E3%82%92%E7%94%A8%E3%81%84%E3%81%A6%E3%82%B9%E3%82%AD%E3%83%B3%E3%82%B1%E3%82%A2%E3%82%92%E8%A1%8C%E3%81%84%E3%81%BE%E3%81%99%E3%80%82%E3%83%98%E3%83%91%E3%83%AA%E3%83%B3%E9%A1%9E%E4%BC%BC%E7%89%A9%E8%B3%AA%E5%90%AB%E6%9C%89%E8%A3%BD%E5%89%A4%E3%80%81%E5%B0%BF%E7%B4%A0%E8%A3%BD%E5%89%A4%E3%80%81%E7%99%BD%E8%89%B2%E3%83%AF%E3%82%BB%E3%83%AA%E3%83%B3%E3%80%81%E4%BA%9C%E9%89%9B%E8%8F%AF%E8%BB%9F%E8%86%8F%E3%81%AA%E3%81%A9%E3%80%81%E6%A7%98%E3%80%85%E3%81%AA%E3%82%BF%E3%82%A4%20%E3%83%97%E3%81%AE%E4%BF%9D%E6%B9%BF%E5%89%A4%E3%81%8C%E3%81%82%E3%82%8A%E3%81%BE%E3%81%99%E3%80%82%E5%85%A5%E6%B5%B4%E5%BE%8C%E3%81%AA%E3%81%A9%E3%80%81%E7%9A%AE%E8%86%9A%E3%81%8C%E6%BD%A4%E3%81%A3%E3%81%A6%E3%81%84%E3%82%8B%E7%8A%B6%E6%85%8B%E3%81%A7%E5%A1%97%E3%82%8B%E3%81%AE%E3%81%8C%E5%8A%B9%E6%9E%9C%E7%9A%84%E3%81%A8%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%E3%80%82\" target=\"_blank\" rel=\"noreferrer noopener\">disease.jp.lilly.com<\/a>\u3002\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3067\u306f\u3053\u306e\u3088\u3046\u306a<strong>\u4fdd\u6e7f\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u6a19\u6e96\u6cbb\u7642<\/strong>\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u85ac\u7269\u7642\u6cd5\u3068\u4e26\u884c\u3057\u3066\u7d99\u7d9a\u3059\u308b\u3053\u3068\u3067\u75c7\u72b6\u60aa\u5316\u3092\u9632\u304e\u307e\u3059<a 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