{"id":704,"date":"2025-08-08T12:35:55","date_gmt":"2025-08-08T03:35:55","guid":{"rendered":"https:\/\/rmnw.jp\/?p=704"},"modified":"2025-09-06T11:44:06","modified_gmt":"2025-09-06T02:44:06","slug":"%e6%a9%9f%e5%99%a8%e3%82%92%e4%bd%bf%e3%82%8f%e3%81%aa%e3%81%84%e7%be%8e%e5%ae%b9%e7%9a%ae%e8%86%9a%e7%a7%91%e5%ad%a6%e3%81%ae%e7%8f%be%e6%b3%81%e3%81%a8%e5%8b%95%e5%90%91%ef%bc%88%e6%97%a5%e6%9c%ac","status":"publish","type":"post","link":"https:\/\/rmnw.jp\/?p=704","title":{"rendered":"D00.\u7f8e\u5bb9\u76ae\u819a\u79d1\u5b66\u3000\u6a5f\u5668\u3092\u4f7f\u308f\u306a\u3044\u6cbb\u7642\uff08\u65e5\u672c\u3068\u56fd\u969b\u6bd4\u8f03\uff09V1.2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u97f3\u58f0\u3001PODCAST\u7684\u306b\u8074\u304f<\/p>\n\n\n\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/rmnw.jp\/wp-content\/uploads\/2025\/08\/D00.mp3\"><\/audio><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube 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class=\"wp-block-heading\">1. \u5916\u7528\u7642\u6cd5\uff1a\u5916\u7528\u85ac\u3068\u6210\u5206\u306e\u73fe\u6cc1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\uff08\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\uff09\u3068\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3<\/strong>\u306f\u3001\u76ae\u819a\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3084\u8272\u7d20\u6027\u75be\u60a3\u6cbb\u7642\u306e\u5206\u91ce\u3067\u53e4\u5178\u7684\u304b\u3064\u6709\u52b9\u306a\u5916\u7528\u85ac\u3067\u3042\u308b\u3002\u7c73\u56fd\u3067\u306f\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5916\u7528\u85ac\u306f\u306b\u304d\u3073\u6cbb\u7642\u85ac\u3084\u5149\u8001\u5316\u5bfe\u7b56\u3068\u3057\u3066\u5e83\u304f\u627f\u8a8d\u30fb\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u30014%\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u5916\u7528\u3082\u809d\u6591\u30fb\u3057\u307f\u6cbb\u7642\u306e\u6a19\u6e96\u7684\u51e6\u65b9\u306e\u4e00\u3064\u3067\u3042\u308b<a href=\"https:\/\/www.zoedraelos.com\/articles\/brown-spots-and-pigmentation\/#:~:text=Articles%20,effect%20on%20skin%20pigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">zoedraelos.com<\/a><a href=\"https:\/\/www.medestheticsmag.com\/news\/news\/21220481\/acara-partners-cares-act-legislation-halting-sales-of-otc-hydroquinone-is-now-in-effect#:~:text=CARES%20ACT%20Legislation%20Halting%20Sales,legislation%20included%20in%20the\" target=\"_blank\" rel=\"noreferrer noopener\">medestheticsmag.com<\/a>\u3002\u4e00\u65b9\u3001\u65e5\u672c\u3067\u306f\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u304a\u3088\u3073\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u88fd\u5264\u306f\u516c\u7684\u306b\u306f<strong>\u627f\u8a8d\u3055\u308c\u3066\u304a\u3089\u305a<\/strong>\u3001\u4fdd\u967a\u9069\u7528\u5916\u306e<strong>\u81ea\u7531\u8a3a\u7642<\/strong>\u3067\u533b\u5e2b\u306e\u88c1\u91cf\u306e\u3082\u3068\u306b\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3042\u308b<a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=%E3%83%88%E3%83%AC%E3%83%81%E3%83%8E%E3%82%A4%E3%83%B3%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%A0%E3%81%AF%E3%80%81%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%A7%E3%81%99%E3%80%82%20%E6%97%A5%E6%9C%AC%E5%9B%BD%E5%86%85%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%83%BB%E5%8C%BB%E7%99%82%E6%A9%9F%E5%99%A8%E7%AD%89%E3%81%AF%E5%8E%9A%E7%94%9F%E5%B1%80%E3%81%AE%E6%AD%A3%E5%BC%8F%E3%81%AA%E3%83%97%E3%83%AD%E3%82%BB%E3%82%B9%E3%82%92%E7%B5%8C%E3%81%A6%E3%80%81%E6%8F%90%E6%90%BA%E3%82%AF%E3%83%AA%E3%83%8B%E3%83%83%E3%82%AF%E3%81%AE%E5%8C%BB%E5%B8%AB%E3%81%AE%E5%88%A4%E6%96%AD%E3%81%AE%E4%B8%8B%E3%80%81%E8%BC%B8%E5%85%A5%E3%82%92%E3%81%97%E3%81%9F%E3%82%82%E3%81%AE%E3%81%AB%E3%81%AA%E3%82%8A%E3%81%BE%E3%81%99%E3%80%82%20%E5%BD%93%E9%99%A2%E3%81%A7%E8%BC%B8%E5%85%A5%E3%81%97%E3%81%A6%E3%81%84%E3%82%8B%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%AF%E3%80%81%E3%82%A4%E3%83%B3%E3%83%89%E3%83%BBHealing%20Pharma\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a><a href=\"https:\/\/oogaki.or.jp\/hifuka\/skin-care\/hydroquinone-whitening-safety\/#:~:text=%E7%BE%8E%E7%99%BD%E5%89%A4%E3%83%8F%E3%82%A4%E3%83%89%E3%83%AD%E3%82%AD%E3%83%8E%E3%83%B3%E4%BD%BF%E3%81%84%E7%B6%9A%E3%81%91%E3%81%9F%E3%82%89%E3%81%A9%E3%81%86%E3%81%AA%E3%82%8B%EF%BC%9F%E5%8A%B9%E6%9E%9C%E3%81%A8%E5%89%AF%E4%BD%9C%E7%94%A8%20,\" target=\"_blank\" rel=\"noreferrer noopener\">oogaki.or.jp<\/a>\u3002\u4f8b\u3048\u3070\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u5916\u7528\u5264\u306f\u56fd\u5185\u672a\u627f\u8a8d\u533b\u85ac\u54c1\u3067\u3042\u308a\u3001\u63d0\u643a\u30af\u30ea\u30cb\u30c3\u30af\u306e\u533b\u5e2b\u304c\u539a\u751f\u5c40\u5c4a\u51fa\u306e\u4e0b\u3067\u6d77\u5916\u304b\u3089\u500b\u4eba\u8f38\u5165\u3057\u3066\u8abf\u5264\u30fb\u51e6\u65b9\u3059\u308b\u5f62\u304c\u4e00\u822c\u7684\u3067\u3042\u308b<a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=%E3%83%88%E3%83%AC%E3%83%81%E3%83%8E%E3%82%A4%E3%83%B3%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%A0%E3%81%AF%E3%80%81%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%A7%E3%81%99%E3%80%82%20%E6%97%A5%E6%9C%AC%E5%9B%BD%E5%86%85%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%83%BB%E5%8C%BB%E7%99%82%E6%A9%9F%E5%99%A8%E7%AD%89%E3%81%AF%E5%8E%9A%E7%94%9F%E5%B1%80%E3%81%AE%E6%AD%A3%E5%BC%8F%E3%81%AA%E3%83%97%E3%83%AD%E3%82%BB%E3%82%B9%E3%82%92%E7%B5%8C%E3%81%A6%E3%80%81%E6%8F%90%E6%90%BA%E3%82%AF%E3%83%AA%E3%83%8B%E3%83%83%E3%82%AF%E3%81%AE%E5%8C%BB%E5%B8%AB%E3%81%AE%E5%88%A4%E6%96%AD%E3%81%AE%E4%B8%8B%E3%80%81%E8%BC%B8%E5%85%A5%E3%82%92%E3%81%97%E3%81%9F%E3%82%82%E3%81%AE%E3%81%AB%E3%81%AA%E3%82%8A%E3%81%BE%E3%81%99%E3%80%82%20%E5%BD%93%E9%99%A2%E3%81%A7%E8%BC%B8%E5%85%A5%E3%81%97%E3%81%A6%E3%81%84%E3%82%8B%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%AF%E3%80%81%E3%82%A4%E3%83%B3%E3%83%89%E3%83%BBHealing%20Pharma\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a>\u3002\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306b\u3064\u3044\u3066\u3082\u30012001\u5e74\u4ee5\u524d\u306f\u533b\u5e2b\u7ba1\u7406\u4e0b\u3067\u306e\u307f\u4f7f\u7528\u3055\u308c\u3066\u3044\u305f\u304c\u30012001\u5e74\u306e\u85ac\u4e8b\u6cd5\u6539\u6b63\u5f8c\u306b\u6fc3\u5ea62%\u4ee5\u4e0b\u3067\u3042\u308c\u3070\u5316\u7ca7\u54c1\u3078\u306e\u914d\u5408\u304c\u8a31\u53ef\u3055\u308c\u3001\u5e02\u8ca9\u7f8e\u767d\u5316\u7ca7\u54c1\u306b\u4f4e\u6fc3\u5ea6\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u304c\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f<a href=\"https:\/\/cosmetic-ingredients.org\/skin-lightening-agents\/1255\/#:~:text=2001%E5%B9%B4%E3%81%AE%E5%8C%96%E7%B2%A7%E5%93%81%E8%A6%8F%E5%88%B6%E7%B7%A9%E5%92%8C%E3%81%AE%E9%9A%9B%E3%81%AB%E9%85%8D%E5%90%88%E7%A6%81%E6%AD%A2%E3%83%AA%E3%82%B9%E3%83%88%E3%81%AB%E5%8F%8E%E8%BC%89%E3%81%95%E3%82%8C%E3%81%9A%E3%80%81%E6%BF%83%E5%BA%A62\" target=\"_blank\" rel=\"noreferrer noopener\">cosmetic-ingredients.org<\/a>\u3002\u3057\u304b\u3057\u9ad8\u6fc3\u5ea6\uff084%\u524d\u5f8c\uff09\u306e\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u30af\u30ea\u30fc\u30e0\u306f\u5f15\u304d\u7d9a\u304d\u533b\u7642\u6a5f\u95a2\u51e6\u65b9\u306e\u9662\u5185\u88fd\u5264\u3084\u500b\u4eba\u8f38\u5165\u88fd\u5264\u306b\u9650\u3089\u308c\u308b<a href=\"https:\/\/www.cocoro-hihuka.com\/hydroquinone.html#:~:text=%E3%83%8F%E3%82%A4%E3%83%89%E3%83%AD%E3%82%AD%E3%83%8E%E3%83%B3%20\" target=\"_blank\" rel=\"noreferrer noopener\">cocoro-hihuka.com<\/a>\u3002\u6b27\u5dde\u9023\u5408\uff08EU\uff09\u3067\u306f2001\u5e74\u4ee5\u964d\u3001\u767a\u304c\u3093\u6027\u30ea\u30b9\u30af\u306a\u3069\u5b89\u5168\u6027\u3078\u306e\u61f8\u5ff5\u304b\u3089\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u5316\u7ca7\u54c1\u914d\u5408\u3092\u7981\u6b62\u3057\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u56fd\u3067OTC\u4f7f\u7528\u304c\u5236\u9650\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/www.researchgate.net\/figure\/List-of-skin-lightening-active-ingredients-approved-in-Japan_tbl1_362311718#:~:text=,\" target=\"_blank\" rel=\"noreferrer noopener\">researchgate.net<\/a>\u3002\u7c73\u56fd\u3067\u30822020\u5e74\u306e\u6cd5\u5f8b\u6539\u6b63\uff08CARES\u6cd5\uff09\u306b\u3088\u308aOTC\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u8ca9\u58f2\u304c\u7981\u6b62\u3055\u308c\u3001\u4ee5\u5f8c\u306fFDA\u627f\u8a8d\u3092\u7d4c\u305f\u88fd\u54c1\u306e\u307f\u304c\u6d41\u901a\u53ef\u80fd\u3068\u306a\u3063\u305f<a href=\"https:\/\/www.medestheticsmag.com\/news\/news\/21220481\/acara-partners-cares-act-legislation-halting-sales-of-otc-hydroquinone-is-now-in-effect#:~:text=CARES%20ACT%20Legislation%20Halting%20Sales,legislation%20included%20in%20the\" target=\"_blank\" rel=\"noreferrer noopener\">medestheticsmag.com<\/a>\u3002\u3053\u306e\u3088\u3046\u306b<strong>\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u898f\u5236\u52d5\u5411<\/strong>\u306f\u5404\u56fd\u3067\u7570\u306a\u308b\u305f\u3081\u3001\u65e5\u672c\u3067\u306f\u60a3\u8005\u3078\u306e\u5341\u5206\u306a\u6ce8\u610f\u559a\u8d77\u3068\u533b\u5e2b\u7ba1\u7406\u4e0b\u3067\u306e\u4f7f\u7528\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u7642\u6cd5<\/strong>\u306f\u3001\u76ae\u819a\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4fc3\u9032\u3068\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u4ea2\u9032\u306b\u3088\u308b<strong>\u6297\u52a0\u9f62\u52b9\u679c<\/strong>\u3068\u8868\u76ae\u8272\u7d20\u306e\u6392\u51fa\u4fc3\u9032\u4f5c\u7528\u3092\u6709\u3057\u3001\u3057\u308f\u30fb\u809d\u6591\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b<a href=\"https:\/\/www.zoedraelos.com\/articles\/brown-spots-and-pigmentation\/#:~:text=Articles%20,effect%20on%20skin%20pigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">zoedraelos.com<\/a>\u3002\u65e5\u672c\u306e\u7f8e\u5bb9\u76ae\u819a\u79d1\u3067\u306f\u7c73\u56fd\u306b\u306a\u3089\u3063\u305f<strong>Kligman\u914d\u5408<\/strong>\uff08\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\uff0b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\uff0b\u30b9\u30c6\u30ed\u30a4\u30c9\uff09\u3092\u7528\u3044\u305f\u809d\u6591\u6cbb\u7642\u3082\u884c\u308f\u308c\u3066\u3044\u308b\u304c\u3001\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u88fd\u5264\u304c\u672a\u627f\u8a8d\u3067\u3042\u308b\u305f\u3081\u3001\u52b9\u679c\u3068\u526f\u4f5c\u7528\u7ba1\u7406\u306b\u7fd2\u719f\u3057\u305f\u533b\u5e2b\u306e\u3082\u3068\u3067\u306e\u307f\u5b9f\u65bd\u3055\u308c\u308b<a href=\"https:\/\/www.zoedraelos.com\/articles\/brown-spots-and-pigmentation\/#:~:text=Articles%20,effect%20on%20skin%20pigmentation\" target=\"_blank\" rel=\"noreferrer noopener\">zoedraelos.com<\/a><a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=%E3%83%88%E3%83%AC%E3%83%81%E3%83%8E%E3%82%A4%E3%83%B3%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%A0%E3%81%AF%E3%80%81%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%A7%E3%81%99%E3%80%82%20%E6%97%A5%E6%9C%AC%E5%9B%BD%E5%86%85%E6%9C%AA%E6%89%BF%E8%AA%8D%E5%8C%BB%E8%96%AC%E5%93%81%E3%83%BB%E5%8C%BB%E7%99%82%E6%A9%9F%E5%99%A8%E7%AD%89%E3%81%AF%E5%8E%9A%E7%94%9F%E5%B1%80%E3%81%AE%E6%AD%A3%E5%BC%8F%E3%81%AA%E3%83%97%E3%83%AD%E3%82%BB%E3%82%B9%E3%82%92%E7%B5%8C%E3%81%A6%E3%80%81%E6%8F%90%E6%90%BA%E3%82%AF%E3%83%AA%E3%83%8B%E3%83%83%E3%82%AF%E3%81%AE%E5%8C%BB%E5%B8%AB%E3%81%AE%E5%88%A4%E6%96%AD%E3%81%AE%E4%B8%8B%E3%80%81%E8%BC%B8%E5%85%A5%E3%82%92%E3%81%97%E3%81%9F%E3%82%82%E3%81%AE%E3%81%AB%E3%81%AA%E3%82%8A%E3%81%BE%E3%81%99%E3%80%82%20%E5%BD%93%E9%99%A2%E3%81%A7%E8%BC%B8%E5%85%A5%E3%81%97%E3%81%A6%E3%81%84%E3%82%8B%E5%8C%BB%E8%96%AC%E5%93%81%E3%81%AF%E3%80%81%E3%82%A4%E3%83%B3%E3%83%89%E3%83%BBHealing%20Pharma\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a>\u3002\u4e00\u65b9\u3001<strong>\u30ec\u30c1\u30ce\u30fc\u30eb<\/strong>\uff08\u30d3\u30bf\u30df\u30f3A\u30a2\u30eb\u30b3\u30fc\u30eb\uff09\u306f\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u306e\u8a98\u5c0e\u4f53\u3068\u3057\u3066\u5e02\u8ca9\u5316\u7ca7\u54c1\uff08\u3044\u308f\u3086\u308b\u30b3\u30b9\u30e1\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\uff09\u306b\u5e83\u304f\u914d\u5408\u3055\u308c\u3001\u7a4f\u3084\u304b\u306a\u6297\u3057\u308f\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u8fd1\u5e74\u3001\u65e5\u672c\u3067\u3082\u30ec\u30c1\u30ce\u30fc\u30eb\u3092\u6709\u52b9\u6210\u5206\u3068\u3059\u308b\u30b7\u30ef\u6539\u5584\u52b9\u679c\u3092\u6a19\u699c\u3067\u304d\u308b<em>\u85ac\u7528\u5316\u7ca7\u54c1<\/em>\uff08\u533b\u85ac\u90e8\u5916\u54c1\uff09\u304c\u627f\u8a8d\u3055\u308c\u3001\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff09\u306f\u30d3\u30bf\u30df\u30f3B3\u8a98\u5c0e\u4f53\u3067\u3001\u5916\u7528\u306b\u3088\u308a\u6297\u9178\u5316\u30fb\u6297\u708e\u75c7\u4f5c\u7528\u3084\u89d2\u8cea\u30d0\u30ea\u30a2\u6a5f\u80fd\u6539\u5584\u4f5c\u7528\u3092\u793a\u3059\u65b0\u92ed\u306e\u6210\u5206\u3067\u3042\u308b\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u3063\u3066\u5c0f\u3058\u308f\u3084\u8272\u7d20\u6c88\u7740\u306e\u6539\u5584<\/strong>\u304c\u8a8d\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u76ae\u819a\u306b\u5bfe\u3059\u308b\u5b89\u5168\u6027\u3082\u9ad8\u3044<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=response%2C%20enhances%20extracellular%20matrix%20and,suggested%20that%20nicotinamide%20will%20be\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=metabolites%20produced%20from%20it,to%20internal%20or%20external%20stressors\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u4f8b\u3048\u30705%\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u914d\u5408\u4e73\u6db2\u306e12\u9031\u9593\u4f7f\u7528\u3067\u7d30\u304b\u3044\u3057\u308f\u304c21%\u8efd\u6e1b\u3057\u3001\u808c\u306e\u660e\u308b\u3055\u304c\u6539\u5584\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<a href=\"https:\/\/www.nature.com\/articles\/s41598-025-88899-0#:~:text=Niacinamide%20and%20its%20impact%20on,due%20to%20its%20beneficial\" target=\"_blank\" rel=\"noreferrer noopener\">nature.com<\/a>\u3002\u3053\u3046\u3057\u305f\u78ba\u304b\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u652f\u3048\u3089\u308c\u3001\u65e5\u672c\u3067\u3082<strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/strong>\u306f\u8fd1\u5e74\u300c\u6297\u30b7\u30ef\u4f5c\u7528\u300d\u306e\u52b9\u80fd\u3067\u533b\u85ac\u90e8\u5916\u54c1\u6709\u52b9\u6210\u5206\u306b\u627f\u8a8d\u3055\u308c\u3001\u591a\u304f\u306e<strong>\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1<\/strong>\u3084\u9ad8\u6a5f\u80fd\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=metabolic%20pathways,of%20cells%20along%20with%20various\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=metabolites%20produced%20from%20it,to%20internal%20or%20external%20stressors\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u56fd\u969b\u7684\u306b\u3082\u4eba\u6c17\u6210\u5206\u3067\u3042\u308a\u3001\u7c73\u56fd\u30fb\u6b27\u5dde\u306e\u5e02\u8ca9\u88fd\u54c1\uff08\u4f8b\uff1aOlay\u3084La Roche-Posay\u306a\u3069\uff09\u306b\u3082\u5e83\u7bc4\u306b\u542b\u6709\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u305d\u306e\u4ed6\u306e\u5916\u7528\u6709\u52b9\u6210\u5206<\/strong>\u3068\u3057\u3066\u3001\u65e5\u672c\u3067\u7f8e\u5bb9\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\u533b\u85ac\u90e8\u5916\u54c1\u306e\u7f8e\u767d\u6709\u52b9\u6210\u5206\u306b\u306f<strong>\u30a2\u30eb\u30d6\u30c1\u30f3<\/strong>\u3001<strong>\u30b3\u30a6\u30b8\u9178<\/strong>\u30014MSK\uff084-\u30e1\u30c8\u30ad\u30b7\u30b5\u30ea\u30c1\u30eb\u9178\u30ab\u30ea\u30a6\u30e0\u5869\uff09\u3001\u30eb\u30b7\u30ce\u30fc\u30eb\uff084-n-\u30d6\u30c1\u30eb\u30ec\u30be\u30eb\u30b7\u30ce\u30fc\u30eb\uff09\u3001\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\uff08\u30ea\u30f3\u9178\u30a2\u30b9\u30b3\u30eb\u30d3\u30ebMg\u306a\u3069\uff09\u7b49\u304c\u6319\u3052\u3089\u308c\u308b<a href=\"https:\/\/www.researchgate.net\/figure\/List-of-skin-lightening-active-ingredients-approved-in-Japan_tbl1_362311718#:~:text=et%20al,\" target=\"_blank\" rel=\"noreferrer noopener\">researchgate.net<\/a><a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=Japanese%20pharmaceutical%20cosmetics%2C%20often%20referred,are%20more%20effective%20than%20quasi\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3002\u3053\u308c\u3089\u306f\u4e3b\u306b<strong>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u963b\u5bb3<\/strong>\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3057\u3001\u30b7\u30df\u30fb\u305d\u3070\u304b\u3059\u4e88\u9632\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u6709\u52b9\u6210\u5206\u306e\u958b\u767a\u306f\u65e5\u672c\u304c\u5148\u884c\u3057\u3066\u304a\u308a\u3001\u3053\u306e35\u5e74\u9593\u3067\u7f8e\u767d\u6709\u52b9\u6210\u5206\u304c\u7d0420\u7a2e\u985e\u3082\u958b\u767a\u627f\u8a8d\u3055\u308c\u3066\u304d\u305f<a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=market%20and%20is%20the%20category,This%20section\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3002\u8fd1\u5e74\u3067\u306f\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u6291\u5236\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u8868\u76ae\u7d30\u80de\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4fc3\u9032<\/strong>\u306b\u3088\u308b\u6392\u51fa\u4fc3\u9032\u4f5c\u7528\uff08\u4f8b\uff1a\u30c7\u30af\u30b9\u30d1\u30f3\u30c6\u30ce\u30fc\u30eb\u3084\u30a2\u30c7\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\u4e8c\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u3082\u91cd\u8996\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b<a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=Japanese%20pharmaceutical%20cosmetics%2C%20often%20referred,are%20more%20effective%20than%20quasi\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3002\u306a\u304a\u3001<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178<\/strong>\u3082\u65e5\u672c\u3067\u306f\u7f8e\u767d\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u4e00\u90e8\u306e\u5916\u7528\u5264\uff08\u533b\u85ac\u90e8\u5916\u54c1\uff09\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u3002\u8907\u6570\u306e\u7814\u7a76\u3067<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u5916\u7528<\/strong>\u306f\u809d\u6591\u3084\u708e\u75c7\u5f8c\u8272\u7d20\u6c88\u7740\u306e\u6539\u5584\u306b\u6709\u52b9\u3068\u306e\u5831\u544a\u304c\u3042\u308a<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-51133-w#:~:text=emerged%20as%20a%20promising%20treatment,for%20melasma3%2C4%2C5\" target=\"_blank\" rel=\"noreferrer noopener\">nature.com<\/a>\u3001\u5e02\u8ca9\u306e\u7f8e\u767d\u7f8e\u5bb9\u6db2\uff08\u4f8b\uff1a\u8cc7\u751f\u5802HAKU\u306a\u3069\uff09\u306b\u3082\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u52b9\u679c\u306f\u5185\u670d\u306b\u6bd4\u3079\u30de\u30a4\u30eb\u30c9\u3067\u3042\u308a\u3001\u5916\u7528\u3067\u306f\u89d2\u8cea\u30d0\u30ea\u30a2\u3092\u901a\u3059\u5de5\u592b\uff08\u30a4\u30aa\u30f3\u30c8\u30d5\u30a9\u30ec\u30fc\u30b7\u30b9\u7b49\uff09\u304c\u306a\u3044\u3068\u6d78\u900f\u304c\u9650\u3089\u308c\u308b\u3068\u306e\u6307\u6458\u3082\u3042\u308b\u3002<\/p>\n\n\n\n<p 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href=\"https:\/\/koenji.clinic\/archives\/8264#:~:text=%E5%86%85%E6%9C%8D%20%E3%83%88%E3%83%A9%E3%83%8D%E3%82%AD%E3%82%B5%E3%83%A0%E9%85%B8%E3%81%AE%E3%82%B7%E3%83%9F%E3%80%81%E8%82%9D%E6%96%91%E3%81%B8%E3%81%AE%E7%BE%8E%E7%99%BD%E5%8A%B9%E6%9E%9C%20%E9%81%8E%E5%8E%BB%E3%81%AE%E7%A0%94%E7%A9%B6%E3%81%A7%E3%82%82%E3%80%81%E3%83%88%E3%83%A9%E3%83%8D%E3%82%AD%E3%82%B5%E3%83%A0%E9%85%B8500mg%EF%BD%9E1500mg%2F%E6%97%A5%E3%81%AE%E7%94%A8%E9%87%8F%E3%81%A7%E3%80%81%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%9C%89%E5%8A%B9%E6%80%A7%E3%81%8C%E5%A0%B1%E5%91%8A%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%E3%80%82%E5%8D%8A%E6%B8%9B%E6%9C%9F%E3%81%8C1\" target=\"_blank\" rel=\"noreferrer noopener\">koenji.clinic<\/a><a href=\"https:\/\/www.shinagawa.com\/column\/66\/#:~:text=%E3%83%88%E3%83%A9%E3%83%8D%E3%82%AD%E3%82%B5%E3%83%A0%E9%85%B8%E5%8D%98%E7%8B%AC%E3%81%A7%E3%81%AE%E5%87%A6%E6%96%B9%E3%81%AE%E5%A0%B4%E5%90%88%E3%80%81250mg%E9%8C%A0%E3%82%921%E5%9B%9E1%E9%8C%A0%E3%80%81%E6%AF%8E%E9%A3%9F%E5%BE%8C%E3%81%AB%E6%91%82%E5%8F%96%E3%81%99%E3%82%8B%E3%82%88%E3%81%86%E6%8C%87%E5%B0%8E%E3%81%99%E3%82%8B%E3%82%B1%E3%83%BC%E3%82%B9%E3%81%8C%E5%A4%9A%E3%81%8F%E3%80%81%E5%86%85%E6%9C%8D%E8%96%AC%E3%81%AE%E6%9C%9F%E9%96%93%E3%81%AF%E3%81%A0%E3%81%84%E3%81%9F%E3%81%844\" target=\"_blank\" rel=\"noreferrer noopener\">shinagawa.com<\/a>\u3002\u5b9f\u969b\u3001\u904e\u53bb\u306e\u7814\u7a76\u306b\u304a\u3044\u3066<strong>\u7d4c\u53e3\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178500\u301c1500mg\/\u65e5\u30928\u301c12\u9031\u9593\u6295\u4e0e<\/strong>\u3059\u308b\u3068\u3001\u809d\u6591\u9762\u7a4d\u30fb\u8272\u8abf\u304c\u30d7\u30e9\u30bb\u30dc\u306b\u6bd4\u3079\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3068\u3055\u308c\u308b<a href=\"https:\/\/koenji.clinic\/archives\/8264#:~:text=%E5%86%85%E6%9C%8D%20%E3%83%88%E3%83%A9%E3%83%8D%E3%82%AD%E3%82%B5%E3%83%A0%E9%85%B8%E3%81%AE%E3%82%B7%E3%83%9F%E3%80%81%E8%82%9D%E6%96%91%E3%81%B8%E3%81%AE%E7%BE%8E%E7%99%BD%E5%8A%B9%E6%9E%9C%20%E9%81%8E%E5%8E%BB%E3%81%AE%E7%A0%94%E7%A9%B6%E3%81%A7%E3%82%82%E3%80%81%E3%83%88%E3%83%A9%E3%83%8D%E3%82%AD%E3%82%B5%E3%83%A0%E9%85%B8500mg%EF%BD%9E1500mg%2F%E6%97%A5%E3%81%AE%E7%94%A8%E9%87%8F%E3%81%A7%E3%80%81%E8%82%9D%E6%96%91%E3%81%AB%E5%AF%BE%E3%81%99%E3%82%8B%E6%9C%89%E5%8A%B9%E6%80%A7%E3%81%8C%E5%A0%B1%E5%91%8A%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%E3%80%82%E5%8D%8A%E6%B8%9B%E6%9C%9F%E3%81%8C1\" target=\"_blank\" rel=\"noreferrer noopener\">koenji.clinic<\/a>\u3002\u97d3\u56fd\u3084\u4e2d\u56fd\u3067\u3082\u7d4c\u53e3TXA\u306eRCT\u304c\u884c\u308f\u308c\u3001\u305d\u306e\u6709\u52b9\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u8fd1\u5e74\u3067\u306f\u6b27\u7c73\u306e\u5c02\u9580\u5bb6\u304b\u3089\u3082\u300c\u30a2\u30b8\u30a2\u3067\u6709\u671b\u306a\u65b0\u6cbb\u7642\u300d\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u59cb\u3081\u3066\u3044\u308b<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-51133-w#:~:text=Targeting%20the%20dermis%20for%20melasma,a%20promising%20treatment%20for%20melasma3%2C4%2C5\" target=\"_blank\" rel=\"noreferrer noopener\">nature.com<\/a><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15561#:~:text=melasma%20and%20other%20hyperpigmentation%20disorders\" target=\"_blank\" rel=\"noreferrer noopener\">onlinelibrary.wiley.com<\/a>\u3002\u65e5\u672c\u56fd\u5185\u3067\u306f<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u542b\u6709\u306e\u4e00\u822c\u7528\u533b\u85ac\u54c1<\/strong>\uff08OTC\u533b\u85ac\u54c1\uff09\u300c\u30c8\u30e9\u30f3\u30b7\u30fc\u30ceII\u300d\u304c2017\u5e74\u306b\u767a\u58f2\u3055\u308c\u3001\u809d\u6591\u6539\u5584\u52b9\u679c\u3092\u6a19\u699c\u3057\u3066\u85ac\u5c40\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u306f1\u56deTranexamic acid 750mg\/\u65e5\u3092\u542b\u307f\u30012\u30f6\u6708\u9593\u306e\u670d\u7528\u3067\u809d\u6591\u304c\u6539\u5584\u3059\u308b\u3068\u306e\u52b9\u80fd\u3067\u627f\u8a8d\u3055\u308c\u305f\u3082\u306e\u3067\u3001\u533b\u7642\u7528\u304b\u3089\u4e00\u822c\u7528\u307e\u3067TXA\u5185\u670d\u304c\u666e\u53ca\u3057\u3066\u3044\u308b\u70b9\u306f\u65e5\u672c\u306e\u7279\u8272\u3067\u3042\u308b<a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=adenosine%20monophosphate%20and%20dexpanthenol%20are,their%20effectiveness%20and%20adverse%20effects\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3002\u4e00\u65b9\u3001\u6b27\u7c73\u3067\u306f\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306f\u4e3b\u306b\u6708\u7d4c\u904e\u591a\u6cbb\u7642\u85ac\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\u3001\u7f8e\u5bb9\u76ee\u7684\u3067\u306e\u5185\u670d\u5229\u7528\u306f\u307e\u3060\u5e83\u304f\u306f\u6d78\u900f\u3057\u3066\u3044\u306a\u3044\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u8fd1\u5e74\u306f\u7c73\u56fd\u76ae\u819a\u79d1\u5b66\u4f1a\u8a8c\u306a\u3069\u3067\u3082\u809d\u6591\u6cbb\u7642\u3078\u306eTXA\u5185\u670d\u306e\u6709\u7528\u6027\u304c\u7d39\u4ecb\u3055\u308c\u59cb\u3081\u3001\u5f90\u3005\u306b\u8a8d\u77e5\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>L-\u30b7\u30b9\u30c6\u30a4\u30f3<\/strong>\u304a\u3088\u3073<strong>\u30d3\u30bf\u30df\u30f3C\u5185\u670d<\/strong>\u3082\u3001\u65e5\u672c\u3067\u4f1d\u7d71\u7684\u306b<strong>\u7f8e\u767d\u76ee\u7684<\/strong>\u3067\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u5185\u670d\u7642\u6cd5\u3067\u3042\u308b<a href=\"https:\/\/www.jcss.jp\/en\/journal\/pdf\/contents_guideline2.pdf#:~:text=During%20the%20period%20of%20the,excessive%20ex%02posure%20to%20UV%20radiation\" target=\"_blank\" rel=\"noreferrer noopener\">jcss.jp<\/a>\u3002L-\u30b7\u30b9\u30c6\u30a4\u30f3\u306f\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u7d4c\u8def\u306b\u304a\u3044\u3066\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u30a2\u30df\u30ce\u9178\u3067\u3001\u9ad8\u7528\u91cf\u5185\u670d\u306b\u3088\u308a\u30e1\u30e9\u30cb\u30f3\u306e\u9ed2\u8272\u5316\u3092\u6291\u5236\u3059\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=in%20%5BFigure%20,1\" target=\"_blank\" rel=\"noreferrer noopener\">ijdvl.com<\/a><a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=,depigmenting%20abilities%20of%20melanocytotoxic%20agents\" target=\"_blank\" rel=\"noreferrer noopener\">ijdvl.com<\/a>\u3002\u307e\u305f\u3001\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u7d2b\u5916\u7dda\u5f8c\u306e\u708e\u75c7\u3092\u7de9\u548c\u3059\u308b\u4f5c\u7528\u3082\u671f\u5f85\u3055\u308c\u308b\u3002\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u76f4\u63a5\u6291\u5236\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089\u3001\u65e5\u672c\u3067\u306f<strong>\u30b7\u30df\u30fb\u305d\u3070\u304b\u3059\u6539\u5584\u85ac<\/strong>\u3068\u3057\u3066\u300c\u30d3\u30bf\u30df\u30f3C 2000mg\uff0bL-\u30b7\u30b9\u30c6\u30a4\u30f3 240mg\u300d\u30921\u65e5\u91cf\u3068\u3059\u308b\u4e00\u822c\u7528\u533b\u85ac\u54c1\uff08\u4f8b\uff1a\u30cf\u30a4\u30c1\u30aa\u30fc\u30ebC\u30db\u30ef\u30a4\u30c6\u30a3\u30a2\u306a\u3069\uff09\u304c\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u81e8\u5e8a\u7684\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u9650\u5b9a\u7684\u3060\u304c\u3001\u9577\u671f\u670d\u7528\u306b\u3088\u308a\u808c\u306e\u304f\u3059\u307f\u8efd\u6e1b\u3084\u8efd\u5ea6\u306e\u8272\u7d20\u6591\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u5b9f\u969b\u3001\u65e5\u672c\u306e\u7f8e\u767d\u88fd\u54c1\u8a55\u4fa1\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u6cbb\u9a13\u4e2d\u306b\u88ab\u9a13\u8005\u304c\u3053\u308c\u3089<strong>\u30d3\u30bf\u30df\u30f3C\u88fd\u5264\u30fb\u30d3\u30bf\u30df\u30f3E\u88fd\u5264\u30fb\u30b7\u30b9\u30c6\u30a4\u30f3\u88fd\u5264<\/strong>\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306f\u7f8e\u767d\u52b9\u679c\u3092\u5de6\u53f3\u3059\u308b\u305f\u3081\u907f\u3051\u308b\u3088\u3046\u898f\u5b9a\u3055\u308c\u3066\u304a\u308a<a href=\"https:\/\/www.jcss.jp\/en\/journal\/pdf\/contents_guideline2.pdf#:~:text=During%20the%20period%20of%20the,excessive%20ex%02posure%20to%20UV%20radiation\" target=\"_blank\" rel=\"noreferrer noopener\">jcss.jp<\/a>\u3001\u88cf\u3092\u8fd4\u305b\u3070\u4e00\u5b9a\u306e\u8272\u7d20\u6539\u5584\u52b9\u679c\u304c\u516c\u7684\u306b\u3082\u8a8d\u77e5\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u3046\u304b\u304c\u3048\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/strong>\u3068\u3057\u3066\u306f\u3001\u8fd1\u5e74\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3084\u30ab\u30eb\u30ce\u30b7\u30f3\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3001\u677e\u6a39\u76ae\u7531\u6765\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\u591a\u69d8\u306a\u88fd\u54c1\u304c\u767b\u5834\u3057\u3066\u3044\u308b\u3002\u306a\u304b\u3067\u3082<strong>\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3<\/strong>\u306f\u6771\u5357\u30a2\u30b8\u30a2\u3092\u4e2d\u5fc3\u306b\u300c\u98f2\u3080\u7f8e\u767d\u5264\u300d\u3068\u3057\u3066\u30d6\u30fc\u30e0\u306b\u306a\u308a\u3001\u7d4c\u53e3\u6442\u53d6\u3084\u9759\u8108\u6ce8\u5c04\u306b\u3088\u308a\u5168\u8eab\u306e\u7f8e\u767d\u52b9\u679c\u3092\u3046\u305f\u3046\u65bd\u8853\u304c\u6d41\u884c\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u5927\u91cf\u6295\u4e0e\u306b\u3088\u308b\u5287\u7684\u306a\u7f8e\u767d\u52b9\u679c\u306b\u306f\u79d1\u5b66\u7684\u6839\u62e0\u304c\u4e4f\u3057\u304f\u3001\u9759\u8108\u6295\u4e0e\u306f\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u5831\u544a\u3082\u76f8\u6b21\u3044\u3060\u305f\u3081\u3001\u7c73\u56fdFDA\u306f\u7f8e\u5bb9\u76ee\u7684\u306e\u9759\u8108\u7528\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u88fd\u5264\u306e\u4f7f\u7528\u306b\u8b66\u544a\u3092\u767a\u3057\u3066\u3044\u308b<a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=marketed%20as%20a%20food%20or,6\" target=\"_blank\" rel=\"noreferrer noopener\">ijdvl.com<\/a><a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=the%20law%20for%20FDA%20to,6\" target=\"_blank\" rel=\"noreferrer 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from within\uff08\u4f53\u306e\u5185\u5074\u304b\u3089\u306e\u7f8e\u5bb9\uff09\u300d\u3068\u3044\u3046\u30b3\u30f3\u30bb\u30d7\u30c8\u3067\u7d4c\u53e3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5e02\u5834\u304c\u62e1\u5927\u3057\u3066\u3044\u308b<a href=\"https:\/\/www.fuji-keizai.co.jp\/press\/detail.html?cid=24100&amp;la=ja#:~:text=%E7%89%B9%E3%81%AB%E3%80%81%E7%BE%8E%E5%AE%B9%E3%82%B5%E3%83%97%E3%83%AA%E3%83%A1%E3%83%B3%E3%83%88%E3%82%84%E3%83%93%E3%82%BF%E3%83%9F%E3%83%B3%E3%83%BB%E3%83%9F%E3%83%8D%E3%83%A9%E3%83%AB%E3%83%81%E3%83%A3%E3%83%BC%E3%82%B8%E3%82%B5%E3%83%97%E3%83%AA%E3%83%A1%E3%83%B3%E3%83%88%E3%81%8C%E5%A5%BD%E8%AA%BF%E3%81%A0%E3%81%A3%E3%81%9F%E3%81%BB%E3%81%8B%E3%80%81%E3%82%B9%E3%83%9D%E3%83%BC%E3%83%84%E3%82%B5%E3%83%9D%E3%83%BC%E3%83%88%E3%82%B5%E3%83%97%E3%83%AA%E3%83%A1%E3%83%B3%E3%83%88%E3%81%AF%E3%83%A6%E3%83%BC%E3%83%81%E3%83%A5%E3%83%BC%E3%83%90%E3%83%BC%E7%9B%A3%E4%BF%AE%E5%95%86%E5%93%81%E3%82%84%E9%81%8B%E5%8B%95%E5%BE%8C%E3%81%AE%20\" target=\"_blank\" 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href=\"https:\/\/biyouhifuko.com\/news\/japan\/6113\/#:~:text=%E7%BE%8E%E5%AE%B9%E9%96%A2%E9%80%A3%E3%81%A7%E8%A8%80%E3%81%88%E3%81%B0%E3%80%81%E3%83%92%E3%82%A2%E3%83%AB%E3%83%AD%E3%83%B3%E9%85%B8%E3%82%84%E3%82%B3%E3%83%A9%E3%83%BC%E3%82%B2%E3%83%B3%E3%80%81%E3%82%B0%E3%83%AA%E3%82%B3%E3%82%B7%E3%83%AB%E3%82%BB%E3%83%A9%E3%83%9F%E3%83%89%E3%81%AA%E3%81%A9%E3%81%8C%E4%BA%BA%E6%B0%97%E3%81%A0%E3%80%82\" target=\"_blank\" rel=\"noreferrer noopener\">biyouhifuko.com<\/a><a href=\"https:\/\/biyouhifuko.com\/news\/japan\/6113\/#:~:text=%E3%81%BF%E3%82%92%E5%AF%BE%E8%B1%A1%E3%81%A8%E3%81%97%E3%81%A6%E3%81%84%E3%82%8B%E3%80%82\" target=\"_blank\" rel=\"noreferrer noopener\">biyouhifuko.com<\/a>\u3002\u6d88\u8cbb\u8005\u306e\u7f8e\u5bb9\u610f\u8b58\u9ad8\u307e\u308a\u3068\u76f8\u307e\u3063\u3066\u3001<strong>\u300c\u5916\u304b\u3089\u5857\u308b\uff0b\u4e2d\u304b\u3089\u6442\u308b\u300d\u7d71\u5408\u7684\u306a\u7f8e\u5bb9\u6cd5<\/strong>\u304c\u5b9a\u7740\u3057\u3064\u3064\u3042\u308b\u3002\u305f\u3060\u3057\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3042\u304f\u307e\u3067\u88dc\u52a9\u7684\u624b\u6bb5\u3067\u3042\u308a\u3001\u305d\u306e\u54c1\u8cea\u3084\u5b89\u5168\u6027\u306f\u7389\u77f3\u6df7\u4ea4\u3067\u3042\u308b\u305f\u3081\u3001\u533b\u7642\u5f93\u4e8b\u8005\u306f\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u6709\u7121\u3084\u904e\u5270\u6442\u53d6\u30ea\u30b9\u30af\u306b\u3082\u76ee\u3092\u914d\u308a\u3001\u60a3\u8005\u306b\u9069\u5207\u306a\u6307\u5c0e\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. 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class=\"wp-block-paragraph\"><strong>\u30b9\u30ad\u30f3\u30b1\u30a2\u6307\u5c0e<\/strong>\u306f\u7f8e\u5bb9\u76ae\u819a\u79d1\u8a3a\u7642\u306e\u57fa\u790e\u3067\u3042\u308a\u3001\u8fd1\u5e74\u3067\u306f\u533b\u5e2b\u304c\u95a2\u4e0e\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u9ad8\u6a5f\u80fd\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u3001\u3044\u308f\u3086\u308b<strong>\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1<\/strong>\uff08\u533b\u5e2b\u76e3\u4fee\u5316\u7ca7\u54c1\uff09\u304c\u5145\u5b9f\u3057\u3066\u3044\u308b\u3002\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1\u306b\u660e\u78ba\u306a\u5b9a\u7fa9\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u304c\u3001\u591a\u304f\u306f\u76ae\u819a\u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u3042\u308b\u6210\u5206\u3092\u9ad8\u6fc3\u5ea6\u914d\u5408\u3057\u3001\u5c02\u9580\u30af\u30ea\u30cb\u30c3\u30af\u3084\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642\u3092\u901a\u3058\u3066\u8ca9\u58f2\u3055\u308c\u308b<strong>\u30b3\u30b9\u30e1\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\uff08cosmeceutical\uff09\u88fd\u54c1\u3067\u3042\u308b<a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=%E3%83%89%E3%82%AF%E3%82%BF%E3%83%BC%E3%82%BA%E3%82%B3%E3%82%B9%E3%83%A1\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a>\u3002\u65e5\u672c\u56fd\u5185\u3067\u306f\u3001\u7c73\u56fd\u767a\u306e\u30bc\u30aa\u30b9\u30ad\u30f3\u30d8\u30eb\u30b9\uff08ZO Skin Health\uff09\u3084\u30b9\u30ad\u30f3\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba<\/strong>\u3001\u56fd\u7523\u306e<strong>\u30ec\u30ab\u30eb\u30ab<\/strong>\u3001<strong>\u30b7\u30b9\u30da\u30e9\uff08cyspera\uff09<\/strong>\uff08\u30b7\u30b9\u30c6\u30a2\u30df\u30f3\u914d\u5408\u30af\u30ea\u30fc\u30e0\uff09\u306a\u3069\u3001\u591a\u5f69\u306a\u30d6\u30e9\u30f3\u30c9\u304c\u533b\u7642\u6a5f\u95a2\u7d4c\u7531\u3067\u63d0\u4f9b\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=,%E3%82%BB%E3%83%AB%E3%83%97%E3%83%AD%E3%82%B8%E3%83%A3%E3%83%91%E3%83%B3\" target=\"_blank\" rel=\"noreferrer 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class=\"wp-block-paragraph\"><strong>\u533b\u7642\u6a5f\u95a2\u5c02\u58f2\u30b3\u30b9\u30e1<\/strong>\u306f\u6cd5\u5f8b\u4e0a\u306f\u3042\u304f\u307e\u3067\u5316\u7ca7\u54c1\u307e\u305f\u306f\u533b\u85ac\u90e8\u5916\u54c1\u3067\u3042\u308a\u3001\u533b\u85ac\u54c1\u6210\u5206\u306f\u914d\u5408\u3067\u304d\u306a\u3044\u3002\u3057\u304b\u3057\u5148\u8ff0\u306e\u3088\u3046\u306b\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f32%\u4ee5\u4e0b\u3084\u30ec\u30c1\u30ce\u30fc\u30eb\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3001\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3001\u30da\u30d7\u30c1\u30c9\u306a\u3069<strong>\u4f5c\u7528\u6a5f\u5e8f\u304c\u660e\u3089\u304b\u306a\u6709\u52b9\u6210\u5206<\/strong>\u3092\u9ad8\u6fc3\u5ea6\u306b\u914d\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u5b9f\u8cea\u7684\u306b\u6cbb\u7642\u7684\u52b9\u679c\u3092\u72d9\u3063\u3066\u3044\u308b<a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=%E3%83%89%E3%82%AF%E3%82%BF%E3%83%BC%E3%82%BA%E3%82%B3%E3%82%B9%E3%83%A1\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a><a href=\"https:\/\/aimed.jp\/items\/tretinoin_cream_0025#:~:text=,39\" target=\"_blank\" rel=\"noreferrer noopener\">aimed.jp<\/a>\u3002\u305f\u3068\u3048\u3070\u3042\u308b\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1\u306e\u7f8e\u767d\u7f8e\u5bb9\u6db2\u306b\u306f<strong>\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53 20%\u3068\u30a2\u30eb\u30d6\u30c1\u30f3<\/strong>\u3001<strong>\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178<\/strong>\u304c\u542b\u6709\u3055\u308c\u3001\u809d\u6591\u6cbb\u7642\u4e2d\u306e\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u51e6\u65b9\u3055\u308c\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308b\u3002<strong>\u30db\u30fc\u30e0\u30b1\u30a2<\/strong>\u3068\u3057\u3066\u60a3\u8005\u81ea\u8eab\u304c\u65e5\u3005\u4f7f\u3046\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u3001\u7f8e\u5bb9\u65bd\u8853\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u7dad\u6301\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308a\u3001\u533b\u5e2b\u304c\u60a3\u8005\u306e\u808c\u8cea\u30fb\u75c7\u72b6\u306b\u5408\u308f\u305b\u3066\u88fd\u54c1\u3092\u9078\u629e\u30fb\u6307\u5c0e\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d77\u5916\u306b\u76ee\u3092\u5411\u3051\u308b\u3068\u3001\u7c73\u56fd\u3067\u306f<strong>\u76ae\u819a\u79d1\u533b\u304c\u81ea\u9662\u3067\u5316\u7ca7\u54c1\u3092\u8ca9\u58f2<\/strong>\u3059\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3001\u300cPhysician-dispensed Cosmeceuticals\uff08\u533b\u5e2b\u8abf\u5264\u5316\u7ca7\u54c1\uff09\u300d\u3068\u3044\u3046\u5e02\u5834\u30ab\u30c6\u30b4\u30ea\u304c\u78ba\u7acb\u3057\u3066\u3044\u308b\u3002\u4e16\u754c\u306e\u533b\u5e2b\u8abf\u5264\u30b3\u30b9\u30e1\u5e02\u5834\u898f\u6a21\u306f2024\u5e74\u6642\u70b9\u3067\u7d04115.9\u5104\u30c9\u30eb\uff08\u7d041.6\u5146\u5186\uff09\u3068\u63a8\u5b9a\u3055\u308c\u30012033\u5e74\u306b\u306f237.5\u5104\u30c9\u30eb\u306b\u9054\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/straitsresearch.com\/report\/physician-dispensed-cosmeceuticals-market#:~:text=The%20global%20physician%20dispensed%20cosmeceuticals,2025%E2%80%932033\" target=\"_blank\" rel=\"noreferrer noopener\">straitsresearch.com<\/a>\u3002\u7279\u306b<strong>\u5317\u7c73<\/strong>\u304c\u5e02\u5834\u3092\u727d\u5f15\u3059\u308b\u4e00\u65b9\u3067\u3001<strong>\u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u57df<\/strong>\u304c\u6700\u3082\u6210\u9577\u7387\u304c\u9ad8\u3044\u3068\u3055\u308c\u308b<a href=\"https:\/\/straitsresearch.com\/report\/physician-dispensed-cosmeceuticals-market#:~:text=Base%20Year%20%202024%20Base,Growing%20Market%20%20Asia%20Pacific\" target=\"_blank\" rel=\"noreferrer noopener\">straitsresearch.com<\/a><a href=\"https:\/\/straitsresearch.com\/report\/physician-dispensed-cosmeceuticals-market#:~:text=The%20global%20physician%20dispensed%20cosmeceuticals,2025%E2%80%932033\" target=\"_blank\" rel=\"noreferrer noopener\">straitsresearch.com<\/a>\u3002\u3053\u308c\u306f\u30a2\u30b8\u30a2\u306e\u7f8e\u5bb9\u9700\u8981\u62e1\u5927\u3068\u5c02\u9580\u7684\u30b9\u30ad\u30f3\u30b1\u30a2\u5fd7\u5411\u306e\u9ad8\u307e\u308a\u306b\u3088\u308b\u3082\u306e\u3060\u3002\u97d3\u56fd\u306b\u304a\u3044\u3066\u3082\u3001\u76ae\u819a\u79d1\u3067<strong>\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1<\/strong>\u3092\u51e6\u65b9\u30fb\u8ca9\u58f2\u3059\u308b\u3053\u3068\u306f\u65e5\u5e38\u7684\u3067\u3042\u308a\u3001\u97d3\u56fd\u7523\u306e\u30ac\u30eb\u30fc\u30c0\uff08Galderma Korea\u306e\u4e00\u90e8\u9580\uff09\u3084DMK\u306a\u3069\u306e\u5c02\u9580\u30e9\u30a4\u30f3\u304c\u5b58\u5728\u3059\u308b\u3002\u6b27\u5dde\u3067\u3082\u533b\u5e2b\u304c\u7279\u5b9a\u30d6\u30e9\u30f3\u30c9\u3092\u63a8\u5968\u3059\u308b\u30b1\u30fc\u30b9\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u85ac\u5c40\u4e3b\u4f53\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6587\u5316\u304c\u5f37\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30c9\u30af\u30bf\u30fc\u30ba\u30b3\u30b9\u30e1\u306e\u5229\u70b9<\/strong>\u306f\u3001\u533b\u5e2b\u306e\u7ba1\u7406\u4e0b\u3067\u808c\u8cea\u3084\u6cbb\u7642\u7d4c\u904e\u306b\u5408\u308f\u305b\u3066\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3067\u304d\u308b\u70b9\u3067\u3042\u308b\u3002\u60a3\u8005\u306b\u3068\u3063\u3066\u3082\u300c\u533b\u5e2b\u304a\u58a8\u4ed8\u304d\u300d\u306e\u5b89\u5fc3\u611f\u304c\u3042\u308a\u3001\u5b9f\u969b\u306b\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf\u3092\u6301\u3064\u88fd\u54c1\u3082\u591a\u3044\u3002\u4e00\u65b9\u3067\u4fa1\u683c\u304c\u9ad8\u4fa1\u306b\u306a\u308a\u304c\u3061\u3067\u3042\u308b\u3053\u3068\u3001\u8aa4\u7528\u3059\u308b\u3068\u5f37\u3044\u53cd\u5fdc\uff08\u4f8b\uff1a\u30ec\u30c1\u30ce\u30fc\u30eb\u53cd\u5fdc\u306b\u3088\u308b\u76ae\u5265\u3051\uff09\u304c\u51fa\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u306b\u306f\u7559\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b<a href=\"https:\/\/straitsresearch.com\/report\/physician-dispensed-cosmeceuticals-market#:~:text=solutions%20for%20addressing%20concerns%20like,skin%20health%20and%20measurable%20results\" target=\"_blank\" rel=\"noreferrer noopener\">straitsresearch.com<\/a><a href=\"https:\/\/straitsresearch.com\/report\/physician-dispensed-cosmeceuticals-market#:~:text=Physician,more%20potent%20ingredients%20and%20may\" target=\"_blank\" rel=\"noreferrer noopener\">straitsresearch.com<\/a>\u3002\u533b\u5e2b\u306f\u88fd\u54c1\u77e5\u8b58\u3092\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\u3057\u3001\u9069\u5207\u306a\u4f7f\u7528\u65b9\u6cd5\u30fb\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3092\u6307\u5c0e\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u3002\u307e\u305f\u3001\u60a3\u8005\u306e\u7d4c\u6e08\u7684\u8ca0\u62c5\u306b\u3082\u914d\u616e\u3057\u3001\u5e02\u8ca9\u54c1\u3068\u306e\u4f75\u7528\u3084\u6bb5\u968e\u7684\u306a\u5c0e\u5165\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u6210\u9577\u56e0\u5b50\u30fb\u5e79\u7d30\u80de\u7531\u6765\u6210\u5206\u306e\u5fdc\u7528\u52d5\u5411<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u518d\u751f\u533b\u7642\u7684\u624b\u6cd5<\/strong>\u3092\u7f8e\u5bb9\u306b\u5fdc\u7528\u3059\u308b\u52d5\u304d\u3082\u6d3b\u767a\u5316\u3057\u3066\u3044\u308b\u3002\u7279\u306b<strong>\u6210\u9577\u56e0\u5b50<\/strong>\uff08\u30b0\u30ed\u30b9\u30d5\u30a1\u30af\u30bf\u30fc\uff09\u3084<strong>\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05<\/strong>\u3001<strong>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0<\/strong>\u3068\u3044\u3063\u305f\u300c\u7d30\u80de\u7531\u6765\u6210\u5206\u300d\u3092\u5229\u7528\u3057\u305f\u6cbb\u7642\u30fb\u88fd\u54c1\u306e\u958b\u767a\u304c\u8fd1\u5e74\u306e\u30c8\u30ec\u30f3\u30c9\u3067\u3042\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=platelet,free\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u7f8e\u5bb9\u76ae\u819a\u79d1\u9818\u57df\u3067\u6ce8\u76ee\u3055\u308c\u308b\u5177\u4f53\u7684\u624b\u6cd5\u3068\u3057\u3066\u306f\u3001\u4ee5\u4e0b\u304c\u6319\u3052\u3089\u308c\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PRP\u7642\u6cd5\uff08\u591a\u8840\u5c0f\u677f\u8840\u6f3f\u7642\u6cd5\uff09<\/strong>\uff1a\u60a3\u8005\u81ea\u8eab\u306e\u8840\u6db2\u304b\u3089\u8840\u5c0f\u677f\u6fc3\u7e2e\u6db2\u3092\u4f5c\u88fd\u3057\u3001\u76ae\u5185\u6ce8\u5c04\u307e\u305f\u306f\u30de\u30a4\u30af\u30ed\u30cb\u30fc\u30c9\u30ea\u30f3\u30b0\u3067\u76ae\u819a\u306b\u5c0e\u5165\u3059\u308b\u6cbb\u7642\u3002\u8840\u5c0f\u677f\u304b\u3089\u653e\u51fa\u3055\u308c\u308bPDGF\u3084TGF-\u03b2\u306a\u3069\u591a\u6570\u306e\u6210\u9577\u56e0\u5b50\u306b\u3088\u308a\u30b3\u30e9\u30fc\u30b2\u30f3\u65b0\u751f\u3084\u5275\u50b7\u6cbb\u7652\u304c\u4fc3\u3055\u308c\u3001<strong>\u808c\u8cea\u6539\u5584\u3084\u6bdb\u9aea\u518d\u751f<\/strong>\u306b\u52b9\u679c\u304c\u3042\u308b\u3068\u3055\u308c\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=regeneration,therapies%2C%20such%20as%20those%20employing\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u65e5\u672c\u3067\u3082\u518d\u751f\u533b\u7642\u7b49\u5b89\u5168\u78ba\u4fdd\u6cd5\u306b\u57fa\u3065\u304d\u3001\u9069\u5207\u306a\u624b\u7d9a\u304d\u3092\u7d4c\u305f\u533b\u7642\u6a5f\u95a2\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u3002PRP\u306f\u81ea\u5df1\u8840\u7531\u6765\u306e\u305f\u3081\u5b89\u5168\u6027\u304c\u9ad8\u304f\u3001\u6b27\u7c73\u3067\u3082<strong>\u30f4\u30a1\u30f3\u30d1\u30a4\u30a2\u30d5\u30a7\u30a4\u30b7\u30e3\u30eb<\/strong>\u3068\u3057\u3066\u4eba\u6c17\u3060\u304c\u3001\u52b9\u679c\u306f\u65bd\u8853\u8005\u306e\u6280\u8853\u3084\u60a3\u8005\u306e\u72b6\u614b\u306b\u4f9d\u5b58\u3057\u3001\u500b\u4eba\u5dee\u304c\u5927\u304d\u3044\u3002<\/li>\n\n\n\n<li><strong>\u5e79\u7d30\u80de\u7531\u6765\u57f9\u990a\u4e0a\u6e05\u30fb\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7642\u6cd5<\/strong>\uff1a\u30d2\u30c8\u8102\u80aa\u7531\u6765\u3084\u9aa8\u9ac4\u7531\u6765\u306e**\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09**\u3092\u57f9\u990a\u3057\u3001\u305d\u306e\u4e0a\u6e05\u4e2d\u306b\u5206\u6ccc\u3055\u308c\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u62bd\u51fa\u3057\u3066\u808c\u306b\u7528\u3044\u308b\u65b9\u6cd5\u3067\u3042\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=platelet,free\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u5e79\u7d30\u80de\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001<strong>\u7d30\u80de\u30d5\u30ea\u30fc\u7642\u6cd5<\/strong>\u306b\u5206\u985e\u3055\u308c\u3001\u7d30\u80de\u3092\u6271\u3046\u3088\u308a\u3082\u5b89\u5168\u304b\u3064\u624b\u8efd\u306b\u518d\u751f\u52b9\u679c\u3092\u5f97\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=platelet,free\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u7814\u7a76\u6bb5\u968e\u3067\u306f\u3001MSC\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u5c40\u6240\u6295\u4e0e\u306b\u3088\u308a\u5275\u50b7\u6cbb\u7652\u4fc3\u9032\u3084\u76ae\u819a\u5f3e\u529b\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u3001\u5c06\u6765\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u304a\u3051\u308b\u30ad\u30fc\u6280\u8853\u3068\u76ee\u3055\u308c\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=platelet,free\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u97d3\u56fd\u3084\u7c73\u56fd\u3067\u306f\u65e2\u306b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u542b\u6709\u306e\u7f8e\u5bb9\u6db2\u3084\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u4f7f\u3063\u305f\u65bd\u8853\uff08\u30de\u30a4\u30af\u30ed\u30cb\u30fc\u30c9\u30ea\u30f3\u30b0\u3068\u4f75\u7528\uff09\u304c\u4e00\u90e8\u306e\u30af\u30ea\u30cb\u30c3\u30af\u3067\u5c0e\u5165\u3055\u308c\u59cb\u3081\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u57f9\u990a\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u79fb\u690d<\/strong>\uff1a\u60a3\u8005\u81ea\u8eab\u306e\u76ae\u819a\u304b\u3089\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u57f9\u990a\u3057\u3001\u5897\u3084\u3057\u305f\u7d30\u80de\u3092\u30b7\u30ef\u90e8\u4f4d\u306a\u3069\u306b\u6ce8\u5165\u3057\u3066\u7d44\u7e54\u518d\u751f\u3092\u56f3\u308b\u6cbb\u7642\u3002\u3053\u308c\u306f\u65e5\u672c\u3067\u306f\u518d\u751f\u533b\u7642\u7b49\u306e\u5206\u985e\u306b\u8a72\u5f53\u3057\u3001\u73fe\u72b6\u3042\u307e\u308a\u666e\u53ca\u3057\u3066\u3044\u306a\u3044\u304c\u3001\u7c73\u56fd\u3067\u306fFibrocell\u793e\u306e\u300c\u30e9\u30dc\u30d5\u30a7\u30eb\uff08LaViv\uff09\u300d\u304c\u65e2\u306bFDA\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u3001\u307b\u3046\u308c\u3044\u7dda\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u305f\u7d4c\u7def\u304c\u3042\u308b\u3002\u305f\u3060\u3057\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3067\u3001\u73fe\u5728\u306f\u4e3b\u6d41\u3067\u306f\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7642\u6cd5<\/strong>\uff1a\u6210\u9577\u56e0\u5b50\u5358\u5264\u3092\u6ce8\u5c04\u30fb\u5857\u5e03\u3059\u308b\u8a66\u307f\u3082\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u4f8b\u3068\u3057\u3066**bFGF\uff08\u5869\u57fa\u6027\u7dda\u7dad\u82bd\u7d30\u80de\u6210\u9577\u56e0\u5b50\uff09**\u6ce8\u5c04\u306f\u9665\u51f9\u6027\u7622\u75d5\u6cbb\u7642\u3068\u3057\u3066\u4ee5\u524d\u65e5\u672c\u3067\u3082\u4e00\u90e8\u30af\u30ea\u30cb\u30c3\u30af\u3067\u884c\u308f\u308c\u3066\u3044\u305f\u304c\u3001\u904e\u5270\u306a\u8089\u82bd\u5897\u751f\u306b\u3088\u308b\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u304c\u3042\u308a\u3001\u73fe\u5728\u306f\u539a\u52b4\u7701\u304b\u3089\u901a\u77e5\u304c\u51fa\u3066\u5b9f\u65bd\u3055\u308c\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3002\u6210\u9577\u56e0\u5b50\u306f\u5f37\u529b\u3067\u5236\u5fa1\u304c\u96e3\u3057\u304f\u3001\u5b89\u5168\u57df\u306e\u78ba\u7acb\u304c\u8ab2\u984c\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6210\u9577\u56e0\u5b50\u3084\u5e79\u7d30\u80de\u7531\u6765\u6210\u5206\u306e\u5fdc\u7528\u306b\u95a2\u3057\u3066\u3001\u65e5\u672c\u306f\u614e\u91cd\u306a\u59ff\u52e2\u3092\u4fdd\u3061\u3064\u3064\u3082\u7740\u5b9f\u306b\u81e8\u5e8a\u7814\u7a76\u3092\u7a4d\u307f\u91cd\u306d\u3066\u3044\u308b\u3002\u7409\u7403\u5927\u5b66\u306a\u3069\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001MSC\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u7528\u3044\u305f\u76ae\u819a\u6cbb\u7642\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3092\u884c\u3063\u3066\u3044\u308b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=platelet,free\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35785041\/#:~:text=marrow%20MSCs%3B%20Cell,derived%20exosomes%3B%20MSCs%2C%20mesenchymal\" target=\"_blank\" rel=\"noreferrer 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href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=The%20Japanese%20skincare%20market%20can,The\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3001\u7279\u306b<strong>\u30b7\u30df\u4e88\u9632<\/strong>\u30ab\u30c6\u30b4\u30ea\u306e\u5e02\u5834\u306f\u904e\u53bb35\u5e74\u3067\u98db\u8e8d\u7684\u306b\u62e1\u5927\u3057\u30b9\u30ad\u30f3\u30b1\u30a2\u5e02\u5834\u306e\u7d0430%\u3092\u5360\u3081\u308b\u307e\u3067\u306b\u306a\u3063\u305f<a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=The%20Japanese%20skincare%20market%20can,ingredients%20in%20Japan%20are%20presented\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a>\u3002\u3053\u308c\u306f\u3001\u65e5\u672c\u4eba\u306e\u808c\u8cea\u30fb\u55dc\u597d\u306b\u5408\u3063\u305f\u7f8e\u767d\u6709\u52b9\u6210\u5206\u306e\u958b\u767a\u304c\u594f\u529f\u3057\u305f\u7d50\u679c\u3068\u3082\u8a00\u3048\u308b\u3002<\/p>\n\n\n\n<p 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href=\"https:\/\/note.com\/jihikencs_sasaki\/n\/n29e96da988bc#:~:text=%E7%BE%8E%E5%AE%B9%E5%8C%BB%E7%99%82%E3%81%AE%E5%B8%82%E5%A0%B4%E8%A6%8F%E6%A8%A1%E3%81%AF%E7%B4%84200%E5%84%84%E3%83%89%E3%83%AB%E3%80%82%202028%E5%B9%B4%E3%81%BE%E3%81%A7%E3%81%AB%E7%B4%84270%E5%84%84%E3%83%89%E3%83%AB%E3%81%BE%E3%81%A7%E6%88%90%E9%95%B7%E3%81%99%E3%82%8B%E8%A6%8B%E8%BE%BC%E3%81%BF%E3%81%A7%E3%81%82%E3%82%8B%E3%81%A8%E3%81%AE%E3%81%93%E3%81%A8%E3%80%82%20%E3%81%97%E3%81%8B%E3%81%97%E3%80%81%E6%97%A5%E6%9C%AC%E4%BA%BA%E3%81%AE%E7%BE%8E%E5%AE%B9%E5%8C%BB%E7%99%82%E3%81%AE%E5%88%A9%E7%94%A8%E7%8E%87%E3%81%AF%E3%81%99%E3%81%B9%E3%81%A6%E3%81%AE%E6%96%BD%E8%A1%93%E3%81%AB%E3%81%8A%E3%81%84%E3%81%A6%E6%9C%80%E4%B8%8B%E4%BD%8D%E3%81%A8%E3%81%84%E3%81%86%E7%B5%90%E6%9E%9C%E3%81%A0%E3%81%A3%E3%81%9F%E3%80%82%20%E7%90%86%E7%94%B1%E3%81%A8%E3%81%97%E3%81%A6%E3%80%81%E4%BB%A5%E4%B8%8B%E3%81%8C%E6%8C%99%E3%81%92%E3%82%89%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%EF%BC%9A\" target=\"_blank\" rel=\"noreferrer noopener\">note.com<\/a>\u3001\u9069\u5207\u306a\u77e5\u8b58\u3092\u6301\u3064\u533b\u7642\u8005\u304c\u5897\u3048\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u7f8e\u5bb9\u30b1\u30a2\u304c\u3088\u308a\u591a\u304f\u306e\u56fd\u6c11\u306b\u5c4a\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002\u305d\u306e\u5b9f\u73fe\u306e\u305f\u3081\u306b\u306f\u3001\u533b\u7642\u8005\u5074\u306e\u7814\u947d\u3068\u8aa0\u5b9f\u306a\u60c5\u5831\u63d0\u4f9b\u3001\u305d\u3057\u3066\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u88fd\u54c1\u30fb\u85ac\u5264\u306e\u9078\u629e\u304c\u307e\u3059\u307e\u3059\u91cd\u8981\u306b\u306a\u308b\u3060\u308d\u3046\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53c2\u8003\u6587\u732e<\/strong>\uff08\u8ad6\u6587\u30fb\u5b66\u4f1a\u8cc7\u6599\u30fb\u653f\u5e9c\u7d71\u8a08\u30fb\u696d\u754c\u30ec\u30dd\u30fc\u30c8\u306a\u3069\uff09\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Maeda K. <em>Timeline of 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Molecules. 2022;27(15):4774<a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=Japanese%20pharmaceutical%20cosmetics%2C%20often%20referred,are%20more%20effective%20than%20quasi\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a><a href=\"https:\/\/encyclopedia.pub\/entry\/25917#:~:text=adenosine%20monophosphate%20and%20dexpanthenol%20are,their%20effectiveness%20and%20adverse%20effects\" target=\"_blank\" rel=\"noreferrer noopener\">encyclopedia.pub<\/a><\/li>\n\n\n\n<li>Boo YC. <em>Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide to Control Skin Aging and Pigmentation<\/em>. Antioxidants (Basel). 2021;10(8):1315<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=response%2C%20enhances%20extracellular%20matrix%20and,suggested%20that%20nicotinamide%20will%20be\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8389214\/#:~:text=metabolites%20produced%20from%20it,to%20internal%20or%20external%20stressors\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov<\/a><\/li>\n\n\n\n<li>Mahajan R. <em>Systemic skin whitening\/lightening agents: What is the evidence?<\/em>. Indian J Dermatol Venereol Leprol. 2022;88(1):19-27<a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=marketed%20as%20a%20food%20or,6\" target=\"_blank\" rel=\"noreferrer noopener\">ijdvl.com<\/a><a href=\"https:\/\/ijdvl.com\/systemic-skin-whitening-lightening-agents-what-is-the-evidence\/#:~:text=Till%20date%20there%20is%20only,study%20was%20conducted%20during%20their\" target=\"_blank\" rel=\"noreferrer noopener\">ijdvl.com<\/a><\/li>\n\n\n\n<li>\u65e5\u672c\u9999\u7ca7\u54c1\u5b66\u4f1a. \u300c\u7f8e\u767d\u88fd\u54c1\u306e\u8a55\u4fa1\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 \u7b2c3\u7248\u300d. Journal of Japanese Cosmetic Science Society. 2018<a href=\"https:\/\/www.jcss.jp\/en\/journal\/pdf\/contents_guideline2.pdf#:~:text=During%20the%20period%20of%20the,excessive%20ex%02posure%20to%20UV%20radiation\" target=\"_blank\" rel=\"noreferrer noopener\">jcss.jp<\/a><\/li>\n\n\n\n<li>\u539a\u751f\u52b4\u50cd\u7701. \u300c\u533b\u7642\u5e83\u544a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3Q&amp;A\uff08\u672a\u627f\u8a8d\u533b\u85ac\u54c1\u7b49\u306b\u4fc2\u308b\u8981\u4ef6\uff09\u300d2021<a 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BCG Japan Report. 2023<a 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